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The map label for this gene is mutL

Identifier: 15602769

GI number: 15602769

Start: 1061860

End: 1063713

Strand: Direct

Name: mutL

Synonym: PM0904

Alternate gene names: 15602769

Gene position: 1061860-1063713 (Clockwise)

Preceding gene: 15602768

Following gene: 15602770

Centisome position: 47.04

GC content: 42.34

Gene sequence:

>1854_bases
ATGGCGATTAAAGTTCTTTCTCCTCAGCTTGCTAACCAGATCGCCGCGGGCGAAGTCGTTGAACGCCCAGCTTCTGTGGT
GAAAGAGTTGGTCGAAAATAGTTTAGATGCGGGCGCAACACGTATTCAAATCGATATTGAAAACGGGGGCAGTACTTTAA
TCCGGATCCGTGATAATGGTATTGGTATTGCAAAAGACGAGCTAAGTCTGGCACTAGCACGTCATGCTACAAGCAAAATT
GCCAGTCTAGATGACCTTGATAATATTTTAAGCCTTGGCTTTCGTGGTGAAGCACTCGCCAGTATCAGCTCTGTTTCACG
TTTAACACTCACCTCACGTCCAGCAACACAAAATGAAGCATGGCAAGTTTATGCTCAGGGGCGAGAGATGGAAACGACTT
TACAACCGGCTTCTCATCCCGTTGGTACGACAGTTGAAGTAGCAAATTTATTTTTTAACACGCCAGCACGCCGTAAATTT
CTGCGCACAGATAAAACGGAATTCGCCCATATTGATGAAGTGATTCGTCGTATCGCCTTGGCTAAAATGGCAATTTCGTT
TACCCTAACTCATAATGGAAAAATCGTACGCCAGTATCGCAGTGCTCATGATCGCACGCAAAAGTTAAAACGGGTCGCGG
CAATTTGTGGGGATGAATTTGTCCAGAATGCGCTCGAAATTGATTGGAAACACGATGATCTACATTTATCTGGTTGGGTT
GCTCAGCCAACTTTTTCACGTACACAAAATGATCTAAGTTATTGCTATATTAATGGCAGAATGGTACGAGATAAGATCAT
TACTCATGCGATTCGCCAAGCCTATGCAGATTTTTTAAGCCCAGAACAATATCCTGCTTTTGTCTTGTTTATTGATTTAA
ATCCTAACGATGTGGATGTGAATGTCCATCCAACCAAACATGAAGTGCGTTTCCACCAGCAACGTTTAGTGCATGATTTT
ATTTGTCAAGGAATCAGTAACGCCCTTCATTCTGAACAAGCGAGCTTATATCAAACGAACGAGGCATGTGTCTCCGCAAA
CTATCAGGTAGAGGAAAGCGCGCAGCATGAATATCGCCCAAGTTATAGCAAGCCGAATCGTGCAGCGGCGGGACAAAATA
TCTTTGACTCCTCCACCACTACGCCATCAACCGCTTTATTTCAAACGAATAAAAAAAATACGCAAAATAGACCGCACTTT
TCGACTAATATCCCTGCTACGCGGATAAGTAAAACAGAACAGGCAGCTTACAGCGCCCTATTATCCAACAGTGAAATGGC
GACAGTCTTACCTCAAGAGGATGGCGCGTTACTCGAGAGAAAAACCCCCTCTATTCTAAAAGCTCTCGCCTTAGTTGAAA
ACAAAGCCTTGTTGCTACAACAGCAACAACAATTTTATTTATTATCTTTACAGCAATTACAGCGCTTAAAAATCGAACTG
AGTTTACAACGTGACCCCGTATTGCAACAGCCGTTACTCATTCCGATTGTATTTCGATTAAATCCACAACAGCTGACTTA
CTGGCAACAACAAAAAACTTTCTTTACTCAAATTGGGTTTGAATTTCATGAAAACCTCGGACAGCAACGTATTACGCTAA
ACCGTGTGCCAAGCTGTTTGCGTCAACAAAACTTACAGAAATGTATCATCGTGTTACTCTCGCAGCCTCTTGATACCTTT
TCTCATTTCTTAACAACGCTTTGTGACGTGATCGAATTGGAACAAATAACGGTCTATGCCGATGCCGTTACCTTACTCAC
TGAAACAGAGCAATTGCTTAATCAGAAACAAGCTATCCGATTATCCGAATTATTCATCGAGCTTAATTGGCAAGCTTACT
TGGAAAAAATGTAA

Upstream 100 bases:

>100_bases
AGTACCATATTCCACCAAATCAGCTATTAAAATTAAATCCCCATTTAAAAGATGGCAAAGTGTTAACAGGACAAAAAATT
AAATTGAGAGATTGATCAGT

Downstream 100 bases:

>100_bases
TCACATGCCTTTAACAACACCTACTGCCATTTTCTTAATGGGTCCCACTGCCTCTGGCAAAACAGACTTAGCAATTCAGT
TGCGTCAGACGCTACCCGTT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MAIKVLSPQLANQIAAGEVVERPASVVKELVENSLDAGATRIQIDIENGGSTLIRIRDNGIGIAKDELSLALARHATSKI
ASLDDLDNILSLGFRGEALASISSVSRLTLTSRPATQNEAWQVYAQGREMETTLQPASHPVGTTVEVANLFFNTPARRKF
LRTDKTEFAHIDEVIRRIALAKMAISFTLTHNGKIVRQYRSAHDRTQKLKRVAAICGDEFVQNALEIDWKHDDLHLSGWV
AQPTFSRTQNDLSYCYINGRMVRDKIITHAIRQAYADFLSPEQYPAFVLFIDLNPNDVDVNVHPTKHEVRFHQQRLVHDF
ICQGISNALHSEQASLYQTNEACVSANYQVEESAQHEYRPSYSKPNRAAAGQNIFDSSTTTPSTALFQTNKKNTQNRPHF
STNIPATRISKTEQAAYSALLSNSEMATVLPQEDGALLERKTPSILKALALVENKALLLQQQQQFYLLSLQQLQRLKIEL
SLQRDPVLQQPLLIPIVFRLNPQQLTYWQQQKTFFTQIGFEFHENLGQQRITLNRVPSCLRQQNLQKCIIVLLSQPLDTF
SHFLTTLCDVIELEQITVYADAVTLLTETEQLLNQKQAIRLSELFIELNWQAYLEKM

Sequences:

>Translated_617_residues
MAIKVLSPQLANQIAAGEVVERPASVVKELVENSLDAGATRIQIDIENGGSTLIRIRDNGIGIAKDELSLALARHATSKI
ASLDDLDNILSLGFRGEALASISSVSRLTLTSRPATQNEAWQVYAQGREMETTLQPASHPVGTTVEVANLFFNTPARRKF
LRTDKTEFAHIDEVIRRIALAKMAISFTLTHNGKIVRQYRSAHDRTQKLKRVAAICGDEFVQNALEIDWKHDDLHLSGWV
AQPTFSRTQNDLSYCYINGRMVRDKIITHAIRQAYADFLSPEQYPAFVLFIDLNPNDVDVNVHPTKHEVRFHQQRLVHDF
ICQGISNALHSEQASLYQTNEACVSANYQVEESAQHEYRPSYSKPNRAAAGQNIFDSSTTTPSTALFQTNKKNTQNRPHF
STNIPATRISKTEQAAYSALLSNSEMATVLPQEDGALLERKTPSILKALALVENKALLLQQQQQFYLLSLQQLQRLKIEL
SLQRDPVLQQPLLIPIVFRLNPQQLTYWQQQKTFFTQIGFEFHENLGQQRITLNRVPSCLRQQNLQKCIIVLLSQPLDTF
SHFLTTLCDVIELEQITVYADAVTLLTETEQLLNQKQAIRLSELFIELNWQAYLEKM
>Mature_616_residues
AIKVLSPQLANQIAAGEVVERPASVVKELVENSLDAGATRIQIDIENGGSTLIRIRDNGIGIAKDELSLALARHATSKIA
SLDDLDNILSLGFRGEALASISSVSRLTLTSRPATQNEAWQVYAQGREMETTLQPASHPVGTTVEVANLFFNTPARRKFL
RTDKTEFAHIDEVIRRIALAKMAISFTLTHNGKIVRQYRSAHDRTQKLKRVAAICGDEFVQNALEIDWKHDDLHLSGWVA
QPTFSRTQNDLSYCYINGRMVRDKIITHAIRQAYADFLSPEQYPAFVLFIDLNPNDVDVNVHPTKHEVRFHQQRLVHDFI
CQGISNALHSEQASLYQTNEACVSANYQVEESAQHEYRPSYSKPNRAAAGQNIFDSSTTTPSTALFQTNKKNTQNRPHFS
TNIPATRISKTEQAAYSALLSNSEMATVLPQEDGALLERKTPSILKALALVENKALLLQQQQQFYLLSLQQLQRLKIELS
LQRDPVLQQPLLIPIVFRLNPQQLTYWQQQKTFFTQIGFEFHENLGQQRITLNRVPSCLRQQNLQKCIIVLLSQPLDTFS
HFLTTLCDVIELEQITVYADAVTLLTETEQLLNQKQAIRLSELFIELNWQAYLEKM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=341, Percent_Identity=35.4838709677419, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI4505911, Length=318, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI189458898, Length=318, Percent_Identity=33.3333333333333, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI4505913, Length=341, Percent_Identity=29.6187683284457, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI310128478, Length=341, Percent_Identity=29.6187683284457, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI189458896, Length=312, Percent_Identity=31.7307692307692, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI263191589, Length=247, Percent_Identity=30.3643724696356, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI91992160, Length=360, Percent_Identity=26.9444444444444, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI91992162, Length=360, Percent_Identity=26.9444444444444, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI310128480, Length=297, Percent_Identity=26.2626262626263, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1790612, Length=608, Percent_Identity=49.0131578947368, Blast_Score=539, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI71991825, Length=326, Percent_Identity=33.4355828220859, Blast_Score=176, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=29.6511627906977, Blast_Score=135, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=346, Percent_Identity=35.8381502890173, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6324247, Length=361, Percent_Identity=29.6398891966759, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323063, Length=345, Percent_Identity=29.5652173913043, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325093, Length=306, Percent_Identity=25.1633986928105, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136968, Length=340, Percent_Identity=34.4117647058824, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17136970, Length=480, Percent_Identity=25, Blast_Score=122, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_PASMU (P57886)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245841.1
- ProteinModelPortal:   P57886
- GeneID:   1244251
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0904
- NMPDR:   fig|272843.1.peg.904
- HOGENOM:   HBG520262
- OMA:   EVANLFF
- ProtClustDB:   PRK00095
- BioCyc:   PMUL272843:PM0904-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 69799; Mature: 69668

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKVLSPQLANQIAAGEVVERPASVVKELVENSLDAGATRIQIDIENGGSTLIRIRDNG
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
IGIAKDELSLALARHATSKIASLDDLDNILSLGFRGEALASISSVSRLTLTSRPATQNEA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCCCCC
WQVYAQGREMETTLQPASHPVGTTVEVANLFFNTPARRKFLRTDKTEFAHIDEVIRRIAL
EEEEECCCCCCHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHH
AKMAISFTLTHNGKIVRQYRSAHDRTQKLKRVAAICGDEFVQNALEIDWKHDDLHLSGWV
HHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECEE
AQPTFSRTQNDLSYCYINGRMVRDKIITHAIRQAYADFLSPEQYPAFVLFIDLNPNDVDV
ECCCHHCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEE
NVHPTKHEVRFHQQRLVHDFICQGISNALHSEQASLYQTNEACVSANYQVEESAQHEYRP
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCEECCCHHHCCCC
SYSKPNRAAAGQNIFDSSTTTPSTALFQTNKKNTQNRPHFSTNIPATRISKTEQAAYSAL
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LSNSEMATVLPQEDGALLERKTPSILKALALVENKALLLQQQQQFYLLSLQQLQRLKIEL
HCCCCEEEECCCCCCCHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHEEE
SLQRDPVLQQPLLIPIVFRLNPQQLTYWQQQKTFFTQIGFEFHENLGQQRITLNRVPSCL
EECCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
RQQNLQKCIIVLLSQPLDTFSHFLTTLCDVIELEQITVYADAVTLLTETEQLLNQKQAIR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHE
LSELFIELNWQAYLEKM
EEHHHEEECHHHHHHCC
>Mature Secondary Structure 
AIKVLSPQLANQIAAGEVVERPASVVKELVENSLDAGATRIQIDIENGGSTLIRIRDNG
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
IGIAKDELSLALARHATSKIASLDDLDNILSLGFRGEALASISSVSRLTLTSRPATQNEA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCCCCC
WQVYAQGREMETTLQPASHPVGTTVEVANLFFNTPARRKFLRTDKTEFAHIDEVIRRIAL
EEEEECCCCCCHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHH
AKMAISFTLTHNGKIVRQYRSAHDRTQKLKRVAAICGDEFVQNALEIDWKHDDLHLSGWV
HHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECEE
AQPTFSRTQNDLSYCYINGRMVRDKIITHAIRQAYADFLSPEQYPAFVLFIDLNPNDVDV
ECCCHHCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEE
NVHPTKHEVRFHQQRLVHDFICQGISNALHSEQASLYQTNEACVSANYQVEESAQHEYRP
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCEECCCHHHCCCC
SYSKPNRAAAGQNIFDSSTTTPSTALFQTNKKNTQNRPHFSTNIPATRISKTEQAAYSAL
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LSNSEMATVLPQEDGALLERKTPSILKALALVENKALLLQQQQQFYLLSLQQLQRLKIEL
HCCCCEEEECCCCCCCHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHEEE
SLQRDPVLQQPLLIPIVFRLNPQQLTYWQQQKTFFTQIGFEFHENLGQQRITLNRVPSCL
EECCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
RQQNLQKCIIVLLSQPLDTFSHFLTTLCDVIELEQITVYADAVTLLTETEQLLNQKQAIR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHE
LSELFIELNWQAYLEKM
EEHHHEEECHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100