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The map label for this gene is serS

Identifier: 15673694

GI number: 15673694

Start: 1767193

End: 1768464

Strand: Direct

Name: serS

Synonym: L150515

Alternate gene names: 15673694

Gene position: 1767193-1768464 (Clockwise)

Preceding gene: 15673693

Following gene: 15673695

Centisome position: 74.7

GC content: 38.6

Gene sequence:

>1272_bases
ATGCTTGATATTAAAAAAATTCGTGCTGATTTTGACGGTGTTGCTGCAAAATTAGCCACTCGTGGTGTTGAAAAAGAGAA
ACTTGAAAAACTTCATGACTTAGACATTAAACGTCGTGAACTCATTGTAAAATCTGAGGCTTTGAAAGCTGAACGTAATA
GTGTTTCTGATGAAATTTCTCAAGTAAAACGTGCAAAAGGCGATGCCAGCGCACAAATTGCTGCAATGCAAAAAGTTTCT
GCTGAAATCAAAGCCATTGATGCTGAACTTGCTGAAATCGAAGAAAACTTGAATGAAATCATTATCATGTTGCCAAATCT
TCCTCATGAAAGTACACCAATTGGTGCTGATGAAGATGATAATGTTGAGGTTCGTCGTGTTGGTCAAACTCCAACTTTCA
ATTTTGAACCTAAAGCTCACTGGGATTTGGGTGAAGATTTAGGAATTTTGGATTGGGAACGTGGTGGTAAAGTCACTGGT
TCACGCTTCCTTTTTTACAAAGGTGCTGGCGCAAGACTTGAACGTGCACTTTATAACTTCATGCTTGATGAGCACGGTAA
AGAAGGTTATACTGAAATGATTACTCCTTATATGGTTAATCAAGAGTCAATGTTTGGAACGGGTCAATATCCTAAATTTA
AAGAAGATACTTTTGAATTGAAAGATGACCGTGGTTTTGTTTTAATTCCAACTGCTGAAGTTCCTTTGACTAACTACTAT
CGTGGGGAAATTTTGGATGGCGCAGAATTGCCAATCAAATTCACAGCAATGAGTCCTTCTTTCCGTTCTGAAGCTGGTTC
TGCTGGTCGTGATACTCGTGGTTTGATTCGTTTGCACCAATTCCATAAAGTTGAAATGGTTAAATTTGCTAAACCTGACC
AATCTTATGATGAACTTGAAAAAATGACAGCAAACGCTGAAAATATTCTGCAAAAATTGGGTCTTGCATACCGTGTCGTG
GCTTTGTCAACTGGTGACATGGGATTCTCTGCTGCTAAAACTTATGATTTAGAAGTTTGGATTCCTGCACAAAATACTTA
CCGTGAAATTTCTTCATGTTCAAACTGTGAAGATTTCCAAGCCCGTCGTGCCCAAATTCGTTATCGTGACGAAGAGGGTA
AAGTTCAACTCCTTCACACTTTGAATGGTTCTGGACTTGCTGTTGGACGTACTGTGGCTGCTATTCTTGAAAATTATCAA
AATGAAGATGGCTCAATCACTGTTCCTGAAGTCCTTCGTCCTTATATGGGTGGACTTGAAGTAATTAAATAA

Upstream 100 bases:

>100_bases
GCCCTAATTCTTTTTGAATTTGGGCGCTTTTTTTCTACTGACAGAACTTTTTCTAAAATATTCTTGTCAGTAAGTTTTAT
ATAAAAATAAAGGAGAGCTT

Downstream 100 bases:

>100_bases
TTAAAAAATCTACTGACAGAAATTTTTTGGGCTTGTTAGTAGATTTTTTTGTTTAATATTACTGACAGAAATTTCTGTCA
GTAACTTTCAAAATATAATC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLDIKKIRADFDGVAAKLATRGVEKEKLEKLHDLDIKRRELIVKSEALKAERNSVSDEISQVKRAKGDASAQIAAMQKVS
AEIKAIDAELAEIEENLNEIIIMLPNLPHESTPIGADEDDNVEVRRVGQTPTFNFEPKAHWDLGEDLGILDWERGGKVTG
SRFLFYKGAGARLERALYNFMLDEHGKEGYTEMITPYMVNQESMFGTGQYPKFKEDTFELKDDRGFVLIPTAEVPLTNYY
RGEILDGAELPIKFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPDQSYDELEKMTANAENILQKLGLAYRVV
ALSTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNCEDFQARRAQIRYRDEEGKVQLLHTLNGSGLAVGRTVAAILENYQ
NEDGSITVPEVLRPYMGGLEVIK

Sequences:

>Translated_423_residues
MLDIKKIRADFDGVAAKLATRGVEKEKLEKLHDLDIKRRELIVKSEALKAERNSVSDEISQVKRAKGDASAQIAAMQKVS
AEIKAIDAELAEIEENLNEIIIMLPNLPHESTPIGADEDDNVEVRRVGQTPTFNFEPKAHWDLGEDLGILDWERGGKVTG
SRFLFYKGAGARLERALYNFMLDEHGKEGYTEMITPYMVNQESMFGTGQYPKFKEDTFELKDDRGFVLIPTAEVPLTNYY
RGEILDGAELPIKFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPDQSYDELEKMTANAENILQKLGLAYRVV
ALSTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNCEDFQARRAQIRYRDEEGKVQLLHTLNGSGLAVGRTVAAILENYQ
NEDGSITVPEVLRPYMGGLEVIK
>Mature_423_residues
MLDIKKIRADFDGVAAKLATRGVEKEKLEKLHDLDIKRRELIVKSEALKAERNSVSDEISQVKRAKGDASAQIAAMQKVS
AEIKAIDAELAEIEENLNEIIIMLPNLPHESTPIGADEDDNVEVRRVGQTPTFNFEPKAHWDLGEDLGILDWERGGKVTG
SRFLFYKGAGARLERALYNFMLDEHGKEGYTEMITPYMVNQESMFGTGQYPKFKEDTFELKDDRGFVLIPTAEVPLTNYY
RGEILDGAELPIKFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPDQSYDELEKMTANAENILQKLGLAYRVV
ALSTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNCEDFQARRAQIRYRDEEGKVQLLHTLNGSGLAVGRTVAAILENYQ
NEDGSITVPEVLRPYMGGLEVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=371, Percent_Identity=38.544474393531, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI225579074, Length=382, Percent_Identity=33.5078534031414, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI8923421, Length=382, Percent_Identity=33.5078534031414, Blast_Score=218, Evalue=7e-57,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=55.1162790697674, Blast_Score=449, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17539260, Length=386, Percent_Identity=34.7150259067358, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17542084, Length=338, Percent_Identity=27.810650887574, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=390, Percent_Identity=34.8717948717949, Blast_Score=229, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6321799, Length=382, Percent_Identity=30.8900523560209, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24581334, Length=339, Percent_Identity=36.8731563421829, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI17737985, Length=346, Percent_Identity=32.9479768786127, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_LACLA (Q9CEX2)

Other databases:

- EMBL:   AE005176
- PIR:   H86838
- RefSeq:   NP_267868.1
- ProteinModelPortal:   Q9CEX2
- SMR:   Q9CEX2
- PhosSite:   Q9CEX2
- GeneID:   1115375
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L150515
- NMPDR:   fig|272623.1.peg.1756
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   LLAC272623:L150515-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47469; Mature: 47469

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKKIRADFDGVAAKLATRGVEKEKLEKLHDLDIKRRELIVKSEALKAERNSVSDEIS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QVKRAKGDASAQIAAMQKVSAEIKAIDAELAEIEENLNEIIIMLPNLPHESTPIGADEDD
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCC
NVEVRRVGQTPTFNFEPKAHWDLGEDLGILDWERGGKVTGSRFLFYKGAGARLERALYNF
CEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHHHHH
MLDEHGKEGYTEMITPYMVNQESMFGTGQYPKFKEDTFELKDDRGFVLIPTAEVPLTNYY
HHHHCCCCCHHHHCCCEEECCHHCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCC
RGEILDGAELPIKFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPDQSYDELE
CCCCCCCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHH
KMTANAENILQKLGLAYRVVALSTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNCEDFQ
HHHCCHHHHHHHHCHHEEEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHCCCCCHHHH
ARRAQIRYRDEEGKVQLLHTLNGSGLAVGRTVAAILENYQNEDGSITVPEVLRPYMGGLE
HHHHHEEEECCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCHH
VIK
HCC
>Mature Secondary Structure
MLDIKKIRADFDGVAAKLATRGVEKEKLEKLHDLDIKRRELIVKSEALKAERNSVSDEIS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QVKRAKGDASAQIAAMQKVSAEIKAIDAELAEIEENLNEIIIMLPNLPHESTPIGADEDD
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCC
NVEVRRVGQTPTFNFEPKAHWDLGEDLGILDWERGGKVTGSRFLFYKGAGARLERALYNF
CEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHHHHH
MLDEHGKEGYTEMITPYMVNQESMFGTGQYPKFKEDTFELKDDRGFVLIPTAEVPLTNYY
HHHHCCCCCHHHHCCCEEECCHHCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCC
RGEILDGAELPIKFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPDQSYDELE
CCCCCCCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHH
KMTANAENILQKLGLAYRVVALSTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNCEDFQ
HHHCCHHHHHHHHCHHEEEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHCCCCCHHHH
ARRAQIRYRDEEGKVQLLHTLNGSGLAVGRTVAAILENYQNEDGSITVPEVLRPYMGGLE
HHHHHEEEECCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCHH
VIK
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471