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The map label for this gene is ung

Identifier: 15601930

GI number: 15601930

Start: 92029

End: 92697

Strand: Direct

Name: ung

Synonym: PM0065

Alternate gene names: 15601930

Gene position: 92029-92697 (Clockwise)

Preceding gene: 15601924

Following gene: 15601931

Centisome position: 4.08

GC content: 42.3

Gene sequence:

>669_bases
ATGAAGACGTGGAAAGATGTGATTGGTACTGAGAAAACACAACCTTATTTTAAACATATTTTAGATCAGGTTCATCAGGC
TAGAGCATCAGGTAAAATTGTCTATCCTCCCCCGCAAGAGGTGTTTAGTGCTTTTCAGTTGACTGAATTTGAAGCTGTAA
AAGTGGTGATTATTGGTCAAGATCCTTATCATGGTCCCAATCAAGCACATGGGTTGGCGTTTTCTGTTAAACCAGGTGTG
GTACCACCGCCTTCCTTGATGAATATGTATAAAGAATTAACACAAGATATTGAAGGCTTTCAGATCCCCAATCATGGCTA
CTTAGTGCCTTGGGCGGAACAAGGAGTTTTGCTGTTAAATACTGTGTTAACGGTAGAACAAGGTAAGGCGCATTCGCATG
CTAGTTTTGGTTGGGAAACCTTTACTGATCGTGTGATAGCAGCCTTAAATGCACAACGTGAGAAGTTGGTGTTTTTGCTT
TGGGGGAGTCATGCACAGAAAAAAGGGCAATTTATTGATCGGCAAAAACATTGCGTCTTCACTGCGCCACATCCTTCGCC
ACTCTCTGCCCATCGTGGTTTTTTAGGTTGTCGTCATTTTTCCAAAACCAATGCCTATCTAATGGCGCAAGGGCTATCGC
CAATTCAATGGCAATTAGCTTCGCTTTAA

Upstream 100 bases:

>100_bases
TTTAACAATAAATAAACATTTATTTAACAATCTGCATGCAATAACTGTCAATTTTATAGGAAGTTCTTTATAATCGGAAA
CTCAACAATTGGAGGAAAAA

Downstream 100 bases:

>100_bases
TCTCAACGTTATTCAGGAAAGAACATTATGTTAGCCATTATTTCTCCAGCCAAAACCTTAGATTTTGAAAGTGCGGTACC
AAAATTTGAATTTTCTCAAC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKTWKDVIGTEKTQPYFKHILDQVHQARASGKIVYPPPQEVFSAFQLTEFEAVKVVIIGQDPYHGPNQAHGLAFSVKPGV
VPPPSLMNMYKELTQDIEGFQIPNHGYLVPWAEQGVLLLNTVLTVEQGKAHSHASFGWETFTDRVIAALNAQREKLVFLL
WGSHAQKKGQFIDRQKHCVFTAPHPSPLSAHRGFLGCRHFSKTNAYLMAQGLSPIQWQLASL

Sequences:

>Translated_222_residues
MKTWKDVIGTEKTQPYFKHILDQVHQARASGKIVYPPPQEVFSAFQLTEFEAVKVVIIGQDPYHGPNQAHGLAFSVKPGV
VPPPSLMNMYKELTQDIEGFQIPNHGYLVPWAEQGVLLLNTVLTVEQGKAHSHASFGWETFTDRVIAALNAQREKLVFLL
WGSHAQKKGQFIDRQKHCVFTAPHPSPLSAHRGFLGCRHFSKTNAYLMAQGLSPIQWQLASL
>Mature_222_residues
MKTWKDVIGTEKTQPYFKHILDQVHQARASGKIVYPPPQEVFSAFQLTEFEAVKVVIIGQDPYHGPNQAHGLAFSVKPGV
VPPPSLMNMYKELTQDIEGFQIPNHGYLVPWAEQGVLLLNTVLTVEQGKAHSHASFGWETFTDRVIAALNAQREKLVFLL
WGSHAQKKGQFIDRQKHCVFTAPHPSPLSAHRGFLGCRHFSKTNAYLMAQGLSPIQWQLASL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=217, Percent_Identity=56.6820276497696, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI6224979, Length=217, Percent_Identity=56.6820276497696, Blast_Score=245, Evalue=2e-65,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=65.5813953488372, Blast_Score=300, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=51.1520737327189, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6323620, Length=222, Percent_Identity=47.7477477477478, Blast_Score=176, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_PASMU (P57807)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245002.1
- ProteinModelPortal:   P57807
- SMR:   P57807
- PRIDE:   P57807
- GeneID:   1243412
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0065
- NMPDR:   fig|272843.1.peg.65
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   PMUL272843:PM0065-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 24906; Mature: 24906

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 61-61

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTWKDVIGTEKTQPYFKHILDQVHQARASGKIVYPPPQEVFSAFQLTEFEAVKVVIIGQ
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHCCCCCEEEEEEECC
DPYHGPNQAHGLAFSVKPGVVPPPSLMNMYKELTQDIEGFQIPNHGYLVPWAEQGVLLLN
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCEECCCCCEEEEECCCCEEEEH
TVLTVEQGKAHSHASFGWETFTDRVIAALNAQREKLVFLLWGSHAQKKGQFIDRQKHCVF
HEEEHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCEEE
TAPHPSPLSAHRGFLGCRHFSKTNAYLMAQGLSPIQWQLASL
ECCCCCCCHHHCCHHHHHHCCCCCEEEEECCCCCHHHHCCCC
>Mature Secondary Structure
MKTWKDVIGTEKTQPYFKHILDQVHQARASGKIVYPPPQEVFSAFQLTEFEAVKVVIIGQ
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHCCCCCEEEEEEECC
DPYHGPNQAHGLAFSVKPGVVPPPSLMNMYKELTQDIEGFQIPNHGYLVPWAEQGVLLLN
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCEECCCCCEEEEECCCCEEEEH
TVLTVEQGKAHSHASFGWETFTDRVIAALNAQREKLVFLLWGSHAQKKGQFIDRQKHCVF
HEEEHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCEEE
TAPHPSPLSAHRGFLGCRHFSKTNAYLMAQGLSPIQWQLASL
ECCCCCCCHHHCCHHHHHHCCCCCEEEEECCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100