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The map label for this gene is tyrS

Identifier: 15602620

GI number: 15602620

Start: 889740

End: 890927

Strand: Direct

Name: tyrS

Synonym: PM0755

Alternate gene names: 15602620

Gene position: 889740-890927 (Clockwise)

Preceding gene: 15602619

Following gene: 15602623

Centisome position: 39.41

GC content: 41.16

Gene sequence:

>1188_bases
ATGACGGAGATAAATACGGTTCTTGCTGAACTTAAACGTGGTGTAGATGAAATTCTTTCAGAAGCGGACTTAATTGAAAA
ACTAAAAGAAAACCGCCCTTTACGCGTAAAATTAGGTGCTGATCCAACAGCCCCTGATATCCATTTAGGACACACCGTCG
TATTAAATAAATTACGTCAATTTCAACAATTTGGTCATGAAGTCATTTTCTTAATTGGTGACTTTACCGGTATGGTTGGT
GACCCATCTGGCAAGAATACTACTCGCCCACCACTCAGTCGTGACGATGTCTTACGCAATGCCGAAACCTACAAGCAACA
AATCTATAAGATTTTAGATCCACAAAAAACCCGTATTGTGTTTAACTCAAGCTGGTTAGGCGAATTAGGGACAGAAGGCA
TGATTCGTTTAACCTCAAATTACACCGTTGCACGTATGTTAGAACGTGATGATTTCAAAAAACGTTTTAGCAACAACCAG
CCTATCGCGATTCATGAATTTATCTATCCTTTATTGCAAGGTTATGACTCTGTGGCATTAGATGCCGATATCGAATTAGG
TGGAACGGACCAAAAATTCAATCTTTTAGTCGGACGTGAATTACAAAAATCGGCGGGTCAAAAACCGCAAGTCGCCATCA
CGTTACCACTACTTGTAGGCTTAGACGGTGAGAAAAAAATGTCGAAGTCACTGGGCAATTACATTGGTGTTGCAGAAAGC
CCGACAGAAATGTTTGGTAAAGTGATGTCAATTTCTGATGAGCTCATGTGGGATTGGTATGACTTACTGTCTTTCCGCCC
ATTAACCGAAATCGCCCAATTAAAACAAGAGGTTGAAAACGGACGTAACCCACGTGATATCAAAGTGTTACTTGCTAAAG
AACTCATTGCTCGTTTCCATAGTGAAGCTGACGCAGAAGCTGCAGAACAAGAATTTATTAATCGTTTCCAAAAAGGCGCA
ATGCCTGAAGATATGCCTGAATTGACCTTTGAAGGTGAAATGGGCTTAGCAAACTTGTTAAAAGAAGCGGGATTAGTCGC
CTCAACCTCTGAAGCAAACCGTATGGTGCAACAAGGTGGCGTGAAAATTGACGGTGAAAAAGTCGAAGATGCCAAATTAG
TTATCAAAGCAAGTACCGCCGTTTATCAAGTAGGTAAACGTAAGTTTGCGCGTGTGACGGTGAAGTAA

Upstream 100 bases:

>100_bases
TTTCCTGCCATAATCATAAATAAAGCCATATCGAGCCTTTTCATTTAACGAATAATCACTATAATGTAGAATTTTAGCCA
AAATGAAACAGGAAATTAGA

Downstream 100 bases:

>100_bases
GCGTTCATACTTAAAAATAAATAAAAAATCCACCGCACTTTAGCTTCATCGTGAAAAGTACGGTGGATTTTCTTTTCTCA
AATATTTACGTATTTTGTGT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTEINTVLAELKRGVDEILSEADLIEKLKENRPLRVKLGADPTAPDIHLGHTVVLNKLRQFQQFGHEVIFLIGDFTGMVG
DPSGKNTTRPPLSRDDVLRNAETYKQQIYKILDPQKTRIVFNSSWLGELGTEGMIRLTSNYTVARMLERDDFKKRFSNNQ
PIAIHEFIYPLLQGYDSVALDADIELGGTDQKFNLLVGRELQKSAGQKPQVAITLPLLVGLDGEKKMSKSLGNYIGVAES
PTEMFGKVMSISDELMWDWYDLLSFRPLTEIAQLKQEVENGRNPRDIKVLLAKELIARFHSEADAEAAEQEFINRFQKGA
MPEDMPELTFEGEMGLANLLKEAGLVASTSEANRMVQQGGVKIDGEKVEDAKLVIKASTAVYQVGKRKFARVTVK

Sequences:

>Translated_395_residues
MTEINTVLAELKRGVDEILSEADLIEKLKENRPLRVKLGADPTAPDIHLGHTVVLNKLRQFQQFGHEVIFLIGDFTGMVG
DPSGKNTTRPPLSRDDVLRNAETYKQQIYKILDPQKTRIVFNSSWLGELGTEGMIRLTSNYTVARMLERDDFKKRFSNNQ
PIAIHEFIYPLLQGYDSVALDADIELGGTDQKFNLLVGRELQKSAGQKPQVAITLPLLVGLDGEKKMSKSLGNYIGVAES
PTEMFGKVMSISDELMWDWYDLLSFRPLTEIAQLKQEVENGRNPRDIKVLLAKELIARFHSEADAEAAEQEFINRFQKGA
MPEDMPELTFEGEMGLANLLKEAGLVASTSEANRMVQQGGVKIDGEKVEDAKLVIKASTAVYQVGKRKFARVTVK
>Mature_394_residues
TEINTVLAELKRGVDEILSEADLIEKLKENRPLRVKLGADPTAPDIHLGHTVVLNKLRQFQQFGHEVIFLIGDFTGMVGD
PSGKNTTRPPLSRDDVLRNAETYKQQIYKILDPQKTRIVFNSSWLGELGTEGMIRLTSNYTVARMLERDDFKKRFSNNQP
IAIHEFIYPLLQGYDSVALDADIELGGTDQKFNLLVGRELQKSAGQKPQVAITLPLLVGLDGEKKMSKSLGNYIGVAESP
TEMFGKVMSISDELMWDWYDLLSFRPLTEIAQLKQEVENGRNPRDIKVLLAKELIARFHSEADAEAAEQEFINRFQKGAM
PEDMPELTFEGEMGLANLLKEAGLVASTSEANRMVQQGGVKIDGEKVEDAKLVIKASTAVYQVGKRKFARVTVK

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Homo sapiens, GI94681057, Length=412, Percent_Identity=25, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1787925, Length=427, Percent_Identity=26.9320843091335, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25145802, Length=378, Percent_Identity=28.042328042328, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325160, Length=434, Percent_Identity=27.1889400921659, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321624, Length=263, Percent_Identity=26.2357414448669, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI20130383, Length=400, Percent_Identity=27.75, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYY_PASMU (Q9CMQ8)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245692.1
- ProteinModelPortal:   Q9CMQ8
- SMR:   Q9CMQ8
- GeneID:   1244102
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0755
- NMPDR:   fig|272843.1.peg.755
- HOGENOM:   HBG288125
- OMA:   YVVQVGK
- ProtClustDB:   PRK05912
- BioCyc:   PMUL272843:PM0755-MONOMER
- BRENDA:   6.1.1.1
- GO:   GO:0005737
- HAMAP:   MF_02007
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11766
- PRINTS:   PR01040
- SMART:   SM00363
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 44225; Mature: 44094

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50889 S4

Important sites: BINDING 229-229

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEINTVLAELKRGVDEILSEADLIEKLKENRPLRVKLGADPTAPDIHLGHTVVLNKLRQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
FQQFGHEVIFLIGDFTGMVGDPSGKNTTRPPLSRDDVLRNAETYKQQIYKILDPQKTRIV
HHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
FNSSWLGELGTEGMIRLTSNYTVARMLERDDFKKRFSNNQPIAIHEFIYPLLQGYDSVAL
ECCCCCHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCEEE
DADIELGGTDQKFNLLVGRELQKSAGQKPQVAITLPLLVGLDGEKKMSKSLGNYIGVAES
ECCEEECCCCCHHHHHCCHHHHHHCCCCCEEEEEEEEEEECCCHHHHHHHHHHHCCCCCC
PTEMFGKVMSISDELMWDWYDLLSFRPLTEIAQLKQEVENGRNPRDIKVLLAKELIARFH
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SEADAEAAEQEFINRFQKGAMPEDMPELTFEGEMGLANLLKEAGLVASTSEANRMVQQGG
CCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHCCCEECCHHHHHHHHHCC
VKIDGEKVEDAKLVIKASTAVYQVGKRKFARVTVK
CEECCCCCCCCEEEEEEHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
TEINTVLAELKRGVDEILSEADLIEKLKENRPLRVKLGADPTAPDIHLGHTVVLNKLRQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
FQQFGHEVIFLIGDFTGMVGDPSGKNTTRPPLSRDDVLRNAETYKQQIYKILDPQKTRIV
HHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
FNSSWLGELGTEGMIRLTSNYTVARMLERDDFKKRFSNNQPIAIHEFIYPLLQGYDSVAL
ECCCCCHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCEEE
DADIELGGTDQKFNLLVGRELQKSAGQKPQVAITLPLLVGLDGEKKMSKSLGNYIGVAES
ECCEEECCCCCHHHHHCCHHHHHHCCCCCEEEEEEEEEEECCCHHHHHHHHHHHCCCCCC
PTEMFGKVMSISDELMWDWYDLLSFRPLTEIAQLKQEVENGRNPRDIKVLLAKELIARFH
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SEADAEAAEQEFINRFQKGAMPEDMPELTFEGEMGLANLLKEAGLVASTSEANRMVQQGG
CCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHCCCEECCHHHHHHHHHCC
VKIDGEKVEDAKLVIKASTAVYQVGKRKFARVTVK
CEECCCCCCCCEEEEEEHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100