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The map label for this gene is fbaA

Identifier: 15673891

GI number: 15673891

Start: 1979402

End: 1980298

Strand: Reverse

Name: fbaA

Synonym: L0009

Alternate gene names: 15673891

Gene position: 1980298-1979402 (Counterclockwise)

Preceding gene: 15673892

Following gene: 15673890

Centisome position: 83.71

GC content: 41.14

Gene sequence:

>897_bases
ATGGCAATCGTTTCAGCAGAAAAATTCGTACAAGCCGCTCGTGATAACGGATACGCTATCGGTGGTTTCAACACAAACAA
CCTTGAATGGACTCAAGCTATCTTGCGTGCAGCAGAAGCTAAAAAGACTCCAGTATTGATCCAAACTTCTATGGGTGCGG
CTAAATACATGGGTGGTTACAAAATGTGTAAACTCCTCATTGAAACTCTTGTAGAATCAATGGGAATCACAGTTCCAGTT
GCTATTCACCTTGACCACGGTCATTTTGATGATGCTTTGGAATGTATCGAAGTTGGTTACTCATCATTGATGTTTGATGG
TTCACATCTTCCAATCGAAGAAAACCTTAAACTTGCTGAAGAAGTAATCGCTAAAGCTCATGCTAAAGGCATCTCAGTTG
AATGTGAAGTTGGTTCAATTGGTGGTGAAGAAGACGGTATCGTTGGTGAAGGTGAACTTGCTCCTATCGATGATGCAGTT
GCAATGGCTAAACTTGGTGTTGACTTCCTTGCAGCAGGTATCGGTAACATTCACGGTCCTTACCCAGAAAACTGGAAAGG
TCTTCACATCGATCACCTTGAAAAATTGAACAAAGCACTTGTTGAAGCTATGGGACACAATGTGCCAATCGTACTTCACG
GTGGTTCTGGTATCCCTGATGATCAAATCAGAGAAGCTATCGCTAATGGTGTAGCTAAAGTTAACGTTAATACTGAATGC
CAACTTGCTTTCGCAGCTGCTACTCGTAAATTCGTTAATGAATTTGATGCTAATGAAGCAGAATACATGAAGAAAAAACT
TTTCGACCCACGTAAATTCTTGAAACCTGGTTTCGATGCAATTACTGCGTCTGTTGAAGAACGTATCGATGTATTCGGTT
CAGCTAACAAAGCTTAA

Upstream 100 bases:

>100_bases
AATAAAGCGGTTACTTTGTATTTTTGCGAGCTTGGACTAGAAAAATACTTCACAAAATGCTATACTAGGTAAGTAATAAA
ATATTCGGAGGAATTTTGAA

Downstream 100 bases:

>100_bases
TCAACTTTTAAAACATGATTAAATAAACGTTTGTCATTTATGATGGACGTTTTTTTATTTTTCAATTTGCTTTGATATAG
TATAAGGTTCTATCTTAGTA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAIVSAEKFVQAARDNGYAIGGFNTNNLEWTQAILRAAEAKKTPVLIQTSMGAAKYMGGYKMCKLLIETLVESMGITVPV
AIHLDHGHFDDALECIEVGYSSLMFDGSHLPIEENLKLAEEVIAKAHAKGISVECEVGSIGGEEDGIVGEGELAPIDDAV
AMAKLGVDFLAAGIGNIHGPYPENWKGLHIDHLEKLNKALVEAMGHNVPIVLHGGSGIPDDQIREAIANGVAKVNVNTEC
QLAFAAATRKFVNEFDANEAEYMKKKLFDPRKFLKPGFDAITASVEERIDVFGSANKA

Sequences:

>Translated_298_residues
MAIVSAEKFVQAARDNGYAIGGFNTNNLEWTQAILRAAEAKKTPVLIQTSMGAAKYMGGYKMCKLLIETLVESMGITVPV
AIHLDHGHFDDALECIEVGYSSLMFDGSHLPIEENLKLAEEVIAKAHAKGISVECEVGSIGGEEDGIVGEGELAPIDDAV
AMAKLGVDFLAAGIGNIHGPYPENWKGLHIDHLEKLNKALVEAMGHNVPIVLHGGSGIPDDQIREAIANGVAKVNVNTEC
QLAFAAATRKFVNEFDANEAEYMKKKLFDPRKFLKPGFDAITASVEERIDVFGSANKA
>Mature_297_residues
AIVSAEKFVQAARDNGYAIGGFNTNNLEWTQAILRAAEAKKTPVLIQTSMGAAKYMGGYKMCKLLIETLVESMGITVPVA
IHLDHGHFDDALECIEVGYSSLMFDGSHLPIEENLKLAEEVIAKAHAKGISVECEVGSIGGEEDGIVGEGELAPIDDAVA
MAKLGVDFLAAGIGNIHGPYPENWKGLHIDHLEKLNKALVEAMGHNVPIVLHGGSGIPDDQIREAIANGVAKVNVNTECQ
LAFAAATRKFVNEFDANEAEYMKKKLFDPRKFLKPGFDAITASVEERIDVFGSANKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=305, Percent_Identity=35.0819672131148, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI87082041, Length=305, Percent_Identity=32.1311475409836, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788072, Length=294, Percent_Identity=32.9931972789116, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789293, Length=342, Percent_Identity=27.1929824561404, Blast_Score=99, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322790, Length=339, Percent_Identity=28.3185840707965, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 31990; Mature: 31859

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVSAEKFVQAARDNGYAIGGFNTNNLEWTQAILRAAEAKKTPVLIQTSMGAAKYMGGY
CCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHH
KMCKLLIETLVESMGITVPVAIHLDHGHFDDALECIEVGYSSLMFDGSHLPIEENLKLAE
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCHHHHEECCCCCCHHHHHHHHH
EVIAKAHAKGISVECEVGSIGGEEDGIVGEGELAPIDDAVAMAKLGVDFLAAGIGNIHGP
HHHHHHHHCCCEEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
YPENWKGLHIDHLEKLNKALVEAMGHNVPIVLHGGSGIPDDQIREAIANGVAKVNVNTEC
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCEEEEECCCCE
QLAFAAATRKFVNEFDANEAEYMKKKLFDPRKFLKPGFDAITASVEERIDVFGSANKA
EHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AIVSAEKFVQAARDNGYAIGGFNTNNLEWTQAILRAAEAKKTPVLIQTSMGAAKYMGGY
CCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHH
KMCKLLIETLVESMGITVPVAIHLDHGHFDDALECIEVGYSSLMFDGSHLPIEENLKLAE
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCHHHHEECCCCCCHHHHHHHHH
EVIAKAHAKGISVECEVGSIGGEEDGIVGEGELAPIDDAVAMAKLGVDFLAAGIGNIHGP
HHHHHHHHCCCEEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
YPENWKGLHIDHLEKLNKALVEAMGHNVPIVLHGGSGIPDDQIREAIANGVAKVNVNTEC
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCEEEEECCCCE
QLAFAAATRKFVNEFDANEAEYMKKKLFDPRKFLKPGFDAITASVEERIDVFGSANKA
EHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]