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The map label for this gene is hisD

Identifier: 15603063

GI number: 15603063

Start: 1392120

End: 1393406

Strand: Direct

Name: hisD

Synonym: PM1198

Alternate gene names: 15603063

Gene position: 1392120-1393406 (Clockwise)

Preceding gene: 15603062

Following gene: 15603064

Centisome position: 61.67

GC content: 45.61

Gene sequence:

>1287_bases
ATGCAAACACTTATTTGGAATACGTTAAATTCAGCACAAAAACAAGCTGCACTTTCTCGCCCAGCTCAAGCCGTTGGTGA
ACAAATTACGCAAGCCGTGAATGCGATCAAAAGCAATGTCATCAACAATGGGGATAAGGCATTATTTGAACTTGCGGAAA
AATTCGATAAGACCACATTAGAAAGCCTTGTCATCTCAAAAGCCCAAGTTGAGCAAGCGAGCCAGCGTATTGCGACGGAA
TTAAAACAAGCGATTCAAACCGCCAAAGGCAATATTGAACGTTTCCACCAAGCACAAAAAAACCAAACGGTGGATCTGGA
AACCCAAGCCGGTGTGCGTTGCCAAGTCGTTACTCGCCCCATTCAAAACGTCGGTTTATATATCCCCGGTGGCTCTGCTC
CACTGTTTTCCACAGTGTTAATGCTTGCCGTCCCTGCCAAAATTGCTGGCTGTAAAACCATTGTGCTGTGTTCCCCACCA
CCTATTGCCGATGAAATTCTTTACACCGCCAATTTATGTGGTGTTGAAACCATTTATGCCATTGGAGGTGCTCAAGCCAT
TTTTGCCATGGCAAACGGCACGGAAAGCGTGCAGAAAGTGGATAAAATTTTCGGTCCGGGCAATGCCTTTGTCACCGAAG
CCAAACGTCAAGTATTACAACAAGGCACTGCGATTGATATGCCAGCCGGTCCCTCTGAAGTGTTAGTGATTGCTGATGAA
TTTGCCGATCCAGATTTTGTCGCCAGCGATTTACTTTCCCAAGCAGAACATGGCTCAGACAGCCAAGTGATTTTAGTCAC
TAACTGTGAAACGTTGGCAAAACAGACCGCACTTTCCATTGAGCAACAACTGGCTCGTTTACCAAGAGCAGAAACGGCTC
GTAAGGCACTTGCTCACAGTCGCACCTTTATCGCCGAAGATCTGCAACAATGTGTAGAAATTAGTAATGCTTATGCGCCT
GAACACTTGGTCGTACAGGTGGAAAATGCGCGTAACTTACTGCCGTTTTTAGATAACGCCGGCTCAATTTTCTTAGGGGC
ATATTCGCCTGAAAGTATGGGCGATTATGCTAGTGGTACCAATCACGTTCTACCGACCTACGGCTATACTCGCACCCATT
CAAGTTTAGGTTTAGCCGATTTTAGCAAACGGATGACAGTACAAGAACTCACCCCACAAGGCTTTAAAGATCTCGCGAAC
ACGGTGATGTTAATGGCAGAAGCAGAACAATTAGAAGCGCATAAGCAAGCAGTGGCAATTCGTTTAGAGAAATTAACTCA
GGAGTAA

Upstream 100 bases:

>100_bases
GCATTAAAATGGTGGGATTGGGAGATTGAGAAAATCACGCGTAATCTTGACTTTTTAACTGGCAAAATCAGTGACCCGAT
TGAGTAATCAAGGAAACAAT

Downstream 100 bases:

>100_bases
GTCATGTCAATTTCATCACTTTCACGCAAAAATATTCAAGCCTTAACGCCGTATCAATCGGCTCGGCGATTAGGCGGCAA
GGGCGATATTTGGTTAAATG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MQTLIWNTLNSAQKQAALSRPAQAVGEQITQAVNAIKSNVINNGDKALFELAEKFDKTTLESLVISKAQVEQASQRIATE
LKQAIQTAKGNIERFHQAQKNQTVDLETQAGVRCQVVTRPIQNVGLYIPGGSAPLFSTVLMLAVPAKIAGCKTIVLCSPP
PIADEILYTANLCGVETIYAIGGAQAIFAMANGTESVQKVDKIFGPGNAFVTEAKRQVLQQGTAIDMPAGPSEVLVIADE
FADPDFVASDLLSQAEHGSDSQVILVTNCETLAKQTALSIEQQLARLPRAETARKALAHSRTFIAEDLQQCVEISNAYAP
EHLVVQVENARNLLPFLDNAGSIFLGAYSPESMGDYASGTNHVLPTYGYTRTHSSLGLADFSKRMTVQELTPQGFKDLAN
TVMLMAEAEQLEAHKQAVAIRLEKLTQE

Sequences:

>Translated_428_residues
MQTLIWNTLNSAQKQAALSRPAQAVGEQITQAVNAIKSNVINNGDKALFELAEKFDKTTLESLVISKAQVEQASQRIATE
LKQAIQTAKGNIERFHQAQKNQTVDLETQAGVRCQVVTRPIQNVGLYIPGGSAPLFSTVLMLAVPAKIAGCKTIVLCSPP
PIADEILYTANLCGVETIYAIGGAQAIFAMANGTESVQKVDKIFGPGNAFVTEAKRQVLQQGTAIDMPAGPSEVLVIADE
FADPDFVASDLLSQAEHGSDSQVILVTNCETLAKQTALSIEQQLARLPRAETARKALAHSRTFIAEDLQQCVEISNAYAP
EHLVVQVENARNLLPFLDNAGSIFLGAYSPESMGDYASGTNHVLPTYGYTRTHSSLGLADFSKRMTVQELTPQGFKDLAN
TVMLMAEAEQLEAHKQAVAIRLEKLTQE
>Mature_428_residues
MQTLIWNTLNSAQKQAALSRPAQAVGEQITQAVNAIKSNVINNGDKALFELAEKFDKTTLESLVISKAQVEQASQRIATE
LKQAIQTAKGNIERFHQAQKNQTVDLETQAGVRCQVVTRPIQNVGLYIPGGSAPLFSTVLMLAVPAKIAGCKTIVLCSPP
PIADEILYTANLCGVETIYAIGGAQAIFAMANGTESVQKVDKIFGPGNAFVTEAKRQVLQQGTAIDMPAGPSEVLVIADE
FADPDFVASDLLSQAEHGSDSQVILVTNCETLAKQTALSIEQQLARLPRAETARKALAHSRTFIAEDLQQCVEISNAYAP
EHLVVQVENARNLLPFLDNAGSIFLGAYSPESMGDYASGTNHVLPTYGYTRTHSSLGLADFSKRMTVQELTPQGFKDLAN
TVMLMAEAEQLEAHKQAVAIRLEKLTQE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=425, Percent_Identity=64.9411764705882, Blast_Score=561, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6319819, Length=422, Percent_Identity=49.7630331753554, Blast_Score=397, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_PASMU (Q9CLM4)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246135.1
- ProteinModelPortal:   Q9CLM4
- SMR:   Q9CLM4
- GeneID:   1244545
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1198
- NMPDR:   fig|272843.1.peg.1198
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   PMUL272843:PM1198-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46150; Mature: 46150

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 321-321 ACT_SITE 322-322 BINDING 127-127 BINDING 185-185 BINDING 208-208 BINDING 232-232 BINDING 254-254 BINDING 257-257 BINDING 322-322 BINDING 355-355 BINDING 409-409 BINDING 414-414

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLIWNTLNSAQKQAALSRPAQAVGEQITQAVNAIKSNVINNGDKALFELAEKFDKTTL
CCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ESLVISKAQVEQASQRIATELKQAIQTAKGNIERFHQAQKNQTVDLETQAGVRCQVVTRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEECCCCCEEEEEECC
IQNVGLYIPGGSAPLFSTVLMLAVPAKIAGCKTIVLCSPPPIADEILYTANLCGVETIYA
HHHCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHH
IGGAQAIFAMANGTESVQKVDKIFGPGNAFVTEAKRQVLQQGTAIDMPAGPSEVLVIADE
HCCHHHEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECC
FADPDFVASDLLSQAEHGSDSQVILVTNCETLAKQTALSIEQQLARLPRAETARKALAHS
CCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RTFIAEDLQQCVEISNAYAPEHLVVQVENARNLLPFLDNAGSIFLGAYSPESMGDYASGT
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHCCCCCEEEECCCCCCCCCCCCCC
NHVLPTYGYTRTHSSLGLADFSKRMTVQELTPQGFKDLANTVMLMAEAEQLEAHKQAVAI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLEKLTQE
HHHHHHCC
>Mature Secondary Structure
MQTLIWNTLNSAQKQAALSRPAQAVGEQITQAVNAIKSNVINNGDKALFELAEKFDKTTL
CCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ESLVISKAQVEQASQRIATELKQAIQTAKGNIERFHQAQKNQTVDLETQAGVRCQVVTRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEECCCCCEEEEEECC
IQNVGLYIPGGSAPLFSTVLMLAVPAKIAGCKTIVLCSPPPIADEILYTANLCGVETIYA
HHHCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHH
IGGAQAIFAMANGTESVQKVDKIFGPGNAFVTEAKRQVLQQGTAIDMPAGPSEVLVIADE
HCCHHHEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECC
FADPDFVASDLLSQAEHGSDSQVILVTNCETLAKQTALSIEQQLARLPRAETARKALAHS
CCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RTFIAEDLQQCVEISNAYAPEHLVVQVENARNLLPFLDNAGSIFLGAYSPESMGDYASGT
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHCCCCCEEEECCCCCCCCCCCCCC
NHVLPTYGYTRTHSSLGLADFSKRMTVQELTPQGFKDLANTVMLMAEAEQLEAHKQAVAI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLEKLTQE
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100