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The map label for this gene is mltA [H]

Identifier: 15602793

GI number: 15602793

Start: 1094961

End: 1096085

Strand: Reverse

Name: mltA [H]

Synonym: PM0928

Alternate gene names: 15602793

Gene position: 1096085-1094961 (Counterclockwise)

Preceding gene: 15602794

Following gene: 15602792

Centisome position: 48.55

GC content: 41.69

Gene sequence:

>1125_bases
ATGCCTCATTATTATTTGGGAAAGAATATGCTATTTCAGACAAAAAATTTAGTCAAACTTACCGCACTTTGTTCGGCAGC
ATTGTTGGTTGCTTGTAGCTCGCAGCCTAGAGGAAGTGCAGGAAACAATCAGGCTGATCCGCAAAAATTTGGTGCAAAAT
ACGAGGGGCGTCAATATCAACACTCAGTGTTTACTCCGGTCGCGAAAGTAGAAAATCAAAGTGCGGTGATTAATCAAGGT
GATTTTTTGACCCAATTATCGCATGTGCGTAGCTATTCGAATAAGCTCGCCAATCAATTCGATCACAGCTATGTCAAAGT
GACTAATTGGATCTTAGCGGGTGGTAATATGCATGATTTAGCACAATTTGGTATTCAGCCGCAATTAATGAAAGGTTTTG
ATGGCTATCAAAATGTTTTAATGACGGGGTATTATTCTCCGGTTATTCATGCTCGCCGTAGTCAACAAGGGAAGTATAAT
CAACCTATTTACGCGTTACCTAAACAAAAACGTGTAACCCGAGCCCAAGTGTATGCAGGTGCTTTAGCACGAAAAGGGTT
GGAGCTGGCTTACAGTGATTCTATGTTAGATAACTTTTTATTAGGCGTTCAAGGAAGTGGCTATGTGGATTTTGGGGACG
GTAAGCTAAATTATTTTGCTTATGCTGGACAAAATGGTTTTCCTTATACCAGTGTCGGACGTTTATTAGTAGAAGATGGC
GAAATTGCTAAAGAGAAAATGTCGATTCAAGCGATTCGTGATTGGGCAAAAGCGAATCCTTCTCGCTTACAAGCCTTATT
AGAACGCAATGAATCTTATGTTTATTTTAAAAATGATCCTTACGGTAAAGTCAAAGGTGCAGCCGGTGTGCCTTTAGTAC
CGATGGCGTCACTTGCGGCAGATCGAAATGTTGTGCCTTTAGGGAGCTTGCTTTTGGTGGAAGTGCCTCAAATGGATAAA
CACGGTAATTGGACAGGTGAGCATCAAATGCATTTGATGGTCGCGCTCGATGTGGGTGGGGCAGTGAAAGGGCATCACTT
TGATTTATATCGTGGGATTGGCGATGACGCGGGTCATATTGCAGGATTATCAAAACATTATGGACGTGTGTGGGTATTAC
AATAA

Upstream 100 bases:

>100_bases
TTATCGTTTGGTACTGTAATTTGCGTTCAGTCAGAGAGAAGAAAAAGCACTGCGCTAGGCTATATTTTTAGCCAGTTTTC
TGATAGCGTATGCAACTTTA

Downstream 100 bases:

>100_bases
TGGAGAGAGTGGATAATTATGAACAACGTTTTGGTGGGATCGCACGTTTATACAGTACTGAAGGGCTTACTCGTTTAAAA
CAGTCTCATGTCTGCGTTAT

Product: murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MPHYYLGKNMLFQTKNLVKLTALCSAALLVACSSQPRGSAGNNQADPQKFGAKYEGRQYQHSVFTPVAKVENQSAVINQG
DFLTQLSHVRSYSNKLANQFDHSYVKVTNWILAGGNMHDLAQFGIQPQLMKGFDGYQNVLMTGYYSPVIHARRSQQGKYN
QPIYALPKQKRVTRAQVYAGALARKGLELAYSDSMLDNFLLGVQGSGYVDFGDGKLNYFAYAGQNGFPYTSVGRLLVEDG
EIAKEKMSIQAIRDWAKANPSRLQALLERNESYVYFKNDPYGKVKGAAGVPLVPMASLAADRNVVPLGSLLLVEVPQMDK
HGNWTGEHQMHLMVALDVGGAVKGHHFDLYRGIGDDAGHIAGLSKHYGRVWVLQ

Sequences:

>Translated_374_residues
MPHYYLGKNMLFQTKNLVKLTALCSAALLVACSSQPRGSAGNNQADPQKFGAKYEGRQYQHSVFTPVAKVENQSAVINQG
DFLTQLSHVRSYSNKLANQFDHSYVKVTNWILAGGNMHDLAQFGIQPQLMKGFDGYQNVLMTGYYSPVIHARRSQQGKYN
QPIYALPKQKRVTRAQVYAGALARKGLELAYSDSMLDNFLLGVQGSGYVDFGDGKLNYFAYAGQNGFPYTSVGRLLVEDG
EIAKEKMSIQAIRDWAKANPSRLQALLERNESYVYFKNDPYGKVKGAAGVPLVPMASLAADRNVVPLGSLLLVEVPQMDK
HGNWTGEHQMHLMVALDVGGAVKGHHFDLYRGIGDDAGHIAGLSKHYGRVWVLQ
>Mature_373_residues
PHYYLGKNMLFQTKNLVKLTALCSAALLVACSSQPRGSAGNNQADPQKFGAKYEGRQYQHSVFTPVAKVENQSAVINQGD
FLTQLSHVRSYSNKLANQFDHSYVKVTNWILAGGNMHDLAQFGIQPQLMKGFDGYQNVLMTGYYSPVIHARRSQQGKYNQ
PIYALPKQKRVTRAQVYAGALARKGLELAYSDSMLDNFLLGVQGSGYVDFGDGKLNYFAYAGQNGFPYTSVGRLLVEDGE
IAKEKMSIQAIRDWAKANPSRLQALLERNESYVYFKNDPYGKVKGAAGVPLVPMASLAADRNVVPLGSLLLVEVPQMDKH
GNWTGEHQMHLMVALDVGGAVKGHHFDLYRGIGDDAGHIAGLSKHYGRVWVLQ

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=356, Percent_Identity=48.314606741573, Blast_Score=331, Evalue=5e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 41310; Mature: 41178

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHYYLGKNMLFQTKNLVKLTALCSAALLVACSSQPRGSAGNNQADPQKFGAKYEGRQYQ
CCCEECCCCCEEHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHCCCCCCCCHH
HSVFTPVAKVENQSAVINQGDFLTQLSHVRSYSNKLANQFDHSYVKVTNWILAGGNMHDL
HHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHH
AQFGIQPQLMKGFDGYQNVLMTGYYSPVIHARRSQQGKYNQPIYALPKQKRVTRAQVYAG
HHHCCCHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHH
ALARKGLELAYSDSMLDNFLLGVQGSGYVDFGDGKLNYFAYAGQNGFPYTSVGRLLVEDG
HHHHCCCCEEEHHHHHHHHEEECCCCCEEEECCCCEEEEEEECCCCCCHHHHCCEEECCC
EIAKEKMSIQAIRDWAKANPSRLQALLERNESYVYFKNDPYGKVKGAAGVPLVPMASLAA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHC
DRNVVPLGSLLLVEVPQMDKHGNWTGEHQMHLMVALDVGGAVKGHHFDLYRGIGDDAGHI
CCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEHHHHCCCCCCHHH
AGLSKHYGRVWVLQ
CCHHHHCCEEEEEC
>Mature Secondary Structure 
PHYYLGKNMLFQTKNLVKLTALCSAALLVACSSQPRGSAGNNQADPQKFGAKYEGRQYQ
CCEECCCCCEEHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHCCCCCCCCHH
HSVFTPVAKVENQSAVINQGDFLTQLSHVRSYSNKLANQFDHSYVKVTNWILAGGNMHDL
HHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHH
AQFGIQPQLMKGFDGYQNVLMTGYYSPVIHARRSQQGKYNQPIYALPKQKRVTRAQVYAG
HHHCCCHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHH
ALARKGLELAYSDSMLDNFLLGVQGSGYVDFGDGKLNYFAYAGQNGFPYTSVGRLLVEDG
HHHHCCCCEEEHHHHHHHHEEECCCCCEEEECCCCEEEEEEECCCCCCHHHHCCEEECCC
EIAKEKMSIQAIRDWAKANPSRLQALLERNESYVYFKNDPYGKVKGAAGVPLVPMASLAA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHC
DRNVVPLGSLLLVEVPQMDKHGNWTGEHQMHLMVALDVGGAVKGHHFDLYRGIGDDAGHI
CCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEHHHHCCCCCCHHH
AGLSKHYGRVWVLQ
CCHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]