Click here to switch to the map view.

The map label for this gene is moaE

Identifier: 15602487

GI number: 15602487

Start: 726202

End: 726654

Strand: Reverse

Name: moaE

Synonym: PM0622

Alternate gene names: 15602487

Gene position: 726654-726202 (Counterclockwise)

Preceding gene: 15602488

Following gene: 15602483

Centisome position: 32.19

GC content: 43.05

Gene sequence:

>453_bases
ATGAGCGATATTCAAATTGCAGTACAAGAACAGCCCTTTGATCAAAATGCGGCATATCGTTGGTTATCAGAACAACATTC
TGTCGGGGCTACCGTGGTTTTTGTGGGCAAAGTACGGGATTTAAATCTCGGCGATGAAGTATCCAGTTTGTATTTAGAAC
ATTATCCCGCGATGACTGAAAAAGCCCTAACAGAGATTGTGGCGCAAGCAAAAGCCCGCTGGGACATTCAACGTGTTTGT
GTCATTCACCGTGTTGGTTTATTACAAACAGGTGATGAGATTGTTTTCGTCGGGGTGAGCTCTGCACATCGTGGTGAAGC
TTATCAAGCTAATGAATTTATTATGGATTTTTTAAAAAGCAAAGCCCCATTTTGGAAAAAAGAAAAAACCACTCAGGGTG
AGCGCTGGATTGAAAGTCGCGATACTGATCAGCAAGCCTTAGCACGCTGGTAA

Upstream 100 bases:

>100_bases
CAAATTATTAGTGGCAATTAATCAGGCTTTAGTGCCTTTAGATACAGAAGTGAAAGCGGGTGATGAAGTCGCGTTTTTCC
CACCCGTGACTGGAGGATAA

Downstream 100 bases:

>100_bases
AAAAAGAAAAAAAGAACCGCACTTTTTATAGTGCGGTTTTTTCTTTGTTATGAAAATATAATTAAAGGACTTTCGCAATA
CTTTCACACAGATAACGAAT

Product: hypothetical protein

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MSDIQIAVQEQPFDQNAAYRWLSEQHSVGATVVFVGKVRDLNLGDEVSSLYLEHYPAMTEKALTEIVAQAKARWDIQRVC
VIHRVGLLQTGDEIVFVGVSSAHRGEAYQANEFIMDFLKSKAPFWKKEKTTQGERWIESRDTDQQALARW

Sequences:

>Translated_150_residues
MSDIQIAVQEQPFDQNAAYRWLSEQHSVGATVVFVGKVRDLNLGDEVSSLYLEHYPAMTEKALTEIVAQAKARWDIQRVC
VIHRVGLLQTGDEIVFVGVSSAHRGEAYQANEFIMDFLKSKAPFWKKEKTTQGERWIESRDTDQQALARW
>Mature_149_residues
SDIQIAVQEQPFDQNAAYRWLSEQHSVGATVVFVGKVRDLNLGDEVSSLYLEHYPAMTEKALTEIVAQAKARWDIQRVCV
IHRVGLLQTGDEIVFVGVSSAHRGEAYQANEFIMDFLKSKAPFWKKEKTTQGERWIESRDTDQQALARW

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family

Homologues:

Organism=Homo sapiens, GI4758732, Length=109, Percent_Identity=34.8623853211009, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1787003, Length=150, Percent_Identity=58.6666666666667, Blast_Score=195, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17509279, Length=114, Percent_Identity=35.9649122807018, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21356259, Length=118, Percent_Identity=34.7457627118644, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAE_PASMU (Q9CN24)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245559.1
- ProteinModelPortal:   Q9CN24
- SMR:   Q9CN24
- GeneID:   1243969
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0622
- NMPDR:   fig|272843.1.peg.622
- HOGENOM:   HBG460564
- OMA:   GAVACFV
- ProtClustDB:   CLSK870173
- BioCyc:   PMUL272843:PM0622-MONOMER
- InterPro:   IPR003448
- Gene3D:   G3DSA:3.90.1170.40
- PANTHER:   PTHR23404:SF2

Pfam domain/function: PF02391 MoaE; SSF54690 Mb_biosynth_MoaE

EC number: NA

Molecular weight: Translated: 17157; Mature: 17025

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: BINDING 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIQIAVQEQPFDQNAAYRWLSEQHSVGATVVFVGKVRDLNLGDEVSSLYLEHYPAMTE
CCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECEECCCCCHHHHHHHHHHCCCHHH
KALTEIVAQAKARWDIQRVCVIHRVGLLQTGDEIVFVGVSSAHRGEAYQANEFIMDFLKS
HHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHC
KAPFWKKEKTTQGERWIESRDTDQQALARW
CCCCCCCCCCCCHHHHHHCCCCCHHHHHCC
>Mature Secondary Structure 
SDIQIAVQEQPFDQNAAYRWLSEQHSVGATVVFVGKVRDLNLGDEVSSLYLEHYPAMTE
CCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECEECCCCCHHHHHHHHHHCCCHHH
KALTEIVAQAKARWDIQRVCVIHRVGLLQTGDEIVFVGVSSAHRGEAYQANEFIMDFLKS
HHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHC
KAPFWKKEKTTQGERWIESRDTDQQALARW
CCCCCCCCCCCCHHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100