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The map label for this gene is metA

Identifier: 15673900

GI number: 15673900

Start: 1996691

End: 1997656

Strand: Reverse

Name: metA

Synonym: L0101

Alternate gene names: 15673900

Gene position: 1997656-1996691 (Counterclockwise)

Preceding gene: 15673901

Following gene: 15673899

Centisome position: 84.45

GC content: 34.58

Gene sequence:

>966_bases
ATGCCGGTAAAAGTGATTGAAGGTCTGCCCGCAATTGATGATTTGCGAGCGGATAATATTTTTGTTATGAATGATGAACG
AGCGAAGAATCAAAATATTCGCCCTTTAAATTTGCTGGTGGTCAATCTCATGCCGCGTAAATTAATAACTGAAAGACAAA
TTTTACGATTACTATCGAACACTCCATTACAAATTAATGTTGAATTTTTATATATGACTTCTCATGATTTTAAAAATACG
AAACAAGGGCATTTAGATTCCTTCTATAAATCTTTTTCTGAGATTAAGAGTCAATATTACGACGGATTAATTGTCACAGG
AGCTCCGGTTGAGCAGTTAAACTTTGAAGAAGTGGACTATTGGAGTGAGCTTTTGAAAATTATTGACTGGTCTAAAAGCC
ATGTCTATTCAAGTCTGCATATTTGTTGGGGGGCACAAGCGGCACTTTATGCTCGCTATGGTGTAACTAAAGAAAATCTT
CCGCAAAAATTGTGTGGTATTTACAAAAGCTCAGTAGAGCAACCTAAAAATCCATTATTTAGAGGATTTGATGATTTTTT
TAATTATCCACAATCGCGATATACCCAATCAAATCCATCAGAAATAAAAAAAGTACCTGATTTGGAAGTCTTGTCAAGCT
CCAAAGAAACCGGATTTTCAATTTTAGCGAAGAAAAATTTGCGTGAAATTTACCTTTTTGGCCATTTAGAATATGACCGT
GAAACTTTAGCTTGGGAATATGAGAGAGATAAAGAAGAAGGACTGAAACCCAATCTTCCCCAAAATTATTTTCCAGAAAA
TGATGATAAAAATAAGCCAAAAAGCACTTGGGCTTCAGCAGCTTCCCTCTTTTTTTCAAATTGGTTGAATTATGCGGTTT
ATCAAGGAACGCCTTATCTAGGAGAACGTCTGAGTCAACATTTGAATGAAGAAAATTATGATTTTAATCAAAAAGAGCAA
AAGTAA

Upstream 100 bases:

>100_bases
TTTTAAATTAGACCATCACAGAATTAAAATACGAGACTATTGCAAAAAAATCACGAAGGGCTATAATTGAGTCTAATTCT
ATTTGAAAGTTGAGTGATTT

Downstream 100 bases:

>100_bases
AAAATAATGAGTTAAAAAATGAGGAAATTTATGGATAAAAGATTAGATACTTTATTGGCGCAAGTCGGAATTCATCAAGA
TGAGGCAACGGGAGCTTTAG

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MPVKVIEGLPAIDDLRADNIFVMNDERAKNQNIRPLNLLVVNLMPRKLITERQILRLLSNTPLQINVEFLYMTSHDFKNT
KQGHLDSFYKSFSEIKSQYYDGLIVTGAPVEQLNFEEVDYWSELLKIIDWSKSHVYSSLHICWGAQAALYARYGVTKENL
PQKLCGIYKSSVEQPKNPLFRGFDDFFNYPQSRYTQSNPSEIKKVPDLEVLSSSKETGFSILAKKNLREIYLFGHLEYDR
ETLAWEYERDKEEGLKPNLPQNYFPENDDKNKPKSTWASAASLFFSNWLNYAVYQGTPYLGERLSQHLNEENYDFNQKEQ
K

Sequences:

>Translated_321_residues
MPVKVIEGLPAIDDLRADNIFVMNDERAKNQNIRPLNLLVVNLMPRKLITERQILRLLSNTPLQINVEFLYMTSHDFKNT
KQGHLDSFYKSFSEIKSQYYDGLIVTGAPVEQLNFEEVDYWSELLKIIDWSKSHVYSSLHICWGAQAALYARYGVTKENL
PQKLCGIYKSSVEQPKNPLFRGFDDFFNYPQSRYTQSNPSEIKKVPDLEVLSSSKETGFSILAKKNLREIYLFGHLEYDR
ETLAWEYERDKEEGLKPNLPQNYFPENDDKNKPKSTWASAASLFFSNWLNYAVYQGTPYLGERLSQHLNEENYDFNQKEQ
K
>Mature_320_residues
PVKVIEGLPAIDDLRADNIFVMNDERAKNQNIRPLNLLVVNLMPRKLITERQILRLLSNTPLQINVEFLYMTSHDFKNTK
QGHLDSFYKSFSEIKSQYYDGLIVTGAPVEQLNFEEVDYWSELLKIIDWSKSHVYSSLHICWGAQAALYARYGVTKENLP
QKLCGIYKSSVEQPKNPLFRGFDDFFNYPQSRYTQSNPSEIKKVPDLEVLSSSKETGFSILAKKNLREIYLFGHLEYDRE
TLAWEYERDKEEGLKPNLPQNYFPENDDKNKPKSTWASAASLFFSNWLNYAVYQGTPYLGERLSQHLNEENYDFNQKEQK

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=299, Percent_Identity=47.1571906354515, Blast_Score=304, Evalue=5e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_LACLA (Q9CEC5)

Other databases:

- EMBL:   AE005176
- PIR:   F86864
- RefSeq:   NP_268075.1
- ProteinModelPortal:   Q9CEC5
- SMR:   Q9CEC5
- GeneID:   1115586
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0101
- NMPDR:   fig|272623.1.peg.1965
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- ProtClustDB:   PRK05368
- BioCyc:   LLAC272623:L0101-MONOMER
- BRENDA:   2.3.1.46
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 37530; Mature: 37399

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKVIEGLPAIDDLRADNIFVMNDERAKNQNIRPLNLLVVNLMPRKLITERQILRLLSN
CCCCHHCCCCCHHHCCCCCEEEECCCCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHCC
TPLQINVEFLYMTSHDFKNTKQGHLDSFYKSFSEIKSQYYDGLIVTGAPVEQLNFEEVDY
CCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCHHHCCCHHHHH
WSELLKIIDWSKSHVYSSLHICWGAQAALYARYGVTKENLPQKLCGIYKSSVEQPKNPLF
HHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHH
RGFDDFFNYPQSRYTQSNPSEIKKVPDLEVLSSSKETGFSILAKKNLREIYLFGHLEYDR
CCHHHHHCCCHHHCCCCCHHHHHHCCCHHHHHCCCCCCHHHHHHCCCEEEEEEEEEEECC
ETLAWEYERDKEEGLKPNLPQNYFPENDDKNKPKSTWASAASLFFSNWLNYAVYQGTPYL
HHHEEECCCCHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCHH
GERLSQHLNEENYDFNQKEQK
HHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVKVIEGLPAIDDLRADNIFVMNDERAKNQNIRPLNLLVVNLMPRKLITERQILRLLSN
CCCHHCCCCCHHHCCCCCEEEECCCCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHCC
TPLQINVEFLYMTSHDFKNTKQGHLDSFYKSFSEIKSQYYDGLIVTGAPVEQLNFEEVDY
CCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCHHHCCCHHHHH
WSELLKIIDWSKSHVYSSLHICWGAQAALYARYGVTKENLPQKLCGIYKSSVEQPKNPLF
HHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHH
RGFDDFFNYPQSRYTQSNPSEIKKVPDLEVLSSSKETGFSILAKKNLREIYLFGHLEYDR
CCHHHHHCCCHHHCCCCCHHHHHHCCCHHHHHCCCCCCHHHHHHCCCEEEEEEEEEEECC
ETLAWEYERDKEEGLKPNLPQNYFPENDDKNKPKSTWASAASLFFSNWLNYAVYQGTPYL
HHHEEECCCCHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCHH
GERLSQHLNEENYDFNQKEQK
HHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471