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The map label for this gene is lpxC [H]

Identifier: 15602013

GI number: 15602013

Start: 175128

End: 176045

Strand: Direct

Name: lpxC [H]

Synonym: PM0148

Alternate gene names: 15602013

Gene position: 175128-176045 (Clockwise)

Preceding gene: 15602012

Following gene: 15602014

Centisome position: 7.76

GC content: 40.74

Gene sequence:

>918_bases
ATGATTAAGCAAAGAACATTAAAACAGAGCATTAAAGTCACCGGCGTAGGCTTACATAGTGGTAATAAAGTAACCTTGAC
GTTACGTCCCGCTATGGCAAATACGGGTGTCATCTACTGTCGTACGGATTTAAATCCGCCAGTGACGTTCCCGGCAAATG
CCAATGCTGTACGTGATACAATGCTGTGTACTTGTTTAGTGAATGAAGAAGGCGTGCGTATTTCAACGGTTGAACATTTG
AATGCCGCGTTAGCTGGATTAGGTATTGATAACGTGATTATTGAAGTGGATGCGCCGGAAATTCCAATTATGGATGGTAG
CGCCAGTCCGTTTATTTACCTTTTACTTGATGCGGGTATTGAAGAGCAAAACGCAGCGAAAAAATTTATTCGCATCAAAC
AAAAAGTTCGTGTTGAGGATGGCGATAAATGGGCAGAGTTCACTCCATATAATGGATTCCGCTTAGACTTTACCATTGAC
TTTGAGCACCCTGCGATTGGTAAAGATGTGCGTAATTATGTGATGGATTTCTCCGCACAAGCCTTTGTTCAACAAATTAG
CCGCGCAAGAACTTTTGGCTTTATGAAAGATATTGAATATCTTCAATCGCAAGGTTTAGCGCTAGGTGGCAGTTTAGATA
ATGCGATTGTGTTAGACGATTATCGTATTTTGAACGAAGACGGCTTACGTTTTAAAGATGAACTTGTGCGTCATAAAATG
TTAGATGCCATTGGTGATTTATACATGGCGGGTTATAACATTATCGGTGACTTTAAAGCCTATAAATCCGGTCATGGGCT
AAATAACAAATTATTGCGTGCGGTTTTAGCTAATCAAGAAGCGTGGGAGTTTGTGACATTTGATGACAAACAAGCTGTTC
CACATGGTTATGAAGCGCCAACACAAGTGCTGATTTAA

Upstream 100 bases:

>100_bases
AAAAGATGAAAATTTGTTTAATGTGCAAAATTTCATCCGCAATACAGATAAATAAATTGAAATTAACCTTGTTGTTATCA
CAATAAGTTAAGAGAAAGAT

Downstream 100 bases:

>100_bases
CGTTATTCATTTTTGCATGAAAAAGCTATATTTCTCACGAAGTATAGCTTTTTTCTTTTTGATATTGTGGAGATTGATTT
CCCAATATCCGTGTTATTTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIKQRTLKQSIKVTGVGLHSGNKVTLTLRPAMANTGVIYCRTDLNPPVTFPANANAVRDTMLCTCLVNEEGVRISTVEHL
NAALAGLGIDNVIIEVDAPEIPIMDGSASPFIYLLLDAGIEEQNAAKKFIRIKQKVRVEDGDKWAEFTPYNGFRLDFTID
FEHPAIGKDVRNYVMDFSAQAFVQQISRARTFGFMKDIEYLQSQGLALGGSLDNAIVLDDYRILNEDGLRFKDELVRHKM
LDAIGDLYMAGYNIIGDFKAYKSGHGLNNKLLRAVLANQEAWEFVTFDDKQAVPHGYEAPTQVLI

Sequences:

>Translated_305_residues
MIKQRTLKQSIKVTGVGLHSGNKVTLTLRPAMANTGVIYCRTDLNPPVTFPANANAVRDTMLCTCLVNEEGVRISTVEHL
NAALAGLGIDNVIIEVDAPEIPIMDGSASPFIYLLLDAGIEEQNAAKKFIRIKQKVRVEDGDKWAEFTPYNGFRLDFTID
FEHPAIGKDVRNYVMDFSAQAFVQQISRARTFGFMKDIEYLQSQGLALGGSLDNAIVLDDYRILNEDGLRFKDELVRHKM
LDAIGDLYMAGYNIIGDFKAYKSGHGLNNKLLRAVLANQEAWEFVTFDDKQAVPHGYEAPTQVLI
>Mature_305_residues
MIKQRTLKQSIKVTGVGLHSGNKVTLTLRPAMANTGVIYCRTDLNPPVTFPANANAVRDTMLCTCLVNEEGVRISTVEHL
NAALAGLGIDNVIIEVDAPEIPIMDGSASPFIYLLLDAGIEEQNAAKKFIRIKQKVRVEDGDKWAEFTPYNGFRLDFTID
FEHPAIGKDVRNYVMDFSAQAFVQQISRARTFGFMKDIEYLQSQGLALGGSLDNAIVLDDYRILNEDGLRFKDELVRHKM
LDAIGDLYMAGYNIIGDFKAYKSGHGLNNKLLRAVLANQEAWEFVTFDDKQAVPHGYEAPTQVLI

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=77.3026315789474, Blast_Score=499, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 33947; Mature: 33947

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQRTLKQSIKVTGVGLHSGNKVTLTLRPAMANTGVIYCRTDLNPPVTFPANANAVRDT
CCCHHHHHHCEEEEEEEEECCCEEEEEEECCCCCCCEEEEEECCCCCEECCCCCCHHHHE
MLCTCLVNEEGVRISTVEHLNAALAGLGIDNVIIEVDAPEIPIMDGSASPFIYLLLDAGI
EEEEEEECCCCCEEEHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCEEEEEEECCC
EEQNAAKKFIRIKQKVRVEDGDKWAEFTPYNGFRLDFTIDFEHPAIGKDVRNYVMDFSAQ
CHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCHH
AFVQQISRARTFGFMKDIEYLQSQGLALGGSLDNAIVLDDYRILNEDGLRFKDELVRHKM
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCHHHHHHHHHH
LDAIGDLYMAGYNIIGDFKAYKSGHGLNNKLLRAVLANQEAWEFVTFDDKQAVPHGYEAP
HHHHHHHHHHCCCEEECHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
TQVLI
CEECC
>Mature Secondary Structure
MIKQRTLKQSIKVTGVGLHSGNKVTLTLRPAMANTGVIYCRTDLNPPVTFPANANAVRDT
CCCHHHHHHCEEEEEEEEECCCEEEEEEECCCCCCCEEEEEECCCCCEECCCCCCHHHHE
MLCTCLVNEEGVRISTVEHLNAALAGLGIDNVIIEVDAPEIPIMDGSASPFIYLLLDAGI
EEEEEEECCCCCEEEHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCEEEEEEECCC
EEQNAAKKFIRIKQKVRVEDGDKWAEFTPYNGFRLDFTIDFEHPAIGKDVRNYVMDFSAQ
CHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCHH
AFVQQISRARTFGFMKDIEYLQSQGLALGGSLDNAIVLDDYRILNEDGLRFKDELVRHKM
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCHHHHHHHHHH
LDAIGDLYMAGYNIIGDFKAYKSGHGLNNKLLRAVLANQEAWEFVTFDDKQAVPHGYEAP
HHHHHHHHHHCCCEEECHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
TQVLI
CEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA