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The map label for this gene is menC

Identifier: 15602959

GI number: 15602959

Start: 1289265

End: 1290278

Strand: Reverse

Name: menC

Synonym: PM1094

Alternate gene names: 15602959

Gene position: 1290278-1289265 (Counterclockwise)

Preceding gene: 15602960

Following gene: 15602958

Centisome position: 57.16

GC content: 43.69

Gene sequence:

>1014_bases
ATGACCATGATAAGAAAATTTAAGTTATATCAATACAGTATTCCCGTCGATAGCCAACTCATTTTACGCAATCGTTTCTT
AAAAAAGCGTGAAGGGTTGCTAGTGCAAGTTTGCTGTGATGATGCACAAGGTTGGGGGGAAATTGCCCCCCTACCTGAGT
TTAGCCAAGAAACTTTAGAGCAGGCGCGTGAACAAGCATTAGCATGGTTAGAAGAATGGTCTGCCAGTGATGGTTCAGCC
GGAAAATTGCCTTTAGAGCATTTATTTCCTTCCGTGGCATTTGGTTTAAGCTGTGCGTTAGCGGAAATGAAGGGGTTACT
ACATGAAGAAGGCAATTATCAAGTGGCACCACTTTGTTATGGTGATCCTGATGAATTATATGATCCCCTCAACCAAATGC
AAGGTGAAAAAGTCGCCAAAATTAAAGTGGGGATGTATGAAGCTAATCGCGATGGGCTAATTGCGGATATGCTCCTTGAA
GCCATTCCTGATTTACATTTACGCCTTGATGCGAACCGCAGTTGGACGCCGAGCAAAGCACAGATGTTTGCGAAATATGT
CAAACCAGAACATCGTGCACGCATTCAATTTTTAGAAGAACCGTGTAAAACGCCAGCAGAAAGCCTGCAATTTGCGGAAG
AAACCGGTATTGCGATAGCCTGGGATGAAACAGTACGTGACGCAGAATTTCAACAAAATCCACCGCACTTTTTTACGCCT
CAAGTGAAAGCCATTGTGATCAAGCCAACGTTAGTGGGTTCTATACAACGCTGTGTTGAATTGATTAAGCAAGCACATGC
GCATGGAATACAAGCGGTAATCAGTTCTTCCATTGAAAGTAGCCTAGGGTTAACGCAATTAGCACGTCTTGCGCAACAAT
ATACCCCAAATACGGTGCCGGGACTGGATACGCTAGATTTGATGGATTACCAAGTGATACGTCCGTGGCCAAGCTCAACG
TTACCACTGATTGACTTAGATTCAGAATATATTGTTCCCATTAAGCTGGACTGA

Upstream 100 bases:

>100_bases
CGGTATTTTTTGTCGGTATGGCGCTGTTAACGCTTGATCCGAAAGACCGTTGTTTAGATTATGGTGGACGTTATGACGAT
GCAACAAAAATATGTGAAAA

Downstream 100 bases:

>100_bases
TAAGACCACAAAAAGGCTGTTATTTCAGAAAAAATAGTTATAATTCTCAACTTTTAATGAGGAAGGCATTATGTCGCAAC
TAAAACGAATTTTGCTGTTA

Product: O-succinylbenzoate synthase

Products: NA

Alternate protein names: OSB synthase; OSBS; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthase

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTMIRKFKLYQYSIPVDSQLILRNRFLKKREGLLVQVCCDDAQGWGEIAPLPEFSQETLEQAREQALAWLEEWSASDGSA
GKLPLEHLFPSVAFGLSCALAEMKGLLHEEGNYQVAPLCYGDPDELYDPLNQMQGEKVAKIKVGMYEANRDGLIADMLLE
AIPDLHLRLDANRSWTPSKAQMFAKYVKPEHRARIQFLEEPCKTPAESLQFAEETGIAIAWDETVRDAEFQQNPPHFFTP
QVKAIVIKPTLVGSIQRCVELIKQAHAHGIQAVISSSIESSLGLTQLARLAQQYTPNTVPGLDTLDLMDYQVIRPWPSST
LPLIDLDSEYIVPIKLD

Sequences:

>Translated_337_residues
MTMIRKFKLYQYSIPVDSQLILRNRFLKKREGLLVQVCCDDAQGWGEIAPLPEFSQETLEQAREQALAWLEEWSASDGSA
GKLPLEHLFPSVAFGLSCALAEMKGLLHEEGNYQVAPLCYGDPDELYDPLNQMQGEKVAKIKVGMYEANRDGLIADMLLE
AIPDLHLRLDANRSWTPSKAQMFAKYVKPEHRARIQFLEEPCKTPAESLQFAEETGIAIAWDETVRDAEFQQNPPHFFTP
QVKAIVIKPTLVGSIQRCVELIKQAHAHGIQAVISSSIESSLGLTQLARLAQQYTPNTVPGLDTLDLMDYQVIRPWPSST
LPLIDLDSEYIVPIKLD
>Mature_336_residues
TMIRKFKLYQYSIPVDSQLILRNRFLKKREGLLVQVCCDDAQGWGEIAPLPEFSQETLEQAREQALAWLEEWSASDGSAG
KLPLEHLFPSVAFGLSCALAEMKGLLHEEGNYQVAPLCYGDPDELYDPLNQMQGEKVAKIKVGMYEANRDGLIADMLLEA
IPDLHLRLDANRSWTPSKAQMFAKYVKPEHRARIQFLEEPCKTPAESLQFAEETGIAIAWDETVRDAEFQQNPPHFFTPQ
VKAIVIKPTLVGSIQRCVELIKQAHAHGIQAVISSSIESSLGLTQLARLAQQYTPNTVPGLDTLDLMDYQVIRPWPSSTL
PLIDLDSEYIVPIKLD

Specific function: Converts SHCHC to OSB

COG id: COG1441

COG function: function code H; O-succinylbenzoate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1788596, Length=326, Percent_Identity=57.361963190184, Blast_Score=371, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENC_PASMU (Q9CLV7)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246031.1
- ProteinModelPortal:   Q9CLV7
- SMR:   Q9CLV7
- GeneID:   1244441
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1094
- NMPDR:   fig|272843.1.peg.1094
- HOGENOM:   HBG644552
- OMA:   YEANRDG
- ProtClustDB:   PRK05105
- BioCyc:   PMUL272843:PM1094-MONOMER
- BRENDA:   4.2.1.113
- HAMAP:   MF_00470
- InterPro:   IPR013342
- InterPro:   IPR001354
- InterPro:   IPR010196
- PANTHER:   PTHR13794
- SMART:   SM00922
- TIGRFAMs:   TIGR01927

Pfam domain/function: PF01188 MR_MLE

EC number: =4.2.1.113

Molecular weight: Translated: 37892; Mature: 37761

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: ACT_SITE 142-142 ACT_SITE 248-248

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMIRKFKLYQYSIPVDSQLILRNRFLKKREGLLVQVCCDDAQGWGEIAPLPEFSQETLE
CCCHHEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
QAREQALAWLEEWSASDGSAGKLPLEHLFPSVAFGLSCALAEMKGLLHEEGNYQVAPLCY
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
GDPDELYDPLNQMQGEKVAKIKVGMYEANRDGLIADMLLEAIPDLHLRLDANRSWTPSKA
CCHHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHH
QMFAKYVKPEHRARIQFLEEPCKTPAESLQFAEETGIAIAWDETVRDAEFQQNPPHFFTP
HHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEECCHHCCCHHCCCCCCEECC
QVKAIVIKPTLVGSIQRCVELIKQAHAHGIQAVISSSIESSLGLTQLARLAQQYTPNTVP
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
GLDTLDLMDYQVIRPWPSSTLPLIDLDSEYIVPIKLD
CCCCHHHCCCCEECCCCCCCCCEEECCCCEEEEEEEC
>Mature Secondary Structure 
TMIRKFKLYQYSIPVDSQLILRNRFLKKREGLLVQVCCDDAQGWGEIAPLPEFSQETLE
CCHHEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
QAREQALAWLEEWSASDGSAGKLPLEHLFPSVAFGLSCALAEMKGLLHEEGNYQVAPLCY
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
GDPDELYDPLNQMQGEKVAKIKVGMYEANRDGLIADMLLEAIPDLHLRLDANRSWTPSKA
CCHHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHH
QMFAKYVKPEHRARIQFLEEPCKTPAESLQFAEETGIAIAWDETVRDAEFQQNPPHFFTP
HHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEECCHHCCCHHCCCCCCEECC
QVKAIVIKPTLVGSIQRCVELIKQAHAHGIQAVISSSIESSLGLTQLARLAQQYTPNTVP
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
GLDTLDLMDYQVIRPWPSSTLPLIDLDSEYIVPIKLD
CCCCHHHCCCCEECCCCCCCCCEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100