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The map label for this gene is aroD

Identifier: 15602958

GI number: 15602958

Start: 1288748

End: 1289194

Strand: Reverse

Name: aroD

Synonym: PM1093

Alternate gene names: 15602958

Gene position: 1289194-1288748 (Counterclockwise)

Preceding gene: 15602959

Following gene: 15602957

Centisome position: 57.11

GC content: 39.15

Gene sequence:

>447_bases
ATGTCGCAACTAAAACGAATTTTGCTGTTAAATGGACCGAACTTAAATATGTTAGGTGTAAGAGAGCCTACCCATTATGG
CAGCCTGTCTTTAAAAACCATTGAGCAAGATTTACAGTCATTGGCACAACAATATGCTGTTGAATTGAGTTGTTTCCAAG
CAAACAGTGAAGAAAAATTAATTGAGAAAATTCACCAAAGTTTTCAACAGATTGATTTTATTATTATCAATCCTGCAGCA
TTTACTCACACCAGTGTGGCACTACGCGATGCGCTTTTGGCTGTGGCGATTCCGTTTGTGGAAGTGCATTTATCGAATGT
GCATAAACGTGAACCTTTCCGTCATCACTCTTATTTTAGTGATGTGGCTGAAGGTGTGATTTGCGGTTTAGGCGCAAAAG
GGTATGAATTTGCGCTACAGTTTGCGGTCAGTTTCCTGAAAAAATAG

Upstream 100 bases:

>100_bases
GAATATATTGTTCCCATTAAGCTGGACTGATAAGACCACAAAAAGGCTGTTATTTCAGAAAAAATAGTTATAATTCTCAA
CTTTTAATGAGGAAGGCATT

Downstream 100 bases:

>100_bases
GCATAAATTAAAGAAATTGACAGAATTTTATCGCAAAGTTGTCGATTTTCAGGTAATCTCTCGCACGAGATGTAGAATTA
ACCAGTTGGCACTTTAACTA

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type II DHQase

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MSQLKRILLLNGPNLNMLGVREPTHYGSLSLKTIEQDLQSLAQQYAVELSCFQANSEEKLIEKIHQSFQQIDFIIINPAA
FTHTSVALRDALLAVAIPFVEVHLSNVHKREPFRHHSYFSDVAEGVICGLGAKGYEFALQFAVSFLKK

Sequences:

>Translated_148_residues
MSQLKRILLLNGPNLNMLGVREPTHYGSLSLKTIEQDLQSLAQQYAVELSCFQANSEEKLIEKIHQSFQQIDFIIINPAA
FTHTSVALRDALLAVAIPFVEVHLSNVHKREPFRHHSYFSDVAEGVICGLGAKGYEFALQFAVSFLKK
>Mature_147_residues
SQLKRILLLNGPNLNMLGVREPTHYGSLSLKTIEQDLQSLAQQYAVELSCFQANSEEKLIEKIHQSFQQIDFIIINPAAF
THTSVALRDALLAVAIPFVEVHLSNVHKREPFRHHSYFSDVAEGVICGLGAKGYEFALQFAVSFLKK

Specific function: Catalyzes a trans-dehydration via an enolate intermediate

COG id: COG0757

COG function: function code E; 3-dehydroquinate dehydratase II

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-II 3-dehydroquinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROQ_PASMU (P57903)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246030.1
- ProteinModelPortal:   P57903
- SMR:   P57903
- PRIDE:   P57903
- GeneID:   1244440
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1093
- NMPDR:   fig|272843.1.peg.1093
- HOGENOM:   HBG284657
- OMA:   TFQSNHE
- ProtClustDB:   PRK05395
- BioCyc:   PMUL272843:PM1093-MONOMER
- BRENDA:   4.2.1.10
- HAMAP:   MF_00169
- InterPro:   IPR001874
- InterPro:   IPR018509
- Gene3D:   G3DSA:3.40.50.9100
- PANTHER:   PTHR21272
- PIRSF:   PIRSF001399
- ProDom:   PD004527
- TIGRFAMs:   TIGR01088

Pfam domain/function: PF01220 DHquinase_II; SSF52304 DHquinase_II

EC number: =4.2.1.10

Molecular weight: Translated: 16626; Mature: 16495

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS01029 DEHYDROQUINASE_II

Important sites: ACT_SITE 26-26 ACT_SITE 103-103 BINDING 77-77 BINDING 83-83 BINDING 90-90 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLKRILLLNGPNLNMLGVREPTHYGSLSLKTIEQDLQSLAQQYAVELSCFQANSEEKL
CCCCCEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IEKIHQSFQQIDFIIINPAAFTHTSVALRDALLAVAIPFVEVHLSNVHKREPFRHHSYFS
HHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DVAEGVICGLGAKGYEFALQFAVSFLKK
HHHHHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQLKRILLLNGPNLNMLGVREPTHYGSLSLKTIEQDLQSLAQQYAVELSCFQANSEEKL
CCCCEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IEKIHQSFQQIDFIIINPAAFTHTSVALRDALLAVAIPFVEVHLSNVHKREPFRHHSYFS
HHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DVAEGVICGLGAKGYEFALQFAVSFLKK
HHHHHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100