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The map label for this gene is metB1

Identifier: 15673899

GI number: 15673899

Start: 1995572

End: 1996660

Strand: Reverse

Name: metB1

Synonym: L0102

Alternate gene names: 15673899

Gene position: 1996660-1995572 (Counterclockwise)

Preceding gene: 15673900

Following gene: 15673898

Centisome position: 84.4

GC content: 36.27

Gene sequence:

>1089_bases
ATGGATAAAAGATTAGATACTTTATTGGCGCAAGTCGGAATTCATCAAGATGAGGCAACGGGAGCTTTAGTTAGTCCTTT
GCATTTTTCAACGACCTATCAACATCCAGAATTTGGCCAATCGACTGGCTTTGATTACACCAGAACCAAAAATCCAACAA
GAGCAACCTTGGAAGAAGCACTTGCTTCAATTGAATCAGGACAATTTGCTCTAGCAACTTCGTCAGGAATGGCTGCAATT
GTCTTGGCCTTTTCAGTTTTCCCAATCGGTTCAAAAATTGTTGCCAGTCGAGATTTGTATGGAGGTTCATTTCGCTGGTT
CGATGAACAAGAAAAAGAGGGACGATTTTACTTTTCCTATGCTAAAACTGAAAAAGAAATGCTTGAGCTAATAGATGAAA
ATACTGATATTGTTTATATTGAAACACCGACAAATCCAATGATGGTTAAATATAATATTGAAAAAATCGCCAATAAAGCA
CAGGCATATCATGCAAAAGTGATTGTTGTCAATACTTTTTATACCCCAATTTATCAAAAACCATTAGAATTGGGTGCGGA
TTTAGTGATTCATTCGGCAACAAAATATTTATCAGGACATAATGACGTCTTGGCTGGAGCGGTCATTGTTTATGATGAAG
AACTTTATGAAAGATTATTATATCAGCTCAATACTACTGGAGCAGTTCTTTCTCCATTTGACAGTTATCTTGTCATGCGA
GGTTTGAAAACTTTAAGCCTCAGAATGGAGAGGGCAACTAAAAATGCCCAAAAAATTGTGACTTTCCTAAAAAAACTTCC
ATCAGTAAAAGAAGTACTTTACTCAGGATTAGGTGGCATGATTTCTCTAAAAGTTACTGACAAAACCAAAATTCCTGCTA
TTTTAAATCACTTGGGCGTTTTTACCTTTGCTGAAAGCTTGGGAGGTGTTGAATCTTTAATCACTTATCCAACAGCGCAA
ACTCACCATGATATTCCACTTGAGATTAGAGAAAGTTATGGTTTAACAGATGATTTGCTTCGCCTTTCGATTGGGATAGA
AGATGTTCGCGATTTAATAGAAGATCTCAAAGAAGCTTTAGAAAATTAA

Upstream 100 bases:

>100_bases
TCTAGGAGAACGTCTGAGTCAACATTTGAATGAAGAAAATTATGATTTTAATCAAAAAGAGCAAAAGTAAAAAATAATGA
GTTAAAAAATGAGGAAATTT

Downstream 100 bases:

>100_bases
AAAATTACTGATGAACAAACTAGCATATCCGTAAAGGCTATCTACGCACTGCGTGCTACGCTGTCCGTTTTGTGACAAAA
AGGCGAAGCGCCAACGGCTA

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CGS; O-acetylhomoserine (thiol)-lyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MDKRLDTLLAQVGIHQDEATGALVSPLHFSTTYQHPEFGQSTGFDYTRTKNPTRATLEEALASIESGQFALATSSGMAAI
VLAFSVFPIGSKIVASRDLYGGSFRWFDEQEKEGRFYFSYAKTEKEMLELIDENTDIVYIETPTNPMMVKYNIEKIANKA
QAYHAKVIVVNTFYTPIYQKPLELGADLVIHSATKYLSGHNDVLAGAVIVYDEELYERLLYQLNTTGAVLSPFDSYLVMR
GLKTLSLRMERATKNAQKIVTFLKKLPSVKEVLYSGLGGMISLKVTDKTKIPAILNHLGVFTFAESLGGVESLITYPTAQ
THHDIPLEIRESYGLTDDLLRLSIGIEDVRDLIEDLKEALEN

Sequences:

>Translated_362_residues
MDKRLDTLLAQVGIHQDEATGALVSPLHFSTTYQHPEFGQSTGFDYTRTKNPTRATLEEALASIESGQFALATSSGMAAI
VLAFSVFPIGSKIVASRDLYGGSFRWFDEQEKEGRFYFSYAKTEKEMLELIDENTDIVYIETPTNPMMVKYNIEKIANKA
QAYHAKVIVVNTFYTPIYQKPLELGADLVIHSATKYLSGHNDVLAGAVIVYDEELYERLLYQLNTTGAVLSPFDSYLVMR
GLKTLSLRMERATKNAQKIVTFLKKLPSVKEVLYSGLGGMISLKVTDKTKIPAILNHLGVFTFAESLGGVESLITYPTAQ
THHDIPLEIRESYGLTDDLLRLSIGIEDVRDLIEDLKEALEN
>Mature_362_residues
MDKRLDTLLAQVGIHQDEATGALVSPLHFSTTYQHPEFGQSTGFDYTRTKNPTRATLEEALASIESGQFALATSSGMAAI
VLAFSVFPIGSKIVASRDLYGGSFRWFDEQEKEGRFYFSYAKTEKEMLELIDENTDIVYIETPTNPMMVKYNIEKIANKA
QAYHAKVIVVNTFYTPIYQKPLELGADLVIHSATKYLSGHNDVLAGAVIVYDEELYERLLYQLNTTGAVLSPFDSYLVMR
GLKTLSLRMERATKNAQKIVTFLKKLPSVKEVLYSGLGGMISLKVTDKTKIPAILNHLGVFTFAESLGGVESLITYPTAQ
THHDIPLEIRESYGLTDDLLRLSIGIEDVRDLIEDLKEALEN

Specific function: Catalyzes the transformation of O-succinylhomoserine into cystathionine, as well as O-acetylhomoserine and sulfide into homocysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=344, Percent_Identity=39.8255813953488, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI299473759, Length=344, Percent_Identity=36.046511627907, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI25453487, Length=341, Percent_Identity=34.3108504398827, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1790375, Length=381, Percent_Identity=40.4199475065617, Blast_Score=278, Evalue=4e-76,
Organism=Escherichia coli, GI1789383, Length=400, Percent_Identity=25.5, Blast_Score=114, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17560056, Length=361, Percent_Identity=39.3351800554017, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17538055, Length=347, Percent_Identity=38.328530259366, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI71980708, Length=390, Percent_Identity=33.8461538461538, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6319307, Length=377, Percent_Identity=40.3183023872679, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6321254, Length=405, Percent_Identity=31.1111111111111, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6323333, Length=441, Percent_Identity=30.8390022675737, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6321904, Length=380, Percent_Identity=27.1052631578947, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6321170, Length=279, Percent_Identity=25.8064516129032, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI19922554, Length=365, Percent_Identity=39.4520547945205, Blast_Score=255, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =2.5.1.48; =2.5.1.49 [H]

Molecular weight: Translated: 40399; Mature: 40399

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRLDTLLAQVGIHQDEATGALVSPLHFSTTYQHPEFGQSTGFDYTRTKNPTRATLEEA
CCHHHHHHHHHHCCCCCCCCCCEECCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LASIESGQFALATSSGMAAIVLAFSVFPIGSKIVASRDLYGGSFRWFDEQEKEGRFYFSY
HHHHCCCCEEEEECCCHHHHHHHHHHCCCCCHHHCCCCCCCCCEECCCCCCCCCCEEEEE
AKTEKEMLELIDENTDIVYIETPTNPMMVKYNIEKIANKAQAYHAKVIVVNTFYTPIYQK
HHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHEEEEEEEECCCCHHHHC
PLELGADLVIHSATKYLSGHNDVLAGAVIVYDEELYERLLYQLNTTGAVLSPFDSYLVMR
HHHHCCHHHHHHHHHHHCCCCCHHCCEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GLKTLSLRMERATKNAQKIVTFLKKLPSVKEVLYSGLGGMISLKVTDKTKIPAILNHLGV
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
FTFAESLGGVESLITYPTAQTHHDIPLEIRESYGLTDDLLRLSIGIEDVRDLIEDLKEAL
HHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHH
EN
CC
>Mature Secondary Structure
MDKRLDTLLAQVGIHQDEATGALVSPLHFSTTYQHPEFGQSTGFDYTRTKNPTRATLEEA
CCHHHHHHHHHHCCCCCCCCCCEECCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LASIESGQFALATSSGMAAIVLAFSVFPIGSKIVASRDLYGGSFRWFDEQEKEGRFYFSY
HHHHCCCCEEEEECCCHHHHHHHHHHCCCCCHHHCCCCCCCCCEECCCCCCCCCCEEEEE
AKTEKEMLELIDENTDIVYIETPTNPMMVKYNIEKIANKAQAYHAKVIVVNTFYTPIYQK
HHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHEEEEEEEECCCCHHHHC
PLELGADLVIHSATKYLSGHNDVLAGAVIVYDEELYERLLYQLNTTGAVLSPFDSYLVMR
HHHHCCHHHHHHHHHHHCCCCCHHCCEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GLKTLSLRMERATKNAQKIVTFLKKLPSVKEVLYSGLGGMISLKVTDKTKIPAILNHLGV
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
FTFAESLGGVESLITYPTAQTHHDIPLEIRESYGLTDDLLRLSIGIEDVRDLIEDLKEAL
HHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHH
EN
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]