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The map label for this gene is aldR

Identifier: 15673211

GI number: 15673211

Start: 1252931

End: 1253311

Strand: Direct

Name: aldR

Synonym: L52644

Alternate gene names: 15673211

Gene position: 1252931-1253311 (Clockwise)

Preceding gene: 15673210

Following gene: 30024029

Centisome position: 52.96

GC content: 34.65

Gene sequence:

>381_bases
ATGAAAATAATTGCAACATTAGATGCACCAGCCGCTATCGGTCCTTATGTTCAAGGCAAAATTGTTAATGGTTTACTCTA
TGCATCAGGCCAAATTCCGTTGAATCCATTGAATGGAGAGATTGTTGGAGATAGCATTGAGACTCAAACCGAACAGGTGA
TGAAAAATATTTCTGCTATTTTGAAAGAAGCACATTCTGATTTTGACTTAGTCATCAAAACAACATGTTTCTTGAAAAAT
ATTGAAGATTTTTCAAGATTTAATGCAATTTATTCAAAGTTTTTTGATAAGGAATTCCCAGCGCGTTCCGCTGTTGGAGT
CGCAGGATTACCTAAAAATGTCCTTATTGAAATAGAAGTCATTGCAGAAGTTAAATCCTAA

Upstream 100 bases:

>100_bases
TTCTTGTTTGCTGACCTTGATATTGAAGCACTAAAAAAAGATATCGATGTAGCTGAATGATAATCACTAGATTTCTTTAG
CTATATTAAAGGAGAAATCT

Downstream 100 bases:

>100_bases
AATTAAAACATATTAGCTATAAAAATTACTGACAAGATTTCTGTCAGTAATTTTTTTGGTTACAAGTCAGTCTTTTTTAC
GTATAGAAAATTATAAGCCA

Product: AldR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 126; Mature: 126

Protein sequence:

>126_residues
MKIIATLDAPAAIGPYVQGKIVNGLLYASGQIPLNPLNGEIVGDSIETQTEQVMKNISAILKEAHSDFDLVIKTTCFLKN
IEDFSRFNAIYSKFFDKEFPARSAVGVAGLPKNVLIEIEVIAEVKS

Sequences:

>Translated_126_residues
MKIIATLDAPAAIGPYVQGKIVNGLLYASGQIPLNPLNGEIVGDSIETQTEQVMKNISAILKEAHSDFDLVIKTTCFLKN
IEDFSRFNAIYSKFFDKEFPARSAVGVAGLPKNVLIEIEVIAEVKS
>Mature_126_residues
MKIIATLDAPAAIGPYVQGKIVNGLLYASGQIPLNPLNGEIVGDSIETQTEQVMKNISAILKEAHSDFDLVIKTTCFLKN
IEDFSRFNAIYSKFFDKEFPARSAVGVAGLPKNVLIEIEVIAEVKS

Specific function: Implicated in the regulation of isoleucine biosynthesis

COG id: COG0251

COG function: function code J; Putative translation initiation inhibitor, yjgF family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RutC family

Homologues:

Organism=Homo sapiens, GI5032215, Length=121, Percent_Identity=45.4545454545455, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI87082396, Length=124, Percent_Identity=49.1935483870968, Blast_Score=113, Evalue=4e-27,
Organism=Escherichia coli, GI87082213, Length=124, Percent_Identity=44.3548387096774, Blast_Score=103, Evalue=4e-24,
Organism=Escherichia coli, GI1787245, Length=114, Percent_Identity=26.3157894736842, Blast_Score=63, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71982068, Length=121, Percent_Identity=42.9752066115703, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71982075, Length=121, Percent_Identity=42.9752066115703, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25148896, Length=121, Percent_Identity=42.9752066115703, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322138, Length=119, Percent_Identity=44.5378151260504, Blast_Score=104, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320899, Length=101, Percent_Identity=45.5445544554455, Blast_Score=92, Evalue=3e-20,
Organism=Drosophila melanogaster, GI19921376, Length=121, Percent_Identity=39.6694214876033, Blast_Score=96, Evalue=6e-21,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ALDR_LACLA (O34133)

Other databases:

- EMBL:   U92974
- EMBL:   AE005176
- PIR:   E86778
- RefSeq:   NP_267385.1
- ProteinModelPortal:   O34133
- SMR:   O34133
- GeneID:   1114878
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L52644
- NMPDR:   fig|272623.1.peg.1264
- HOGENOM:   HBG695954
- OMA:   SKPARSC
- ProtClustDB:   CLSK697640
- BioCyc:   LLAC272623:L52644-MONOMER
- InterPro:   IPR013813
- InterPro:   IPR006175
- InterPro:   IPR006056
- InterPro:   IPR019897
- Gene3D:   G3DSA:3.30.1330.40
- PANTHER:   PTHR11803
- TIGRFAMs:   TIGR00004

Pfam domain/function: PF01042 Ribonuc_L-PSP; SSF55298 YjgF/chorismate_mutase-like

EC number: NA

Molecular weight: Translated: 13713; Mature: 13713

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS01094 UPF0076

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIATLDAPAAIGPYVQGKIVNGLLYASGQIPLNPLNGEIVGDSIETQTEQVMKNISAI
CEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHHHH
LKEAHSDFDLVIKTTCFLKNIEDFSRFNAIYSKFFDKEFPARSAVGVAGLPKNVLIEIEV
HHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEE
IAEVKS
EEEECC
>Mature Secondary Structure
MKIIATLDAPAAIGPYVQGKIVNGLLYASGQIPLNPLNGEIVGDSIETQTEQVMKNISAI
CEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHHHH
LKEAHSDFDLVIKTTCFLKNIEDFSRFNAIYSKFFDKEFPARSAVGVAGLPKNVLIEIEV
HHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEE
IAEVKS
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9335274; 11337471