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The map label for this gene is cirA [C]

Identifier: 15602165

GI number: 15602165

Start: 349240

End: 352131

Strand: Direct

Name: cirA [C]

Synonym: PM0300

Alternate gene names: 15602165

Gene position: 349240-352131 (Clockwise)

Preceding gene: 15602164

Following gene: 15602166

Centisome position: 15.47

GC content: 35.03

Gene sequence:

>2892_bases
ATGCGTACAACAACAATAAAATTTTCTGCAATTACATTGGCATTATTGAGTTATTGTGGGGCCATTTTGGCGGATAGTCA
TCAAGAGGCGACTGAACTTGATACGATTACCGTTTCTTCTCAACAAGATGAGATGAATATTAAAGAGAAAAAAGTCGGTG
AAACTGTGAAAACGGCGAGTCAATTGAAACGCCAGCAAGTACAGGATAGTCGTGATCTTGTGCGCTATGAAACCGGTGTG
ACTGTAGTAGAAGCTGGACGTTTTGGTTCGAGCGGTTATGCCATTCGTGGTGTGGATGAGAACCGAGTGGCAATTACAGT
AGATGGCTTACATCAAGCAGAAACCCTTTCTTCTCAAGGCTTTAAAGAATTATTTGAAGGTTACGGCAATTTTAACAATA
CCCGAAATAGTGTGGAAATTGAGACGTTGAAAGTCGCTAAAATCGCGAAAGGTGCTGATTCTGTAAAAGTGGGTAGTGGT
TCTTTGGGAGGCGCTGTACTTTTTGAAACAAAAGATGCCAGAGATTTCCTGACTGAAAAAGATTGGCATATCGGCTATAA
AGCGGGCTACTCAACGGCAGATAATCAGGGATTAAATGCTGTGACTCTTGCAGGTCGCTATCAAATGTTTGATGCATTGA
TTATGCATTCTAAGCGACATGGACATGAATTAGAAAATTATGACTATAAAAATGGCAGAGATATTCAAGGGAAAGAAAGA
GAAAAAGCGGATCCTTATACGATTACGAAAGAAAGTACATTAGTGAAATTCTCTTTTTCGCCAACAGAAAATCATCGTTT
TACAGTTGCTTCTGATACTTATATACAACGTTCTCGTGGTCATGATCGCTCTTATTCTTTACAGCCTCAATCTAATTATT
TCACATATGACGAGAAAGAATCGCGTCATGCAAATGATTTGACAAAACGTAAAAATGTTTCTTTTACTTATGAAAACTAT
AGCATAACTCCATTTTGGGATACGCTAAAATTGAGTTATTCACAACAAAAGATCAGAACAAGAGCAAGAACAGAAGATTA
TTGTGATGGTAATGAAAAATGTGATTCTTATAAAAATCCATTAGGGCTTCAGTTGAAAGATGGAAAAATTGTTGATCCAG
CAGGTAATCAGATTACTTTAAAAGGAACAGGATTTAATACAGAAATAGTTGATAAAGATGGGAAACCATTCCCTACTACA
TCTGGCACTAATAATGCTGCTTTCAGTAATAATTTGCAATTATCACCAACAGGTTTTTGGTTAGATTGTACTATTTTTGA
TTGCACGAAACCCTTTACAGTTTATAACTATAAACAAAATAAATATGAACCAAGAGAGGTGATGTTGTCAGAAGAAATTA
CTATTGATGGTAAATTATATAAAACTGCAAAAGAAGAAAGTGGTGTTAGGAATTATTTAATTTTACCGAACTCAAAAGGT
TATTTACCATATGATTACAAAGAAAGAGATCTTGATTCAAATACAAAACAAATCAATTTGGATTTAACAAAAACATTTTC
GACTTTTAATATAGAAAATGAATTATTATACGGTGCCATTTATTCACGTACAGAGAAGAAAATGGTTAATAAAGCAGGTT
ACGATGGGAGAAATCCTACATGGTGGGCTGATAGAATTTTAGGGAAGAGTACGAATTGTAACTATAATGGACTGAAATGT
CCTCGTCATGAACCTTTAACTTCTTTCTTAATTCCAGTAGAAGCGACAACCAAGTCTCTATATTTTTCAGATAATATCAA
ATTACACAACATGTTGAGTGTAGATTTAGGTTATCGTTATGACGATATTAAATATCAACCAGAATATATTCCTGGTGTAA
CACCTAAAATTGCAGATGATATGGTGAAAGGTATTTTTATTCCATTACCTAAAGGAGAAAAAATTAAAATAGGAAATTAT
GAAACAACAAAACCATTGACCCCAGAACAAATTCGTAAGAATGCGGAGGAAAATATTGCTTATATTGCACAAGAAAAACG
CTTTAAGAAACATTCTTATTCTCTTGGTGCAACGTTCGATCCTCTGAATTTTTTACGAGTACAAGTAAAATATTCAAAAG
GGTTTAGAGCTCCGACTTCGGATGAACTTTATTTTACCTTTAAGCATCCAGATTTTACGATTTTACCGAACCCCGTGTTG
AAACCAGAGGAAGCAAAAAATCAAGAGATTGCATTAACAGTACACGATAATTGGGGATTTGTTAGCACAAGTGTTTTCCA
AACAAAGTATCGTCATTTTATTGATTTAGCGTATTTAGGTTCAAGGAATTTATCGAACTCTGTGGGGGGAAAAGCACAAG
CAAGAGATTTCCAAGTTTATCAAAATGTCAATGTCGATAATGCCAAGGTTAAAGGAGTTGAAATTAATGCACGTTTGAAT
TTGGGATATTTTTGGCATGTGTTGGATGGATTTAATACGAGCTATAAATTCACTTACCAACGTGGTCGTTTGGATGGTGA
TCGTCCAATGAATGCGATTCAGCCTAAAGCCTCTGTTTTTGGTTTAGGCTACGATCATAAAGAAAATAAATTTGGCGCTG
ATTTATATATCACACGTGTGAGTGAGAAAAAAGCGAAAGACACTTATAATATGTTCTATAAAGAACAGGGGTATAAAGAT
AGTGCTATTCGTTGGAGAAGCGATGACTATACGCTAATTGATGCGGTTGGTTATATTAAACCGATTAAGAATTTAACGTT
ACAGTTTGGCGTTTATAATTTGACAGACCGTAAATACTTGACATGGGAATCTGCTCGTTCGATTAAACCATTTGGTACAA
GTAATTTAATTAATCAGAAAACAGGCGCAGGAATTAATCGTTTTTACTCACCAGGTCGTAACTTTAAACTCAGTGCCGAA
ATCACCTTCTAA

Upstream 100 bases:

>100_bases
AAGTGAGTAATGATGATTTAGTGAGCTTTGTTCACTTGGTTGAAGGACACCAAGAATAAATTTTGTCAACTTTTTAGGGT
ATTTACTTGAGGTTAGGAAA

Downstream 100 bases:

>100_bases
TCCTAAGCCTGCGTATGCAGGCTTTCTTTTTGCGTGAAAGTGCGGTGGATTTGACAAAGATTTATTGCTTTTCTGTAAAT
CAATGCTAAAATTCACACTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 963; Mature: 963

Protein sequence:

>963_residues
MRTTTIKFSAITLALLSYCGAILADSHQEATELDTITVSSQQDEMNIKEKKVGETVKTASQLKRQQVQDSRDLVRYETGV
TVVEAGRFGSSGYAIRGVDENRVAITVDGLHQAETLSSQGFKELFEGYGNFNNTRNSVEIETLKVAKIAKGADSVKVGSG
SLGGAVLFETKDARDFLTEKDWHIGYKAGYSTADNQGLNAVTLAGRYQMFDALIMHSKRHGHELENYDYKNGRDIQGKER
EKADPYTITKESTLVKFSFSPTENHRFTVASDTYIQRSRGHDRSYSLQPQSNYFTYDEKESRHANDLTKRKNVSFTYENY
SITPFWDTLKLSYSQQKIRTRARTEDYCDGNEKCDSYKNPLGLQLKDGKIVDPAGNQITLKGTGFNTEIVDKDGKPFPTT
SGTNNAAFSNNLQLSPTGFWLDCTIFDCTKPFTVYNYKQNKYEPREVMLSEEITIDGKLYKTAKEESGVRNYLILPNSKG
YLPYDYKERDLDSNTKQINLDLTKTFSTFNIENELLYGAIYSRTEKKMVNKAGYDGRNPTWWADRILGKSTNCNYNGLKC
PRHEPLTSFLIPVEATTKSLYFSDNIKLHNMLSVDLGYRYDDIKYQPEYIPGVTPKIADDMVKGIFIPLPKGEKIKIGNY
ETTKPLTPEQIRKNAEENIAYIAQEKRFKKHSYSLGATFDPLNFLRVQVKYSKGFRAPTSDELYFTFKHPDFTILPNPVL
KPEEAKNQEIALTVHDNWGFVSTSVFQTKYRHFIDLAYLGSRNLSNSVGGKAQARDFQVYQNVNVDNAKVKGVEINARLN
LGYFWHVLDGFNTSYKFTYQRGRLDGDRPMNAIQPKASVFGLGYDHKENKFGADLYITRVSEKKAKDTYNMFYKEQGYKD
SAIRWRSDDYTLIDAVGYIKPIKNLTLQFGVYNLTDRKYLTWESARSIKPFGTSNLINQKTGAGINRFYSPGRNFKLSAE
ITF

Sequences:

>Translated_963_residues
MRTTTIKFSAITLALLSYCGAILADSHQEATELDTITVSSQQDEMNIKEKKVGETVKTASQLKRQQVQDSRDLVRYETGV
TVVEAGRFGSSGYAIRGVDENRVAITVDGLHQAETLSSQGFKELFEGYGNFNNTRNSVEIETLKVAKIAKGADSVKVGSG
SLGGAVLFETKDARDFLTEKDWHIGYKAGYSTADNQGLNAVTLAGRYQMFDALIMHSKRHGHELENYDYKNGRDIQGKER
EKADPYTITKESTLVKFSFSPTENHRFTVASDTYIQRSRGHDRSYSLQPQSNYFTYDEKESRHANDLTKRKNVSFTYENY
SITPFWDTLKLSYSQQKIRTRARTEDYCDGNEKCDSYKNPLGLQLKDGKIVDPAGNQITLKGTGFNTEIVDKDGKPFPTT
SGTNNAAFSNNLQLSPTGFWLDCTIFDCTKPFTVYNYKQNKYEPREVMLSEEITIDGKLYKTAKEESGVRNYLILPNSKG
YLPYDYKERDLDSNTKQINLDLTKTFSTFNIENELLYGAIYSRTEKKMVNKAGYDGRNPTWWADRILGKSTNCNYNGLKC
PRHEPLTSFLIPVEATTKSLYFSDNIKLHNMLSVDLGYRYDDIKYQPEYIPGVTPKIADDMVKGIFIPLPKGEKIKIGNY
ETTKPLTPEQIRKNAEENIAYIAQEKRFKKHSYSLGATFDPLNFLRVQVKYSKGFRAPTSDELYFTFKHPDFTILPNPVL
KPEEAKNQEIALTVHDNWGFVSTSVFQTKYRHFIDLAYLGSRNLSNSVGGKAQARDFQVYQNVNVDNAKVKGVEINARLN
LGYFWHVLDGFNTSYKFTYQRGRLDGDRPMNAIQPKASVFGLGYDHKENKFGADLYITRVSEKKAKDTYNMFYKEQGYKD
SAIRWRSDDYTLIDAVGYIKPIKNLTLQFGVYNLTDRKYLTWESARSIKPFGTSNLINQKTGAGINRFYSPGRNFKLSAE
ITF
>Mature_963_residues
MRTTTIKFSAITLALLSYCGAILADSHQEATELDTITVSSQQDEMNIKEKKVGETVKTASQLKRQQVQDSRDLVRYETGV
TVVEAGRFGSSGYAIRGVDENRVAITVDGLHQAETLSSQGFKELFEGYGNFNNTRNSVEIETLKVAKIAKGADSVKVGSG
SLGGAVLFETKDARDFLTEKDWHIGYKAGYSTADNQGLNAVTLAGRYQMFDALIMHSKRHGHELENYDYKNGRDIQGKER
EKADPYTITKESTLVKFSFSPTENHRFTVASDTYIQRSRGHDRSYSLQPQSNYFTYDEKESRHANDLTKRKNVSFTYENY
SITPFWDTLKLSYSQQKIRTRARTEDYCDGNEKCDSYKNPLGLQLKDGKIVDPAGNQITLKGTGFNTEIVDKDGKPFPTT
SGTNNAAFSNNLQLSPTGFWLDCTIFDCTKPFTVYNYKQNKYEPREVMLSEEITIDGKLYKTAKEESGVRNYLILPNSKG
YLPYDYKERDLDSNTKQINLDLTKTFSTFNIENELLYGAIYSRTEKKMVNKAGYDGRNPTWWADRILGKSTNCNYNGLKC
PRHEPLTSFLIPVEATTKSLYFSDNIKLHNMLSVDLGYRYDDIKYQPEYIPGVTPKIADDMVKGIFIPLPKGEKIKIGNY
ETTKPLTPEQIRKNAEENIAYIAQEKRFKKHSYSLGATFDPLNFLRVQVKYSKGFRAPTSDELYFTFKHPDFTILPNPVL
KPEEAKNQEIALTVHDNWGFVSTSVFQTKYRHFIDLAYLGSRNLSNSVGGKAQARDFQVYQNVNVDNAKVKGVEINARLN
LGYFWHVLDGFNTSYKFTYQRGRLDGDRPMNAIQPKASVFGLGYDHKENKFGADLYITRVSEKKAKDTYNMFYKEQGYKD
SAIRWRSDDYTLIDAVGYIKPIKNLTLQFGVYNLTDRKYLTWESARSIKPFGTSNLINQKTGAGINRFYSPGRNFKLSAE
ITF

Specific function: Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake [H]

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR006970
- InterPro:   IPR000531
- InterPro:   IPR010949
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF04886 PT; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 109714; Mature: 109714

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTTTIKFSAITLALLSYCGAILADSHQEATELDTITVSSQQDEMNIKEKKVGETVKTAS
CCCEEEEHHHHHHHHHHHHHHHHCCCCCHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
QLKRQQVQDSRDLVRYETGVTVVEAGRFGSSGYAIRGVDENRVAITVDGLHQAETLSSQG
HHHHHHHHHHHHHEEEECCCEEEECCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHH
FKELFEGYGNFNNTRNSVEIETLKVAKIAKGADSVKVGSGSLGGAVLFETKDARDFLTEK
HHHHHHHHCCCCCCCCEEEEEEEEEEHHHCCCCCEEECCCCCCCEEEEECCCHHHHHCCC
DWHIGYKAGYSTADNQGLNAVTLAGRYQMFDALIMHSKRHGHELENYDYKNGRDIQGKER
CCEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
EKADPYTITKESTLVKFSFSPTENHRFTVASDTYIQRSRGHDRSYSLQPQSNYFTYDEKE
CCCCCEEEECCCEEEEEEECCCCCCEEEEECCCHHHHCCCCCCCEECCCCCCCCCCCCCC
SRHANDLTKRKNVSFTYENYSITPFWDTLKLSYSQQKIRTRARTEDYCDGNEKCDSYKNP
CCHHHHHHHHCCCEEEECCEEECCCHHHEEECCCHHHHHHHHCCCCCCCCCCHHHHHCCC
LGLQLKDGKIVDPAGNQITLKGTGFNTEIVDKDGKPFPTTSGTNNAAFSNNLQLSPTGFW
CCEEECCCEEECCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCEECCCEEECCCCEE
LDCTIFDCTKPFTVYNYKQNKYEPREVMLSEEITIDGKLYKTAKEESGVRNYLILPNSKG
EEEEEEECCCCEEEEECCCCCCCHHHEEEECCEEECCCEEECHHHCCCCCEEEEEECCCC
YLPYDYKERDLDSNTKQINLDLTKTFSTFNIENELLYGAIYSRTEKKMVNKAGYDGRNPT
CCCCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCC
WWADRILGKSTNCNYNGLKCPRHEPLTSFLIPVEATTKSLYFSDNIKLHNMLSVDLGYRY
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEEEEECCEEEEEEEEEECCCEE
DDIKYQPEYIPGVTPKIADDMVKGIFIPLPKGEKIKIGNYETTKPLTPEQIRKNAEENIA
CCCEECCCCCCCCCHHHHHHHHCCEEEECCCCCEEEECCCCCCCCCCHHHHHCCHHHHHH
YIAQEKRFKKHSYSLGATFDPLNFLRVQVKYSKGFRAPTSDELYFTFKHPDFTILPNPVL
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEEECCCEEECCCCCC
KPEEAKNQEIALTVHDNWGFVSTSVFQTKYRHFIDLAYLGSRNLSNSVGGKAQARDFQVY
CCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCEEEEE
QNVNVDNAKVKGVEINARLNLGYFWHVLDGFNTSYKFTYQRGRLDGDRPMNAIQPKASVF
ECCCCCCCEEEEEEEEEEEECCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCEE
GLGYDHKENKFGADLYITRVSEKKAKDTYNMFYKEQGYKDSAIRWRSDDYTLIDAVGYIK
ECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEHHHHHH
PIKNLTLQFGVYNLTDRKYLTWESARSIKPFGTSNLINQKTGAGINRFYSPGRNFKLSAE
HHHCCEEEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEE
ITF
EEC
>Mature Secondary Structure
MRTTTIKFSAITLALLSYCGAILADSHQEATELDTITVSSQQDEMNIKEKKVGETVKTAS
CCCEEEEHHHHHHHHHHHHHHHHCCCCCHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
QLKRQQVQDSRDLVRYETGVTVVEAGRFGSSGYAIRGVDENRVAITVDGLHQAETLSSQG
HHHHHHHHHHHHHEEEECCCEEEECCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHH
FKELFEGYGNFNNTRNSVEIETLKVAKIAKGADSVKVGSGSLGGAVLFETKDARDFLTEK
HHHHHHHHCCCCCCCCEEEEEEEEEEHHHCCCCCEEECCCCCCCEEEEECCCHHHHHCCC
DWHIGYKAGYSTADNQGLNAVTLAGRYQMFDALIMHSKRHGHELENYDYKNGRDIQGKER
CCEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
EKADPYTITKESTLVKFSFSPTENHRFTVASDTYIQRSRGHDRSYSLQPQSNYFTYDEKE
CCCCCEEEECCCEEEEEEECCCCCCEEEEECCCHHHHCCCCCCCEECCCCCCCCCCCCCC
SRHANDLTKRKNVSFTYENYSITPFWDTLKLSYSQQKIRTRARTEDYCDGNEKCDSYKNP
CCHHHHHHHHCCCEEEECCEEECCCHHHEEECCCHHHHHHHHCCCCCCCCCCHHHHHCCC
LGLQLKDGKIVDPAGNQITLKGTGFNTEIVDKDGKPFPTTSGTNNAAFSNNLQLSPTGFW
CCEEECCCEEECCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCEECCCEEECCCCEE
LDCTIFDCTKPFTVYNYKQNKYEPREVMLSEEITIDGKLYKTAKEESGVRNYLILPNSKG
EEEEEEECCCCEEEEECCCCCCCHHHEEEECCEEECCCEEECHHHCCCCCEEEEEECCCC
YLPYDYKERDLDSNTKQINLDLTKTFSTFNIENELLYGAIYSRTEKKMVNKAGYDGRNPT
CCCCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCC
WWADRILGKSTNCNYNGLKCPRHEPLTSFLIPVEATTKSLYFSDNIKLHNMLSVDLGYRY
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEEEEECCEEEEEEEEEECCCEE
DDIKYQPEYIPGVTPKIADDMVKGIFIPLPKGEKIKIGNYETTKPLTPEQIRKNAEENIA
CCCEECCCCCCCCCHHHHHHHHCCEEEECCCCCEEEECCCCCCCCCCHHHHHCCHHHHHH
YIAQEKRFKKHSYSLGATFDPLNFLRVQVKYSKGFRAPTSDELYFTFKHPDFTILPNPVL
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEEECCCEEECCCCCC
KPEEAKNQEIALTVHDNWGFVSTSVFQTKYRHFIDLAYLGSRNLSNSVGGKAQARDFQVY
CCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCEEEEE
QNVNVDNAKVKGVEINARLNLGYFWHVLDGFNTSYKFTYQRGRLDGDRPMNAIQPKASVF
ECCCCCCCEEEEEEEEEEEECCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCEE
GLGYDHKENKFGADLYITRVSEKKAKDTYNMFYKEQGYKDSAIRWRSDDYTLIDAVGYIK
ECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEHHHHHH
PIKNLTLQFGVYNLTDRKYLTWESARSIKPFGTSNLINQKTGAGINRFYSPGRNFKLSAE
HHHCCEEEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEE
ITF
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]