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The map label for this gene is coaE

Identifier: 15601953

GI number: 15601953

Start: 114736

End: 115356

Strand: Direct

Name: coaE

Synonym: PM0088

Alternate gene names: 15601953

Gene position: 114736-115356 (Clockwise)

Preceding gene: 15601952

Following gene: 15601954

Centisome position: 5.08

GC content: 40.42

Gene sequence:

>621_bases
ATGACATATATTGTGGGACTCACGGGTGGTATAGGCAGTGGCAAAAGTACTATTGCCCATTTATTCATGGCACTTGGCGT
ACCTGTTATTGATGCAGATGTCGTGGCGAGAGATATCGTTACAAAAGGATCTGAACTGCTTTCCAAAATAGTCGATTATT
TTGGTGAGCATATCTTATGCGAAAATGGCGAGCTTAACCGTGCGAAATTACGTGAGCGTATTTTTCGTCATCCAGAGGAT
AAAGTCTGGCTTAATCAGTTATTACATCCTGCCATTCGTGAAGAGATGTTGCGCCAATTACAGATACAAACGTATCCTTA
TGTATTATGGGTGGTGCCTTTATTGATCGAGAATAACTTAACTGCTTTTTGTCAGCGCGTACTCGTGGTTGATGTAGAAC
CGGAAACGCAGATACAGCGTGCGATGCAACGGGATAATAATTCGATTGAGCTTATTCAACATATTATGGCTTCACAAGTT
GATCGACAAACACGATTACAATTTGCGGATGACGTGATCCAGAATGATGCGGATTTAAAGGGAAATTTACCTGTTTTAAA
ACAAAAAGTGCTAGAATTACACCATCAATATTTACAGTTAGCCAACGCGCAAAATGCGTAA

Upstream 100 bases:

>100_bases
TTGCACCTTTCCTGATATTCAGTGCGTTATGTGTTATCTTGCCTAATTGGTATAGTCCAAGTATGATGAGCAAGCTTTGG
ATCTAATAAGAGGGAAATCA

Downstream 100 bases:

>100_bases
TGAGAAATTTATGACAGACGATATTTTCAGTGTGCCTTGTCCGATTTGTCAAAAACAGGTGGAGTGGTCAGATAAAAGCC
CATTCCGCCCTTTTTGTTGC

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTYIVGLTGGIGSGKSTIAHLFMALGVPVIDADVVARDIVTKGSELLSKIVDYFGEHILCENGELNRAKLRERIFRHPED
KVWLNQLLHPAIREEMLRQLQIQTYPYVLWVVPLLIENNLTAFCQRVLVVDVEPETQIQRAMQRDNNSIELIQHIMASQV
DRQTRLQFADDVIQNDADLKGNLPVLKQKVLELHHQYLQLANAQNA

Sequences:

>Translated_206_residues
MTYIVGLTGGIGSGKSTIAHLFMALGVPVIDADVVARDIVTKGSELLSKIVDYFGEHILCENGELNRAKLRERIFRHPED
KVWLNQLLHPAIREEMLRQLQIQTYPYVLWVVPLLIENNLTAFCQRVLVVDVEPETQIQRAMQRDNNSIELIQHIMASQV
DRQTRLQFADDVIQNDADLKGNLPVLKQKVLELHHQYLQLANAQNA
>Mature_205_residues
TYIVGLTGGIGSGKSTIAHLFMALGVPVIDADVVARDIVTKGSELLSKIVDYFGEHILCENGELNRAKLRERIFRHPEDK
VWLNQLLHPAIREEMLRQLQIQTYPYVLWVVPLLIENNLTAFCQRVLVVDVEPETQIQRAMQRDNNSIELIQHIMASQVD
RQTRLQFADDVIQNDADLKGNLPVLKQKVLELHHQYLQLANAQNA

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=198, Percent_Identity=35.3535353535354, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI191252795, Length=198, Percent_Identity=35.3535353535354, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI110227607, Length=166, Percent_Identity=32.5301204819277, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI110227605, Length=166, Percent_Identity=32.5301204819277, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI110227603, Length=166, Percent_Identity=32.5301204819277, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI110227601, Length=166, Percent_Identity=32.5301204819277, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI205277394, Length=166, Percent_Identity=32.5301204819277, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786292, Length=202, Percent_Identity=53.4653465346535, Blast_Score=209, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17554944, Length=192, Percent_Identity=36.4583333333333, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320402, Length=184, Percent_Identity=36.9565217391304, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644728, Length=182, Percent_Identity=32.967032967033, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24658602, Length=163, Percent_Identity=32.5153374233129, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_PASMU (Q9CPF5)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245025.1
- ProteinModelPortal:   Q9CPF5
- SMR:   Q9CPF5
- GeneID:   1243435
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0088
- NMPDR:   fig|272843.1.peg.88
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- ProtClustDB:   PRK00081
- BioCyc:   PMUL272843:PM0088-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 23484; Mature: 23352

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYIVGLTGGIGSGKSTIAHLFMALGVPVIDADVVARDIVTKGSELLSKIVDYFGEHILC
CEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEE
ENGELNRAKLRERIFRHPEDKVWLNQLLHPAIREEMLRQLQIQTYPYVLWVVPLLIENNL
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCH
TAFCQRVLVVDVEPETQIQRAMQRDNNSIELIQHIMASQVDRQTRLQFADDVIQNDADLK
HHHHHHHHHEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GNLPVLKQKVLELHHQYLQLANAQNA
CCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TYIVGLTGGIGSGKSTIAHLFMALGVPVIDADVVARDIVTKGSELLSKIVDYFGEHILC
EEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEE
ENGELNRAKLRERIFRHPEDKVWLNQLLHPAIREEMLRQLQIQTYPYVLWVVPLLIENNL
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCH
TAFCQRVLVVDVEPETQIQRAMQRDNNSIELIQHIMASQVDRQTRLQFADDVIQNDADLK
HHHHHHHHHEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GNLPVLKQKVLELHHQYLQLANAQNA
CCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100