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The map label for this gene is sppA [H]

Identifier: 15602536

GI number: 15602536

Start: 779547

End: 781430

Strand: Reverse

Name: sppA [H]

Synonym: PM0671

Alternate gene names: 15602536

Gene position: 781430-779547 (Counterclockwise)

Preceding gene: 15602538

Following gene: 15602535

Centisome position: 34.62

GC content: 38.06

Gene sequence:

>1884_bases
ATGCAATTAATTGTACAGTTTTTCCGTTTATGCTGGCGTATTTTAAATTTTATTCGTGAGCTCGTCATGAATATTGTTTT
TTTATTTTTTGTACTTCTTGTCGCGGCAGTCGTTGGGATCTTTTTTCATTCAAATAAAATACAACACCCTATGATGTTAG
AGAATGAAAAATATGCCTTATTGTTAAATTTAGATGGCTATCTTGCGGATAATCGTGAAGAGAGTATGTCTTGGCAGAAA
GCATTAAAAGAATTAGATAATCAACATGTGCCACGCCAAATTTCTACTTTTGATATTGTGTATATGATTGATCATGCGAA
AAAGGATGATCGTATTAGTGGATTAGTGTTAGATCTGAATTTCTTTGAGGGTGCAGATTTACCTGCATTAGAATATGTTG
GTCAGACCATCAATGCCTTTAAAGAAAGTCAAAAACCAGTCATTGCCTTTGCGGATAACCTAGGACAATCACAATATTTA
TTGGCGAGTTATGCAGATGAAATTTATATCAACCCAATTGGTCAGGTGGATATTACGGGATTACGTCAAGAAAATCTGTA
TTTTAAATCAATGCTAGAAAACTTAGATGTCACAGCGCATATTTTTAGAGTCGGCACCTATAAATCCGCTGTTGAGCCGT
TTCTACGCGATAATATGTCGCCAGAAGCGAAGACTGATCTGAGCGAGTGGCTCGGGGCAATGTGGCATAATTATAAGCAA
ATTGTGGCAAAAAACCGTCAAATTGATCCAGATGATGTGTTACCTGCGTCTTCAAAATACATACAAGCCTTAAAAATGTT
AAAAGGAGACAGTACGGCATATACACAGCAACGTCAGTTGGTGACAGGTTTAGCCAATCGTTTAGAAATAGATGAAAAAT
TATTGGAACGTTTTGGACAAGACAAAAACGATAATATACGCTTAATTGATTATGAGGATTATTTGTCCTTGTTACCAGAT
CGACTTTCTGAAGAAGGACAATATAAAATTGCCGTTGTCAATGTTGAAGGTGCCATTATTGATGGTGAAAGTGATGAGCA
TGAAGTGGGAGGAGATACGATTGCACGCCTTTTACGCCAAGCGCACGATGATGACAATGTAAAAGCGGTGATTCTTCGAG
TCAACAGTCCGGGTGGCAGTGCTTTTGCTTCTGAAATAATTCGTCAAGAAGTAGATAATTTACAAGCGCTCGGAAAACCA
GTTGTTGTTTCTATGGGGGCGATGGCGGCCTCTGGAGGCTATTGGATTTCTAGTACCGCAGATTATATTATCGCAGATAA
AAATACGATTACAGGCTCGATTGGTATTTTTGCGCTGTTCCCAACATTTGAAAAAACACTTAAGAAAGTGGGCATTTCGG
CAGATGGCGTATCAACCTCAGCACTGAGTTCAAGTTCTCGTTTTAGTGGATTATCCAGTGAAATGTCAGATATTCTTCAA
CTGGAAATTGAAAGTGGATACGATAAATTCTTATCCGTTGTTAGCCGTGGTCGAGGCATGACAGTGGAAGAAGTCGATAA
AGTAGCACAGGGTAAAATTTGGTTAGGCGAAGAGGCGGTTAAACACAATCTTGTGGATGAACTCGGTCACTTTAATCTTG
CCGTAGAGAAAGCTTCAGAGCTCGCTAATCAATTACTCGATGAAAAAGAGAAAGTCGATTATTTTGCCCTTCAATGGATG
GTTGAAGACGAACAGAATTTCTTGAGTGATTTGTTGCCAACCCTTAAACGAAAAATACAAGCATGGGTAGGGAATACATT
GTTAGAAAGTATTGCACTCCCAGTAGAATATCGTGAAGTGAGAAAACAGATTGGGTTATTAAATAAAATGAATGATCCAA
AAGGGAAATATTTATATTGCCTCACTTGTAGCACAATAAACTAA

Upstream 100 bases:

>100_bases
TGCGGTAGATTTTAGCATATTTTACGATGAGCGTTTATTGCTATCGGAGTTTGTGGTATGTTAGCAAAATTCCTTTATTC
TGTTTATTTGATGAGGTTTT

Downstream 100 bases:

>100_bases
GATTCGTTAGAATAATCGAGCCATTATTGTGCGGTTAATGGTTCGATTTTTTTTATAATTCATTGTGGGAGAATAATAAA
TGCATAAATTGCTAAAATTA

Product: hypothetical protein

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MQLIVQFFRLCWRILNFIRELVMNIVFLFFVLLVAAVVGIFFHSNKIQHPMMLENEKYALLLNLDGYLADNREESMSWQK
ALKELDNQHVPRQISTFDIVYMIDHAKKDDRISGLVLDLNFFEGADLPALEYVGQTINAFKESQKPVIAFADNLGQSQYL
LASYADEIYINPIGQVDITGLRQENLYFKSMLENLDVTAHIFRVGTYKSAVEPFLRDNMSPEAKTDLSEWLGAMWHNYKQ
IVAKNRQIDPDDVLPASSKYIQALKMLKGDSTAYTQQRQLVTGLANRLEIDEKLLERFGQDKNDNIRLIDYEDYLSLLPD
RLSEEGQYKIAVVNVEGAIIDGESDEHEVGGDTIARLLRQAHDDDNVKAVILRVNSPGGSAFASEIIRQEVDNLQALGKP
VVVSMGAMAASGGYWISSTADYIIADKNTITGSIGIFALFPTFEKTLKKVGISADGVSTSALSSSSRFSGLSSEMSDILQ
LEIESGYDKFLSVVSRGRGMTVEEVDKVAQGKIWLGEEAVKHNLVDELGHFNLAVEKASELANQLLDEKEKVDYFALQWM
VEDEQNFLSDLLPTLKRKIQAWVGNTLLESIALPVEYREVRKQIGLLNKMNDPKGKYLYCLTCSTIN

Sequences:

>Translated_627_residues
MQLIVQFFRLCWRILNFIRELVMNIVFLFFVLLVAAVVGIFFHSNKIQHPMMLENEKYALLLNLDGYLADNREESMSWQK
ALKELDNQHVPRQISTFDIVYMIDHAKKDDRISGLVLDLNFFEGADLPALEYVGQTINAFKESQKPVIAFADNLGQSQYL
LASYADEIYINPIGQVDITGLRQENLYFKSMLENLDVTAHIFRVGTYKSAVEPFLRDNMSPEAKTDLSEWLGAMWHNYKQ
IVAKNRQIDPDDVLPASSKYIQALKMLKGDSTAYTQQRQLVTGLANRLEIDEKLLERFGQDKNDNIRLIDYEDYLSLLPD
RLSEEGQYKIAVVNVEGAIIDGESDEHEVGGDTIARLLRQAHDDDNVKAVILRVNSPGGSAFASEIIRQEVDNLQALGKP
VVVSMGAMAASGGYWISSTADYIIADKNTITGSIGIFALFPTFEKTLKKVGISADGVSTSALSSSSRFSGLSSEMSDILQ
LEIESGYDKFLSVVSRGRGMTVEEVDKVAQGKIWLGEEAVKHNLVDELGHFNLAVEKASELANQLLDEKEKVDYFALQWM
VEDEQNFLSDLLPTLKRKIQAWVGNTLLESIALPVEYREVRKQIGLLNKMNDPKGKYLYCLTCSTIN
>Mature_627_residues
MQLIVQFFRLCWRILNFIRELVMNIVFLFFVLLVAAVVGIFFHSNKIQHPMMLENEKYALLLNLDGYLADNREESMSWQK
ALKELDNQHVPRQISTFDIVYMIDHAKKDDRISGLVLDLNFFEGADLPALEYVGQTINAFKESQKPVIAFADNLGQSQYL
LASYADEIYINPIGQVDITGLRQENLYFKSMLENLDVTAHIFRVGTYKSAVEPFLRDNMSPEAKTDLSEWLGAMWHNYKQ
IVAKNRQIDPDDVLPASSKYIQALKMLKGDSTAYTQQRQLVTGLANRLEIDEKLLERFGQDKNDNIRLIDYEDYLSLLPD
RLSEEGQYKIAVVNVEGAIIDGESDEHEVGGDTIARLLRQAHDDDNVKAVILRVNSPGGSAFASEIIRQEVDNLQALGKP
VVVSMGAMAASGGYWISSTADYIIADKNTITGSIGIFALFPTFEKTLKKVGISADGVSTSALSSSSRFSGLSSEMSDILQ
LEIESGYDKFLSVVSRGRGMTVEEVDKVAQGKIWLGEEAVKHNLVDELGHFNLAVEKASELANQLLDEKEKVDYFALQWM
VEDEQNFLSDLLPTLKRKIQAWVGNTLLESIALPVEYREVRKQIGLLNKMNDPKGKYLYCLTCSTIN

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=630, Percent_Identity=42.2222222222222, Blast_Score=492, Evalue=1e-140,
Organism=Escherichia coli, GI1787527, Length=222, Percent_Identity=27.9279279279279, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 70609; Mature: 70609

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLIVQFFRLCWRILNFIRELVMNIVFLFFVLLVAAVVGIFFHSNKIQHPMMLENEKYAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEE
LLNLDGYLADNREESMSWQKALKELDNQHVPRQISTFDIVYMIDHAKKDDRISGLVLDLN
EEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEEE
FFEGADLPALEYVGQTINAFKESQKPVIAFADNLGQSQYLLASYADEIYINPIGQVDITG
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCEEECCCCCEEECC
LRQENLYFKSMLENLDVTAHIFRVGTYKSAVEPFLRDNMSPEAKTDLSEWLGAMWHNYKQ
CCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IVAKNRQIDPDDVLPASSKYIQALKMLKGDSTAYTQQRQLVTGLANRLEIDEKLLERFGQ
HHHCCCCCCHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DKNDNIRLIDYEDYLSLLPDRLSEEGQYKIAVVNVEGAIIDGESDEHEVGGDTIARLLRQ
CCCCCEEEEEHHHHHHHCHHHCCCCCCEEEEEEEECEEEECCCCCCCCCCHHHHHHHHHH
AHDDDNVKAVILRVNSPGGSAFASEIIRQEVDNLQALGKPVVVSMGAMAASGGYWISSTA
HCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCEECCCCEEECCCC
DYIIADKNTITGSIGIFALFPTFEKTLKKVGISADGVSTSALSSSSRFSGLSSEMSDILQ
CEEEECCCEEEECCHHEEEHHHHHHHHHHHCCCCCCCCHHHHCCCHHHCCHHHHHHHHHH
LEIESGYDKFLSVVSRGRGMTVEEVDKVAQGKIWLGEEAVKHNLVDELGHFNLAVEKASE
HHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEECHHHHHHHHHHHHCCCHHHHHHHHH
LANQLLDEKEKVDYFALQWMVEDEQNFLSDLLPTLKRKIQAWVGNTLLESIALPVEYREV
HHHHHHHHHHHCCEEHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RKQIGLLNKMNDPKGKYLYCLTCSTIN
HHHHHHHHCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MQLIVQFFRLCWRILNFIRELVMNIVFLFFVLLVAAVVGIFFHSNKIQHPMMLENEKYAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEE
LLNLDGYLADNREESMSWQKALKELDNQHVPRQISTFDIVYMIDHAKKDDRISGLVLDLN
EEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEEE
FFEGADLPALEYVGQTINAFKESQKPVIAFADNLGQSQYLLASYADEIYINPIGQVDITG
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCEEECCCCCEEECC
LRQENLYFKSMLENLDVTAHIFRVGTYKSAVEPFLRDNMSPEAKTDLSEWLGAMWHNYKQ
CCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IVAKNRQIDPDDVLPASSKYIQALKMLKGDSTAYTQQRQLVTGLANRLEIDEKLLERFGQ
HHHCCCCCCHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DKNDNIRLIDYEDYLSLLPDRLSEEGQYKIAVVNVEGAIIDGESDEHEVGGDTIARLLRQ
CCCCCEEEEEHHHHHHHCHHHCCCCCCEEEEEEEECEEEECCCCCCCCCCHHHHHHHHHH
AHDDDNVKAVILRVNSPGGSAFASEIIRQEVDNLQALGKPVVVSMGAMAASGGYWISSTA
HCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCEECCCCEEECCCC
DYIIADKNTITGSIGIFALFPTFEKTLKKVGISADGVSTSALSSSSRFSGLSSEMSDILQ
CEEEECCCEEEECCHHEEEHHHHHHHHHHHCCCCCCCCHHHHCCCHHHCCHHHHHHHHHH
LEIESGYDKFLSVVSRGRGMTVEEVDKVAQGKIWLGEEAVKHNLVDELGHFNLAVEKASE
HHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEECHHHHHHHHHHHHCCCHHHHHHHHH
LANQLLDEKEKVDYFALQWMVEDEQNFLSDLLPTLKRKIQAWVGNTLLESIALPVEYREV
HHHHHHHHHHHCCEEHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RKQIGLLNKMNDPKGKYLYCLTCSTIN
HHHHHHHHCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]