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The map label for this gene is parC

Identifier: 15672966

GI number: 15672966

Start: 1010895

End: 1013369

Strand: Direct

Name: parC

Synonym: L0291

Alternate gene names: 15672966

Gene position: 1010895-1013369 (Clockwise)

Preceding gene: 15672965

Following gene: 15672968

Centisome position: 42.73

GC content: 38.14

Gene sequence:

>2475_bases
ATGTCAAACATTCAAACCTTACCATTAGAAGATATAATGGGTGACCGATTTGGTCGATATTCAAAATATATCATTCAGGA
GCGGGCCCTTCCCGATATCCGTGATGGTTTAAAACCGGTACAACGCCGTATTCTTTATTCAATGAATAAAGACGGAAACA
CATTTGATAAGTCTTATCGTAAATCAGCGAAATCAGTCGGAAATGTCATGGGTAATTTCCACCCACATGGAGATAGCTCA
ATTTATGAAGCAATGATTCGGATGAGTCAAGACTGGAAGATGGGCGAACCTTTAATCGAAATGCATGGTAATAATGGTTC
AATGGATGGTGACCCACCAGCCGCTATGCGTTATACTGAAGCCCGTCTTTCAGAAATTTCAGGCTATCTTTTAGCAGATA
TTGAGAAAGATACAGTAAGTCAAGCTTGGAACTTTGATGATACTGAGAAAGAACCAACGGTTTTACCAGCAGCTTTCCCA
AATCTTTTAGTCAATGGCTCAACCGGGATTTCAGCTGGTTATGCGACAGATATTCCACCTCACAATTTGGGGGAAGTCAT
TGATGCAACCATTCATATGATTGACCATCCTAAAGCTGATGTAGAAAAAATCATGGAATTCTTACCAGGACCAGATTTTC
CTACTGGTGGGATTATTCAAGGAAAAGGCGAAATCAGAAAAGCTTACGAAAAAGGAAAAGGCCGCATCGTTGTTCGTTCA
AAAGTCGATATTGAACCAATGAAAGGCGGTCGTGAGCAACTTATTGTTACTGAAATTCCTTTTGAGCTCAATAAAGCAAA
CTTAGTCAAGAAAATTGATGATGTTCGTGTCAATGCTAAAGTGCCCGGAATTGCAGAAGTCAGAGATGAGTCAGACCGTG
AAGGGCTTCGGATTGCAATTGAATTAAAGAAAGAAGCTGATAGCCAGCTTGTTTTGAATTACTTGTTTAAAAATACTGAT
TTACAAGTGAATTATAACTTCAACATGGTCGCAATTGATAATATGACTCCTGTTCAAACCGGTGTCTTACAAATGCTCCG
TTCTTATGTCAAACACCGTGAAGATGTTATCGTTAAACGTTCACAATTTGATTTAAATAAAGCAGAAAAAAGACTTCATA
TTGTTGAAGGGTTGATTCGCATGGTTTCTATTTTAGATGAAGTGGTCGCAACGATTCGTGCTTCAGAAAATAAAGCAGAT
GCCAAAGAAAATATCAAAGTTTCATTTGGATTTACCGAAGAGCAAGCCGAAGCCATTGTTACTTTACAACTTTATCGTTT
GACCAACACCGATATTGTCACTCTACAAAATGAACAAGCTGAATTAGAGCAAAAAATTCTCGAACTTAAAGCGATTATTA
ACGATGAACGTACCTTGTTTAATTTAATGAAACGCGAACTTCGTGAAGTTAAGAAAAAATTTGCCAAACCACGCCGTAGC
GAATTACAAGATGAAGTTCAAACTATTGAAATTGAAGCGAGCGAATTGATTGTGGCAGAGGATACTGTAGTTTCAGTAAC
TCGTTCAGGTTACATCAAACGTACTTCACCACGTTCATTTGCTTCCTCAGCACTTGAAGAAATTGGTAAACGTGATGATG
ACGAGCTCCTTTATTATGCCAATGCTAAAACAACTCAACATCTCTTACTTTTCACAAATCTTGGCAATGTCATTTATCGC
CCAATACATGAACTTTCTGATATCCGTTGGAAAGATATTGGTGAGCATCTATCTCAAAGTCTCTCTAATTTCTCAGCTGA
TGAGAAAGTAATTTTTGTTCAGATTGTGGACGAATTTGCTGGTGAAAATCTACTGGTTGTCACAAGAAATGGACAAATAA
AACAAATTGAACGTGAAAGTTTCTCCCCTTGGCGGACCTATCGTTCAAAATCTACTCCATATGCTAAACTTAAAGGAGAA
GATGATGAAATTGTTCTAATCACTCCAGTTCAATTTGCAGACCTCATGCTTATTTCTGAAAATGGTTATGCCCTTCGCTT
TAATCTTGATGACGTTCCAGTTTTGGGTGCTAGAGCTGCAGGAGTCAAGGCCATGAATCTCAAAAATGGCGATAAAATTA
AGTCCGCCTTCTTTGTTAACTCAAATAGTTGGTACCTTTTGACTCAACGGGCATTTATCAAACGTGTTAAGACGGATGAT
ATTCCGGCCACCTCACGTGCTAACCGTGGCCTTCAAGTACTACGAACATTGAAGACAAATAATCATACCGTCTTTGCAGC
CGGCTTAATCAATTCAACTGCTGATTTATCAGCATTGACCGAAGAATTAGATTTGTTCAGTCAAGCTAAAGCACCAGCGA
CAAAAGAAACTGATGAACAAGTATTAGAAGTTATCAGTGAGACTGGCAAGAAATACGATATCAATTTGTGCGATTTATCA
TTATCAGATCGAACAAGCAATGGACATCCAATTGCTGATGATCTTGAAAAAATTGCAAGCGTAAAAATAAAATAA

Upstream 100 bases:

>100_bases
CAAAAGCAGAGAACTGTCAGTAAAAATCAAAGATTTATTTATAAATTAGCAAATAATTAATTAAAAAAGTAAACAAATTT
TCTAAAAAGAAAGTTAAAAT

Downstream 100 bases:

>100_bases
AAAAAATCAGCTTTGGCTGATTTTTTTATTGTCTTCGACCAATAATATAACGAAAGAGTGCCGCGTAAAGTAGCCAAAGA
ATAATACAAGCACCAATAAT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 824; Mature: 823

Protein sequence:

>824_residues
MSNIQTLPLEDIMGDRFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFDKSYRKSAKSVGNVMGNFHPHGDSS
IYEAMIRMSQDWKMGEPLIEMHGNNGSMDGDPPAAMRYTEARLSEISGYLLADIEKDTVSQAWNFDDTEKEPTVLPAAFP
NLLVNGSTGISAGYATDIPPHNLGEVIDATIHMIDHPKADVEKIMEFLPGPDFPTGGIIQGKGEIRKAYEKGKGRIVVRS
KVDIEPMKGGREQLIVTEIPFELNKANLVKKIDDVRVNAKVPGIAEVRDESDREGLRIAIELKKEADSQLVLNYLFKNTD
LQVNYNFNMVAIDNMTPVQTGVLQMLRSYVKHREDVIVKRSQFDLNKAEKRLHIVEGLIRMVSILDEVVATIRASENKAD
AKENIKVSFGFTEEQAEAIVTLQLYRLTNTDIVTLQNEQAELEQKILELKAIINDERTLFNLMKRELREVKKKFAKPRRS
ELQDEVQTIEIEASELIVAEDTVVSVTRSGYIKRTSPRSFASSALEEIGKRDDDELLYYANAKTTQHLLLFTNLGNVIYR
PIHELSDIRWKDIGEHLSQSLSNFSADEKVIFVQIVDEFAGENLLVVTRNGQIKQIERESFSPWRTYRSKSTPYAKLKGE
DDEIVLITPVQFADLMLISENGYALRFNLDDVPVLGARAAGVKAMNLKNGDKIKSAFFVNSNSWYLLTQRAFIKRVKTDD
IPATSRANRGLQVLRTLKTNNHTVFAAGLINSTADLSALTEELDLFSQAKAPATKETDEQVLEVISETGKKYDINLCDLS
LSDRTSNGHPIADDLEKIASVKIK

Sequences:

>Translated_824_residues
MSNIQTLPLEDIMGDRFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFDKSYRKSAKSVGNVMGNFHPHGDSS
IYEAMIRMSQDWKMGEPLIEMHGNNGSMDGDPPAAMRYTEARLSEISGYLLADIEKDTVSQAWNFDDTEKEPTVLPAAFP
NLLVNGSTGISAGYATDIPPHNLGEVIDATIHMIDHPKADVEKIMEFLPGPDFPTGGIIQGKGEIRKAYEKGKGRIVVRS
KVDIEPMKGGREQLIVTEIPFELNKANLVKKIDDVRVNAKVPGIAEVRDESDREGLRIAIELKKEADSQLVLNYLFKNTD
LQVNYNFNMVAIDNMTPVQTGVLQMLRSYVKHREDVIVKRSQFDLNKAEKRLHIVEGLIRMVSILDEVVATIRASENKAD
AKENIKVSFGFTEEQAEAIVTLQLYRLTNTDIVTLQNEQAELEQKILELKAIINDERTLFNLMKRELREVKKKFAKPRRS
ELQDEVQTIEIEASELIVAEDTVVSVTRSGYIKRTSPRSFASSALEEIGKRDDDELLYYANAKTTQHLLLFTNLGNVIYR
PIHELSDIRWKDIGEHLSQSLSNFSADEKVIFVQIVDEFAGENLLVVTRNGQIKQIERESFSPWRTYRSKSTPYAKLKGE
DDEIVLITPVQFADLMLISENGYALRFNLDDVPVLGARAAGVKAMNLKNGDKIKSAFFVNSNSWYLLTQRAFIKRVKTDD
IPATSRANRGLQVLRTLKTNNHTVFAAGLINSTADLSALTEELDLFSQAKAPATKETDEQVLEVISETGKKYDINLCDLS
LSDRTSNGHPIADDLEKIASVKIK
>Mature_823_residues
SNIQTLPLEDIMGDRFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFDKSYRKSAKSVGNVMGNFHPHGDSSI
YEAMIRMSQDWKMGEPLIEMHGNNGSMDGDPPAAMRYTEARLSEISGYLLADIEKDTVSQAWNFDDTEKEPTVLPAAFPN
LLVNGSTGISAGYATDIPPHNLGEVIDATIHMIDHPKADVEKIMEFLPGPDFPTGGIIQGKGEIRKAYEKGKGRIVVRSK
VDIEPMKGGREQLIVTEIPFELNKANLVKKIDDVRVNAKVPGIAEVRDESDREGLRIAIELKKEADSQLVLNYLFKNTDL
QVNYNFNMVAIDNMTPVQTGVLQMLRSYVKHREDVIVKRSQFDLNKAEKRLHIVEGLIRMVSILDEVVATIRASENKADA
KENIKVSFGFTEEQAEAIVTLQLYRLTNTDIVTLQNEQAELEQKILELKAIINDERTLFNLMKRELREVKKKFAKPRRSE
LQDEVQTIEIEASELIVAEDTVVSVTRSGYIKRTSPRSFASSALEEIGKRDDDELLYYANAKTTQHLLLFTNLGNVIYRP
IHELSDIRWKDIGEHLSQSLSNFSADEKVIFVQIVDEFAGENLLVVTRNGQIKQIERESFSPWRTYRSKSTPYAKLKGED
DEIVLITPVQFADLMLISENGYALRFNLDDVPVLGARAAGVKAMNLKNGDKIKSAFFVNSNSWYLLTQRAFIKRVKTDDI
PATSRANRGLQVLRTLKTNNHTVFAAGLINSTADLSALTEELDLFSQAKAPATKETDEQVLEVISETGKKYDINLCDLSL
SDRTSNGHPIADDLEKIASVKIK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=182, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI19913408, Length=188, Percent_Identity=26.5957446808511, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788562, Length=770, Percent_Identity=36.1038961038961, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1789396, Length=521, Percent_Identity=38.3877159309021, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI212645845, Length=397, Percent_Identity=23.9294710327456, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=173, Percent_Identity=28.3236994219653, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 92779; Mature: 92648

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIQTLPLEDIMGDRFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFDKSYR
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KSAKSVGNVMGNFHPHGDSSIYEAMIRMSQDWKMGEPLIEMHGNNGSMDGDPPAAMRYTE
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHH
ARLSEISGYLLADIEKDTVSQAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPP
HHHHHHCCCEEEECCHHHHHHCCCCCCCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCC
HNLGEVIDATIHMIDHPKADVEKIMEFLPGPDFPTGGIIQGKGEIRKAYEKGKGRIVVRS
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCEEEEEE
KVDIEPMKGGREQLIVTEIPFELNKANLVKKIDDVRVNAKVPGIAEVRDESDREGLRIAI
ECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCEEECCCCCHHHHCCCCCCCCEEEEE
ELKKEADSQLVLNYLFKNTDLQVNYNFNMVAIDNMTPVQTGVLQMLRSYVKHREDVIVKR
EECCCCCHHHHHHHHHCCCCEEEEECEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEC
SQFDLNKAEKRLHIVEGLIRMVSILDEVVATIRASENKADAKENIKVSFGFTEEQAEAIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHCEEE
TLQLYRLTNTDIVTLQNEQAELEQKILELKAIINDERTLFNLMKRELREVKKKFAKPRRS
EEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
ELQDEVQTIEIEASELIVAEDTVVSVTRSGYIKRTSPRSFASSALEEIGKRDDDELLYYA
HHHHHHHEEEEECCEEEEECCCEEEEECCCCEEECCCHHHHHHHHHHHCCCCCCCEEEEE
NAKTTQHLLLFTNLGNVIYRPIHELSDIRWKDIGEHLSQSLSNFSADEKVIFVQIVDEFA
CCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHH
GENLLVVTRNGQIKQIERESFSPWRTYRSKSTPYAKLKGEDDEIVLITPVQFADLMLISE
CCCEEEEECCCCEEEHHHHCCCHHHHHCCCCCCCEEECCCCCCEEEEECCCEEEEEEECC
NGYALRFNLDDVPVLGARAAGVKAMNLKNGDKIKSAFFVNSNSWYLLTQRAFIKRVKTDD
CCEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCCEEEEEHHHHHHHHCCCC
IPATSRANRGLQVLRTLKTNNHTVFAAGLINSTADLSALTEELDLFSQAKAPATKETDEQ
CCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
VLEVISETGKKYDINLCDLSLSDRTSNGHPIADDLEKIASVKIK
HHHHHHHCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SNIQTLPLEDIMGDRFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFDKSYR
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KSAKSVGNVMGNFHPHGDSSIYEAMIRMSQDWKMGEPLIEMHGNNGSMDGDPPAAMRYTE
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHH
ARLSEISGYLLADIEKDTVSQAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPP
HHHHHHCCCEEEECCHHHHHHCCCCCCCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCC
HNLGEVIDATIHMIDHPKADVEKIMEFLPGPDFPTGGIIQGKGEIRKAYEKGKGRIVVRS
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCEEEEEE
KVDIEPMKGGREQLIVTEIPFELNKANLVKKIDDVRVNAKVPGIAEVRDESDREGLRIAI
ECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCEEECCCCCHHHHCCCCCCCCEEEEE
ELKKEADSQLVLNYLFKNTDLQVNYNFNMVAIDNMTPVQTGVLQMLRSYVKHREDVIVKR
EECCCCCHHHHHHHHHCCCCEEEEECEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEC
SQFDLNKAEKRLHIVEGLIRMVSILDEVVATIRASENKADAKENIKVSFGFTEEQAEAIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHCEEE
TLQLYRLTNTDIVTLQNEQAELEQKILELKAIINDERTLFNLMKRELREVKKKFAKPRRS
EEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
ELQDEVQTIEIEASELIVAEDTVVSVTRSGYIKRTSPRSFASSALEEIGKRDDDELLYYA
HHHHHHHEEEEECCEEEEECCCEEEEECCCCEEECCCHHHHHHHHHHHCCCCCCCEEEEE
NAKTTQHLLLFTNLGNVIYRPIHELSDIRWKDIGEHLSQSLSNFSADEKVIFVQIVDEFA
CCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHH
GENLLVVTRNGQIKQIERESFSPWRTYRSKSTPYAKLKGEDDEIVLITPVQFADLMLISE
CCCEEEEECCCCEEEHHHHCCCHHHHHCCCCCCCEEECCCCCCEEEEECCCEEEEEEECC
NGYALRFNLDDVPVLGARAAGVKAMNLKNGDKIKSAFFVNSNSWYLLTQRAFIKRVKTDD
CCEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCCEEEEEHHHHHHHHCCCC
IPATSRANRGLQVLRTLKTNNHTVFAAGLINSTADLSALTEELDLFSQAKAPATKETDEQ
CCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
VLEVISETGKKYDINLCDLSLSDRTSNGHPIADDLEKIASVKIK
HHHHHHHCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]