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The map label for this gene is menB [H]

Identifier: 15602961

GI number: 15602961

Start: 1290531

End: 1291388

Strand: Reverse

Name: menB [H]

Synonym: PM1096

Alternate gene names: 15602961

Gene position: 1291388-1290531 (Counterclockwise)

Preceding gene: 15602962

Following gene: 15602960

Centisome position: 57.2

GC content: 43.47

Gene sequence:

>858_bases
ATGCAAAATCCAAAAGATGACGTACTTTATGCGCCGATTGAATGGCAAGACCACAGTGAAGGGTATACCGATATTCTTTA
TCATAAATCGCTCGATGGGATTGCGAAAATTACCATTAATCGCCCTGAAGTACGTAACGCATTTCGTCCCCAAACCGTGA
AAGAAATGATTCAAGCCTTTGCCGATGCGCGTTTTGATGAACAAATTGGTGTGATTGTATTAACGGGACAAGGTGAAAAA
GCGTTTTGTTCTGGGGGTGATCAAAAAGTGCGTGGCGATTATGGCGGTTATCAAGATGAGAGCGGTGTACATCATTTAAA
TGTATTGGATTTTCAACGTGATATTCGTACTTGTCCAAAACCAGTGGTCGCCATGGTGGCGGGTTATGCGATTGGTGGTG
GGCATGTATTACATATGATTTGTGATTTAACCATTGCTGCAGACAATGCGATTTTTGGTCAAACAGGACCTAAAGTGGGT
TCCTTTGACGGTGGTTGGGGCGCAAGTTATATGGCGCGTATCGTTGGTCAGAAAAAAGCGCGTGAAATTTGGTTCTTATG
TCGTCAATATGACGCCAAAGAAGCCTTGGAAATGGGGTTAGTGAATACAGTCGTGCCTTACGCGGAGTTAGAAAAAGAAA
CCGTGCGTTGGTGCCGTGAAATGTTGCGTAATAGTCCAATTGCATTACGTTGTTTAAAAGCTGCATTAAATGCAGACTGT
GATGGACAAGCGGGCTTACAAGAGTTAGCGGGCAATGCGACGATGTTATTCTATATGACAGAAGAAGGCCAAGAAGGGCG
CAATGCGTTTAATGAAAAACGTGCGCCTGACTTCAGTAAATTTAAACGTAATCCCTGA

Upstream 100 bases:

>100_bases
TGCAATAGGCAGAGCTAAGAATTTATCACCGATTGATAAAACATCCGCTATAATGGACGAACTTTTTAGAACAAGAGAAC
TCAAATTTAAGGAATTTATC

Downstream 100 bases:

>100_bases
TCCAAGTATTGTTGTAAGCGGTGAGCTTGTTGCGAGTGAACTGCATTGTTTAACATGAAGTAAATACATAAGGAAGATGT
CTATGTTTTCTTGGAAGAAA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MQNPKDDVLYAPIEWQDHSEGYTDILYHKSLDGIAKITINRPEVRNAFRPQTVKEMIQAFADARFDEQIGVIVLTGQGEK
AFCSGGDQKVRGDYGGYQDESGVHHLNVLDFQRDIRTCPKPVVAMVAGYAIGGGHVLHMICDLTIAADNAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAKEALEMGLVNTVVPYAELEKETVRWCREMLRNSPIALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRAPDFSKFKRNP

Sequences:

>Translated_285_residues
MQNPKDDVLYAPIEWQDHSEGYTDILYHKSLDGIAKITINRPEVRNAFRPQTVKEMIQAFADARFDEQIGVIVLTGQGEK
AFCSGGDQKVRGDYGGYQDESGVHHLNVLDFQRDIRTCPKPVVAMVAGYAIGGGHVLHMICDLTIAADNAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAKEALEMGLVNTVVPYAELEKETVRWCREMLRNSPIALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRAPDFSKFKRNP
>Mature_285_residues
MQNPKDDVLYAPIEWQDHSEGYTDILYHKSLDGIAKITINRPEVRNAFRPQTVKEMIQAFADARFDEQIGVIVLTGQGEK
AFCSGGDQKVRGDYGGYQDESGVHHLNVLDFQRDIRTCPKPVVAMVAGYAIGGGHVLHMICDLTIAADNAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAKEALEMGLVNTVVPYAELEKETVRWCREMLRNSPIALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRAPDFSKFKRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=250, Percent_Identity=32.8, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI31542718, Length=252, Percent_Identity=31.7460317460317, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI4502327, Length=253, Percent_Identity=30.0395256916996, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI45643119, Length=220, Percent_Identity=30, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI260275230, Length=220, Percent_Identity=30, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI260274832, Length=220, Percent_Identity=30, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI70995211, Length=241, Percent_Identity=29.045643153527, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4757966, Length=235, Percent_Identity=25.9574468085106, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538581, Length=235, Percent_Identity=25.9574468085106, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI25453481, Length=235, Percent_Identity=25.9574468085106, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538573, Length=235, Percent_Identity=25.9574468085106, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4757968, Length=233, Percent_Identity=25.7510729613734, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI49355787, Length=233, Percent_Identity=25.7510729613734, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI157694516, Length=225, Percent_Identity=25.3333333333333, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI213417737, Length=225, Percent_Identity=25.3333333333333, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI37594469, Length=175, Percent_Identity=24, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI37594471, Length=175, Percent_Identity=24, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788597, Length=285, Percent_Identity=87.3684210526316, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1787659, Length=244, Percent_Identity=30.7377049180328, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI221142681, Length=207, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87082183, Length=257, Percent_Identity=28.0155642023346, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787660, Length=265, Percent_Identity=29.0566037735849, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788682, Length=230, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=251, Percent_Identity=33.4661354581673, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17554946, Length=248, Percent_Identity=32.258064516129, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=206, Percent_Identity=29.126213592233, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17549921, Length=199, Percent_Identity=28.643216080402, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=264, Percent_Identity=27.6515151515151, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=215, Percent_Identity=27.4418604651163, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=203, Percent_Identity=27.0935960591133, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=34.9397590361446, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=34.9397590361446, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24653139, Length=267, Percent_Identity=28.4644194756554, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357171, Length=188, Percent_Identity=31.9148936170213, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19922422, Length=199, Percent_Identity=29.1457286432161, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24654903, Length=203, Percent_Identity=28.0788177339901, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24650670, Length=178, Percent_Identity=30.3370786516854, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31733; Mature: 31733

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNPKDDVLYAPIEWQDHSEGYTDILYHKSLDGIAKITINRPEVRNAFRPQTVKEMIQAF
CCCCCCCEEECCCCCCCCCCCCHHHHHHCCCCCEEEEEECCHHHHHCCCCHHHHHHHHHH
ADARFDEQIGVIVLTGQGEKAFCSGGDQKVRGDYGGYQDESGVHHLNVLDFQRDIRTCPK
HCCCCCCCCCEEEEECCCCCHHHCCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHHCCH
PVVAMVAGYAIGGGHVLHMICDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRQYDAKEALEMGLVNTVVPYAELEKETVRWCREMLRNSPIALRCLKAALNADC
HHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRAPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure
MQNPKDDVLYAPIEWQDHSEGYTDILYHKSLDGIAKITINRPEVRNAFRPQTVKEMIQAF
CCCCCCCEEECCCCCCCCCCCCHHHHHHCCCCCEEEEEECCHHHHHCCCCHHHHHHHHHH
ADARFDEQIGVIVLTGQGEKAFCSGGDQKVRGDYGGYQDESGVHHLNVLDFQRDIRTCPK
HCCCCCCCCCEEEEECCCCCHHHCCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHHCCH
PVVAMVAGYAIGGGHVLHMICDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRQYDAKEALEMGLVNTVVPYAELEKETVRWCREMLRNSPIALRCLKAALNADC
HHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRAPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]