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The map label for this gene is lysP

Identifier: 15674175

GI number: 15674175

Start: 2276518

End: 2278038

Strand: Direct

Name: lysP

Synonym: L59950

Alternate gene names: 15674175

Gene position: 2276518-2278038 (Clockwise)

Preceding gene: 15674169

Following gene: 15674179

Centisome position: 96.23

GC content: 39.84

Gene sequence:

>1521_bases
TTGAGTCTGAGTCAAACAAGTCGGTGTAGAATAAATTTTATTAGGGAGAGAATTTTGGAAAATTCTTCAAACTCAACTAC
TGAGACGCAAGTAAAACGCGGCTTAAAATCACGTCATGTTTCCATGATTGCCCTTGGCGGAACAATCGGAACTGGATTGT
TTCTGACTTCAGGCGATGTCATTCACACGGCAGGACCATTTGGTGCACTGACTGCCTATGTTCTTATCGGAGCAATGGTT
TACTTCCTCATGACATCACTTGGTGAAATGGCCACTTATTTACCCACTTCTGGTTCTTTTTCAGACTATGGAACACGTTA
TGTTGACCCAGCTTTTGGTTTTGCTCTAGGTTGGAATTACTGGTTAAACTGGGCAATTACCGTAGCGGTTGATTTAACAG
CCGTTGCCCTTTGTATCAAATTCTGGTTACCAGATGTTCCAAGTTGGATTTTTTCACTGATTGCCTTAATTATTGTCTTT
GCAATCAATGCCTTATCAGTTAAAACTTTTGGCGAAACTGAATATTGGTTGTCAGCCATTAAAATTACTGTTGTTGTTTT
ATTCTTGATTATTGGTTTCTTATCTATTTTTGGAATTATGGGCGGTCATATTGACGTCGCTAAAAATCTTTCAGTTGGTA
ATCATGGTTTTGTCGGAGGACTTGGTAGTTTCACTACCGGCGGAGGGATTCTCGGCGTACTCTTAGTCGCTGGTTTCTCT
TTCCAAGGAACAGAATTGCTCGGAATTACAGCTGGCGAAGCTGAAAATCCTGAAAAATCAATTCCTAAAGCTATGAACTC
TATCTTCTGGCGTATTCTTGTCTTTTATATCTTATCTATCTTCGTGATGGCGGCTATCATTCCATTTACCGACCCACACT
TAGTTGGAGGAAATTCAGCTGCTCAAAGCCCTTTCACAATTGTATTTGAACGTGTTGGTCTCTCTATTGCAGCTTCTATC
ATGAACGCCGTTGTTTTAACTTCTGTCGTTTCAGCAGCAAATTCTGGAATGTATGCCTCTACTCGGATGCTTTATTCACT
AGCTAAAGATGGTGGCGCACCAAAGATTTTCTCAAAAACTTCAAAAAACGGGATCCCTTTCATTGCTTTATTAGCTACAA
CTGCTATTGCTTTACTCACATTCTTGACATCAATTTACGGAGTTAGCTTCTTTACATTCCTCGTCTCAGCCTCTGGTTTA
ACAGGATTTATTGCTTGGATTGGGATTGCAATTAGCCACTTCCGCTTCCGCCGCGCCTATGTTGCTCAAGGAAAAGATGT
TAAAAAATTACCTTATCATGCAAAACTATTCCCATTTGGTCCAATCTTAGCCTTAATTATGACCGTTTTAGTCACACTCG
GCCAAGACCCAATGCTTCTTTTTGGTAAAACTTGGGTGCAAGGTGTCATCATGTATGCCGCAATTCCACTCTTCTTCATC
CTTTACTTGGGTTATAAATTTAAAAACAAAACGAAACTTATCCCCCTTAAAGAGGTTGATTTAAGTCGTCATAAAGATTA
A

Upstream 100 bases:

>100_bases
AAATTTTTAAAATTTTGTCGGACCTTTAGCAATCTATTCTATCTAGTAGGATTGCTTTTTTTGTTTTTCTCAGACTTTTC
TAAACTAAACAGGAGTGAGG

Downstream 100 bases:

>100_bases
AAAAAGTCGCTCAATGAGCGGCTTTTTTATTAGTTTAATCATTAATTTCAACTACTTTTTCACCAAAGAGTTCTTTAGCT
AAGTTTACCGTTTCATCCGG

Product: lysine specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSLSQTSRCRINFIRERILENSSNSTTETQVKRGLKSRHVSMIALGGTIGTGLFLTSGDVIHTAGPFGALTAYVLIGAMV
YFLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGWNYWLNWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALIIVF
AINALSVKTFGETEYWLSAIKITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAGFS
FQGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGNSAAQSPFTIVFERVGLSIAASI
MNAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFSKTSKNGIPFIALLATTAIALLTFLTSIYGVSFFTFLVSASGL
TGFIAWIGIAISHFRFRRAYVAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVIMYAAIPLFFI
LYLGYKFKNKTKLIPLKEVDLSRHKD

Sequences:

>Translated_506_residues
MSLSQTSRCRINFIRERILENSSNSTTETQVKRGLKSRHVSMIALGGTIGTGLFLTSGDVIHTAGPFGALTAYVLIGAMV
YFLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGWNYWLNWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALIIVF
AINALSVKTFGETEYWLSAIKITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAGFS
FQGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGNSAAQSPFTIVFERVGLSIAASI
MNAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFSKTSKNGIPFIALLATTAIALLTFLTSIYGVSFFTFLVSASGL
TGFIAWIGIAISHFRFRRAYVAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVIMYAAIPLFFI
LYLGYKFKNKTKLIPLKEVDLSRHKD
>Mature_505_residues
SLSQTSRCRINFIRERILENSSNSTTETQVKRGLKSRHVSMIALGGTIGTGLFLTSGDVIHTAGPFGALTAYVLIGAMVY
FLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGWNYWLNWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALIIVFA
INALSVKTFGETEYWLSAIKITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAGFSF
QGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGNSAAQSPFTIVFERVGLSIAASIM
NAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFSKTSKNGIPFIALLATTAIALLTFLTSIYGVSFFTFLVSASGLT
GFIAWIGIAISHFRFRRAYVAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVIMYAAIPLFFIL
YLGYKFKNKTKLIPLKEVDLSRHKD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=403, Percent_Identity=24.5657568238213, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788480, Length=492, Percent_Identity=51.8292682926829, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI87081708, Length=469, Percent_Identity=36.6737739872068, Blast_Score=322, Evalue=5e-89,
Organism=Escherichia coli, GI1786302, Length=470, Percent_Identity=38.5106382978723, Blast_Score=292, Evalue=4e-80,
Organism=Escherichia coli, GI1786789, Length=447, Percent_Identity=37.8076062639821, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI48994972, Length=435, Percent_Identity=37.7011494252874, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1789017, Length=407, Percent_Identity=35.3808353808354, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI1786602, Length=408, Percent_Identity=39.4607843137255, Blast_Score=255, Evalue=6e-69,
Organism=Escherichia coli, GI1790653, Length=488, Percent_Identity=33.1967213114754, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI87081915, Length=439, Percent_Identity=35.0797266514806, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI87082023, Length=483, Percent_Identity=24.0165631469979, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081869, Length=357, Percent_Identity=24.0896358543417, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87082250, Length=240, Percent_Identity=25.8333333333333, Blast_Score=62, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17540018, Length=496, Percent_Identity=24.7983870967742, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320772, Length=433, Percent_Identity=41.3394919168591, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324061, Length=510, Percent_Identity=35.8823529411765, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6324990, Length=511, Percent_Identity=36.399217221135, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6324059, Length=508, Percent_Identity=37.2047244094488, Blast_Score=289, Evalue=7e-79,
Organism=Saccharomyces cerevisiae, GI6324924, Length=527, Percent_Identity=32.8273244781784, Blast_Score=286, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6322892, Length=492, Percent_Identity=34.5528455284553, Blast_Score=272, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321629, Length=516, Percent_Identity=32.1705426356589, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6320717, Length=508, Percent_Identity=31.2992125984252, Blast_Score=259, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6319824, Length=527, Percent_Identity=31.4990512333966, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6321053, Length=492, Percent_Identity=32.1138211382114, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319542, Length=528, Percent_Identity=31.8181818181818, Blast_Score=252, Evalue=8e-68,
Organism=Saccharomyces cerevisiae, GI6324553, Length=438, Percent_Identity=34.0182648401827, Blast_Score=250, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6320251, Length=515, Percent_Identity=31.4563106796116, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6319543, Length=514, Percent_Identity=31.7120622568093, Blast_Score=236, Evalue=8e-63,
Organism=Saccharomyces cerevisiae, GI6322967, Length=489, Percent_Identity=30.6748466257669, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6319608, Length=500, Percent_Identity=27.4, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324981, Length=513, Percent_Identity=30.4093567251462, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6320364, Length=557, Percent_Identity=26.032315978456, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI281366235, Length=430, Percent_Identity=22.7906976744186, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI116007820, Length=430, Percent_Identity=22.7906976744186, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54745; Mature: 54614

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSQTSRCRINFIRERILENSSNSTTETQVKRGLKSRHVSMIALGGTIGTGLFLTSGDV
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCCHHCCEEEECCCE
IHTAGPFGALTAYVLIGAMVYFLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGWNY
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
WLNWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALIIVFAINALSVKTFGETEYWLSAI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHH
KITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAGFS
HHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
FQGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGNSA
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCC
AQSPFTIVFERVGLSIAASIMNAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFSKT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHCCC
SKNGIPFIALLATTAIALLTFLTSIYGVSFFTFLVSASGLTGFIAWIGIAISHFRFRRAY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVIMYAAIPLFFI
HHCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHH
LYLGYKFKNKTKLIPLKEVDLSRHKD
HHHHHHCCCCCEECCHHHCCHHCCCC
>Mature Secondary Structure 
SLSQTSRCRINFIRERILENSSNSTTETQVKRGLKSRHVSMIALGGTIGTGLFLTSGDV
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCCHHCCEEEECCCE
IHTAGPFGALTAYVLIGAMVYFLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGWNY
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
WLNWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALIIVFAINALSVKTFGETEYWLSAI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHH
KITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAGFS
HHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
FQGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGNSA
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCC
AQSPFTIVFERVGLSIAASIMNAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFSKT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHCCC
SKNGIPFIALLATTAIALLTFLTSIYGVSFFTFLVSASGLTGFIAWIGIAISHFRFRRAY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVIMYAAIPLFFI
HHCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHH
LYLGYKFKNKTKLIPLKEVDLSRHKD
HHHHHHCCCCCEECCHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]