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The map label for this gene is uxuB

Identifier: 15673614

GI number: 15673614

Start: 1678399

End: 1680033

Strand: Reverse

Name: uxuB

Synonym: L0241

Alternate gene names: 15673614

Gene position: 1680033-1678399 (Counterclockwise)

Preceding gene: 15673616

Following gene: 15673613

Centisome position: 71.02

GC content: 36.15

Gene sequence:

>1635_bases
ATGGTGAAATTGCTTGATGATTATTTGATAAAGGGTGAGGAATTTAAAAAAGCAAAAATTAAAATTCCTAACTTTAATCA
AGACAAAGTTATAGAGTCAACAGCTGATAATCCAGTCTGGGTCCACTTTGGTGGAGGAAATCTTTTTAGATGTTTCCATG
CGGTTGTCGCCCAAGACTTACTCAATCAAGGAGAACTCAACTCAGGTCTTATTGTGGCTGAAACTTATGATGATGAGGTA
ATTGATAAAATCTATCGGGCATATAATAATCGTTTTCTGTCAGTGACAATGAAATCAGATGGAACTTTTGACAAAGAATT
GATTGCGAGTGTTGCTGAAAGTTTTTATTTTAATGCAGAAAATACCGAGGGTTGGGCTCATTTAACAAAAGTCTTTGAAA
ATCCGTCTTTGCAATTGACAACTTTTTCGATTACAGAAAAAGGTTATTCACTACGGGATTCAAAAGACCAATTGACGCCT
TTGGCACTTGAAGATATGCAAGGAAGAAGCAAGCCCAAAACCAATATGGGGGCCGTTACTTATCTCCTTTATGCAAGATT
TAAAGCTGGTAAATTTCCGATTGCCATGGTCAGCACAGATAATTTTTCAGAGAATGGTTTGAAGTTACAAGAAGCGATTT
TGACCATTGCTAAAGCTTGGGTGGAAAATGAAATCGTAGAACAAGATTTTTATGATTACCTTATCAATCCTAAAAAAGTT
AGTTTCCCCTGGTCAATGATTGACCGAATTACACCCAATCCGTCTGAAAAAGTTGCAAAATTACTGACAGCTGATGGTTT
TGAGGATACAGAAATTTTACATAGTCAAAAACATACAAATATTGCTCCTTTTGGTAATACGGAAGAAGTTCATTATTTGG
TGATTGAAGATGCTTTCCCAAATGGCCGGCCGGCATTAGAAAAATCTGGAGTTATCTTGACTGATCGTGAAACAGTCAAT
GATGCTGATCAGATGAAAGTTACAGCTTGTTTGAACCCCTTGCATACTGCCTTAGCTATTTTTGGAAGTTTATTAGATTA
TCATTCAATTTGGGAAGAAGTTGCCAATCCAGATTTGTTAGCACTCATTAAGAATTTGGGGTATGGCGAGGCTTTACCTG
TGGTTAAGAATCCGAAAATTATCAATCCGAAAGATTTTATTGACCAGTTATTGACTAAACGTTTACCAAATAAAAATATT
CCAGATACACCACAGAGAATTGCGGCAGATACGTCACAAAAAATTCCTGTTCGCTATGGCGTAACAATTGGACACTATAT
TGCCAATCCAAGATTTTCTGTTAAAGAATTGGAATTTATTCCATTAGTCATTGCTGCTTGGTGCCGTTATTTAATCGGAA
TTAATGATGAGTTAGAAAGTTTCTCTCCAAGTCCTGACCCTCTTCTTGAAGAGTTGCAAGCTTTTGTTGCCGATGTAAAA
TTAGATGGTAGTCAGCAAGAAATTCATGAAATCCTAAAACCTATCTTATCTAATCACCAAATTTTTCCAAATGAGATGTA
CCAAACAGGACTAGCTCAAAAGATTGAAAATTACTTTGAGCAAATGCTTCAAGGCAAAGGAGCAGTGCTTAATACGCTAC
AAAATGTCCTAAAGGAACACGGAAAAAATTACTGA

Upstream 100 bases:

>100_bases
TTTTTAATATATTCTTGACAACGGTTTCTTAAAAGTGATATACTAGTTTTCGTAGGAGAAAAAACTGATATATCACTTTT
TGAGATTTAAAGGAGAAATC

Downstream 100 bases:

>100_bases
CAGAATGTTTAATTTTGAGCTGTCAGTAAAAATACTGCTATCAGTTTTCCATTTCTGCCAAATTGAGAAAAGAAAAAACT
GACCAACTTTTTAATCAAGC

Product: fructuronate reductase

Products: D-fructuronate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MVKLLDDYLIKGEEFKKAKIKIPNFNQDKVIESTADNPVWVHFGGGNLFRCFHAVVAQDLLNQGELNSGLIVAETYDDEV
IDKIYRAYNNRFLSVTMKSDGTFDKELIASVAESFYFNAENTEGWAHLTKVFENPSLQLTTFSITEKGYSLRDSKDQLTP
LALEDMQGRSKPKTNMGAVTYLLYARFKAGKFPIAMVSTDNFSENGLKLQEAILTIAKAWVENEIVEQDFYDYLINPKKV
SFPWSMIDRITPNPSEKVAKLLTADGFEDTEILHSQKHTNIAPFGNTEEVHYLVIEDAFPNGRPALEKSGVILTDRETVN
DADQMKVTACLNPLHTALAIFGSLLDYHSIWEEVANPDLLALIKNLGYGEALPVVKNPKIINPKDFIDQLLTKRLPNKNI
PDTPQRIAADTSQKIPVRYGVTIGHYIANPRFSVKELEFIPLVIAAWCRYLIGINDELESFSPSPDPLLEELQAFVADVK
LDGSQQEIHEILKPILSNHQIFPNEMYQTGLAQKIENYFEQMLQGKGAVLNTLQNVLKEHGKNY

Sequences:

>Translated_544_residues
MVKLLDDYLIKGEEFKKAKIKIPNFNQDKVIESTADNPVWVHFGGGNLFRCFHAVVAQDLLNQGELNSGLIVAETYDDEV
IDKIYRAYNNRFLSVTMKSDGTFDKELIASVAESFYFNAENTEGWAHLTKVFENPSLQLTTFSITEKGYSLRDSKDQLTP
LALEDMQGRSKPKTNMGAVTYLLYARFKAGKFPIAMVSTDNFSENGLKLQEAILTIAKAWVENEIVEQDFYDYLINPKKV
SFPWSMIDRITPNPSEKVAKLLTADGFEDTEILHSQKHTNIAPFGNTEEVHYLVIEDAFPNGRPALEKSGVILTDRETVN
DADQMKVTACLNPLHTALAIFGSLLDYHSIWEEVANPDLLALIKNLGYGEALPVVKNPKIINPKDFIDQLLTKRLPNKNI
PDTPQRIAADTSQKIPVRYGVTIGHYIANPRFSVKELEFIPLVIAAWCRYLIGINDELESFSPSPDPLLEELQAFVADVK
LDGSQQEIHEILKPILSNHQIFPNEMYQTGLAQKIENYFEQMLQGKGAVLNTLQNVLKEHGKNY
>Mature_544_residues
MVKLLDDYLIKGEEFKKAKIKIPNFNQDKVIESTADNPVWVHFGGGNLFRCFHAVVAQDLLNQGELNSGLIVAETYDDEV
IDKIYRAYNNRFLSVTMKSDGTFDKELIASVAESFYFNAENTEGWAHLTKVFENPSLQLTTFSITEKGYSLRDSKDQLTP
LALEDMQGRSKPKTNMGAVTYLLYARFKAGKFPIAMVSTDNFSENGLKLQEAILTIAKAWVENEIVEQDFYDYLINPKKV
SFPWSMIDRITPNPSEKVAKLLTADGFEDTEILHSQKHTNIAPFGNTEEVHYLVIEDAFPNGRPALEKSGVILTDRETVN
DADQMKVTACLNPLHTALAIFGSLLDYHSIWEEVANPDLLALIKNLGYGEALPVVKNPKIINPKDFIDQLLTKRLPNKNI
PDTPQRIAADTSQKIPVRYGVTIGHYIANPRFSVKELEFIPLVIAAWCRYLIGINDELESFSPSPDPLLEELQAFVADVK
LDGSQQEIHEILKPILSNHQIFPNEMYQTGLAQKIENYFEQMLQGKGAVLNTLQNVLKEHGKNY

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=511, Percent_Identity=25.8317025440313, Blast_Score=125, Evalue=9e-30,
Organism=Escherichia coli, GI1790779, Length=482, Percent_Identity=25.103734439834, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1787823, Length=536, Percent_Identity=24.6268656716418, Blast_Score=116, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324401, Length=523, Percent_Identity=24.6653919694073, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320765, Length=523, Percent_Identity=24.6653919694073, Blast_Score=116, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: 1.1.1.57

Molecular weight: Translated: 61395; Mature: 61395

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLLDDYLIKGEEFKKAKIKIPNFNQDKVIESTADNPVWVHFGGGNLFRCFHAVVAQDL
CCCCHHHHHHCCCCCCEEEEECCCCCCCHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
LNQGELNSGLIVAETYDDEVIDKIYRAYNNRFLSVTMKSDGTFDKELIASVAESFYFNAE
HCCCCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHEECCC
NTEGWAHLTKVFENPSLQLTTFSITEKGYSLRDSKDQLTPLALEDMQGRSKPKTNMGAVT
CCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHH
YLLYARFKAGKFPIAMVSTDNFSENGLKLQEAILTIAKAWVENEIVEQDFYDYLINPKKV
HHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
SFPWSMIDRITPNPSEKVAKLLTADGFEDTEILHSQKHTNIAPFGNTEEVHYLVIEDAFP
CCCHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCC
NGRPALEKSGVILTDRETVNDADQMKVTACLNPLHTALAIFGSLLDYHSIWEEVANPDLL
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALIKNLGYGEALPVVKNPKIINPKDFIDQLLTKRLPNKNIPDTPQRIAADTSQKIPVRYG
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEC
VTIGHYIANPRFSVKELEFIPLVIAAWCRYLIGINDELESFSPSPDPLLEELQAFVADVK
CEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHC
LDGSQQEIHEILKPILSNHQIFPNEMYQTGLAQKIENYFEQMLQGKGAVLNTLQNVLKEH
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GKNY
CCCC
>Mature Secondary Structure
MVKLLDDYLIKGEEFKKAKIKIPNFNQDKVIESTADNPVWVHFGGGNLFRCFHAVVAQDL
CCCCHHHHHHCCCCCCEEEEECCCCCCCHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
LNQGELNSGLIVAETYDDEVIDKIYRAYNNRFLSVTMKSDGTFDKELIASVAESFYFNAE
HCCCCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHEECCC
NTEGWAHLTKVFENPSLQLTTFSITEKGYSLRDSKDQLTPLALEDMQGRSKPKTNMGAVT
CCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHH
YLLYARFKAGKFPIAMVSTDNFSENGLKLQEAILTIAKAWVENEIVEQDFYDYLINPKKV
HHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
SFPWSMIDRITPNPSEKVAKLLTADGFEDTEILHSQKHTNIAPFGNTEEVHYLVIEDAFP
CCCHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCC
NGRPALEKSGVILTDRETVNDADQMKVTACLNPLHTALAIFGSLLDYHSIWEEVANPDLL
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALIKNLGYGEALPVVKNPKIINPKDFIDQLLTKRLPNKNIPDTPQRIAADTSQKIPVRYG
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEC
VTIGHYIANPRFSVKELEFIPLVIAAWCRYLIGINDELESFSPSPDPLLEELQAFVADVK
CEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHC
LDGSQQEIHEILKPILSNHQIFPNEMYQTGLAQKIENYFEQMLQGKGAVLNTLQNVLKEH
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GKNY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-mannonate; NAD+

Specific reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA