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The map label for this gene is mtr [H]

Identifier: 15603057

GI number: 15603057

Start: 1386286

End: 1387542

Strand: Direct

Name: mtr [H]

Synonym: PM1192

Alternate gene names: 15603057

Gene position: 1386286-1387542 (Clockwise)

Preceding gene: 15603054

Following gene: 15603058

Centisome position: 61.41

GC content: 43.2

Gene sequence:

>1257_bases
ATGACAACAAAACAATTGCCTTCTCTTTTAGGTGGCGCCATGATTATTGCCGGTACAGCGATCGGTGCTGGTATGTTAGC
CAATCCAACGGCTACAGCAGGCGTTTGGTTTATCGGTTCTCTTCTTCTATTAGCCTACACTTGGTTTTGCATGACCACGT
CAGGCTTAATGATCCTTGAAGCCAATTTACACTACCCAACAGGGGCGAGTTTTGACACCATCGTGAAAGATTTACTCGGC
AAACGCTGGAATCTCATCAATGGCTTATCTATCGCTTTTGTATTATATATTTTAACGTATGCTTATATCACATCTGGTGG
TGGCATTACCCAACATCTCTTAAATCAAGTTCTCAGCCGCCCTGACAATACGGTGGAAATTGGACGTGGCTTGGGGTCTT
TACTTTTTTGTTGCGTGCTCGCTGGATTTGTCTGGTTATCGACTAAAGCCGTGGATCGTTTTACCACTGTACTGATCGGT
GGCATGATCATCGCCTTTCTTCTTTCCACGAGTGGACTCATGGCTTCTGTCAGAAGTGATGTGCTTTTCAATAATCTTGC
GCAAGGGGAAACACACTATTTACCTTATTTTCTCACCGCACTTCCTGTTTGCTTAGTCTCCTTTGGCTTTCACGGTAATG
TACCAAGCTTAGTAAAATACTACGATCGTCATGCTCAATCTGTGGTCAAAGCAATCTTCCTCGGTACCGGTATCGCCTTC
GTGATCTATGCATTTTGGCAGCTTGCGGTACAAGGGAATTTACCTCGCCATCAATTTGCACCAGTCATTGAAAAAGGGGG
TGATATTGCTGCCTTACTAAAAGCCTTATCGCAATATATCCAAACCGATTACATGGGCGTCGTACTTAATTTCTTTGCTT
ATATGGCGATTGCAAGCTCATTTTTAGGCGTCAGTTTGGGTTTATTTGATTACCTTGCGGACTTATTAAAATTTGATGAC
AGTAGCTTAGGGCGAACTAAAACCACGTTAGTGACCTTTCTGCCTCCGCTCTTACTCAGCTTACAATTCCCTTATGGGTT
TGTCGTGGCAATTGGGTATGCAGGCTTAGCCGCCACCATTTGGGCAGCGATTGTCCCAGCCCTATTAGCGAAAGCCACAC
GCCAGCGTTTCACGGAATCTCACTATACTGTTTATGGTGGTAACTTCATGATTTATTTTGTGATTTTATTTGGTTTGTTA
AATATTTTGGCACAAATTGCTGCTCAATTTGGTGTTTTACCGACATTTTTAGGTTAA

Upstream 100 bases:

>100_bases
AATTGCGTTGTTTAACAAAAATCCATTGCTTTTTATTTTTGCACTATTAAAATAGTGCAAATTATTTTTTATAAACTCAT
AACAACACAGTGGTACTTTT

Downstream 100 bases:

>100_bases
AGCTCACAAATTTAATGCAAAGTACTTGGCTTGACACAAAATTTTAAGTATATAGTTAGCGGATTTTTTTCTCTTAAGAG
GTTTACCATGAAAAAATTAA

Product: Mtr

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTTKQLPSLLGGAMIIAGTAIGAGMLANPTATAGVWFIGSLLLLAYTWFCMTTSGLMILEANLHYPTGASFDTIVKDLLG
KRWNLINGLSIAFVLYILTYAYITSGGGITQHLLNQVLSRPDNTVEIGRGLGSLLFCCVLAGFVWLSTKAVDRFTTVLIG
GMIIAFLLSTSGLMASVRSDVLFNNLAQGETHYLPYFLTALPVCLVSFGFHGNVPSLVKYYDRHAQSVVKAIFLGTGIAF
VIYAFWQLAVQGNLPRHQFAPVIEKGGDIAALLKALSQYIQTDYMGVVLNFFAYMAIASSFLGVSLGLFDYLADLLKFDD
SSLGRTKTTLVTFLPPLLLSLQFPYGFVVAIGYAGLAATIWAAIVPALLAKATRQRFTESHYTVYGGNFMIYFVILFGLL
NILAQIAAQFGVLPTFLG

Sequences:

>Translated_418_residues
MTTKQLPSLLGGAMIIAGTAIGAGMLANPTATAGVWFIGSLLLLAYTWFCMTTSGLMILEANLHYPTGASFDTIVKDLLG
KRWNLINGLSIAFVLYILTYAYITSGGGITQHLLNQVLSRPDNTVEIGRGLGSLLFCCVLAGFVWLSTKAVDRFTTVLIG
GMIIAFLLSTSGLMASVRSDVLFNNLAQGETHYLPYFLTALPVCLVSFGFHGNVPSLVKYYDRHAQSVVKAIFLGTGIAF
VIYAFWQLAVQGNLPRHQFAPVIEKGGDIAALLKALSQYIQTDYMGVVLNFFAYMAIASSFLGVSLGLFDYLADLLKFDD
SSLGRTKTTLVTFLPPLLLSLQFPYGFVVAIGYAGLAATIWAAIVPALLAKATRQRFTESHYTVYGGNFMIYFVILFGLL
NILAQIAAQFGVLPTFLG
>Mature_417_residues
TTKQLPSLLGGAMIIAGTAIGAGMLANPTATAGVWFIGSLLLLAYTWFCMTTSGLMILEANLHYPTGASFDTIVKDLLGK
RWNLINGLSIAFVLYILTYAYITSGGGITQHLLNQVLSRPDNTVEIGRGLGSLLFCCVLAGFVWLSTKAVDRFTTVLIGG
MIIAFLLSTSGLMASVRSDVLFNNLAQGETHYLPYFLTALPVCLVSFGFHGNVPSLVKYYDRHAQSVVKAIFLGTGIAFV
IYAFWQLAVQGNLPRHQFAPVIEKGGDIAALLKALSQYIQTDYMGVVLNFFAYMAIASSFLGVSLGLFDYLADLLKFDDS
SLGRTKTTLVTFLPPLLLSLQFPYGFVVAIGYAGLAATIWAAIVPALLAKATRQRFTESHYTVYGGNFMIYFVILFGLLN
ILAQIAAQFGVLPTFLG

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=416, Percent_Identity=52.1634615384615, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1790145, Length=414, Percent_Identity=45.4106280193237, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI1788218, Length=407, Percent_Identity=37.8378378378378, Blast_Score=229, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 45202; Mature: 45071

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
TTKQLPSLLGGAMIIAGTAIGAGMLANPTATAGVWFIGSLLLLAYTWFCMTTSGLMILE
CHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ANLHYPTGASFDTIVKDLLGKRWNLINGLSIAFVLYILTYAYITSGGGITQHLLNQVLSR
ECCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
PDNTVEIGRGLGSLLFCCVLAGFVWLSTKAVDRFTTVLIGGMIIAFLLSTSGLMASVRSD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLFNNLAQGETHYLPYFLTALPVCLVSFGFHGNVPSLVKYYDRHAQSVVKAIFLGTGIAF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VIYAFWQLAVQGNLPRHQFAPVIEKGGDIAALLKALSQYIQTDYMGVVLNFFAYMAIASS
HHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVSLGLFDYLADLLKFDDSSLGRTKTTLVTFLPPLLLSLQFPYGFVVAIGYAGLAATI
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WAAIVPALLAKATRQRFTESHYTVYGGNFMIYFVILFGLLNILAQIAAQFGVLPTFLG
HHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]