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The map label for this gene is pyrE

Identifier: 15673050

GI number: 15673050

Start: 1080700

End: 1081329

Strand: Direct

Name: pyrE

Synonym: L80411

Alternate gene names: 15673050

Gene position: 1080700-1081329 (Clockwise)

Preceding gene: 15673049

Following gene: 15673051

Centisome position: 45.68

GC content: 36.67

Gene sequence:

>630_bases
ATGTCAATATCAAAAGCCATTGCTGCAGATTTATTAGAAATTAAAGCGGTCAGTCTTTCACCAAGTCAACCTTTTACTTG
GGCTTCAGGAATTAAGTCACCAATATATACTGATAATCGGGTGACTTTAGCTTATCCAGAAGTTAGAAGCCAAATCGAAG
GTGCTTTTGCAGAATTGATTAAAGCGGAATTTCCAGAAGTTGAAGTCATTGCAGGAACTGCTACAGCAGGAATTCCTCAT
GGTGCAATTATTGCTGACTATCTTAAATTACCATTTGCTTATATTCGTAGTAAACCAAAAGACCATGGAGCAGGTAATCA
AGTTGAGGGACGTGTGACAAAAGGCCAAAAAATGGTTGTGGTTGAAGATTTGATTTCGACTGGTGGTTCTGTTTTAGAAG
CTGTTGCAGCCGCTGAACGTGAAGGTGCTGATGTTCTTGGTGTGGTTGCAATTTTCACTTATGAATTAGAAAAAGCGAAC
AGAAAATTTGCTGATGCTGGTGTTAAATTAGCCACTTTGACAACTTATTCTGAATTGATTGAAATTGCTAAAGAAACGGG
TTATGTGACAAAAGAAGAATTAGAATTACTTAAAAAGTTCAAAGAAAATCAAGAAACTTGGCAAAATTAA

Upstream 100 bases:

>100_bases
TTCTGTCAGTTCAATATGACCAAAGGGAATTATTGAATCGGTAGAAAAATGAACTGTCAGCTTTGCTGATGGTTCTGTCA
GTAAACTAGAAGGAGAAATT

Downstream 100 bases:

>100_bases
TTTACTGACAGAAATTCAAGGAGCCTGTCAGTAAATAATTAGGTTCTGGAATAGCTGTCAGTTCAATGCGACCAAAGGGA
GACATTGAATCGGAGGATAA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSISKAIAADLLEIKAVSLSPSQPFTWASGIKSPIYTDNRVTLAYPEVRSQIEGAFAELIKAEFPEVEVIAGTATAGIPH
GAIIADYLKLPFAYIRSKPKDHGAGNQVEGRVTKGQKMVVVEDLISTGGSVLEAVAAAEREGADVLGVVAIFTYELEKAN
RKFADAGVKLATLTTYSELIEIAKETGYVTKEELELLKKFKENQETWQN

Sequences:

>Translated_209_residues
MSISKAIAADLLEIKAVSLSPSQPFTWASGIKSPIYTDNRVTLAYPEVRSQIEGAFAELIKAEFPEVEVIAGTATAGIPH
GAIIADYLKLPFAYIRSKPKDHGAGNQVEGRVTKGQKMVVVEDLISTGGSVLEAVAAAEREGADVLGVVAIFTYELEKAN
RKFADAGVKLATLTTYSELIEIAKETGYVTKEELELLKKFKENQETWQN
>Mature_208_residues
SISKAIAADLLEIKAVSLSPSQPFTWASGIKSPIYTDNRVTLAYPEVRSQIEGAFAELIKAEFPEVEVIAGTATAGIPHG
AIIADYLKLPFAYIRSKPKDHGAGNQVEGRVTKGQKMVVVEDLISTGGSVLEAVAAAEREGADVLGVVAIFTYELEKANR
KFADAGVKLATLTTYSELIEIAKETGYVTKEELELLKKFKENQETWQN

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

Organism=Homo sapiens, GI4507835, Length=180, Percent_Identity=27.2222222222222, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17554964, Length=172, Percent_Identity=29.0697674418605, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508631, Length=170, Percent_Identity=25.2941176470588, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17933654, Length=196, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_LACLA (Q9CGM8)

Other databases:

- EMBL:   AE005176
- PIR:   D86758
- RefSeq:   NP_267224.1
- ProteinModelPortal:   Q9CGM8
- SMR:   Q9CGM8
- GeneID:   1114708
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L80411
- NMPDR:   fig|272623.1.peg.1100
- HOGENOM:   HBG404341
- OMA:   LPMTYVR
- ProtClustDB:   PRK00455
- BioCyc:   LLAC272623:L80411-MONOMER
- BRENDA:   2.4.2.10
- HAMAP:   MF_01208
- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836
- TIGRFAMs:   TIGR00336

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 22633; Mature: 22502

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 96-96 BINDING 100-100 BINDING 102-102 BINDING 126-126

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISKAIAADLLEIKAVSLSPSQPFTWASGIKSPIYTDNRVTLAYPEVRSQIEGAFAELI
CCCHHHHHHHHHHHHEEECCCCCCCCHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
KAEFPEVEVIAGTATAGIPHGAIIADYLKLPFAYIRSKPKDHGAGNQVEGRVTKGQKMVV
HHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCEEEH
VEDLISTGGSVLEAVAAAEREGADVLGVVAIFTYELEKANRKFADAGVKLATLTTYSELI
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHH
EIAKETGYVTKEELELLKKFKENQETWQN
HHHHHCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SISKAIAADLLEIKAVSLSPSQPFTWASGIKSPIYTDNRVTLAYPEVRSQIEGAFAELI
CCHHHHHHHHHHHHEEECCCCCCCCHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
KAEFPEVEVIAGTATAGIPHGAIIADYLKLPFAYIRSKPKDHGAGNQVEGRVTKGQKMVV
HHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCEEEH
VEDLISTGGSVLEAVAAAEREGADVLGVVAIFTYELEKANRKFADAGVKLATLTTYSELI
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHH
EIAKETGYVTKEELELLKKFKENQETWQN
HHHHHCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471