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The map label for this gene is yuiA

Identifier: 15673984

GI number: 15673984

Start: 2080271

End: 2082148

Strand: Direct

Name: yuiA

Synonym: L63697

Alternate gene names: 15673984

Gene position: 2080271-2082148 (Clockwise)

Preceding gene: 15673981

Following gene: 15673985

Centisome position: 87.94

GC content: 35.36

Gene sequence:

>1878_bases
ATGAAACTTCAAGCTTTACTAAAAAAATATAGTAATCAATTAACTGGTCTTTCAGCCTTATTAATTTTAATCGCTTATAG
TGGAAAATATCTTTTGAATTCTTATTTTCTTTGGGCCTTTGCACTCTTATTAGCTACATTTATTGGTCTTGTCCCAATTG
CTTTTCAAGCAGTCCAAGCACTTAAATTCAAACAAGTTTCAATTGAATTATTGGTATCAATTGCTGTTATTGCTGCTCTT
TTTATTCAAGAGTATGAGGAGTCAGCAATTGTTACTTTTCTTTTCGCATTCGGAGCTTTTTTGGAAAAGAAAACTTTAGA
AAAAACACGTTCTTCCATTAAATCTTTGACAGAAATTACTCCCTCGACCGCTCTTCGGATTTCTGGAGAAGTCATTGATA
TTGATGATGTCAAGATTAATGACGAATTATTAGTAAAAACTGGCGCTCAAATTCCTGTAGATGGCTCTATTTATGAGGGG
GCTGGTTTTGTCAATGAATCAAGTATTAGTGGGGAGTCCGCTGAAATAAAAAAAGGAGTCGGAGATAAGGTTTTTGCTGG
AACACTTCTTGAAAATGGAAGTCTTTTGATTCAAGCTGAAAAGGTAGGAGAGGATACCACCTTTGGTAAAATTATTGAAT
TAGTGGAAGAAGCTCAAGATACAAAATCCTCTGCTGAAAAATTTATTGACCGTTTCGCAAAATATTATACTCCTAGTGTT
TTAGTTCTCTCTTTTTTAATTTTCATTGTCAGTCAAGATATCAAGTTGGCAATTACTTTATTAGTTTTAGGTTGTCCGGG
TGCCCTTGTCATTGGACCTCCTGTCAGTAATGTCGCAGGGATAGGGAATGGAGCCAAAAAGGGAATTTTAATTAAAGGTG
GAAATATCATGACTAATTTTAGTCAGACTGACCTGCTTCTTTTTGACAAAACGGGAACACTTACCAAAGGAAAGACTCAG
GTCTCCATTACTAAAAATTATGGCGCTTCTACCGAACTTATCAACCAGGTCGCTATGCTTGAAAGTCAATCAGATCATCC
TTTAGCTAAAGCAATCATTGATGAAATCGGTGAATTTACTAAAGTACCTCTTCAAAATATCGAAGTCATAAAAGGACAGG
GGATTTCTGCTGACCATTTATTGATTGGAAACGAAAAACTCCTTGAGAATCATCAAATTTTTTTAAACGCTCAACAAAAA
AATGATTTAATGAAACTTCAAAAACATGGACTTTCAACAGTATTAATTGCTGATGATAAGGTGCGTTTACTTTATGGAAT
TACTGACAAAATCCGACCAAATGTAAAAGAAACATTGACCAGACTCAAAAAACAAGGGATTAAAGAGCTGATAATGCTGA
CAGGCGACAATGAAAGTACCGCTCAATCAATTGCACAACAAGTGGGAATCAGTCAGGTTTACGCTAATCTCCTACCTGAA
GACAAGGCAAAAATCGTGCAAGACTATAAACTAGCTGGTAAAAAAGTGGCATTTATAGGCGACGGTATTAATGATAGCCC
TAGTATTGCCCTTGCCGATGTGGGAATCGCAATGTCATCTGGGACTGACATCGCCATTGAAACTTCGGATATTGTCCTTA
TGAGTTCTAATTTTGATAACCTTTCTTATGCTCATTCCCTTGCAAAAAGTACAAGGAAAAATATGAGACAAAATATTTTA
ATTGCTCTCTTTGTTGTAATCTTTCTTCTTTCCGGATTAATCTTGGGGAATAGTTCAGGATTTATTGGACAATATGTCAA
TATGGCGACTGGAATGTTTGTCCATGAAGCAAGTATTTTATTGGTTATTCTCAACGCAATGCGTTTAATTCCTCATAAAA
AAATACTATCCAAAAATTTCACTGTCGCAAATGACTAA

Upstream 100 bases:

>100_bases
TTTTCTTTGTTTACGAAAGGTTAATTTTCTTGATGGCTATCAATTTTTTTAAGTTACAAGTAATCTATAATAGAACTATC
AAACCAAGAAAGGTTAATTC

Downstream 100 bases:

>100_bases
AAATAAGGTTATAATTAAAGAAAATCTTTCAGGAAAAATATCTACTCAAATAAGGAGAATAAAATGACTTTAGATAATCA
TCATTGCGTCCAATTAGTTC

Product: metal transporting ATPase

Products: NA

Alternate protein names: Cadmium efflux ATPase [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MKLQALLKKYSNQLTGLSALLILIAYSGKYLLNSYFLWAFALLLATFIGLVPIAFQAVQALKFKQVSIELLVSIAVIAAL
FIQEYEESAIVTFLFAFGAFLEKKTLEKTRSSIKSLTEITPSTALRISGEVIDIDDVKINDELLVKTGAQIPVDGSIYEG
AGFVNESSISGESAEIKKGVGDKVFAGTLLENGSLLIQAEKVGEDTTFGKIIELVEEAQDTKSSAEKFIDRFAKYYTPSV
LVLSFLIFIVSQDIKLAITLLVLGCPGALVIGPPVSNVAGIGNGAKKGILIKGGNIMTNFSQTDLLLFDKTGTLTKGKTQ
VSITKNYGASTELINQVAMLESQSDHPLAKAIIDEIGEFTKVPLQNIEVIKGQGISADHLLIGNEKLLENHQIFLNAQQK
NDLMKLQKHGLSTVLIADDKVRLLYGITDKIRPNVKETLTRLKKQGIKELIMLTGDNESTAQSIAQQVGISQVYANLLPE
DKAKIVQDYKLAGKKVAFIGDGINDSPSIALADVGIAMSSGTDIAIETSDIVLMSSNFDNLSYAHSLAKSTRKNMRQNIL
IALFVVIFLLSGLILGNSSGFIGQYVNMATGMFVHEASILLVILNAMRLIPHKKILSKNFTVAND

Sequences:

>Translated_625_residues
MKLQALLKKYSNQLTGLSALLILIAYSGKYLLNSYFLWAFALLLATFIGLVPIAFQAVQALKFKQVSIELLVSIAVIAAL
FIQEYEESAIVTFLFAFGAFLEKKTLEKTRSSIKSLTEITPSTALRISGEVIDIDDVKINDELLVKTGAQIPVDGSIYEG
AGFVNESSISGESAEIKKGVGDKVFAGTLLENGSLLIQAEKVGEDTTFGKIIELVEEAQDTKSSAEKFIDRFAKYYTPSV
LVLSFLIFIVSQDIKLAITLLVLGCPGALVIGPPVSNVAGIGNGAKKGILIKGGNIMTNFSQTDLLLFDKTGTLTKGKTQ
VSITKNYGASTELINQVAMLESQSDHPLAKAIIDEIGEFTKVPLQNIEVIKGQGISADHLLIGNEKLLENHQIFLNAQQK
NDLMKLQKHGLSTVLIADDKVRLLYGITDKIRPNVKETLTRLKKQGIKELIMLTGDNESTAQSIAQQVGISQVYANLLPE
DKAKIVQDYKLAGKKVAFIGDGINDSPSIALADVGIAMSSGTDIAIETSDIVLMSSNFDNLSYAHSLAKSTRKNMRQNIL
IALFVVIFLLSGLILGNSSGFIGQYVNMATGMFVHEASILLVILNAMRLIPHKKILSKNFTVAND
>Mature_625_residues
MKLQALLKKYSNQLTGLSALLILIAYSGKYLLNSYFLWAFALLLATFIGLVPIAFQAVQALKFKQVSIELLVSIAVIAAL
FIQEYEESAIVTFLFAFGAFLEKKTLEKTRSSIKSLTEITPSTALRISGEVIDIDDVKINDELLVKTGAQIPVDGSIYEG
AGFVNESSISGESAEIKKGVGDKVFAGTLLENGSLLIQAEKVGEDTTFGKIIELVEEAQDTKSSAEKFIDRFAKYYTPSV
LVLSFLIFIVSQDIKLAITLLVLGCPGALVIGPPVSNVAGIGNGAKKGILIKGGNIMTNFSQTDLLLFDKTGTLTKGKTQ
VSITKNYGASTELINQVAMLESQSDHPLAKAIIDEIGEFTKVPLQNIEVIKGQGISADHLLIGNEKLLENHQIFLNAQQK
NDLMKLQKHGLSTVLIADDKVRLLYGITDKIRPNVKETLTRLKKQGIKELIMLTGDNESTAQSIAQQVGISQVYANLLPE
DKAKIVQDYKLAGKKVAFIGDGINDSPSIALADVGIAMSSGTDIAIETSDIVLMSSNFDNLSYAHSLAKSTRKNMRQNIL
IALFVVIFLLSGLILGNSSGFIGQYVNMATGMFVHEASILLVILNAMRLIPHKKILSKNFTVAND

Specific function: This electroneutral antiporter ejects one cadmium ion while accumulating two protons by an energy-dependent efflux mechanism [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=651, Percent_Identity=32.258064516129, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI55743071, Length=632, Percent_Identity=30.2215189873418, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI55743073, Length=509, Percent_Identity=31.237721021611, Blast_Score=227, Evalue=3e-59,
Organism=Homo sapiens, GI28373113, Length=205, Percent_Identity=29.2682926829268, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI28373103, Length=205, Percent_Identity=29.2682926829268, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI28373115, Length=205, Percent_Identity=29.2682926829268, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI28373111, Length=205, Percent_Identity=29.2682926829268, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI28373105, Length=205, Percent_Identity=29.2682926829268, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI28373107, Length=205, Percent_Identity=29.2682926829268, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI28373109, Length=205, Percent_Identity=29.2682926829268, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI48762687, Length=161, Percent_Identity=31.055900621118, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI48762691, Length=161, Percent_Identity=31.055900621118, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI48762685, Length=161, Percent_Identity=31.055900621118, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI48762689, Length=161, Percent_Identity=31.055900621118, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1786691, Length=560, Percent_Identity=33.0357142857143, Blast_Score=298, Evalue=8e-82,
Organism=Escherichia coli, GI1789879, Length=620, Percent_Identity=33.2258064516129, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1786914, Length=496, Percent_Identity=27.4193548387097, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI2367363, Length=575, Percent_Identity=23.8260869565217, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17556548, Length=576, Percent_Identity=29.8611111111111, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17554158, Length=185, Percent_Identity=28.1081081081081, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71988506, Length=185, Percent_Identity=28.1081081081081, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193210130, Length=185, Percent_Identity=28.1081081081081, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320475, Length=540, Percent_Identity=31.6666666666667, Blast_Score=227, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6319772, Length=558, Percent_Identity=25.6272401433692, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325221, Length=654, Percent_Identity=23.7003058103976, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321430, Length=652, Percent_Identity=23.159509202454, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321271, Length=180, Percent_Identity=34.4444444444444, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6321432, Length=181, Percent_Identity=32.0441988950276, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320244, Length=203, Percent_Identity=30.0492610837438, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320243, Length=203, Percent_Identity=30.0492610837438, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320245, Length=203, Percent_Identity=29.5566502463054, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221329854, Length=377, Percent_Identity=28.9124668435013, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24762455, Length=185, Percent_Identity=28.6486486486486, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762453, Length=185, Percent_Identity=28.6486486486486, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762447, Length=185, Percent_Identity=28.6486486486486, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762457, Length=185, Percent_Identity=28.6486486486486, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762449, Length=185, Percent_Identity=28.6486486486486, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762445, Length=185, Percent_Identity=28.6486486486486, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762451, Length=185, Percent_Identity=28.6486486486486, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136664, Length=185, Percent_Identity=28.6486486486486, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281366617, Length=161, Percent_Identity=31.055900621118, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24668704, Length=161, Percent_Identity=31.055900621118, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24668708, Length=161, Percent_Identity=31.055900621118, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24668696, Length=161, Percent_Identity=31.055900621118, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI161085803, Length=161, Percent_Identity=31.055900621118, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3 [H]

Molecular weight: Translated: 67699; Mature: 67699

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLQALLKKYSNQLTGLSALLILIAYSGKYLLNSYFLWAFALLLATFIGLVPIAFQAVQA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKFKQVSIELLVSIAVIAALFIQEYEESAIVTFLFAFGAFLEKKTLEKTRSSIKSLTEIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PSTALRISGEVIDIDDVKINDELLVKTGAQIPVDGSIYEGAGFVNESSISGESAEIKKGV
CCCEEEECCCEEECCCCEECCEEEEECCCCCCCCCCEECCCCCCCCCCCCCCCHHHHCCC
GDKVFAGTLLENGSLLIQAEKVGEDTTFGKIIELVEEAQDTKSSAEKFIDRFAKYYTPSV
CCHHHHHHEECCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LVLSFLIFIVSQDIKLAITLLVLGCPGALVIGPPVSNVAGIGNGAKKGILIKGGNIMTNF
HHHHHHHHHHCCCHHHHHHHHHCCCCCCEEECCCCHHHCCCCCCCCCCEEEECCCEEECC
SQTDLLLFDKTGTLTKGKTQVSITKNYGASTELINQVAMLESQSDHPLAKAIIDEIGEFT
CCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KVPLQNIEVIKGQGISADHLLIGNEKLLENHQIFLNAQQKNDLMKLQKHGLSTVLIADDK
CCCCCCEEEEECCCCCCCEEEECCHHHHCCCEEEEEEHHHHHHHHHHHCCCCEEEEECCC
VRLLYGITDKIRPNVKETLTRLKKQGIKELIMLTGDNESTAQSIAQQVGISQVYANLLPE
EEEEECCCHHCCCCHHHHHHHHHHHCHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
DKAKIVQDYKLAGKKVAFIGDGINDSPSIALADVGIAMSSGTDIAIETSDIVLMSSNFDN
HHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECEEECCCCEEEEEECCEEEEECCCCC
LSYAHSLAKSTRKNMRQNILIALFVVIFLLSGLILGNSSGFIGQYVNMATGMFVHEASIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHH
LVILNAMRLIPHKKILSKNFTVAND
HHHHHHHHHCCCHHHHHCCCCCCCC
>Mature Secondary Structure
MKLQALLKKYSNQLTGLSALLILIAYSGKYLLNSYFLWAFALLLATFIGLVPIAFQAVQA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKFKQVSIELLVSIAVIAALFIQEYEESAIVTFLFAFGAFLEKKTLEKTRSSIKSLTEIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PSTALRISGEVIDIDDVKINDELLVKTGAQIPVDGSIYEGAGFVNESSISGESAEIKKGV
CCCEEEECCCEEECCCCEECCEEEEECCCCCCCCCCEECCCCCCCCCCCCCCCHHHHCCC
GDKVFAGTLLENGSLLIQAEKVGEDTTFGKIIELVEEAQDTKSSAEKFIDRFAKYYTPSV
CCHHHHHHEECCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LVLSFLIFIVSQDIKLAITLLVLGCPGALVIGPPVSNVAGIGNGAKKGILIKGGNIMTNF
HHHHHHHHHHCCCHHHHHHHHHCCCCCCEEECCCCHHHCCCCCCCCCCEEEECCCEEECC
SQTDLLLFDKTGTLTKGKTQVSITKNYGASTELINQVAMLESQSDHPLAKAIIDEIGEFT
CCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KVPLQNIEVIKGQGISADHLLIGNEKLLENHQIFLNAQQKNDLMKLQKHGLSTVLIADDK
CCCCCCEEEEECCCCCCCEEEECCHHHHCCCEEEEEEHHHHHHHHHHHCCCCEEEEECCC
VRLLYGITDKIRPNVKETLTRLKKQGIKELIMLTGDNESTAQSIAQQVGISQVYANLLPE
EEEEECCCHHCCCCHHHHHHHHHHHCHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
DKAKIVQDYKLAGKKVAFIGDGINDSPSIALADVGIAMSSGTDIAIETSDIVLMSSNFDN
HHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECEEECCCCEEEEEECCEEEEECCCCC
LSYAHSLAKSTRKNMRQNILIALFVVIFLLSGLILGNSSGFIGQYVNMATGMFVHEASIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHH
LVILNAMRLIPHKKILSKNFTVAND
HHHHHHHHHCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188605; 8188606 [H]