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The map label for this gene is kinD

Identifier: 15672872

GI number: 15672872

Start: 911482

End: 912480

Strand: Direct

Name: kinD

Synonym: L0126

Alternate gene names: 15672872

Gene position: 911482-912480 (Clockwise)

Preceding gene: 15672871

Following gene: 15672873

Centisome position: 38.53

GC content: 35.44

Gene sequence:

>999_bases
ATGAAAAAATCACTTTTCACAACCTTTTTAGCAGTTTTTAGTATCATCCTTATTATGTACCTTCTACTATTTATAATGAT
GAATAGTGGTCAACCTTTAGGGGGACTAAATACCGCTAATATTATTAGGGAACTTCGAGATAATTTCTATGGTTTATGGA
TATTTATATCAGTTGCAGGATTACTTGCGCTGATTTTTACCCTTTTTAATCATATTGAAAATATGGCTATTCAACAAAAA
TTTCAAGATGATATTAAACTTTTAGAAGAAAATCAACAACCTGAATCTCCTGAATTACAAGCTGTTCATGATAAAATTAT
GAATATGTCAGCTGAACTCCAAGAATTATCTAAGCAAAAATCTGCTGACAAAGCTGAAATTATTGAATTAGAGCGTAAAA
GAATTTCACGTGAACTTCATGATTCTGTCAGTCAAGAACTTTTTGCAACGACAATGATTTTATCTTCTTTTGCTGGTTCG
ACACCAAATTTGACTAAAGAACAAATCGAAACACGGACACAATTGGTTTTAAAAGTGCTCCATTCTGCACAAAATGAAAT
GCGAGCACTCTTACTACATCTTAGACCAGTAGAATTAGATGGTAAGAGTTTAGCAGAAGGGCTGTCAGCACTGACAGACG
AGCTCCAAGCGAAAATTTCAGCAAATATTACAGTTAAATTGGCTGACATTGAAGCGACGAGTAATGTTGAGGACAATTTA
TTTCGAATGGCTCAAGAGATTTTATCGAATACTTTGCGTCATTCGCAAGCCGAGCACATTGAAGTTTCTTTAAGAGAATC
ACTTGGAAACATTTTTTTGAAAATTGCTGATGATGGAGTTGGTTTTGATGTTTCTACTAGTGATAAGACGGCCAGTTACG
GTTTAGCCAATATCAAAGAACGTGCTTTATTAATCGGCGGAGATGCCAAAGTAATCTCGGCACCAGGTGCGGGGACAACT
GTTGAAATCATTATCCCTAAAGCGAAGCCGAGCCTTTAA

Upstream 100 bases:

>100_bases
CGGGAAATGTTCGTTATTTTAGTGAAAATTTAGATCAGGCGGAAAAACGAATTAAAATCAATATCCGTGTTGATTCAGGA
AATATTGAGGTGATTAGAGG

Downstream 100 bases:

>100_bases
AAATGATGCGTATTTAGAAAGAACAAAATGGAAAAAATTAAACTTTTAATTGTTGATGACCACCAGATGGTGCGACTAGG
TTTATCAAGTTTCATGAATA

Product: sensor protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKKSLFTTFLAVFSIILIMYLLLFIMMNSGQPLGGLNTANIIRELRDNFYGLWIFISVAGLLALIFTLFNHIENMAIQQK
FQDDIKLLEENQQPESPELQAVHDKIMNMSAELQELSKQKSADKAEIIELERKRISRELHDSVSQELFATTMILSSFAGS
TPNLTKEQIETRTQLVLKVLHSAQNEMRALLLHLRPVELDGKSLAEGLSALTDELQAKISANITVKLADIEATSNVEDNL
FRMAQEILSNTLRHSQAEHIEVSLRESLGNIFLKIADDGVGFDVSTSDKTASYGLANIKERALLIGGDAKVISAPGAGTT
VEIIIPKAKPSL

Sequences:

>Translated_332_residues
MKKSLFTTFLAVFSIILIMYLLLFIMMNSGQPLGGLNTANIIRELRDNFYGLWIFISVAGLLALIFTLFNHIENMAIQQK
FQDDIKLLEENQQPESPELQAVHDKIMNMSAELQELSKQKSADKAEIIELERKRISRELHDSVSQELFATTMILSSFAGS
TPNLTKEQIETRTQLVLKVLHSAQNEMRALLLHLRPVELDGKSLAEGLSALTDELQAKISANITVKLADIEATSNVEDNL
FRMAQEILSNTLRHSQAEHIEVSLRESLGNIFLKIADDGVGFDVSTSDKTASYGLANIKERALLIGGDAKVISAPGAGTT
VEIIIPKAKPSL
>Mature_332_residues
MKKSLFTTFLAVFSIILIMYLLLFIMMNSGQPLGGLNTANIIRELRDNFYGLWIFISVAGLLALIFTLFNHIENMAIQQK
FQDDIKLLEENQQPESPELQAVHDKIMNMSAELQELSKQKSADKAEIIELERKRISRELHDSVSQELFATTMILSSFAGS
TPNLTKEQIETRTQLVLKVLHSAQNEMRALLLHLRPVELDGKSLAEGLSALTDELQAKISANITVKLADIEATSNVEDNL
FRMAQEILSNTLRHSQAEHIEVSLRESLGNIFLKIADDGVGFDVSTSDKTASYGLANIKERALLIGGDAKVISAPGAGTT
VEIIIPKAKPSL

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=215, Percent_Identity=27.906976744186, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788812, Length=198, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR017202 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 36776; Mature: 36776

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSLFTTFLAVFSIILIMYLLLFIMMNSGQPLGGLNTANIIRELRDNFYGLWIFISVAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLALIFTLFNHIENMAIQQKFQDDIKLLEENQQPESPELQAVHDKIMNMSAELQELSKQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SADKAEIIELERKRISRELHDSVSQELFATTMILSSFAGSTPNLTKEQIETRTQLVLKVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
HSAQNEMRALLLHLRPVELDGKSLAEGLSALTDELQAKISANITVKLADIEATSNVEDNL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHH
FRMAQEILSNTLRHSQAEHIEVSLRESLGNIFLKIADDGVGFDVSTSDKTASYGLANIKE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHCCHHHHHH
RALLIGGDAKVISAPGAGTTVEIIIPKAKPSL
CEEEEECCCEEEECCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MKKSLFTTFLAVFSIILIMYLLLFIMMNSGQPLGGLNTANIIRELRDNFYGLWIFISVAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLALIFTLFNHIENMAIQQKFQDDIKLLEENQQPESPELQAVHDKIMNMSAELQELSKQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SADKAEIIELERKRISRELHDSVSQELFATTMILSSFAGSTPNLTKEQIETRTQLVLKVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
HSAQNEMRALLLHLRPVELDGKSLAEGLSALTDELQAKISANITVKLADIEATSNVEDNL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHH
FRMAQEILSNTLRHSQAEHIEVSLRESLGNIFLKIADDGVGFDVSTSDKTASYGLANIKE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHCCHHHHHH
RALLIGGDAKVISAPGAGTTVEIIIPKAKPSL
CEEEEECCCEEEECCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]