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The map label for this gene is fpg

Identifier: 15603010

GI number: 15603010

Start: 1344583

End: 1345395

Strand: Reverse

Name: fpg

Synonym: PM1145

Alternate gene names: 15603010

Gene position: 1345395-1344583 (Counterclockwise)

Preceding gene: 15603011

Following gene: 15603006

Centisome position: 59.6

GC content: 39.61

Gene sequence:

>813_bases
ATGCCAGAATTACCTGAAGTTGAAACCACAAAAAATGGAATTAGCCCTTATCTTGAAGGGGCTATCATTGAAAAAATTGT
TGTTCGCCAACCGAAATTACGCTGGATGGTAAGCGAAGAATTAGCGCAAATTACACAACAAAAAGTCATCGCATTAAGTC
GCCGTGCGAAGTATTTAATTATCCAACTTGAAACAGGCTATATGATTGGACATTTAGGGATGTCAGGGTCATTGAGAGTT
GTGGAGAAAGGGGATCTTATTGATAAACATGATCATCTTGATATCGTAGTGAATAACGGAAAAGTTGTGCGTTATAACGA
TCCTCGTCGTTTTGGCGCGTGGTTATGGACAGAGAAGTTGGACGAATTTCCTCTTTTTCTGAAATTAGGTCCAGAGCCTC
TGTCTGAGGAATTTGATTCTGATTACTTGTGGCAAAAAAGTCGTAAAAAACAGACCGCACTTAAAACTTTTTTAATGGAT
AATGCTGTCGTCGTTGGCGTTGGGAATATCTATGCGAATGAAACGTTATTTCTTTGTAACCTACATCCGCAAAAAACAGC
AGGAAGTTTAACTAAGGCACAATGTGGGCAGTTAGTAGAACAAATAAAACAAGTGCTGTCTAACGCAATCCAACAAGGTG
GTACGACGCTAAAAGATTTTCTCCAACCGGATGGGCGTCCAGGTTATTTTGTCCAAGAATTGCGGGTTTATGGTAATAAG
GATAAGCCTTGTCCAACATGTGGCACAAAAATAGAAAGTTTAGTGATAGGGCAACGAAATAGTTTCTATTGCCCCAAGTG
TCAGAAGAGATAA

Upstream 100 bases:

>100_bases
CGGACAAAAATATTTACGCGATTGCGGCTTTTTGCCTGCCAATCATACCTGATGAATAGTTTGGATATTATCAATTATAA
GATTTATGGATATATAACCT

Downstream 100 bases:

>100_bases
GACTATCTGACAAGCCATGCAGGGTCAATTTGTTCAGGTGAGAGCTCATTAATATTTTCTTTATAGAAAAGTATGTGCGT
TTCTGCCTGACTTTTGGGTT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MPELPEVETTKNGISPYLEGAIIEKIVVRQPKLRWMVSEELAQITQQKVIALSRRAKYLIIQLETGYMIGHLGMSGSLRV
VEKGDLIDKHDHLDIVVNNGKVVRYNDPRRFGAWLWTEKLDEFPLFLKLGPEPLSEEFDSDYLWQKSRKKQTALKTFLMD
NAVVVGVGNIYANETLFLCNLHPQKTAGSLTKAQCGQLVEQIKQVLSNAIQQGGTTLKDFLQPDGRPGYFVQELRVYGNK
DKPCPTCGTKIESLVIGQRNSFYCPKCQKR

Sequences:

>Translated_270_residues
MPELPEVETTKNGISPYLEGAIIEKIVVRQPKLRWMVSEELAQITQQKVIALSRRAKYLIIQLETGYMIGHLGMSGSLRV
VEKGDLIDKHDHLDIVVNNGKVVRYNDPRRFGAWLWTEKLDEFPLFLKLGPEPLSEEFDSDYLWQKSRKKQTALKTFLMD
NAVVVGVGNIYANETLFLCNLHPQKTAGSLTKAQCGQLVEQIKQVLSNAIQQGGTTLKDFLQPDGRPGYFVQELRVYGNK
DKPCPTCGTKIESLVIGQRNSFYCPKCQKR
>Mature_269_residues
PELPEVETTKNGISPYLEGAIIEKIVVRQPKLRWMVSEELAQITQQKVIALSRRAKYLIIQLETGYMIGHLGMSGSLRVV
EKGDLIDKHDHLDIVVNNGKVVRYNDPRRFGAWLWTEKLDEFPLFLKLGPEPLSEEFDSDYLWQKSRKKQTALKTFLMDN
AVVVGVGNIYANETLFLCNLHPQKTAGSLTKAQCGQLVEQIKQVLSNAIQQGGTTLKDFLQPDGRPGYFVQELRVYGNKD
KPCPTCGTKIESLVIGQRNSFYCPKCQKR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=269, Percent_Identity=57.2490706319703, Blast_Score=328, Evalue=3e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_PASMU (P57910)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246082.1
- ProteinModelPortal:   P57910
- SMR:   P57910
- GeneID:   1244492
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1145
- NMPDR:   fig|272843.1.peg.1145
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- ProtClustDB:   PRK01103
- BioCyc:   PMUL272843:PM1145-MONOMER
- BRENDA:   3.2.2.23
- BRENDA:   4.2.99.18
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30613; Mature: 30482

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 57-57 ACT_SITE 259-259 BINDING 90-90 BINDING 109-109 BINDING 150-150

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETTKNGISPYLEGAIIEKIVVRQPKLRWMVSEELAQITQQKVIALSRRAKYLI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
IQLETGYMIGHLGMSGSLRVVEKGDLIDKHDHLDIVVNNGKVVRYNDPRRFGAWLWTEKL
EEEECCEEEEECCCCCCEEEEECCCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHH
DEFPLFLKLGPEPLSEEFDSDYLWQKSRKKQTALKTFLMDNAVVVGVGNIYANETLFLCN
CCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEECCEEEEEE
LHPQKTAGSLTKAQCGQLVEQIKQVLSNAIQQGGTTLKDFLQPDGRPGYFVQELRVYGNK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHCCC
DKPCPTCGTKIESLVIGQRNSFYCPKCQKR
CCCCCCCHHHHHHHEECCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETTKNGISPYLEGAIIEKIVVRQPKLRWMVSEELAQITQQKVIALSRRAKYLI
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
IQLETGYMIGHLGMSGSLRVVEKGDLIDKHDHLDIVVNNGKVVRYNDPRRFGAWLWTEKL
EEEECCEEEEECCCCCCEEEEECCCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHH
DEFPLFLKLGPEPLSEEFDSDYLWQKSRKKQTALKTFLMDNAVVVGVGNIYANETLFLCN
CCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEECCEEEEEE
LHPQKTAGSLTKAQCGQLVEQIKQVLSNAIQQGGTTLKDFLQPDGRPGYFVQELRVYGNK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHCCC
DKPCPTCGTKIESLVIGQRNSFYCPKCQKR
CCCCCCCHHHHHHHEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100