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The map label for this gene is murC

Identifier: 161723236

GI number: 161723236

Start: 2118244

End: 2119575

Strand: Reverse

Name: murC

Synonym: L101678

Alternate gene names: 161723236

Gene position: 2119575-2118244 (Counterclockwise)

Preceding gene: 15674023

Following gene: 15674020

Centisome position: 89.6

GC content: 38.06

Gene sequence:

>1332_bases
ATGGAAAAAACATATCATTTTACCGGTATTAAAGGTTCAGGCATGAGTGCACTTGCGCTAATGTTACATCAAATGGGAAA
GAAAGTTCAAGGTTCGGACTCAACAGATTACTTTTTCACACAACGTGGTCTTGAACAAGCTGACGTACCACTTTTGCCTT
TTGACGAAAAAAATATTAAGCCCGAATTTGAATTGATTGCTGGAAATGCTTTTCGCGATGATAACAATGTTGAAATTGCA
TTTGCCCATAAAAATGGATTTCCATTCAAACGTTATCATGAATTTTTGGGACATTTCATGGAAGATTTTACTAGCATCGG
GGTTGCAGGTGCACATGGTAAAACTTCAACAACTGGAATGTTAGCTCACGTGATGTCTAATATCGTGGACACTTCTTACT
TGATTGGTGACGGAACTGGTCGTGGGATTGAGGGAAGTGAATATTTTGTCTTTGAATCTGATGAATATGAACGTCATTTC
ATGCCTTATCATCCTGAATATACAATTATGACAAATATTGACTTTGACCATCCTGACTACTTTGAAGGAATTGAAGATGT
CACCTCAGCTTTCCAAGATTATGCAAATAATATTAAAAAAGGTATTTTTGCTTACGGGGAAGATGTTAACTTACGTAAAT
TGACTGCCAAAGCACCTATTTACTATTATGGTTTTGAGGCTAATGACGATTATCGTGCCGAAAATTTGGTCAGAAGTACA
CGTGGCTCATCTTTTGATGCTTATTTCCGCGGTGAAAAAATTGGTCATTTTGTCGTTCCAGCTTATGGTAAACACAATGT
ATTGAATGCCTTGTCAGTTGTAGCCGTTTGTCATAATCTTGGGTTGGATATGACGGAAGTTGCAGACCACTTATTGACTT
TCCGTGGAGTGAAACGTCGTTTCACTGAGAAAAAAGTAGGTGAGACAGTCATTATTGATGATTTTGCTCATCATCCAACT
GAAATCGAAGCAACATTGGATGCTGCACGTCAAAAATATCCTGATCGTGAAATCGTTGCTGTTTTCCAACCTCATACTTT
TACTAGAACAATTGCATTTGCTGACGAATTTGCAGAGGTGCTTGACCATGCGGATACCGTTTACCTTGCTCAAATTTACG
GTTCAGCACGTGAAGTAGACCATCATGAAATTACGGCACAAGATTTAGCTGACAAAGTTCGTAAACCAGCCAAAGTAATT
GATCTTGACAATGTTTCGCCATTGTTGGATCATGACCGTGGGGTTTACGTCTTTATGGGAGCAGGAAATATTCAAAAATA
TGAACTTGCTTTTGAAAAGTTACTTAGCCAAGTCTCAACTAACTTACAATAA

Upstream 100 bases:

>100_bases
CATAAAAATTTAAGTAAATAAAAAAATAATTGTAAGAAAAGAAGGGAAATTTCTGTCAGTGATTGATAAAGAAATAGAAT
TACTGACAGAAAATTTTATC

Downstream 100 bases:

>100_bases
AATAAAAAAGTACTGACAGCTTTTTGGTCAGTACTTTTTTTTGTTTTATTCAATTTTTGTTAGTAAAAAAAATTCAAGTC
ACGGGAGTGCGACTTGAATC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MEKTYHFTGIKGSGMSALALMLHQMGKKVQGSDSTDYFFTQRGLEQADVPLLPFDEKNIKPEFELIAGNAFRDDNNVEIA
FAHKNGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGMLAHVMSNIVDTSYLIGDGTGRGIEGSEYFVFESDEYERHF
MPYHPEYTIMTNIDFDHPDYFEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLTAKAPIYYYGFEANDDYRAENLVRST
RGSSFDAYFRGEKIGHFVVPAYGKHNVLNALSVVAVCHNLGLDMTEVADHLLTFRGVKRRFTEKKVGETVIIDDFAHHPT
EIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEVLDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVI
DLDNVSPLLDHDRGVYVFMGAGNIQKYELAFEKLLSQVSTNLQ

Sequences:

>Translated_443_residues
MEKTYHFTGIKGSGMSALALMLHQMGKKVQGSDSTDYFFTQRGLEQADVPLLPFDEKNIKPEFELIAGNAFRDDNNVEIA
FAHKNGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGMLAHVMSNIVDTSYLIGDGTGRGIEGSEYFVFESDEYERHF
MPYHPEYTIMTNIDFDHPDYFEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLTAKAPIYYYGFEANDDYRAENLVRST
RGSSFDAYFRGEKIGHFVVPAYGKHNVLNALSVVAVCHNLGLDMTEVADHLLTFRGVKRRFTEKKVGETVIIDDFAHHPT
EIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEVLDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVI
DLDNVSPLLDHDRGVYVFMGAGNIQKYELAFEKLLSQVSTNLQ
>Mature_443_residues
MEKTYHFTGIKGSGMSALALMLHQMGKKVQGSDSTDYFFTQRGLEQADVPLLPFDEKNIKPEFELIAGNAFRDDNNVEIA
FAHKNGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGMLAHVMSNIVDTSYLIGDGTGRGIEGSEYFVFESDEYERHF
MPYHPEYTIMTNIDFDHPDYFEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLTAKAPIYYYGFEANDDYRAENLVRST
RGSSFDAYFRGEKIGHFVVPAYGKHNVLNALSVVAVCHNLGLDMTEVADHLLTFRGVKRRFTEKKVGETVIIDDFAHHPT
EIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEVLDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVI
DLDNVSPLLDHDRGVYVFMGAGNIQKYELAFEKLLSQVSTNLQ

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1790680, Length=388, Percent_Identity=30.4123711340206, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1786279, Length=404, Percent_Identity=30.4455445544554, Blast_Score=151, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_LACLA (Q9CE10)

Other databases:

- EMBL:   AE005176
- PIR:   H86879
- RefSeq:   NP_268197.2
- ProteinModelPortal:   Q9CE10
- SMR:   Q9CE10
- GeneID:   1115716
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L101678
- NMPDR:   fig|272623.1.peg.2094
- HOGENOM:   HBG476594
- OMA:   NETNVAN
- ProtClustDB:   PRK00421
- BioCyc:   LLAC272623:L101678-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50051; Mature: 50051

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTYHFTGIKGSGMSALALMLHQMGKKVQGSDSTDYFFTQRGLEQADVPLLPFDEKNIK
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCC
PEFELIAGNAFRDDNNVEIAFAHKNGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGM
CCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LAHVMSNIVDTSYLIGDGTGRGIEGSEYFVFESDEYERHFMPYHPEYTIMTNIDFDHPDY
HHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCHH
FEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLTAKAPIYYYGFEANDDYRAENLVRST
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHH
RGSSFDAYFRGEKIGHFVVPAYGKHNVLNALSVVAVCHNLGLDMTEVADHLLTFRGVKRR
CCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FTEKKVGETVIIDDFAHHPTEIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEV
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHH
LDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVIDLDNVSPLLDHDRGVYVFMG
HCCCCCEEEHHHHCCHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCCEEEEEE
AGNIQKYELAFEKLLSQVSTNLQ
CCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKTYHFTGIKGSGMSALALMLHQMGKKVQGSDSTDYFFTQRGLEQADVPLLPFDEKNIK
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCC
PEFELIAGNAFRDDNNVEIAFAHKNGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGM
CCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LAHVMSNIVDTSYLIGDGTGRGIEGSEYFVFESDEYERHFMPYHPEYTIMTNIDFDHPDY
HHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCHH
FEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLTAKAPIYYYGFEANDDYRAENLVRST
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHH
RGSSFDAYFRGEKIGHFVVPAYGKHNVLNALSVVAVCHNLGLDMTEVADHLLTFRGVKRR
CCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FTEKKVGETVIIDDFAHHPTEIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEV
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHH
LDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVIDLDNVSPLLDHDRGVYVFMG
HCCCCCEEEHHHHCCHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCCEEEEEE
AGNIQKYELAFEKLLSQVSTNLQ
CCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471