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The map label for this gene is htrA

Identifier: 15674118

GI number: 15674118

Start: 2204341

End: 2205567

Strand: Direct

Name: htrA

Synonym: L187771

Alternate gene names: 15674118

Gene position: 2204341-2205567 (Clockwise)

Preceding gene: 15674094

Following gene: 15674119

Centisome position: 93.18

GC content: 38.22

Gene sequence:

>1227_bases
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACAGGTGTCGTGGGCGGAGCCATCGCACTTGGAGGAAGTGCAATCTA
TCAAAGCACTACAAATCAATCGGCAAATAATAGTCGTTCAAATACAACTAGTACAAAGGTTAGTAACGTTTCGGTAAATG
TCAATACCGATGTTACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAAGATAACTCA
CAAAGTAGTGACTTCAGTTCAATTTTTGGTGGAAATAGCGGTTCAAGTTCATCGACTGATGGCTTACAGCTTTCTAGTGA
AGGCTCTGGTGTCATCTACAAAAAATCTGGTGGTGATGCCTACGTTGTAACTAACTACCACGTTATTGCTGGTAATAGCT
CACTTGATGTTCTGCTTTCTGGTGGACAAAAAGTCAAAGCTTCTGTGGTTGGTTATGATGAATACACAGACCTTGCTGTT
CTTAAAATCAGTTCTGAACATGTCAAAGATGTGGCGACATTCGCTGATTCTAGTAAATTAACAATTGGTGAACCTGCCAT
TGCCGTTGGCTCACCTTTAGGTAGTCAATTTGCAAACACCGCAACTGAAGGAATTTTATCTGCAACAAGCCGTCAAGTGA
CTTTGACCCAAGAAAATGGTCAAACAACTAATATCAATGCAATTCAAACAGATGCTGCCATTAACCCTGGTAACTCTGGA
GGGGCTTTGATTAATATTGAAGGACAAGTTATTGGAATTACTCAAAGTAAAATTACAACAACTGAAGATGGTTCTACTTC
TGTCGAAGGTTTAGGATTTGCGATTCCTTCTAATGATGTCGTAAATATCATTAATAAACTTGAAGCTGATGGTAAGATTT
CACGCCCTGCTTTAGGTATCCGAATGGTTGACCTTTCACAATTATCAACAAATGACAGTTCTCAATTGAAATTACCAAGC
AGTGTAACAGGTGGGGTTGTTGTTTACTCCGTCCAATCTGGACTTCCTGCTGCCTCAGCTGGTTTGAAAGCTGGAGATGT
AATTACAAAGGTTGGCGATACAGCAGTAACCTCTTCAACAGACTTGCAAAGTGCTCTTTACTCACACAATATCAATGATA
CAGTAAAAGTTACTTATTATCGTGATGGTAAATCAAATACAGCAGATGTTAAACTTTCTAAATCAACCAGTGACTTAGAA
ACAAGCAGTCCATCTTCTTCTAATTAA

Upstream 100 bases:

>100_bases
TTAGTTTGATTTTTGTTACTATTAAGGTATTATTAAGTGAGAGTAGATATAATTACATCATAGAAATGCTACAAAGATTA
ATAATTGAAAGGAATTATTT

Downstream 100 bases:

>100_bases
TAACTTAATAATTTAATAAAAGTCTTCTGTAAATAGAAGGCTTTTTTCATACTAAAGTCTGAAATTTTTAAAAATAATAA
ATTTCCATTTTTCTTTTATT

Product: exported serine protease

Products: NA

Alternate protein names: HtrALl

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNS
QSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAV
LKISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPS
SVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLE
TSSPSSSN

Sequences:

>Translated_408_residues
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNS
QSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAV
LKISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPS
SVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLE
TSSPSSSN
>Mature_407_residues
AKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNSQ
SSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAVL
KISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSGG
ALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPSS
VTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLET
SSPSSSN

Specific function: Degrades abnormal exported proteins. Needed for the propeptide processing of a natural pro-protein and for the maturation of a native protein. Responsible for the housekeeping of exported proteins

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain

Homologues:

Organism=Homo sapiens, GI22129776, Length=324, Percent_Identity=30.5555555555556, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI24308541, Length=337, Percent_Identity=31.7507418397626, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI7019477, Length=276, Percent_Identity=34.7826086956522, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4506141, Length=266, Percent_Identity=34.5864661654135, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1786356, Length=293, Percent_Identity=36.8600682593857, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789629, Length=341, Percent_Identity=35.7771260997067, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789630, Length=302, Percent_Identity=33.7748344370861, Blast_Score=131, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24646839, Length=277, Percent_Identity=35.0180505415162, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTRA_LACLA (Q9LA06)

Other databases:

- EMBL:   AF155705
- EMBL:   AE005176
- PIR:   H86891
- RefSeq:   NP_268293.1
- ProteinModelPortal:   Q9LA06
- SMR:   Q9LA06
- MEROPS:   S01.447
- GeneID:   1115813
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L187771
- NMPDR:   fig|272623.1.peg.2191
- HOGENOM:   HBG585708
- OMA:   ANTATEG
- ProtClustDB:   CLSK698129
- BioCyc:   LLAC272623:L187771-MONOMER
- BRENDA:   3.4.21.107
- GO:   GO:0006508
- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940
- PRINTS:   PR00834
- SMART:   SM00228

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin; SSF50156 PDZ; SSF50494 Pept_Ser_Cys

EC number: 3.4.21.- [C]

Molecular weight: Translated: 41648; Mature: 41517

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50106 PDZ

Important sites: ACT_SITE 127-127 ACT_SITE 157-157 ACT_SITE 239-239

Signals:

None

Transmembrane regions:

HASH(0x1003f5fc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTS
CCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEEEEEEEEECCHHHH
AIKKVSNSVVSVMNYQKDNSQSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECCCCE
YVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAVLKISSEHVKDVATFADSSKL
EEEEEEEEEECCCCEEEEEECCCEEEEEEECCCCCCCEEEEEECHHHHHHHHHHCCCCCE
TIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
EECCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEECEEEEECCEECCCCCC
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGI
CEEEEECCEEEEEECCEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCEE
RMVDLSQLSTNDSSQLKLPSSVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSST
EEEEHHHCCCCCCCEEECCCCCCCCEEEEEECCCCCHHHCCCCCCCHHHHCCCCEECCCH
DLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLETSSPSSSN
HHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCH
>Mature Secondary Structure 
AKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTS
CCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEEEEEEEEECCHHHH
AIKKVSNSVVSVMNYQKDNSQSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECCCCE
YVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAVLKISSEHVKDVATFADSSKL
EEEEEEEEEECCCCEEEEEECCCEEEEEEECCCCCCCEEEEEECHHHHHHHHHHCCCCCE
TIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
EECCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEECEEEEECCEECCCCCC
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGI
CEEEEECCEEEEEECCEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCEE
RMVDLSQLSTNDSSQLKLPSSVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSST
EEEEHHHCCCCCCCEEECCCCCCCCEEEEEECCCCCHHHCCCCCCCHHHHCCCCEECCCH
DLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLETSSPSSSN
HHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10712686; 11337471