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The map label for this gene is accC [H]

Identifier: 15602956

GI number: 15602956

Start: 1286684

End: 1288030

Strand: Reverse

Name: accC [H]

Synonym: PM1091

Alternate gene names: 15602956

Gene position: 1288030-1286684 (Counterclockwise)

Preceding gene: 15602957

Following gene: 15602955

Centisome position: 57.06

GC content: 42.98

Gene sequence:

>1347_bases
ATGTTAGAGAAAGTGGTTATTGCCAATCGTGGTGAAATTGCGCTACGTATTTTGCGTGCTTGCAAAGAATTAGGCATAAA
AACTGTTGCGGTGCATTCCACAGCAGACCGTGAATTGAAACATGTTTTACTTGCAGATGAAACTGTTTGTATTGGTCCTG
CGCCTTCAACGAAAAGTTATCTTAATATTCCGGCTATCATTGCAGCGGCTGAAGTAACAGGTGCGGATGCCATTCACCCT
GGTTATGGTTTTTTATCTGAAAATGCAGATTTTGCGGAGCAAGTTGAACGTTCTGGATTTATTTTTATTGGTCCCACTGC
AGACGTGATCCGTTTAATGGGTGACAAAGTTTCTGCGATTGAAGCAATGAAGAAATCAGGTGTACCTTGTGTACCGGGCT
CTGATGGTCCTGTGGGTAGCGATATGGTAAAAAATAAAGAAATCGCCAAACGTATTGGTTACCCTGTGATTATTAAAGCT
TCAGGCGGCGGTGGTGGTCGTGGTATGCGTGTAGTGCGTGATGAGGCCTCTTTAGAAGAATCTATCGCGATGACCAAAGC
AGAAGCAAAAGCGGCTTTTAATAACGATATGGTGTATATGGAAAAATACCTAGAAAATCCACGTCATATTGAAATTCAAG
TCTTAGCCGATACCCATGGTAATGCCATTTATTTAGCGGAGCGTGATTGCTCAATGCAACGTCGCCATCAAAAAGTAGTA
GAAGAAGCCCCAGCACCGGGTATTTCCGATGAAGTTCGTCGTGATATTGGTGAACGTTGTGCCAAAGCATGCGTAGAAAT
TGGTTATCGTGGGGCAGGTACGTTTGAGTTCTTGTATGAAAATGGGGAGTTCTATTTCATTGAGATGAATACCCGTATTC
AAGTAGAACATCCAGTCACAGAAATGATCACGGGTGTGGACTTGGTGAAAGAACAATTGCGTATCGCAGCCGGATTGCCG
ATCTCCATTAAGCAAGAAGATGTGAAAGTGCGTGGTCATGCGATCGAATGCCGTATTAATGCAGAAGATCCTAAATCCTT
CTTGCCTTCACCGGGTAAGGTGGATCATTTACACTCTCCGGGTGGATTAGGTGTGCGTTGGGATTCACATGTTTATGCGG
GTTATACCGTCCCACCACATTATGATTCAATGATTGCAAAATTGATTACTTATGGTGATACTCGTGAAGTCGCGATTCGT
CGTATGCAAAATGCACTGGGTGAAACGATTTTAACCGGTATTAAAACCAATATTCCTCTGCACGAATTGATTCTGGCAGA
TGAAAATTTTCAACAGGGTGGCACGAATATCCATTACCTAGAGAAAAAACTTGGCATGCGTGACTAA

Upstream 100 bases:

>100_bases
CAACTAAATTTGTAATAAGCGATGTGATATCGCTTATTTTTCATATCAATCTATTGCTAGATAGTGAGCTCACTATTTAC
TTACAAAGTGGAATTTTCTT

Downstream 100 bases:

>100_bases
TTAAAATCTGTCACTTAACGAAGGAACGAGAAAAGTGGATTTATCCACTTTTCTTATATCAGTTTTACAAGGAATTTATA
AAATGAATCTTAATTCCCGC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRELKHVLLADETVCIGPAPSTKSYLNIPAIIAAAEVTGADAIHP
GYGFLSENADFAEQVERSGFIFIGPTADVIRLMGDKVSAIEAMKKSGVPCVPGSDGPVGSDMVKNKEIAKRIGYPVIIKA
SGGGGGRGMRVVRDEASLEESIAMTKAEAKAAFNNDMVYMEKYLENPRHIEIQVLADTHGNAIYLAERDCSMQRRHQKVV
EEAPAPGISDEVRRDIGERCAKACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLVKEQLRIAAGLP
ISIKQEDVKVRGHAIECRINAEDPKSFLPSPGKVDHLHSPGGLGVRWDSHVYAGYTVPPHYDSMIAKLITYGDTREVAIR
RMQNALGETILTGIKTNIPLHELILADENFQQGGTNIHYLEKKLGMRD

Sequences:

>Translated_448_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRELKHVLLADETVCIGPAPSTKSYLNIPAIIAAAEVTGADAIHP
GYGFLSENADFAEQVERSGFIFIGPTADVIRLMGDKVSAIEAMKKSGVPCVPGSDGPVGSDMVKNKEIAKRIGYPVIIKA
SGGGGGRGMRVVRDEASLEESIAMTKAEAKAAFNNDMVYMEKYLENPRHIEIQVLADTHGNAIYLAERDCSMQRRHQKVV
EEAPAPGISDEVRRDIGERCAKACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLVKEQLRIAAGLP
ISIKQEDVKVRGHAIECRINAEDPKSFLPSPGKVDHLHSPGGLGVRWDSHVYAGYTVPPHYDSMIAKLITYGDTREVAIR
RMQNALGETILTGIKTNIPLHELILADENFQQGGTNIHYLEKKLGMRD
>Mature_448_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRELKHVLLADETVCIGPAPSTKSYLNIPAIIAAAEVTGADAIHP
GYGFLSENADFAEQVERSGFIFIGPTADVIRLMGDKVSAIEAMKKSGVPCVPGSDGPVGSDMVKNKEIAKRIGYPVIIKA
SGGGGGRGMRVVRDEASLEESIAMTKAEAKAAFNNDMVYMEKYLENPRHIEIQVLADTHGNAIYLAERDCSMQRRHQKVV
EEAPAPGISDEVRRDIGERCAKACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLVKEQLRIAAGLP
ISIKQEDVKVRGHAIECRINAEDPKSFLPSPGKVDHLHSPGGLGVRWDSHVYAGYTVPPHYDSMIAKLITYGDTREVAIR
RMQNALGETILTGIKTNIPLHELILADENFQQGGTNIHYLEKKLGMRD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=50.4545454545455, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=49.2099322799097, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=49.2099322799097, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=49.2099322799097, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=45.7777777777778, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=45.7777777777778, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=45.7777777777778, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI38679974, Length=504, Percent_Identity=30.7539682539683, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI38679971, Length=504, Percent_Identity=30.7539682539683, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=30.7539682539683, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=30.7539682539683, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI38679960, Length=504, Percent_Identity=30.7539682539683, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI134142062, Length=505, Percent_Identity=31.2871287128713, Blast_Score=231, Evalue=8e-61,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=83.2589285714286, Blast_Score=756, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=243, Percent_Identity=25.5144032921811, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=47.8555304740406, Blast_Score=411, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.2850678733032, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=44.6428571428571, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71997168, Length=515, Percent_Identity=29.3203883495146, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI71997163, Length=515, Percent_Identity=29.3203883495146, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI133931226, Length=496, Percent_Identity=29.4354838709677, Blast_Score=198, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6319695, Length=439, Percent_Identity=46.9248291571754, Blast_Score=357, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6321376, Length=439, Percent_Identity=47.380410022779, Blast_Score=349, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.5349887133183, Blast_Score=348, Evalue=7e-97,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=31.3953488372093, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6323863, Length=458, Percent_Identity=32.7510917030568, Blast_Score=226, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=45.1901565995526, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=47.5446428571429, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=47.5446428571429, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=47.5446428571429, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=47.5446428571429, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=47.5446428571429, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=47.5446428571429, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=47.5446428571429, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=47.5446428571429, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=47.5446428571429, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=47.5446428571429, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.0980392156863, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI161076407, Length=508, Percent_Identity=29.7244094488189, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24586460, Length=508, Percent_Identity=29.7244094488189, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24586458, Length=508, Percent_Identity=29.7244094488189, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI161076409, Length=508, Percent_Identity=29.7244094488189, Blast_Score=214, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49088; Mature: 49088

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRELKHVLLADETVCIGPAPSTKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHEEECCEEEECCCCCCCCC
LNIPAIIAAAEVTGADAIHPGYGFLSENADFAEQVERSGFIFIGPTADVIRLMGDKVSAI
CCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHCCHHHHH
EAMKKSGVPCVPGSDGPVGSDMVKNKEIAKRIGYPVIIKASGGGGGRGMRVVRDEASLEE
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECHHHHHH
SIAMTKAEAKAAFNNDMVYMEKYLENPRHIEIQVLADTHGNAIYLAERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHH
EEAPAPGISDEVRRDIGERCAKACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDLVKEQLRIAAGLPISIKQEDVKVRGHAIECRINAEDPKSFLPSPGKVDHLHSP
HHHHHHHHHHHHHHHHCCCCEEEECCCEEEECEEEEEEECCCCCHHHCCCCCCCCCCCCC
GGLGVRWDSHVYAGYTVPPHYDSMIAKLITYGDTREVAIRRMQNALGETILTGIKTNIPL
CCCCEEECCEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
HELILADENFQQGGTNIHYLEKKLGMRD
HHEEEECCCHHCCCCEEEHHHHHCCCCC
>Mature Secondary Structure
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRELKHVLLADETVCIGPAPSTKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHEEECCEEEECCCCCCCCC
LNIPAIIAAAEVTGADAIHPGYGFLSENADFAEQVERSGFIFIGPTADVIRLMGDKVSAI
CCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHCCHHHHH
EAMKKSGVPCVPGSDGPVGSDMVKNKEIAKRIGYPVIIKASGGGGGRGMRVVRDEASLEE
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECHHHHHH
SIAMTKAEAKAAFNNDMVYMEKYLENPRHIEIQVLADTHGNAIYLAERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHH
EEAPAPGISDEVRRDIGERCAKACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDLVKEQLRIAAGLPISIKQEDVKVRGHAIECRINAEDPKSFLPSPGKVDHLHSP
HHHHHHHHHHHHHHHHCCCCEEEECCCEEEECEEEEEEECCCCCHHHCCCCCCCCCCCCC
GGLGVRWDSHVYAGYTVPPHYDSMIAKLITYGDTREVAIRRMQNALGETILTGIKTNIPL
CCCCEEECCEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
HELILADENFQQGGTNIHYLEKKLGMRD
HHEEEECCCHHCCCCEEEHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]