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The map label for this gene is xpt

Identifier: 15673128

GI number: 15673128

Start: 1159718

End: 1160311

Strand: Direct

Name: xpt

Synonym: L159396

Alternate gene names: 15673128

Gene position: 1159718-1160311 (Clockwise)

Preceding gene: 15673127

Following gene: 15673129

Centisome position: 49.02

GC content: 36.36

Gene sequence:

>594_bases
ATGAAGTTATTAGAAGACCGCATTCATACAGACGGTCAAGTATTAGGACAAGACATTCTTAAAGTTGACCGCTTTTTGAC
ACACCAAGTGGATTATCAATTGATGAAGGAAATCGGGAAACGTTTTGCACAGGTTTATGCAAATGCAGGAGTTACAAAAG
TCGTAACCATTGAAGCAAGTGGGATTGCCCCTGCTTTATATGCTGCTGAATCACTCAACGTTCCAATGATTTTTGCTAAA
AAAGCAAAAAATGTAACTATGAATGATGATTTATTGATTACAGAAGTTTATTCTTTCACTAAAAAATTAACTTCAACTGT
CCAAATTTCAAGCAAACTCATTGAAGAAGGCGATAAAGTCTTGATTATTGATGACTTTTTAGCTAATGGTCAAGCAGCAC
TTGGTTTGGTTCATTTAATGGAACAAGCTAAAGCAGAAGTTGTCGGTTTAGGAATGGTAATTGAAAAATCTTTCCAAGAT
GGCCGTCAAAAACTTCTTGACCAAGGAATGAAACTTACCAGTCTTGCCCGGATTGAAAAATTTGAAGATGGTAAAGTCAT
CTTCGCCCCAGCCGATGATAAAGATTTCGACTAA

Upstream 100 bases:

>100_bases
TTCTTTTTTGCGTATTTGAAACGTCTTGTTATTTTTTATAACGAGACGTTTTTCTCACCTGTGGGCACAGATGAGAAAAA
ATTTTTTTAAGGAGAGAATA

Downstream 100 bases:

>100_bases
GCTTAAGCAATAAGAAAATAAAAAAAGAAAAATTTAAGGAAAATCAAAATGTCTCAAAAAAATGAACAAAGCCAGGAGCA
AAGTAACTCAAAATCTGCTG

Product: xanthine phosphoribosyltransferase

Products: NA

Alternate protein names: XPRTase

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MKLLEDRIHTDGQVLGQDILKVDRFLTHQVDYQLMKEIGKRFAQVYANAGVTKVVTIEASGIAPALYAAESLNVPMIFAK
KAKNVTMNDDLLITEVYSFTKKLTSTVQISSKLIEEGDKVLIIDDFLANGQAALGLVHLMEQAKAEVVGLGMVIEKSFQD
GRQKLLDQGMKLTSLARIEKFEDGKVIFAPADDKDFD

Sequences:

>Translated_197_residues
MKLLEDRIHTDGQVLGQDILKVDRFLTHQVDYQLMKEIGKRFAQVYANAGVTKVVTIEASGIAPALYAAESLNVPMIFAK
KAKNVTMNDDLLITEVYSFTKKLTSTVQISSKLIEEGDKVLIIDDFLANGQAALGLVHLMEQAKAEVVGLGMVIEKSFQD
GRQKLLDQGMKLTSLARIEKFEDGKVIFAPADDKDFD
>Mature_197_residues
MKLLEDRIHTDGQVLGQDILKVDRFLTHQVDYQLMKEIGKRFAQVYANAGVTKVVTIEASGIAPALYAAESLNVPMIFAK
KAKNVTMNDDLLITEVYSFTKKLTSTVQISSKLIEEGDKVLIIDDFLANGQAALGLVHLMEQAKAEVVGLGMVIEKSFQD
GRQKLLDQGMKLTSLARIEKFEDGKVIFAPADDKDFD

Specific function: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XPT subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XPT_LACLA (Q9CGF0)

Other databases:

- EMBL:   AE005176
- PIR:   B86768
- RefSeq:   NP_267302.1
- HSSP:   P42085
- ProteinModelPortal:   Q9CGF0
- SMR:   Q9CGF0
- GeneID:   1114787
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L159396
- NMPDR:   fig|272623.1.peg.1179
- HOGENOM:   HBG288993
- OMA:   ATVYSFT
- ProtClustDB:   PRK09219
- BioCyc:   LLAC272623:L159396-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01184
- InterPro:   IPR000836
- InterPro:   IPR010079
- TIGRFAMs:   TIGR01744

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 21807; Mature: 21807

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 20-20 BINDING 27-27 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLEDRIHTDGQVLGQDILKVDRFLTHQVDYQLMKEIGKRFAQVYANAGVTKVVTIEAS
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GIAPALYAAESLNVPMIFAKKAKNVTMNDDLLITEVYSFTKKLTSTVQISSKLIEEGDKV
CCCHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LIIDDFLANGQAALGLVHLMEQAKAEVVGLGMVIEKSFQDGRQKLLDQGMKLTSLARIEK
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FEDGKVIFAPADDKDFD
CCCCCEEEECCCCCCCC
>Mature Secondary Structure
MKLLEDRIHTDGQVLGQDILKVDRFLTHQVDYQLMKEIGKRFAQVYANAGVTKVVTIEAS
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GIAPALYAAESLNVPMIFAKKAKNVTMNDDLLITEVYSFTKKLTSTVQISSKLIEEGDKV
CCCHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LIIDDFLANGQAALGLVHLMEQAKAEVVGLGMVIEKSFQDGRQKLLDQGMKLTSLARIEK
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FEDGKVIFAPADDKDFD
CCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471