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The map label for this gene is tyrR [H]

Identifier: 15602773

GI number: 15602773

Start: 1066491

End: 1067444

Strand: Reverse

Name: tyrR [H]

Synonym: PM0908

Alternate gene names: 15602773

Gene position: 1067444-1066491 (Counterclockwise)

Preceding gene: 15602774

Following gene: 15602764

Centisome position: 47.28

GC content: 41.93

Gene sequence:

>954_bases
ATGTCCTTGAATGAAAGTGTGGAGGCGCCTTTTGCTGGGCTTGTTGCACGGAGTGCTAAAATGCAGAATCTTGTTGCTCA
AGCAATGAAATTTGCGATGAGTGACGCACCCTTATTAATTCAAGGTGAAACGGGGACAGGCAAAGATCTGATTGCTAAAC
TATGCCATCTTGCGAGCCCTCGTCATCATAAGAAATTTATTGCGGTCAATTGTGCAGGTTTACCTGCGCAAGATGCGGAA
AGTGAAATGTTTGGTCGCCGTGAGCAAGACAAAGAATATGTAGGCTTTTTTGAGTACGCAGAGGGGGGAACCGTATTATT
AGATAGTGTGGCTGAATTGTCCCTCGAGTTACAAGCCAAATTATTGCGTTTTTTAAACGACGGTACCTTCCGCCGAGTTG
GTGAAGAAAAAGAACATTACGCCAATGTTCGGGTGATCTGTACTTCTCAAGTTCCTTTACAATATTATGTGGATAAAGGA
AAAATGCGAAGTGACTTATTTCACCGTTTAAATGTACTCACGCTTAATTTGCCACCACTACGTGAGCGTCAAGAAGATTT
ACCGGATTTAGTACAACTGTTTGTACAACAAATTAGTCAAGAATTAGCCATGCCAGTACCGCACTTTGATGCACATTTTG
TTCAATATTTACAAGATTATCCGTGGGCAGGTAATGTGCGTGAATTATATAATGCATTATATCGTGCCTGCTCGTTGGTG
GAGGATGGGCAATTAAGTATCGCGGGACTCAACTTAATTGAGCAGGACGTGATGCCTGTAACGTTAGAGCAGTTTAGTCA
CCAAACTTTAGAAGAAATTATGAGTAAATTTGAGGCAACCGTCTTGCGAAAATTTTATGAGCAATATCCCAGTACACGGA
AATTAGCGGCGCGTTTGGGGGTTTCTCATACTGCAATCGCGAATAAGTTGCGGCAATACGGTATTAATAAGTAA

Upstream 100 bases:

>100_bases
AACAGCAAGTTTAAAATGTAAATTTATCTTTCCAGTGTTTCTTTAATCTTTACAGTTTTAGTGCTATCATAGAGCCATTT
TTTACGAGTGAGGAAATGTT

Downstream 100 bases:

>100_bases
ACAAAAAAGGACAAAAGTGAATTTGTCCTTTTTTGTTTTTAGCCACGTTTAACATATAAAAGTCTCGAGTTCTGGAAATT
GTTTCAATAATTTTAGCCAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSLNESVEAPFAGLVARSAKMQNLVAQAMKFAMSDAPLLIQGETGTGKDLIAKLCHLASPRHHKKFIAVNCAGLPAQDAE
SEMFGRREQDKEYVGFFEYAEGGTVLLDSVAELSLELQAKLLRFLNDGTFRRVGEEKEHYANVRVICTSQVPLQYYVDKG
KMRSDLFHRLNVLTLNLPPLRERQEDLPDLVQLFVQQISQELAMPVPHFDAHFVQYLQDYPWAGNVRELYNALYRACSLV
EDGQLSIAGLNLIEQDVMPVTLEQFSHQTLEEIMSKFEATVLRKFYEQYPSTRKLAARLGVSHTAIANKLRQYGINK

Sequences:

>Translated_317_residues
MSLNESVEAPFAGLVARSAKMQNLVAQAMKFAMSDAPLLIQGETGTGKDLIAKLCHLASPRHHKKFIAVNCAGLPAQDAE
SEMFGRREQDKEYVGFFEYAEGGTVLLDSVAELSLELQAKLLRFLNDGTFRRVGEEKEHYANVRVICTSQVPLQYYVDKG
KMRSDLFHRLNVLTLNLPPLRERQEDLPDLVQLFVQQISQELAMPVPHFDAHFVQYLQDYPWAGNVRELYNALYRACSLV
EDGQLSIAGLNLIEQDVMPVTLEQFSHQTLEEIMSKFEATVLRKFYEQYPSTRKLAARLGVSHTAIANKLRQYGINK
>Mature_316_residues
SLNESVEAPFAGLVARSAKMQNLVAQAMKFAMSDAPLLIQGETGTGKDLIAKLCHLASPRHHKKFIAVNCAGLPAQDAES
EMFGRREQDKEYVGFFEYAEGGTVLLDSVAELSLELQAKLLRFLNDGTFRRVGEEKEHYANVRVICTSQVPLQYYVDKGK
MRSDLFHRLNVLTLNLPPLRERQEDLPDLVQLFVQQISQELAMPVPHFDAHFVQYLQDYPWAGNVRELYNALYRACSLVE
DGQLSIAGLNLIEQDVMPVTLEQFSHQTLEEIMSKFEATVLRKFYEQYPSTRKLAARLGVSHTAIANKLRQYGINK

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport [H]

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=308, Percent_Identity=52.5974025974026, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI87082117, Length=326, Percent_Identity=35.5828220858896, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1788550, Length=328, Percent_Identity=35.0609756097561, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI1789087, Length=324, Percent_Identity=34.5679012345679, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1788905, Length=295, Percent_Identity=35.9322033898305, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1790299, Length=339, Percent_Identity=32.4483775811209, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1790437, Length=311, Percent_Identity=34.0836012861736, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=34.7003154574132, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1789233, Length=316, Percent_Identity=31.3291139240506, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI87081872, Length=230, Percent_Identity=36.9565217391304, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1786524, Length=243, Percent_Identity=37.037037037037, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789828, Length=264, Percent_Identity=29.1666666666667, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87081858, Length=321, Percent_Identity=26.1682242990654, Blast_Score=105, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR002078 [H]

Pfam domain/function: PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 35897; Mature: 35765

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNESVEAPFAGLVARSAKMQNLVAQAMKFAMSDAPLLIQGETGTGKDLIAKLCHLASP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCC
RHHKKFIAVNCAGLPAQDAESEMFGRREQDKEYVGFFEYAEGGTVLLDSVAELSLELQAK
CCCCEEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHHHHHH
LLRFLNDGTFRRVGEEKEHYANVRVICTSQVPLQYYVDKGKMRSDLFHRLNVLTLNLPPL
HHHHHCCCHHHHHCCHHHHHCCEEEEEECCCCHHHHHCCCHHHHHHHHHHHEEEECCCCC
RERQEDLPDLVQLFVQQISQELAMPVPHFDAHFVQYLQDYPWAGNVRELYNALYRACSLV
HHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
EDGQLSIAGLNLIEQDVMPVTLEQFSHQTLEEIMSKFEATVLRKFYEQYPSTRKLAARLG
CCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
VSHTAIANKLRQYGINK
CHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLNESVEAPFAGLVARSAKMQNLVAQAMKFAMSDAPLLIQGETGTGKDLIAKLCHLASP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCC
RHHKKFIAVNCAGLPAQDAESEMFGRREQDKEYVGFFEYAEGGTVLLDSVAELSLELQAK
CCCCEEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHHHHHH
LLRFLNDGTFRRVGEEKEHYANVRVICTSQVPLQYYVDKGKMRSDLFHRLNVLTLNLPPL
HHHHHCCCHHHHHCCHHHHHCCEEEEEECCCCHHHHHCCCHHHHHHHHHHHEEEECCCCC
RERQEDLPDLVQLFVQQISQELAMPVPHFDAHFVQYLQDYPWAGNVRELYNALYRACSLV
HHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
EDGQLSIAGLNLIEQDVMPVTLEQFSHQTLEEIMSKFEATVLRKFYEQYPSTRKLAARLG
CCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
VSHTAIANKLRQYGINK
CHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]