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The map label for this gene is norM

Identifier: 15602516

GI number: 15602516

Start: 753314

End: 754708

Strand: Direct

Name: norM

Synonym: PM0651

Alternate gene names: 15602516

Gene position: 753314-754708 (Clockwise)

Preceding gene: 15602514

Following gene: 15602517

Centisome position: 33.37

GC content: 41.58

Gene sequence:

>1395_bases
ATGAAATTTATAGATTTTAGTGCTTATAAAGTGGAAGCAAAAAAATTATTGCTTATTGCCCTCCCGATCTTACTGGCACA
AATTGCCCAAAACTCAATGGGGTTAGTTGATACCATCATGTCTGGACGCGTCAGTTCGGCAGATATGGCAGCGATTTCAG
TGGGCGCATCCATTTGGTTCCCCTTAGTGCTGTTTGGTCACGGACTTCTACTAGCGCTACCACCAACGATCTCCTATCTC
AATGGCTCAGGCAAACGCGATCAAATTGCCCATCAAGTACGACAAGGTATTTGGATTATTTTATTTAGTTGCCTACCTTT
AGGTATTCTCATTTATTATAGCAACCTCGTTTTTGACTATATGCAAGTGGAAGATCATCTCAAAGAGATCACTATTGGCT
ATTTACATGCAATGATTTGGGGCTTGCCCGCTTATTTACTGATGATTAATTTTCGTTGCTTAAATGATGGTATTGCGAAA
ACCAAACCAGCTATGGTGATCACGTTTTTAGGCTTAGGTTTAAATATTCCACTCAATTATATTTTTATTTATGGAAAACT
TGGTATCCCCGCCTTTGGTGCGGTTGGATGTGGTATTGCGACCGCCATTGTGAACTGGTTTATGTGTATTTTGATGATCG
CCTATTGTAAAAATGCACGTAATCAACGTGACCTTAAAGTCTTTGCCAAAATCCTAGAAAAACCTAATTTTACTACCTTA
AAAAAACTCCTCAACTTAGGTTTCCCGATTGCTGTCGCCTTATTCTGCGAAGTGGCACTGTTCGCCCTTACCGCCTTGCT
ATTATCCCCATTAGGTACAGATATCGTTGCAAGCCATCAAATTGCATTGAATACCAGCTCCTTCTTGTTTATGCTTCCTA
TGTCATTAGGTATGGCTGCAACCATTCTAGTAGGACAGCGTTTAGGTGAAGGCGCTGCGGATAAGGCGAAACAGGTATCC
TACTCCGCCTTAATTGTCGGCTTACTGATTGCGGTCATCACGGCGACATTAACGGTCATCTTCCGTGTTGAGATTGCTGA
AATTTTTGTCAAAGATCGAGATGTGATTGCGATGGCTGGCACACTCCTTTTAATTGCTGCCCTTTATCAATTCTCTGATA
CCGTTCAAGTCGTAGCCGGCGGTGCATTACGTGGCTATAAAGATACAAAAGCTATCTTATACATTACACTCTTTTGTTAT
TGGGTAGTGGGTATGCCAATGGGCTATACCTTAGCTCGTACAGATCTGTTGATGCCTGCTCTAGGGGCGGAAGGTTTTTG
GATTGGCTTTGTTGTCAGCCTGACTATTGCCGCTACACTGTTGATGATCAGAATGCGCAAAATCCAAGCTCAACCAGATG
CCATTTTATTTGCTAAACTTGAGAAATTAAAATAA

Upstream 100 bases:

>100_bases
AATAGAAACAATTTTTGCAGTTCCTTGAACAATACCTGTAAACATAGTCATCTCTCTTTAAAACTCAATATTCTATTATT
ATAACAAACTCGGAATTTTT

Downstream 100 bases:

>100_bases
TGTCGAAGATCATTCATGTTGGTATTGCAGGTTTTGGTATGTCAGCCAAAACTTTCCATACTCCTTTTTTACATCAAGAT
CCCCGTTTCTGTATCCATAA

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKFIDFSAYKVEAKKLLLIALPILLAQIAQNSMGLVDTIMSGRVSSADMAAISVGASIWFPLVLFGHGLLLALPPTISYL
NGSGKRDQIAHQVRQGIWIILFSCLPLGILIYYSNLVFDYMQVEDHLKEITIGYLHAMIWGLPAYLLMINFRCLNDGIAK
TKPAMVITFLGLGLNIPLNYIFIYGKLGIPAFGAVGCGIATAIVNWFMCILMIAYCKNARNQRDLKVFAKILEKPNFTTL
KKLLNLGFPIAVALFCEVALFALTALLLSPLGTDIVASHQIALNTSSFLFMLPMSLGMAATILVGQRLGEGAADKAKQVS
YSALIVGLLIAVITATLTVIFRVEIAEIFVKDRDVIAMAGTLLLIAALYQFSDTVQVVAGGALRGYKDTKAILYITLFCY
WVVGMPMGYTLARTDLLMPALGAEGFWIGFVVSLTIAATLLMIRMRKIQAQPDAILFAKLEKLK

Sequences:

>Translated_464_residues
MKFIDFSAYKVEAKKLLLIALPILLAQIAQNSMGLVDTIMSGRVSSADMAAISVGASIWFPLVLFGHGLLLALPPTISYL
NGSGKRDQIAHQVRQGIWIILFSCLPLGILIYYSNLVFDYMQVEDHLKEITIGYLHAMIWGLPAYLLMINFRCLNDGIAK
TKPAMVITFLGLGLNIPLNYIFIYGKLGIPAFGAVGCGIATAIVNWFMCILMIAYCKNARNQRDLKVFAKILEKPNFTTL
KKLLNLGFPIAVALFCEVALFALTALLLSPLGTDIVASHQIALNTSSFLFMLPMSLGMAATILVGQRLGEGAADKAKQVS
YSALIVGLLIAVITATLTVIFRVEIAEIFVKDRDVIAMAGTLLLIAALYQFSDTVQVVAGGALRGYKDTKAILYITLFCY
WVVGMPMGYTLARTDLLMPALGAEGFWIGFVVSLTIAATLLMIRMRKIQAQPDAILFAKLEKLK
>Mature_464_residues
MKFIDFSAYKVEAKKLLLIALPILLAQIAQNSMGLVDTIMSGRVSSADMAAISVGASIWFPLVLFGHGLLLALPPTISYL
NGSGKRDQIAHQVRQGIWIILFSCLPLGILIYYSNLVFDYMQVEDHLKEITIGYLHAMIWGLPAYLLMINFRCLNDGIAK
TKPAMVITFLGLGLNIPLNYIFIYGKLGIPAFGAVGCGIATAIVNWFMCILMIAYCKNARNQRDLKVFAKILEKPNFTTL
KKLLNLGFPIAVALFCEVALFALTALLLSPLGTDIVASHQIALNTSSFLFMLPMSLGMAATILVGQRLGEGAADKAKQVS
YSALIVGLLIAVITATLTVIFRVEIAEIFVKDRDVIAMAGTLLLIAALYQFSDTVQVVAGGALRGYKDTKAILYITLFCY
WVVGMPMGYTLARTDLLMPALGAEGFWIGFVVSLTIAATLLMIRMRKIQAQPDAILFAKLEKLK

Specific function: Multidrug efflux pump

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

Homologues:

Organism=Homo sapiens, GI22907060, Length=467, Percent_Identity=22.9122055674518, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI48994890, Length=455, Percent_Identity=50.1098901098901, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI226510954, Length=451, Percent_Identity=24.6119733924612, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6321821, Length=394, Percent_Identity=22.0812182741117, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320545, Length=405, Percent_Identity=21.9753086419753, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NORM_PASMU (Q9CMZ9)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245588.1
- GeneID:   1243998
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0651
- NMPDR:   fig|272843.1.peg.651
- HOGENOM:   HBG479615
- OMA:   HQIALNT
- ProtClustDB:   PRK01766
- BioCyc:   PMUL272843:PM0651-MONOMER
- InterPro:   IPR002528
- PANTHER:   PTHR11206
- TIGRFAMs:   TIGR00797

Pfam domain/function: PF01554 MatE

EC number: NA

Molecular weight: Translated: 50668; Mature: 50668

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xbafc060)-; HASH(0xcf20010)-; HASH(0xd277234)-; HASH(0xd61cf38)-; HASH(0xd3ad30c)-; HASH(0xbf17518)-; HASH(0x9499488)-; HASH(0xaf85ab0)-; HASH(0xd26beec)-; HASH(0xd24744c)-; HASH(0xd36873c)-; HASH(0xd244664)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFIDFSAYKVEAKKLLLIALPILLAQIAQNSMGLVDTIMSGRVSSADMAAISVGASIWF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
PLVLFGHGLLLALPPTISYLNGSGKRDQIAHQVRQGIWIILFSCLPLGILIYYSNLVFDY
HHHHHCCCCEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQVEDHLKEITIGYLHAMIWGLPAYLLMINFRCLNDGIAKTKPAMVITFLGLGLNIPLNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEE
IFIYGKLGIPAFGAVGCGIATAIVNWFMCILMIAYCKNARNQRDLKVFAKILEKPNFTTL
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHH
KKLLNLGFPIAVALFCEVALFALTALLLSPLGTDIVASHQIALNTSSFLFMLPMSLGMAA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCHHHHHHHHHHHHHH
TILVGQRLGEGAADKAKQVSYSALIVGLLIAVITATLTVIFRVEIAEIFVKDRDVIAMAG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TLLLIAALYQFSDTVQVVAGGALRGYKDTKAILYITLFCYWVVGMPMGYTLARTDLLMPA
HHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
LGAEGFWIGFVVSLTIAATLLMIRMRKIQAQPDAILFAKLEKLK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCH
>Mature Secondary Structure
MKFIDFSAYKVEAKKLLLIALPILLAQIAQNSMGLVDTIMSGRVSSADMAAISVGASIWF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
PLVLFGHGLLLALPPTISYLNGSGKRDQIAHQVRQGIWIILFSCLPLGILIYYSNLVFDY
HHHHHCCCCEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQVEDHLKEITIGYLHAMIWGLPAYLLMINFRCLNDGIAKTKPAMVITFLGLGLNIPLNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEE
IFIYGKLGIPAFGAVGCGIATAIVNWFMCILMIAYCKNARNQRDLKVFAKILEKPNFTTL
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHH
KKLLNLGFPIAVALFCEVALFALTALLLSPLGTDIVASHQIALNTSSFLFMLPMSLGMAA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCHHHHHHHHHHHHHH
TILVGQRLGEGAADKAKQVSYSALIVGLLIAVITATLTVIFRVEIAEIFVKDRDVIAMAG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TLLLIAALYQFSDTVQVVAGGALRGYKDTKAILYITLFCYWVVGMPMGYTLARTDLLMPA
HHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
LGAEGFWIGFVVSLTIAATLLMIRMRKIQAQPDAILFAKLEKLK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11248100