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The map label for this gene is pbuX

Identifier: 15673129

GI number: 15673129

Start: 1160360

End: 1161664

Strand: Direct

Name: pbuX

Synonym: L160092

Alternate gene names: 15673129

Gene position: 1160360-1161664 (Clockwise)

Preceding gene: 15673128

Following gene: 15673132

Centisome position: 49.05

GC content: 35.1

Gene sequence:

>1305_bases
ATGTCTCAAAAAAATGAACAAAGCCAGGAGCAAAGTAACTCAAAATCTGCTGTTTTAGGATTACAACATCTGCTGGCCAT
GTATTCAGGTTCAATTCTTGTTCCAATCATGATTGCTGGAGCTTTAAATTACTCAGCTACTCAGTTAACCTATTTAATTT
CGGCAGATATTTTCATGTGTGGTTTAGCCACTTTCTTGCAACTCCAACTACGTAAGCACTTTGGGATTGGCTTACCAGTT
GTCCTTGGTGTTGCTTTTCAATCTGTTGCTCCATTAATTATTATTGGTCAAAGACATGGCTCTGGAGCAATGTTTGGTTC
ATTAATGGTTGCAGGGGTTTTCGTTATTTTGGTTTCAGGAATTTTCTCTAAAATCCGAAAACTATTTCCACCAATCGTTA
CTGGTTCAGTAATTACAACAATTGGTTTAAGCCTTATTCCTGTTGCTATTGGCAATATGGGTAATAATGTTGATAAACCA
ACAATCCAAAGTTTAATTTTAGCTGTTTCCACTATAGTGATTATTCTTTTAATTAATATCTTTACTACTGGATTTATTCG
TTCTATTGCTATTTTAATTGGACTTATTGCTGGAACAATTTTGGCTGCTAGCATGGGCTTAGTTGATTTTTCAGTTGTTT
CTCAAGCACCATGGGCACACTTGCCACAACCTTTTTATTTCTCAGCACCTAAATTTTATTTGGCTGATTCATTAATGATG
ATTATTATTGCTATCGTGTCATTGGTTGAATCAACAGGAGTTTATTTAGCTCTTGCTGATATTACTGGTGAAAATCTTGA
TGAAAAACGTTTGCGTAATGGTTATCGTGCGGAAGGATTTGCTGTATTTCTTGGTGGTGTTTTCAACACTTTCCCTTACA
CTGGTTTTTCACAAAACGTTGGTTTAGTGCAATTATCAGGAATTAAAACACGTAAACCTATTTATTTCACAGCTGGATTT
TTAATTGTATTAGGACTTATTCCAAAATTTGCCGCTGTTGCACAACTTATTCCAACTCCAGTATTGGGTGGAGCGATGTT
GATTATGTTTGGTATGGTTGCCACACAAGGAATTAGAATGCTGGCAAAAGTTGAATTTGAAGGAAATCAAAATCTTCTGA
TTGCTGCAGTTGCTATTGCGATGGGTGTTGGTTTTAACTCAACAAACTTATTTACAGCACTTCCAAGCTTTATTCAACCT
TTTGTTTCTAATGGGATTGTGATGAGTACTGTTTCAGCAATTATCCTGAATTTAGTATTTAATCATGGAAAAAAAGATGA
ATTAGTTACTGACGAAACAAAATAA

Upstream 100 bases:

>100_bases
TGAAGATGGTAAAGTCATCTTCGCCCCAGCCGATGATAAAGATTTCGACTAAGCTTAAGCAATAAGAAAATAAAAAAAGA
AAAATTTAAGGAAAATCAAA

Downstream 100 bases:

>100_bases
AATAAAAACCACCGTTGAGGTGGTTTTTTTATTGAATTTTTTCTAAATCTCGCTGAAATTTCTTTTCAGAGTAAATTTCA
AAAGAACCATCAGGTGCTAC

Product: xanthine/uracil permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSQKNEQSQEQSNSKSAVLGLQHLLAMYSGSILVPIMIAGALNYSATQLTYLISADIFMCGLATFLQLQLRKHFGIGLPV
VLGVAFQSVAPLIIIGQRHGSGAMFGSLMVAGVFVILVSGIFSKIRKLFPPIVTGSVITTIGLSLIPVAIGNMGNNVDKP
TIQSLILAVSTIVIILLINIFTTGFIRSIAILIGLIAGTILAASMGLVDFSVVSQAPWAHLPQPFYFSAPKFYLADSLMM
IIIAIVSLVESTGVYLALADITGENLDEKRLRNGYRAEGFAVFLGGVFNTFPYTGFSQNVGLVQLSGIKTRKPIYFTAGF
LIVLGLIPKFAAVAQLIPTPVLGGAMLIMFGMVATQGIRMLAKVEFEGNQNLLIAAVAIAMGVGFNSTNLFTALPSFIQP
FVSNGIVMSTVSAIILNLVFNHGKKDELVTDETK

Sequences:

>Translated_434_residues
MSQKNEQSQEQSNSKSAVLGLQHLLAMYSGSILVPIMIAGALNYSATQLTYLISADIFMCGLATFLQLQLRKHFGIGLPV
VLGVAFQSVAPLIIIGQRHGSGAMFGSLMVAGVFVILVSGIFSKIRKLFPPIVTGSVITTIGLSLIPVAIGNMGNNVDKP
TIQSLILAVSTIVIILLINIFTTGFIRSIAILIGLIAGTILAASMGLVDFSVVSQAPWAHLPQPFYFSAPKFYLADSLMM
IIIAIVSLVESTGVYLALADITGENLDEKRLRNGYRAEGFAVFLGGVFNTFPYTGFSQNVGLVQLSGIKTRKPIYFTAGF
LIVLGLIPKFAAVAQLIPTPVLGGAMLIMFGMVATQGIRMLAKVEFEGNQNLLIAAVAIAMGVGFNSTNLFTALPSFIQP
FVSNGIVMSTVSAIILNLVFNHGKKDELVTDETK
>Mature_433_residues
SQKNEQSQEQSNSKSAVLGLQHLLAMYSGSILVPIMIAGALNYSATQLTYLISADIFMCGLATFLQLQLRKHFGIGLPVV
LGVAFQSVAPLIIIGQRHGSGAMFGSLMVAGVFVILVSGIFSKIRKLFPPIVTGSVITTIGLSLIPVAIGNMGNNVDKPT
IQSLILAVSTIVIILLINIFTTGFIRSIAILIGLIAGTILAASMGLVDFSVVSQAPWAHLPQPFYFSAPKFYLADSLMMI
IIAIVSLVESTGVYLALADITGENLDEKRLRNGYRAEGFAVFLGGVFNTFPYTGFSQNVGLVQLSGIKTRKPIYFTAGFL
IVLGLIPKFAAVAQLIPTPVLGGAMLIMFGMVATQGIRMLAKVEFEGNQNLLIAAVAIAMGVGFNSTNLFTALPSFIQPF
VSNGIVMSTVSAIILNLVFNHGKKDELVTDETK

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=437, Percent_Identity=24.0274599542334, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI44680148, Length=186, Percent_Identity=28.494623655914, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI40316845, Length=186, Percent_Identity=28.494623655914, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI44680143, Length=175, Percent_Identity=27.4285714285714, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI87082181, Length=441, Percent_Identity=38.3219954648526, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1790087, Length=430, Percent_Identity=33.2558139534884, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1788843, Length=438, Percent_Identity=28.9954337899543, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI87081818, Length=445, Percent_Identity=30.1123595505618, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87082178, Length=441, Percent_Identity=29.4784580498866, Blast_Score=145, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17542262, Length=177, Percent_Identity=28.8135593220339, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17541904, Length=175, Percent_Identity=27.4285714285714, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=178, Percent_Identity=26.4044943820225, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356175, Length=426, Percent_Identity=26.2910798122066, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46214; Mature: 46083

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCC
>Mature Secondary Structure 
SQKNEQSQEQSNSKSAVLGLQHLLAMYSGSILVPIMIAGALNYSATQLTYLISADIFMC
CCCCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GLATFLQLQLRKHFGIGLPVVLGVAFQSVAPLIIIGQRHGSGAMFGSLMVAGVFVILVSG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
IFSKIRKLFPPIVTGSVITTIGLSLIPVAIGNMGNNVDKPTIQSLILAVSTIVIILLINI
HHHHHHHHCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FTTGFIRSIAILIGLIAGTILAASMGLVDFSVVSQAPWAHLPQPFYFSAPKFYLADSLMM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
IIIAIVSLVESTGVYLALADITGENLDEKRLRNGYRAEGFAVFLGGVFNTFPYTGFSQNV
HHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCCCCCCHHEEECHHHHHCCCCCCCCCC
GLVQLSGIKTRKPIYFTAGFLIVLGLIPKFAAVAQLIPTPVLGGAMLIMFGMVATQGIRM
CEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LAKVEFEGNQNLLIAAVAIAMGVGFNSTNLFTALPSFIQPFVSNGIVMSTVSAIILNLVF
HHEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
NHGKKDELVTDETK
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]