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The map label for this gene is uppS

Identifier: 15674112

GI number: 15674112

Start: 2200157

End: 2200891

Strand: Reverse

Name: uppS

Synonym: L183602

Alternate gene names: 15674112

Gene position: 2200891-2200157 (Counterclockwise)

Preceding gene: 15674113

Following gene: 15674111

Centisome position: 93.04

GC content: 37.28

Gene sequence:

>735_bases
ATGTTTAATAACTTAAAAAATAAAGAGCAAGAAGAATTACTTCCAGAGCATATCGGAATTATCATGGATGGTAATGGACG
ATGGGCTAAGCAGAAAGGGAAACCACGAATCTTTGGACACAAAGCAGGAATGGATTCGCTAAAAGATGTTGCTGTTCATG
GTGCGAGACGTGGCATAAAAGTGATGACTGTTTATGCTTTTTCCACAGAAAATTGGACAAGACCAGTTGATGAAGTGAAA
TTCATCATGAGTTTACCTATCGATTTTTATAGTAAATATGTTCCAGTTTTAAAAGAAGAAAATATTCAGATTCGGATGAT
TGGTGAACGCGAAGGTTTGCCAAAAGCAACGTTAGATTCAATTGACCGTGCGGCTCAAGAAACTTCAGAAAATGACGGAA
TGATTTTGAATTTTGCAATGAATTATGGTGGCCGTCGTGATATTATTTTAGCCATTCAAGAGCTTGCTAAAAGTGGTCAG
GATTTAAGTTTACTGACAGAAGAAGAGTTGTCAAAACATCTACAAACCGCTGTTTTGTCTGAAAATCTTCGGGATCCAGA
CTTGATTATCAGAACATCTGGTGAACAAAGAATGTCTAATTTCTTGACTTGGCAGTCAGCTTATAGTGAATTATATTTTG
CGCAAACTGCTTGGCCAGATTTCGATGATAAAGAATTGGACAAGGCTATTTCTGCTTTTCAAAAGCGTGACCGCAGATAT
GGAGGAGTCAAATAA

Upstream 100 bases:

>100_bases
CTTTCTTAGAGTCTTTGGTGTAAAAAAACTTTAATAACCAAAGAGCATAATGGTGAATTTATGATAAATATTTTTGCATA
AAATTCTCATGTGAGGTACT

Downstream 100 bases:

>100_bases
TGATGCAACGAATTATCACAGGAGTAGTTGCGGGAGGAATCTTTTTAGCCCTCTTGCTTCTTGGAGGAGCTTACTTTCAA
ATTTTAGTCGCTCTGCTTGT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MFNNLKNKEQEELLPEHIGIIMDGNGRWAKQKGKPRIFGHKAGMDSLKDVAVHGARRGIKVMTVYAFSTENWTRPVDEVK
FIMSLPIDFYSKYVPVLKEENIQIRMIGEREGLPKATLDSIDRAAQETSENDGMILNFAMNYGGRRDIILAIQELAKSGQ
DLSLLTEEELSKHLQTAVLSENLRDPDLIIRTSGEQRMSNFLTWQSAYSELYFAQTAWPDFDDKELDKAISAFQKRDRRY
GGVK

Sequences:

>Translated_244_residues
MFNNLKNKEQEELLPEHIGIIMDGNGRWAKQKGKPRIFGHKAGMDSLKDVAVHGARRGIKVMTVYAFSTENWTRPVDEVK
FIMSLPIDFYSKYVPVLKEENIQIRMIGEREGLPKATLDSIDRAAQETSENDGMILNFAMNYGGRRDIILAIQELAKSGQ
DLSLLTEEELSKHLQTAVLSENLRDPDLIIRTSGEQRMSNFLTWQSAYSELYFAQTAWPDFDDKELDKAISAFQKRDRRY
GGVK
>Mature_244_residues
MFNNLKNKEQEELLPEHIGIIMDGNGRWAKQKGKPRIFGHKAGMDSLKDVAVHGARRGIKVMTVYAFSTENWTRPVDEVK
FIMSLPIDFYSKYVPVLKEENIQIRMIGEREGLPKATLDSIDRAAQETSENDGMILNFAMNYGGRRDIILAIQELAKSGQ
DLSLLTEEELSKHLQTAVLSENLRDPDLIIRTSGEQRMSNFLTWQSAYSELYFAQTAWPDFDDKELDKAISAFQKRDRRY
GGVK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=36, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=36, Blast_Score=129, Evalue=2e-30,
Organism=Escherichia coli, GI1786371, Length=232, Percent_Identity=43.9655172413793, Blast_Score=206, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=33.920704845815, Blast_Score=120, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=32.2429906542056, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6323748, Length=214, Percent_Identity=29.4392523364486, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18857969, Length=229, Percent_Identity=33.6244541484716, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_LACLA (Q9CDT1)

Other databases:

- EMBL:   AE005176
- PIR:   B86891
- RefSeq:   NP_268287.1
- ProteinModelPortal:   Q9CDT1
- SMR:   Q9CDT1
- GeneID:   1115807
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L183602
- NMPDR:   fig|272623.1.peg.2185
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14830
- BioCyc:   LLAC272623:L183602-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 27906; Mature: 27906

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 23-23

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNNLKNKEQEELLPEHIGIIMDGNGRWAKQKGKPRIFGHKAGMDSLKDVAVHGARRGIK
CCCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCEE
VMTVYAFSTENWTRPVDEVKFIMSLPIDFYSKYVPVLKEENIQIRMIGEREGLPKATLDS
EEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHCCCEECCCEEEEEEECCCCCCHHHHHH
IDRAAQETSENDGMILNFAMNYGGRRDIILAIQELAKSGQDLSLLTEEELSKHLQTAVLS
HHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
ENLRDPDLIIRTSGEQRMSNFLTWQSAYSELYFAQTAWPDFDDKELDKAISAFQKRDRRY
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GGVK
CCCC
>Mature Secondary Structure
MFNNLKNKEQEELLPEHIGIIMDGNGRWAKQKGKPRIFGHKAGMDSLKDVAVHGARRGIK
CCCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCEE
VMTVYAFSTENWTRPVDEVKFIMSLPIDFYSKYVPVLKEENIQIRMIGEREGLPKATLDS
EEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHCCCEECCCEEEEEEECCCCCCHHHHHH
IDRAAQETSENDGMILNFAMNYGGRRDIILAIQELAKSGQDLSLLTEEELSKHLQTAVLS
HHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
ENLRDPDLIIRTSGEQRMSNFLTWQSAYSELYFAQTAWPDFDDKELDKAISAFQKRDRRY
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GGVK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471