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The map label for this gene is zwf

Identifier: 15674202

GI number: 15674202

Start: 2301320

End: 2302831

Strand: Direct

Name: zwf

Synonym: L0044

Alternate gene names: 15674202

Gene position: 2301320-2302831 (Clockwise)

Preceding gene: 15674201

Following gene: 15674204

Centisome position: 97.28

GC content: 39.29

Gene sequence:

>1512_bases
ATGACCGAACAAAAACAAGCACTTTTCACCATCTTCGGAGCAACTGGTGACCTCGCTAAAAGAAAGCTCTACCCTTCACT
CTTTCGCCTCTTCAAAAAAGGTGAACTAGCTGACAATTTTGCAGTCATCGGTACCGCTCGCCGTCCATGGACAAACGAGT
ATTATCGTGAAGTTGTTTTAGAGTCTATCAAAGATTTAATGAACTCAAAAACGGAAGCCGAAAATTTCGCCAGCCATTTT
TATTATCAAAGTCACGATGTTAGCGACAGCTCACATTACGTTAACTTAAAAGATTTGGGTGAAAAATTGCGTAAACAGTA
TAAAACTGCTGGCAATCAAGTCTTCTTTTTAGCAATGGCTCCTCAATTTTTTGGCACTATCTCTGAACACCTTAAATCAG
AAAATATTTTGACAGGTGAGGGTTTTGAGAGAATCGTCATTGAAAAACCATTTGGAACAAGCTACGATACGGCAAAATCA
CTTAATGACAGCCTCGCAAAAGTATTTAGTGAAGAACAAATTTTCCGAATCGACCACTACCTTGGAAAAGAAATGATCCA
GGCCGTTTCTGCCGTTCGTTTTGCCAATCCAATCTTTGAATCGCTTTGGAATAATCAACACATTGATAACGTTCAGATTA
CTTTTGCCGAATTTATCGGTGTTGAAGACCGTGGCGGTTACTACGAAACTTCTGGTGCTTTAAAAGATATGATTCAAAAC
CATGTCTTACAAGTACTCAGCCTCATTGCCATGGAAAAACCTGAAAAATTTGATGAATCTTATATTGTAAAAGAAAAAGT
TAAAGCCCTTAATGCAATCCGTCAATATTCTTCTGAGGAAGCTTTAGAAAACTTCGTTCGTGGTCAATATATCGCAGGAC
GTTTTGACGGTGAAGATTACCTAGGCTATCGCGAAGAAGATTCTGTTGCAACAGACAGTCGAACTGAAACTTTCGCCGCT
GGAAAATTTGTCATTGATAATGAGCGTTGGTCAGGCGTCCCTTTCTATGTTCGCTCAGGAAAACGTATGACTGAAAAAGG
AACTCGTATTAATATCGTTTTCAAAAAAGATAAAGACAATCTCTTTGCAGAAAATTGCGATGACCAATCCGTTCAAAATG
TTTTGACCATTTATATTCAACCAACTGAAGGGTTTTCACTTTCAGTAAATGGAAAAGCGGCTGGTCAAGGCTTCCATTTA
GAGCCTTTGCGGTTAAATTTCCGACACGATAGTGAATTTCTTGGAAATTCTCCTGAAGCATATGAAAAACTTTTCCTAGA
TGTCCTTAATGGAGACGGAACAAATTTCTCACATTGGGAAGAAGCGGCTCGCGCCTGGGAACTTATTGATGTTATTCGAG
AAGCTTGGGATAAAGAAACTTCTGAGCTTCCAACTTATGCGGCTCGCACAATGGGACCTAAGGCTGCATTTGACTTACTA
GAAAAAAATGGTCACGAATGGGCTTGGCAACCTGATTTATGGTATCAAGAACGTGGTTACTACAATAAATAA

Upstream 100 bases:

>100_bases
TACGTCAATGAAACTAATACAAATGGTTAAATTTTACTGACAGAAATTCTAAATCAGTCTGTCAGTAAATTAATTATTGT
TTTTTAAAAAAGGAAAAAAT

Downstream 100 bases:

>100_bases
ATAAAAAACCTGTCTTAATGATAGGTTTTTTATTTTTTCCACAAACTTTTACACAGTTTTCCACATATTTGTGGAAAGAC
TTCACAATTCTGTGGAAAAC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTEQKQALFTIFGATGDLAKRKLYPSLFRLFKKGELADNFAVIGTARRPWTNEYYREVVLESIKDLMNSKTEAENFASHF
YYQSHDVSDSSHYVNLKDLGEKLRKQYKTAGNQVFFLAMAPQFFGTISEHLKSENILTGEGFERIVIEKPFGTSYDTAKS
LNDSLAKVFSEEQIFRIDHYLGKEMIQAVSAVRFANPIFESLWNNQHIDNVQITFAEFIGVEDRGGYYETSGALKDMIQN
HVLQVLSLIAMEKPEKFDESYIVKEKVKALNAIRQYSSEEALENFVRGQYIAGRFDGEDYLGYREEDSVATDSRTETFAA
GKFVIDNERWSGVPFYVRSGKRMTEKGTRINIVFKKDKDNLFAENCDDQSVQNVLTIYIQPTEGFSLSVNGKAAGQGFHL
EPLRLNFRHDSEFLGNSPEAYEKLFLDVLNGDGTNFSHWEEAARAWELIDVIREAWDKETSELPTYAARTMGPKAAFDLL
EKNGHEWAWQPDLWYQERGYYNK

Sequences:

>Translated_503_residues
MTEQKQALFTIFGATGDLAKRKLYPSLFRLFKKGELADNFAVIGTARRPWTNEYYREVVLESIKDLMNSKTEAENFASHF
YYQSHDVSDSSHYVNLKDLGEKLRKQYKTAGNQVFFLAMAPQFFGTISEHLKSENILTGEGFERIVIEKPFGTSYDTAKS
LNDSLAKVFSEEQIFRIDHYLGKEMIQAVSAVRFANPIFESLWNNQHIDNVQITFAEFIGVEDRGGYYETSGALKDMIQN
HVLQVLSLIAMEKPEKFDESYIVKEKVKALNAIRQYSSEEALENFVRGQYIAGRFDGEDYLGYREEDSVATDSRTETFAA
GKFVIDNERWSGVPFYVRSGKRMTEKGTRINIVFKKDKDNLFAENCDDQSVQNVLTIYIQPTEGFSLSVNGKAAGQGFHL
EPLRLNFRHDSEFLGNSPEAYEKLFLDVLNGDGTNFSHWEEAARAWELIDVIREAWDKETSELPTYAARTMGPKAAFDLL
EKNGHEWAWQPDLWYQERGYYNK
>Mature_502_residues
TEQKQALFTIFGATGDLAKRKLYPSLFRLFKKGELADNFAVIGTARRPWTNEYYREVVLESIKDLMNSKTEAENFASHFY
YQSHDVSDSSHYVNLKDLGEKLRKQYKTAGNQVFFLAMAPQFFGTISEHLKSENILTGEGFERIVIEKPFGTSYDTAKSL
NDSLAKVFSEEQIFRIDHYLGKEMIQAVSAVRFANPIFESLWNNQHIDNVQITFAEFIGVEDRGGYYETSGALKDMIQNH
VLQVLSLIAMEKPEKFDESYIVKEKVKALNAIRQYSSEEALENFVRGQYIAGRFDGEDYLGYREEDSVATDSRTETFAAG
KFVIDNERWSGVPFYVRSGKRMTEKGTRINIVFKKDKDNLFAENCDDQSVQNVLTIYIQPTEGFSLSVNGKAAGQGFHLE
PLRLNFRHDSEFLGNSPEAYEKLFLDVLNGDGTNFSHWEEAARAWELIDVIREAWDKETSELPTYAARTMGPKAAFDLLE
KNGHEWAWQPDLWYQERGYYNK

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=482, Percent_Identity=34.0248962655602, Blast_Score=288, Evalue=8e-78,
Organism=Homo sapiens, GI109389365, Length=482, Percent_Identity=34.0248962655602, Blast_Score=288, Evalue=9e-78,
Organism=Homo sapiens, GI52145310, Length=362, Percent_Identity=29.8342541436464, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1788158, Length=494, Percent_Identity=37.8542510121458, Blast_Score=335, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17538218, Length=481, Percent_Identity=36.3825363825364, Blast_Score=306, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6324088, Length=500, Percent_Identity=33.6, Blast_Score=274, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24643352, Length=483, Percent_Identity=35.1966873706004, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24643350, Length=483, Percent_Identity=35.1966873706004, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI221513548, Length=496, Percent_Identity=26.8145161290323, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57829; Mature: 57698

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQKQALFTIFGATGDLAKRKLYPSLFRLFKKGELADNFAVIGTARRPWTNEYYREVVL
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHH
ESIKDLMNSKTEAENFASHFYYQSHDVSDSSHYVNLKDLGEKLRKQYKTAGNQVFFLAMA
HHHHHHHCCCHHHHHHHHHHEECCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEEC
PQFFGTISEHLKSENILTGEGFERIVIEKPFGTSYDTAKSLNDSLAKVFSEEQIFRIDHY
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHH
LGKEMIQAVSAVRFANPIFESLWNNQHIDNVQITFAEFIGVEDRGGYYETSGALKDMIQN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCCCCCCEEECHHHHHHHHHH
HVLQVLSLIAMEKPEKFDESYIVKEKVKALNAIRQYSSEEALENFVRGQYIAGRFDGEDY
HHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCC
LGYREEDSVATDSRTETFAAGKFVIDNERWSGVPFYVRSGKRMTEKGTRINIVFKKDKDN
CCCCCCCCCCCCCCCHHEECCEEEEECCCCCCCCEEEECCCEECCCCCEEEEEEECCCCC
LFAENCDDQSVQNVLTIYIQPTEGFSLSVNGKAAGQGFHLEPLRLNFRHDSEFLGNSPEA
CCCCCCCHHHHCCEEEEEEECCCCCEEEECCCCCCCCCCCCCEEEECCCCHHHHCCCHHH
YEKLFLDVLNGDGTNFSHWEEAARAWELIDVIREAWDKETSELPTYAARTMGPKAAFDLL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCCHHHHHHHH
EKNGHEWAWQPDLWYQERGYYNK
HCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TEQKQALFTIFGATGDLAKRKLYPSLFRLFKKGELADNFAVIGTARRPWTNEYYREVVL
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHH
ESIKDLMNSKTEAENFASHFYYQSHDVSDSSHYVNLKDLGEKLRKQYKTAGNQVFFLAMA
HHHHHHHCCCHHHHHHHHHHEECCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEEC
PQFFGTISEHLKSENILTGEGFERIVIEKPFGTSYDTAKSLNDSLAKVFSEEQIFRIDHY
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHH
LGKEMIQAVSAVRFANPIFESLWNNQHIDNVQITFAEFIGVEDRGGYYETSGALKDMIQN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCCCCCCEEECHHHHHHHHHH
HVLQVLSLIAMEKPEKFDESYIVKEKVKALNAIRQYSSEEALENFVRGQYIAGRFDGEDY
HHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCC
LGYREEDSVATDSRTETFAAGKFVIDNERWSGVPFYVRSGKRMTEKGTRINIVFKKDKDN
CCCCCCCCCCCCCCCHHEECCEEEEECCCCCCCCEEEECCCEECCCCCEEEEEEECCCCC
LFAENCDDQSVQNVLTIYIQPTEGFSLSVNGKAAGQGFHLEPLRLNFRHDSEFLGNSPEA
CCCCCCCHHHHCCEEEEEEECCCCCEEEECCCCCCCCCCCCCEEEECCCCHHHHCCCHHH
YEKLFLDVLNGDGTNFSHWEEAARAWELIDVIREAWDKETSELPTYAARTMGPKAAFDLL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCCHHHHHHHH
EKNGHEWAWQPDLWYQERGYYNK
HCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916; 9466257; 9533725 [H]