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The map label for this gene is cobC

Identifier: 15673802

GI number: 15673802

Start: 1889232

End: 1889756

Strand: Direct

Name: cobC

Synonym: L1889160

Alternate gene names: 15673802

Gene position: 1889232-1889756 (Clockwise)

Preceding gene: 15673798

Following gene: 15673803

Centisome position: 79.86

GC content: 32.19

Gene sequence:

>525_bases
ATGAAATTATATTTAGTAAGACATGGTGAAACGCAAAATAATCAGCAAAATTTGCTGACGGGTTGGTTGAACAGTCCTCT
CACTGGCACAGGAATTCAACAGTCCGAAATTTTAGCTGACAAACTTTCGTCAGTAAAATTTGACTTGATTTTATCATCAG
ATTTACAAGGTGCTAAGGAAACTGCAATGATAATTTCTAATAAAATAGGAGCCCTACTACTCTTTGAACCTTTATTACGT
GAACGAGGCCTTGGAAAATTGGAAAATCAAACAAAAGAAAATCGAGATTGGGCACAACTTAATATAGAAAATGAAGAAAA
TCTTACTTTAGGTATTGAATCTCTTGCTTCTATTCATGAACGTGCTAAAATATTTTTAGAAAAACTTCCTCAACTTTTTC
CTTCTGCTCAAAATATTCTCATTGTTTCTCACAATGGAATGATCAATCAATTTCAAAAGATTTGGGAGCCTACTCATGAA
TTTACTCCTTTTGAATTTCTCACTATTTTAGAAAAAAACTTATGA

Upstream 100 bases:

>100_bases
AGACTTGAAAGAATCGTAAGTGAAGTAATCATACTCTTATTATACCACGAATGGCAAGCTATCTCTTAACTTTGGCTACG
TTAAATGGTATAATCTGACT

Downstream 100 bases:

>100_bases
ACCAATATTTTACTTACATTTTACAATGCTCAGATAAGACTCTCTACTGTGGCTATACCACTGATTTAGAAAAAAGACTT
GCCACTCATAACTCTGGTAA

Product: alpha-ribazole-5'-phosphate phosphatase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MKLYLVRHGETQNNQQNLLTGWLNSPLTGTGIQQSEILADKLSSVKFDLILSSDLQGAKETAMIISNKIGALLLFEPLLR
ERGLGKLENQTKENRDWAQLNIENEENLTLGIESLASIHERAKIFLEKLPQLFPSAQNILIVSHNGMINQFQKIWEPTHE
FTPFEFLTILEKNL

Sequences:

>Translated_174_residues
MKLYLVRHGETQNNQQNLLTGWLNSPLTGTGIQQSEILADKLSSVKFDLILSSDLQGAKETAMIISNKIGALLLFEPLLR
ERGLGKLENQTKENRDWAQLNIENEENLTLGIESLASIHERAKIFLEKLPQLFPSAQNILIVSHNGMINQFQKIWEPTHE
FTPFEFLTILEKNL
>Mature_174_residues
MKLYLVRHGETQNNQQNLLTGWLNSPLTGTGIQQSEILADKLSSVKFDLILSSDLQGAKETAMIISNKIGALLLFEPLLR
ERGLGKLENQTKENRDWAQLNIENEENLTLGIESLASIHERAKIFLEKLPQLFPSAQNILIVSHNGMINQFQKIWEPTHE
FTPFEFLTILEKNL

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=157, Percent_Identity=33.7579617834395, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790856, Length=152, Percent_Identity=34.2105263157895, Blast_Score=76, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 19808; Mature: 19808

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYLVRHGETQNNQQNLLTGWLNSPLTGTGIQQSEILADKLSSVKFDLILSSDLQGAKE
CEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCCCHHH
TAMIISNKIGALLLFEPLLRERGLGKLENQTKENRDWAQLNIENEENLTLGIESLASIHE
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCCEEECHHHHHHHHH
RAKIFLEKLPQLFPSAQNILIVSHNGMINQFQKIWEPTHEFTPFEFLTILEKNL
HHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKLYLVRHGETQNNQQNLLTGWLNSPLTGTGIQQSEILADKLSSVKFDLILSSDLQGAKE
CEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCCCHHH
TAMIISNKIGALLLFEPLLRERGLGKLENQTKENRDWAQLNIENEENLTLGIESLASIHE
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCCEEECHHHHHHHHH
RAKIFLEKLPQLFPSAQNILIVSHNGMINQFQKIWEPTHEFTPFEFLTILEKNL
HHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]