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The map label for this gene is alr

Identifier: 15602278

GI number: 15602278

Start: 484293

End: 485375

Strand: Direct

Name: alr

Synonym: PM0413

Alternate gene names: 15602278

Gene position: 484293-485375 (Clockwise)

Preceding gene: 15602277

Following gene: 15602280

Centisome position: 21.45

GC content: 41.64

Gene sequence:

>1083_bases
ATGAATATGAAACCTGCCACAGCAAAAATCAGTTCTGTGGCATTAAAACACAACATTCAAACGATTAAACAAAAAGCCCC
GCAAAGTAAAATTATTGCTGTTGTGAAAGCCAACGCCTATGGTCATGGTGTTGTGTTTGTGTCCGCTGCCGTAGAAGAGT
TGGTCGATTGTTTTGGCGTCGCCCGTTTAGAAGAAGCCTTAAGTTTACGCTCAAATGGGATTACGAAACCTATTTTGCTC
TTAGAAGGTTTTTTTTGCGATAAAGATTTACCGGTGATTGCGATAAATAATATTCAAACTGTGGTGCATAACGTCGAACA
ATTGGAAGCGTTAAAAGCAGCTAAAGTTCCTAATCCGATTAAAGTCTGGCTAAAAATTGATACCGGTATGCACCGTTTAG
GGGTAGCACTAGAAGACGTTGAGTATTTTTACCAAGCGCTCCGCGATTCAGAGAATGTTGATCCACAGATTGGTTTTGTC
AGCCATTTTAGTCGCGCGGATGAATTGGAATGTGACTATACCAAGTTACAATTGACACGTTTTTTAAATGCTACGCAAAA
TAAAGCGGGCGAAAAAAGTATTGCTGCCTCAGGTGGGATCTTATTTTGGGAAAGTTCCCATTTAGACTGGATTCGTCCGG
GCATTATTATGTATGGGATTTCACCGATTAATGTACCAGCACAAGAATATGATTTAACCCCTGTGATGACCTTAACCTCC
TCTCTTATTGCAATTAAACAGCATAAAAAAGGGGAGCCAGTAGGATATGGCGGGATTTGGGTCAGCGATAAAGACACGAA
AATTGGTGTGGTTGCCATTGGTTATGGCGATGGTTATCCGCGTGACATACCAACAGGCACACCGGTTTACCTCAATGGTC
GTCGTGTGCCCATTGTGGGACGTGTCTCGATGGATATGTTGACAGTCGATCTCGGTGCAGAAGCACAAGACAAAGTTGGC
GATGAAGTCATTCTTTGGGGCAAAGAATTGCCCATTGAAGAAATCGCGGATATTAGTGGGGTGATTAGTTATGAATTGAT
TACAAAATTAACGCCACGTGTTTTAACGGAATATATTGATTAA

Upstream 100 bases:

>100_bases
AGCGTAATGGTCCGATTGGACGCGTGAGATTGGCGTTTAGAGGACAATTCTCACGCTTTGATAACTTAGCCGAACAACGA
GATATAAGAGACGATTATTA

Downstream 100 bases:

>100_bases
TTAATTAGCGATGAAAAAGTGCGGTAGAATTTACCGCACTTTTTGTCTTTTTAGTATTATTTATAAAATCAGAGCTAATC
TGACGAATCATTATAAAAAA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MNMKPATAKISSVALKHNIQTIKQKAPQSKIIAVVKANAYGHGVVFVSAAVEELVDCFGVARLEEALSLRSNGITKPILL
LEGFFCDKDLPVIAINNIQTVVHNVEQLEALKAAKVPNPIKVWLKIDTGMHRLGVALEDVEYFYQALRDSENVDPQIGFV
SHFSRADELECDYTKLQLTRFLNATQNKAGEKSIAASGGILFWESSHLDWIRPGIIMYGISPINVPAQEYDLTPVMTLTS
SLIAIKQHKKGEPVGYGGIWVSDKDTKIGVVAIGYGDGYPRDIPTGTPVYLNGRRVPIVGRVSMDMLTVDLGAEAQDKVG
DEVILWGKELPIEEIADISGVISYELITKLTPRVLTEYID

Sequences:

>Translated_360_residues
MNMKPATAKISSVALKHNIQTIKQKAPQSKIIAVVKANAYGHGVVFVSAAVEELVDCFGVARLEEALSLRSNGITKPILL
LEGFFCDKDLPVIAINNIQTVVHNVEQLEALKAAKVPNPIKVWLKIDTGMHRLGVALEDVEYFYQALRDSENVDPQIGFV
SHFSRADELECDYTKLQLTRFLNATQNKAGEKSIAASGGILFWESSHLDWIRPGIIMYGISPINVPAQEYDLTPVMTLTS
SLIAIKQHKKGEPVGYGGIWVSDKDTKIGVVAIGYGDGYPRDIPTGTPVYLNGRRVPIVGRVSMDMLTVDLGAEAQDKVG
DEVILWGKELPIEEIADISGVISYELITKLTPRVLTEYID
>Mature_360_residues
MNMKPATAKISSVALKHNIQTIKQKAPQSKIIAVVKANAYGHGVVFVSAAVEELVDCFGVARLEEALSLRSNGITKPILL
LEGFFCDKDLPVIAINNIQTVVHNVEQLEALKAAKVPNPIKVWLKIDTGMHRLGVALEDVEYFYQALRDSENVDPQIGFV
SHFSRADELECDYTKLQLTRFLNATQNKAGEKSIAASGGILFWESSHLDWIRPGIIMYGISPINVPAQEYDLTPVMTLTS
SLIAIKQHKKGEPVGYGGIWVSDKDTKIGVVAIGYGDGYPRDIPTGTPVYLNGRRVPIVGRVSMDMLTVDLGAEAQDKVG
DEVILWGKELPIEEIADISGVISYELITKLTPRVLTEYID

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=360, Percent_Identity=57.7777777777778, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1787439, Length=356, Percent_Identity=41.2921348314607, Blast_Score=271, Evalue=4e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_PASMU (Q9CNL5)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245350.1
- ProteinModelPortal:   Q9CNL5
- SMR:   Q9CNL5
- GeneID:   1243760
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0413
- NMPDR:   fig|272843.1.peg.413
- HOGENOM:   HBG712172
- OMA:   EGTPVWV
- ProtClustDB:   PRK00053
- BioCyc:   PMUL272843:PM0413-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 39514; Mature: 39514

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 36-36 ACT_SITE 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMKPATAKISSVALKHNIQTIKQKAPQSKIIAVVKANAYGHGVVFVSAAVEELVDCFGV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHH
ARLEEALSLRSNGITKPILLLEGFFCDKDLPVIAINNIQTVVHNVEQLEALKAAKVPNPI
HHHHHHHHHHHCCCCCHHHEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCE
KVWLKIDTGMHRLGVALEDVEYFYQALRDSENVDPQIGFVSHFSRADELECDYTKLQLTR
EEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHH
FLNATQNKAGEKSIAASGGILFWESSHLDWIRPGIIMYGISPINVPAQEYDLTPVMTLTS
HHHHHHCCCCCCHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHHCCCCHHHHHHH
SLIAIKQHKKGEPVGYGGIWVSDKDTKIGVVAIGYGDGYPRDIPTGTPVYLNGRRVPIVG
HHHHHHHCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCCCCCCCCCEEECCEEEEEEE
RVSMDMLTVDLGAEAQDKVGDEVILWGKELPIEEIADISGVISYELITKLTPRVLTEYID
ECEEEEEEEECCCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MNMKPATAKISSVALKHNIQTIKQKAPQSKIIAVVKANAYGHGVVFVSAAVEELVDCFGV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHH
ARLEEALSLRSNGITKPILLLEGFFCDKDLPVIAINNIQTVVHNVEQLEALKAAKVPNPI
HHHHHHHHHHHCCCCCHHHEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCE
KVWLKIDTGMHRLGVALEDVEYFYQALRDSENVDPQIGFVSHFSRADELECDYTKLQLTR
EEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHH
FLNATQNKAGEKSIAASGGILFWESSHLDWIRPGIIMYGISPINVPAQEYDLTPVMTLTS
HHHHHHCCCCCCHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHHCCCCHHHHHHH
SLIAIKQHKKGEPVGYGGIWVSDKDTKIGVVAIGYGDGYPRDIPTGTPVYLNGRRVPIVG
HHHHHHHCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCCCCCCCCCEEECCEEEEEEE
RVSMDMLTVDLGAEAQDKVGDEVILWGKELPIEEIADISGVISYELITKLTPRVLTEYID
ECEEEEEEEECCCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100