Click here to switch to the map view.

The map label for this gene is lacR

Identifier: 15672939

GI number: 15672939

Start: 983589

End: 984290

Strand: Direct

Name: lacR

Synonym: L0031

Alternate gene names: 15672939

Gene position: 983589-984290 (Clockwise)

Preceding gene: 15672938

Following gene: 15672940

Centisome position: 41.58

GC content: 34.9

Gene sequence:

>702_bases
ATGTTAGCAAATGAAAGAAAAAGACGGATTGTTGACTATCTAAAATTAAAAAGAAGAGCAACGATTGAAGAACTTCTTAC
GTTAATGGATTGCTCTATATCGACGCTTAGGCGAGATTTGAATGAATTGGAAAAAGAAAAATCTTTAAGACGAGTTCATG
GTGGTGCAGAACTTACACAAGACTTATCGGAAGAATTAAGTATTTCTGAAAAAACTTCCAAAAACATTCAAGAAAAAGAA
GAAATCGCTCAAAAAGCATTATCGAAAATTAAAGATGGGGATATTATTTTTTTAGATGCTGGGACTACAACTGGTATCTT
AGCTGAACTTATCAATCAATCTCATCTTTATTTAACGATTGTAACCAACTCTGTCAGTCATTTGGCAAAATTAACAGATG
ACCGATTAATCGTCTATCTGCTCGGTGGACGAGTGAAAAAGGTAACAGATGCAATAATTGGGAGTCAGGCTTTAGAACAA
CTTTCTGCTTATCAATTCAATAGTGCTTTTGTTGGAGCTAACGGCTTTGACAATGAACACGGAGCAATGACGCCAGACCA
TGAAGAAGCAGCAATAAAAGGACTAGCAGTCAAACAAAGCCAGAATGCTTTCATATTAGCCGATTCTTCTAAATTAGGAC
AAATGAGTTTTGTCAAATTTGCTAATTCTGAAGAAGTTGAATTAATTACCGAGAACAATTAG

Upstream 100 bases:

>100_bases
TTATTTTTGAGTTTTTTTTGGAAGAAAATGATAGTTAATGATTGATTTTGAAAGATAAAGGTGTTATAATGATTTTTGTA
AACGAATTCAGGAGATGGAA

Downstream 100 bases:

>100_bases
CGTTTGTTTTTAAATGAATCGTGTGAAAAAAATTTCACTAAAAGTTAGTATTTGCAAACCTACGTCTTACATAAAGGAGA
ATTATGATTTATACAGTAAC

Product: lactose transport regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MLANERKRRIVDYLKLKRRATIEELLTLMDCSISTLRRDLNELEKEKSLRRVHGGAELTQDLSEELSISEKTSKNIQEKE
EIAQKALSKIKDGDIIFLDAGTTTGILAELINQSHLYLTIVTNSVSHLAKLTDDRLIVYLLGGRVKKVTDAIIGSQALEQ
LSAYQFNSAFVGANGFDNEHGAMTPDHEEAAIKGLAVKQSQNAFILADSSKLGQMSFVKFANSEEVELITENN

Sequences:

>Translated_233_residues
MLANERKRRIVDYLKLKRRATIEELLTLMDCSISTLRRDLNELEKEKSLRRVHGGAELTQDLSEELSISEKTSKNIQEKE
EIAQKALSKIKDGDIIFLDAGTTTGILAELINQSHLYLTIVTNSVSHLAKLTDDRLIVYLLGGRVKKVTDAIIGSQALEQ
LSAYQFNSAFVGANGFDNEHGAMTPDHEEAAIKGLAVKQSQNAFILADSSKLGQMSFVKFANSEEVELITENN
>Mature_233_residues
MLANERKRRIVDYLKLKRRATIEELLTLMDCSISTLRRDLNELEKEKSLRRVHGGAELTQDLSEELSISEKTSKNIQEKE
EIAQKALSKIKDGDIIFLDAGTTTGILAELINQSHLYLTIVTNSVSHLAKLTDDRLIVYLLGGRVKKVTDAIIGSQALEQ
LSAYQFNSAFVGANGFDNEHGAMTPDHEEAAIKGLAVKQSQNAFILADSSKLGQMSFVKFANSEEVELITENN

Specific function: Repressor Of The Glycerol-3-Phosphate Regulon. [C]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=232, Percent_Identity=29.7413793103448, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1789059, Length=235, Percent_Identity=31.4893617021277, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1789519, Length=229, Percent_Identity=27.5109170305677, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI226510968, Length=236, Percent_Identity=29.2372881355932, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787540, Length=213, Percent_Identity=29.5774647887324, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788069, Length=230, Percent_Identity=29.5652173913043, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI87082344, Length=229, Percent_Identity=26.2008733624454, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1790753, Length=212, Percent_Identity=25, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789170, Length=229, Percent_Identity=25.764192139738, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790635, Length=219, Percent_Identity=26.4840182648402, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787063, Length=229, Percent_Identity=23.1441048034935, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 25880; Mature: 25880

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLANERKRRIVDYLKLKRRATIEELLTLMDCSISTLRRDLNELEKEKSLRRVHGGAELTQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
DLSEELSISEKTSKNIQEKEEIAQKALSKIKDGDIIFLDAGTTTGILAELINQSHLYLTI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCEEEEE
VTNSVSHLAKLTDDRLIVYLLGGRVKKVTDAIIGSQALEQLSAYQFNSAFVGANGFDNEH
ECHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
GAMTPDHEEAAIKGLAVKQSQNAFILADSSKLGQMSFVKFANSEEVELITENN
CCCCCCHHHHHHHHHEEECCCCEEEEECCCCCCCHHHHEECCCCCEEEEECCC
>Mature Secondary Structure
MLANERKRRIVDYLKLKRRATIEELLTLMDCSISTLRRDLNELEKEKSLRRVHGGAELTQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
DLSEELSISEKTSKNIQEKEEIAQKALSKIKDGDIIFLDAGTTTGILAELINQSHLYLTI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCEEEEE
VTNSVSHLAKLTDDRLIVYLLGGRVKKVTDAIIGSQALEQLSAYQFNSAFVGANGFDNEH
ECHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
GAMTPDHEEAAIKGLAVKQSQNAFILADSSKLGQMSFVKFANSEEVELITENN
CCCCCCHHHHHHHHHEEECCCCEEEEECCCCCCCHHHHEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]