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The map label for this gene is fhs

Identifier: 15672917

GI number: 15672917

Start: 959757

End: 961424

Strand: Direct

Name: fhs

Synonym: L159505

Alternate gene names: 15672917

Gene position: 959757-961424 (Clockwise)

Preceding gene: 15672916

Following gene: 15672918

Centisome position: 40.57

GC content: 38.97

Gene sequence:

>1668_bases
ATGAAAACGGATATTGAAATTGCTCAAGCTGCTGACATTCAACCTATTACCAAAATTGCTGAAAAGATTGGACTATCATT
TGATGATATCGAACTTTATGGTAAATACAAAGCTAAAATTCCTTTAGAGGTTTTAGATAAGTTTGACCAACAGTCTGAAG
GAAAACTTGTTTTGGTGACATCAATTAATCCCACACCTGCTGGAGAAGGAAAATCGACAGTTACTGTCGGTTTGGCTGAT
GCATTTGCAAGACAAGGTAAAAATGTAATGGTGGCCTTGCGTGAACCTTCTTTAGGGCCTGTTATGGGAATTAAGGGTGG
AGCTGCTGGTGGTGGTTTTGCACAGGTATTACCAATGGAAGATATTAATCTTCATTTTACAGGGGATATTCATGCGATTA
CAACTGCCAATAATGCTATTTCGGCATTTCTTGATAATTCGCTTCATCAAGGAAATCCGTTAAATATCGACCCAAGAAGA
ATCATTTGGAAACGTGTTGTTGATTTGAATGACCGTGCCCTTCGTCATGTCACTGTTGGACTTGGTGGCCCTTTAAATGG
TGTGCCCCGTGAAGATGGTTTTGATATTACAGTAGTCAGTGAAATTATGGCGGTTTTATGTTTGGCAACTTCAATCAGCG
ATTTGAAAGAACGTTTAGGAAAAATTGTTCTGGCTCAGTCTTATGACCGTAAACCTGTAACCCTTGGTGATTTGGGGGTT
CAAGGGGCTATTGCGATGCTCTTGAAAGATGCACTGAAACCAAACCTTGTTCAGACAATTGAAGGAACGCCAGCTTTGAT
TCACGGTGGGCCTTTTGCCAATATTGCGCATGGTTGTAATTCTGTTTTGGCAACAAAAACAGCCTTAAAATTATCTGATA
TTGTCATTACAGAAGCTGGGTTTGGAGCTGACCTTGGTGGTGAGAAATTTTTAGATATCAAAACTCGTCAGCTCGGAAAA
CAACCTGATGCGGTAGTAATTGTGGCTACACTTCGTGCACTTAAAATGCATGGTGGCCTTGATAAAAAAGAATTGACTAA
GGAAAACGTAGAGGCTGTTAAAAAGGGCTTTGCTAATTTAGAACGTCATATTAAAAATATGCAGAGTTACGGTTTGCCAG
TAATTGTGGCAATTAATGAGTTTGCATCAGATACTAAATCTGAAATTTCAGCATTAAAAGATCTGACAGAAGCATTGGGA
GTTCCAGTTTCATTGACCCAAGTCTTTGCTAAGGGTGGTGAAGGTGGTTTAGATTTGGCCGAAAAACTGTCAGGAATGTT
ACAAGAAAAATCTGATTTTAGCTATCTTTATGACCTAAAAGAGCCATTATCAGCTAAAATTGACAAAGTTGTGACAGAAA
TTTATGGCGGTTCCAAAGTCAATTATTCACCAAAGGCTAAGCGTCAGATGAGAGAAATTGAAGAAAATGGTTGGAATGAT
TTGCCAGTATGCATGGCTAAAACTCAATATTCATTTTCAGACCAACCAAATCTTTTAGCGGCACCAGAAGGCTTTGAAGT
TACAGTTCGTGAACTACTTCCAAAAATTGGAGCTGGATTTATCGTTGCTCTTTTGGGGGACGTAATGACAATGCCAGGGC
TTCCTAAAAATCCAGCATCTTTAAAAATGGATGTCACTGATGATGGAAAAATCTCAGGATTATTTTAG

Upstream 100 bases:

>100_bases
AAAGAAATACTATTAAGGGAAAATTCCTTCATTTTTTGTTAGAATAATATTAAAATTAGTATAATTAAACTCAAATATGA
GAAGCCTTTAGAGGAGAATT

Downstream 100 bases:

>100_bases
AAATGAGTTTAAGTGGTTTTGTTACGTAAAGATTAAATGTAAATTTTTTCGGTAACAAATTTACAAAAAATTAAAAGCTT
GTAAAACCGCTTGTCAGGCG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MKTDIEIAQAADIQPITKIAEKIGLSFDDIELYGKYKAKIPLEVLDKFDQQSEGKLVLVTSINPTPAGEGKSTVTVGLAD
AFARQGKNVMVALREPSLGPVMGIKGGAAGGGFAQVLPMEDINLHFTGDIHAITTANNAISAFLDNSLHQGNPLNIDPRR
IIWKRVVDLNDRALRHVTVGLGGPLNGVPREDGFDITVVSEIMAVLCLATSISDLKERLGKIVLAQSYDRKPVTLGDLGV
QGAIAMLLKDALKPNLVQTIEGTPALIHGGPFANIAHGCNSVLATKTALKLSDIVITEAGFGADLGGEKFLDIKTRQLGK
QPDAVVIVATLRALKMHGGLDKKELTKENVEAVKKGFANLERHIKNMQSYGLPVIVAINEFASDTKSEISALKDLTEALG
VPVSLTQVFAKGGEGGLDLAEKLSGMLQEKSDFSYLYDLKEPLSAKIDKVVTEIYGGSKVNYSPKAKRQMREIEENGWND
LPVCMAKTQYSFSDQPNLLAAPEGFEVTVRELLPKIGAGFIVALLGDVMTMPGLPKNPASLKMDVTDDGKISGLF

Sequences:

>Translated_555_residues
MKTDIEIAQAADIQPITKIAEKIGLSFDDIELYGKYKAKIPLEVLDKFDQQSEGKLVLVTSINPTPAGEGKSTVTVGLAD
AFARQGKNVMVALREPSLGPVMGIKGGAAGGGFAQVLPMEDINLHFTGDIHAITTANNAISAFLDNSLHQGNPLNIDPRR
IIWKRVVDLNDRALRHVTVGLGGPLNGVPREDGFDITVVSEIMAVLCLATSISDLKERLGKIVLAQSYDRKPVTLGDLGV
QGAIAMLLKDALKPNLVQTIEGTPALIHGGPFANIAHGCNSVLATKTALKLSDIVITEAGFGADLGGEKFLDIKTRQLGK
QPDAVVIVATLRALKMHGGLDKKELTKENVEAVKKGFANLERHIKNMQSYGLPVIVAINEFASDTKSEISALKDLTEALG
VPVSLTQVFAKGGEGGLDLAEKLSGMLQEKSDFSYLYDLKEPLSAKIDKVVTEIYGGSKVNYSPKAKRQMREIEENGWND
LPVCMAKTQYSFSDQPNLLAAPEGFEVTVRELLPKIGAGFIVALLGDVMTMPGLPKNPASLKMDVTDDGKISGLF
>Mature_555_residues
MKTDIEIAQAADIQPITKIAEKIGLSFDDIELYGKYKAKIPLEVLDKFDQQSEGKLVLVTSINPTPAGEGKSTVTVGLAD
AFARQGKNVMVALREPSLGPVMGIKGGAAGGGFAQVLPMEDINLHFTGDIHAITTANNAISAFLDNSLHQGNPLNIDPRR
IIWKRVVDLNDRALRHVTVGLGGPLNGVPREDGFDITVVSEIMAVLCLATSISDLKERLGKIVLAQSYDRKPVTLGDLGV
QGAIAMLLKDALKPNLVQTIEGTPALIHGGPFANIAHGCNSVLATKTALKLSDIVITEAGFGADLGGEKFLDIKTRQLGK
QPDAVVIVATLRALKMHGGLDKKELTKENVEAVKKGFANLERHIKNMQSYGLPVIVAINEFASDTKSEISALKDLTEALG
VPVSLTQVFAKGGEGGLDLAEKLSGMLQEKSDFSYLYDLKEPLSAKIDKVVTEIYGGSKVNYSPKAKRQMREIEENGWND
LPVCMAKTQYSFSDQPNLLAAPEGFEVTVRELLPKIGAGFIVALLGDVMTMPGLPKNPASLKMDVTDDGKISGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=43.4571890145396, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI36796743, Length=621, Percent_Identity=44.122383252818, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17568737, Length=624, Percent_Identity=41.3461538461538, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17568739, Length=624, Percent_Identity=41.3461538461538, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319558, Length=630, Percent_Identity=41.2698412698413, Blast_Score=473, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=41.6, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI62472483, Length=618, Percent_Identity=43.3656957928803, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI45551871, Length=618, Percent_Identity=43.3656957928803, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24645718, Length=618, Percent_Identity=43.3656957928803, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI17137370, Length=618, Percent_Identity=43.3656957928803, Blast_Score=479, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_LACLA (Q9CH07)

Other databases:

- EMBL:   AE005176
- PIR:   G86741
- RefSeq:   NP_267091.1
- ProteinModelPortal:   Q9CH07
- SMR:   Q9CH07
- GeneID:   1114565
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L159505
- NMPDR:   fig|272623.1.peg.957
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- ProtClustDB:   PRK13505
- BioCyc:   LLAC272623:L159505-MONOMER
- BRENDA:   6.3.4.3
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59444; Mature: 59444

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDIEIAQAADIQPITKIAEKIGLSFDDIELYGKYKAKIPLEVLDKFDQQSEGKLVLVT
CCCCCCHHHHCCCCHHHHHHHHHCCCCCCEEEEECEECCCCHHHHHHHCCCCCCCEEEEE
SINPTPAGEGKSTVTVGLADAFARQGKNVMVALREPSLGPVMGIKGGAAGGGFAQVLPME
ECCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCCCCCEEEEECC
DINLHFTGDIHAITTANNAISAFLDNSLHQGNPLNIDPRRIIWKRVVDLNDRALRHVTVG
CCCEEEECCEEEEEECCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEE
LGGPLNGVPREDGFDITVVSEIMAVLCLATSISDLKERLGKIVLAQSYDRKPVTLGDLGV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEECCCCH
QGAIAMLLKDALKPNLVQTIEGTPALIHGGPFANIAHGCNSVLATKTALKLSDIVITEAG
HHHHHHHHHHHCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEECCC
FGADLGGEKFLDIKTRQLGKQPDAVVIVATLRALKMHGGLDKKELTKENVEAVKKGFANL
CCCCCCCCCEEEEHHHHCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ERHIKNMQSYGLPVIVAINEFASDTKSEISALKDLTEALGVPVSLTQVFAKGGEGGLDLA
HHHHHHHHHCCCEEEEEECHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHH
EKLSGMLQEKSDFSYLYDLKEPLSAKIDKVVTEIYGGSKVNYSPKAKRQMREIEENGWND
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
LPVCMAKTQYSFSDQPNLLAAPEGFEVTVRELLPKIGAGFIVALLGDVMTMPGLPKNPAS
CCEEEEECCCCCCCCCCEEECCCCCEEHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCC
LKMDVTDDGKISGLF
EEEEECCCCCCCCCC
>Mature Secondary Structure
MKTDIEIAQAADIQPITKIAEKIGLSFDDIELYGKYKAKIPLEVLDKFDQQSEGKLVLVT
CCCCCCHHHHCCCCHHHHHHHHHCCCCCCEEEEECEECCCCHHHHHHHCCCCCCCEEEEE
SINPTPAGEGKSTVTVGLADAFARQGKNVMVALREPSLGPVMGIKGGAAGGGFAQVLPME
ECCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCCCCCEEEEECC
DINLHFTGDIHAITTANNAISAFLDNSLHQGNPLNIDPRRIIWKRVVDLNDRALRHVTVG
CCCEEEECCEEEEEECCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEE
LGGPLNGVPREDGFDITVVSEIMAVLCLATSISDLKERLGKIVLAQSYDRKPVTLGDLGV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEECCCCH
QGAIAMLLKDALKPNLVQTIEGTPALIHGGPFANIAHGCNSVLATKTALKLSDIVITEAG
HHHHHHHHHHHCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEECCC
FGADLGGEKFLDIKTRQLGKQPDAVVIVATLRALKMHGGLDKKELTKENVEAVKKGFANL
CCCCCCCCCEEEEHHHHCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ERHIKNMQSYGLPVIVAINEFASDTKSEISALKDLTEALGVPVSLTQVFAKGGEGGLDLA
HHHHHHHHHCCCEEEEEECHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHH
EKLSGMLQEKSDFSYLYDLKEPLSAKIDKVVTEIYGGSKVNYSPKAKRQMREIEENGWND
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
LPVCMAKTQYSFSDQPNLLAAPEGFEVTVRELLPKIGAGFIVALLGDVMTMPGLPKNPAS
CCEEEEECCCCCCCCCCEEECCCCCEEHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCC
LKMDVTDDGKISGLF
EEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471