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The map label for this gene is xseA

Identifier: 15672836

GI number: 15672836

Start: 877881

End: 879134

Strand: Direct

Name: xseA

Synonym: L0254

Alternate gene names: 15672836

Gene position: 877881-879134 (Clockwise)

Preceding gene: 15672835

Following gene: 15672837

Centisome position: 37.11

GC content: 38.28

Gene sequence:

>1254_bases
ATGACAGAATATTTATCAGTATCAACCTTAACAAAATATTTAAAAGCGAAATTTGACCGTGATCGATATCTTGAACGGGT
TTATTTGACAGGAGAAATTTCAAATTTTAGAAGAAGACCAAATCATCAATATTTTGCACTTAAAGATGAGGGCGCTGTGA
TTCAAGCTACGATGTGGGCGGGACAATTTCGCAAATTAGACTTTGAATTAGAAGAAGGGATGAAAGTTTTGGCTGTCGGT
CGAATCAGTATTTATCCACCTTCTGGCTCTTATTCTATAAATATTGAAAGTTTAGTTCCAGATGGCGTTGGAGCTCTTGC
GGTTAAGTTTGAACAGTTGAAGAAAAAGCTGACTGCTGAAGGGCTATTTGAACAACGTTGGAAACAAACTTTGCCACAAT
TTTCTAAGAAAATAGCTGTGGTAACTAGCCCGTCAGGAGCGGTCATTCGAGATATTATCACGACGGTTCAACGTCGTTTT
CCGATGAGTCAAATCGTTCTTTATCCGACAAAAGTTCAAGGACAAGGTTCGGCTGAAGAAATTGCTGGAAATATCCGTCG
AGCTAATCAACGTGGTGATTTTGATGTCATGATTATTGGTCGTGGTGGTGGGTCTATCGAAGATTTATGGGGATTTAATG
AAGAAATTGTGGTTCGAGCAATTTTTGAATCACGTATTCCAATTATTTCATCGGTTGGACATGAAACAGATGTGACTTTA
GCTGATTTTGTTGCTGATAGTCGTGCAGCGACTCCAACAGCGGCAGCCGAATTAGCAACACCAAATACGAAGGTTGATTT
AATAAATTGGGCGAATGAGCAGGAAAAACGACTTTTTAACCGCTTAACACATGTAATTAAAATAAGGCGTGAACGAGTAG
ATAAATTAAGCCAGTCAGTCGTTTTTAGACAGCCAGAACGCTTGTACGATGGACACTTACAAAAACTTGACCGTCTGTGT
GAACGTTTGTCAGTGCTGACGGAAAATAAAGTTGCAAATATGAAACACCGTTATGAGCTGTCAGCTGGGAAATTAATTCC
GACTTACGGAAAGATAGTTGAAGCTAAAAAGAATAAGACGGAGCAACTTTATCAGTCTTTACTTTTATTAGATATTTCGA
AAATAAAAGCGCGTGGTTTTTCCCTCGTTACTGACGAAAAGGGAAAGATTATTAAATCCGTAAGTGATGTGAAAAAAGGT
CAGACTTTAGATGTTGAATTGACTGACGGAAAAGTAATAGTGGAGGTAAAATAA

Upstream 100 bases:

>100_bases
TTTGAAGATAAACTTTTTACTTTTTTTCGATTTTAGCAGTAGAAATTTTACTAACAGAATGATTAGTAAAAAGATTAATT
GAGAACTAAAGAGTGAGGGA

Downstream 100 bases:

>100_bases
TGGCAACCAAAAAAGAAGATGTAAAATTTGAAGATAATTTGGCAGAGTTAGAAAATATTGTTCGTAAGTTGGAATCTGGT
GATGTAGCATTGGAAGATGC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTEYLSVSTLTKYLKAKFDRDRYLERVYLTGEISNFRRRPNHQYFALKDEGAVIQATMWAGQFRKLDFELEEGMKVLAVG
RISIYPPSGSYSINIESLVPDGVGALAVKFEQLKKKLTAEGLFEQRWKQTLPQFSKKIAVVTSPSGAVIRDIITTVQRRF
PMSQIVLYPTKVQGQGSAEEIAGNIRRANQRGDFDVMIIGRGGGSIEDLWGFNEEIVVRAIFESRIPIISSVGHETDVTL
ADFVADSRAATPTAAAELATPNTKVDLINWANEQEKRLFNRLTHVIKIRRERVDKLSQSVVFRQPERLYDGHLQKLDRLC
ERLSVLTENKVANMKHRYELSAGKLIPTYGKIVEAKKNKTEQLYQSLLLLDISKIKARGFSLVTDEKGKIIKSVSDVKKG
QTLDVELTDGKVIVEVK

Sequences:

>Translated_417_residues
MTEYLSVSTLTKYLKAKFDRDRYLERVYLTGEISNFRRRPNHQYFALKDEGAVIQATMWAGQFRKLDFELEEGMKVLAVG
RISIYPPSGSYSINIESLVPDGVGALAVKFEQLKKKLTAEGLFEQRWKQTLPQFSKKIAVVTSPSGAVIRDIITTVQRRF
PMSQIVLYPTKVQGQGSAEEIAGNIRRANQRGDFDVMIIGRGGGSIEDLWGFNEEIVVRAIFESRIPIISSVGHETDVTL
ADFVADSRAATPTAAAELATPNTKVDLINWANEQEKRLFNRLTHVIKIRRERVDKLSQSVVFRQPERLYDGHLQKLDRLC
ERLSVLTENKVANMKHRYELSAGKLIPTYGKIVEAKKNKTEQLYQSLLLLDISKIKARGFSLVTDEKGKIIKSVSDVKKG
QTLDVELTDGKVIVEVK
>Mature_416_residues
TEYLSVSTLTKYLKAKFDRDRYLERVYLTGEISNFRRRPNHQYFALKDEGAVIQATMWAGQFRKLDFELEEGMKVLAVGR
ISIYPPSGSYSINIESLVPDGVGALAVKFEQLKKKLTAEGLFEQRWKQTLPQFSKKIAVVTSPSGAVIRDIITTVQRRFP
MSQIVLYPTKVQGQGSAEEIAGNIRRANQRGDFDVMIIGRGGGSIEDLWGFNEEIVVRAIFESRIPIISSVGHETDVTLA
DFVADSRAATPTAAAELATPNTKVDLINWANEQEKRLFNRLTHVIKIRRERVDKLSQSVVFRQPERLYDGHLQKLDRLCE
RLSVLTENKVANMKHRYELSAGKLIPTYGKIVEAKKNKTEQLYQSLLLLDISKIKARGFSLVTDEKGKIIKSVSDVKKGQ
TLDVELTDGKVIVEVK

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=437, Percent_Identity=36.3844393592677, Blast_Score=276, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_LACLA (Q9CH84)

Other databases:

- EMBL:   AE005176
- PIR:   F86731
- RefSeq:   NP_267010.1
- GeneID:   1114483
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0254
- NMPDR:   fig|272623.1.peg.875
- HOGENOM:   HBG634411
- OMA:   LINWANE
- ProtClustDB:   PRK00286
- BioCyc:   LLAC272623:L0254-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 47123; Mature: 46992

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEYLSVSTLTKYLKAKFDRDRYLERVYLTGEISNFRRRPNHQYFALKDEGAVIQATMWA
CCCEEHHHHHHHHHHHHCCHHHHHEEEEEEEEHHHHHCCCCCCEEEEECCCCEEEEEECC
GQFRKLDFELEEGMKVLAVGRISIYPPSGSYSINIESLVPDGVGALAVKFEQLKKKLTAE
CCHHEECEEHHCCCEEEEEEEEEEECCCCCEEEEEHEECCCCCHHHHHHHHHHHHHHHHH
GLFEQRWKQTLPQFSKKIAVVTSPSGAVIRDIITTVQRRFPMSQIVLYPTKVQGQGSAEE
HHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHH
IAGNIRRANQRGDFDVMIIGRGGGSIEDLWGFNEEIVVRAIFESRIPIISSVGHETDVTL
HHHHHHHCCCCCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCCCCHH
ADFVADSRAATPTAAAELATPNTKVDLINWANEQEKRLFNRLTHVIKIRRERVDKLSQSV
HHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFRQPERLYDGHLQKLDRLCERLSVLTENKVANMKHRYELSAGKLIPTYGKIVEAKKNKT
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCCCCHHHHHHHHCCHH
EQLYQSLLLLDISKIKARGFSLVTDEKGKIIKSVSDVKKGQTLDVELTDGKVIVEVK
HHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCEEEEEEECCEEEEEEC
>Mature Secondary Structure 
TEYLSVSTLTKYLKAKFDRDRYLERVYLTGEISNFRRRPNHQYFALKDEGAVIQATMWA
CCEEHHHHHHHHHHHHCCHHHHHEEEEEEEEHHHHHCCCCCCEEEEECCCCEEEEEECC
GQFRKLDFELEEGMKVLAVGRISIYPPSGSYSINIESLVPDGVGALAVKFEQLKKKLTAE
CCHHEECEEHHCCCEEEEEEEEEEECCCCCEEEEEHEECCCCCHHHHHHHHHHHHHHHHH
GLFEQRWKQTLPQFSKKIAVVTSPSGAVIRDIITTVQRRFPMSQIVLYPTKVQGQGSAEE
HHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHH
IAGNIRRANQRGDFDVMIIGRGGGSIEDLWGFNEEIVVRAIFESRIPIISSVGHETDVTL
HHHHHHHCCCCCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCCCCHH
ADFVADSRAATPTAAAELATPNTKVDLINWANEQEKRLFNRLTHVIKIRRERVDKLSQSV
HHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFRQPERLYDGHLQKLDRLCERLSVLTENKVANMKHRYELSAGKLIPTYGKIVEAKKNKT
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCCCCHHHHHHHHCCHH
EQLYQSLLLLDISKIKARGFSLVTDEKGKIIKSVSDVKKGQTLDVELTDGKVIVEVK
HHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCEEEEEEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471