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The map label for this gene is copA

Identifier: 15672816

GI number: 15672816

Start: 845963

End: 848125

Strand: Direct

Name: copA

Synonym: L45966

Alternate gene names: 15672816

Gene position: 845963-848125 (Clockwise)

Preceding gene: 15672815

Following gene: 15672819

Centisome position: 35.76

GC content: 35.69

Gene sequence:

>2163_bases
ATGCGGAGTCAATCATTTGTAATTACAGGAATGACCTGTGCAAATTGTGTAAATACAGTTTCAAAAACATTGAATCAGTC
AGATAAAATTATGGAAGCAACGGTAAATTTGGCGACTGAGAAAGCCAAAATTGTTGCTGACGATAATATTTCTGACCAAG
AAATTATTAACTTAGTGGAAAAAGCGGGTTATGGAGCCATTGTTAATGACAAAGCTCATCAGGAAAAAATTGCACGTCAA
GCTGCAAAAAAAGCAAGAAATTTGGCTTTGTCTTTTTGGATTGCTTTAATTTTGACTTTACCTTTAGTAGTTGCAATGTT
TGCTGATATCTTCGGAGTACATGCAAATTGGGTCATGTTTTTACATGAACCAATCGTACAATTGATTTTGGCAACTCCAG
TACAATTCGTTATTGGTTGGCGCTTTTATGTTGGCGCTTATCATGCTTTGCGAAATAAATCGGCAAATATGGATGTTTTA
GTGGCTTTAGGAACTTCGGTTGCTTACTTTTCGAGTTTGATTTTGGCTGTTTTTATGAGCCAAGCGAATGCTTTGAATTT
TGAATCATCGATGGTAATTATCACTTTGGTGGTCATGGGTAAACTTTTAGAACATAATGCAAAAGAGAAAACAACGCAAG
CAATTACTGGATTAATGTCTAGTCGAGCAAATTTTGTTCATACGGAATCGACTGATTTAGCGATTGAAGAAGTTCAAATG
GGACAAGTGATTCGCATTTTGCCAGGGGAGAAAGTGCCTTTGGATGCGATGATTCTTTCTGGCAAAGCATCCTTTGATGA
ATCTATTTTGACAGGTGAAGCCTTACCTGTTGTAAAAATGGATGATGAAGTCATTTTTGAAGGAACAATTAATTTAGATG
GTGAAGTTAAAGCGGTTGTTGTTCATGATTTAAATGATTCAACAATTTCAAGAATGGTTAAAATGATGAGTGAAGCACAA
GGCTCAAAACCAAACATTCAAAAATTAGCTGACAAGATTTCAGGGATTTTTGTGCCAGTTGTGTTAGTTATTGCTCTGAT
AACTTTCATTGCGACTTGGGCTGTCAGTGGAATTTTACTGACAGCAATCATGCATTCAGTAGCAGTTTTGGTCATTGCTT
GTCCTTGTGCGCTTGGTTTAGCTACACCAACTGCCATTATTTCTGGGACTGGTTTGGCTGCTAAAAATGGTTTGTTGATT
AAAAATGCCAATGCTTTGGAACTTGCCGGATTAGTTAAAACAGTATTTTTTGATAAAACTGGGACAATTACAACAGGTGA
ATTTGAACTGACAGATTTTAAATTGCTGACAGAAAGTGAAAAAGTTACTGACAGCTTTAATTCTATTGAAGAAAAACTAG
CAAGTGATAAGTTTAAATTATTGGCTAGTCTAGAAGCTCACTCTAATCACCCTTTGGCTAAATCTCTTAAATTTCAAGGT
GATTTATATGAACTGACAGATTTATCAGAACTTGCGGGTCGTGGACTTTCTGCTAAAATTAATGGTCAGGAATATTTTGC
GGGCAATGATAAATTAATGACAGACTTAAATCTGTCAGTCCCAGAAACAGATGATACGGTCATTTATTTGGCAAATAAAG
AAAAATTATTAGCGATGGCTGTTTTTAGTTCAAGTCTCAAAGATGATGCGCTTAAGACAATTCAAACCTTGCAAAAACGT
GGTCTAAAGACTGTTATGTTGACAGGAGATAATCAAAATTCGGCAGAAAAAATTCAAAAACTTGTTCATTTAGATGAAGT
TAAAAGTGGTTTAAGACCTGAAGAAAAAGCAGAAATTGTGCAAAATAGCCCAAATTCAATGATGGTTGGTGATGGAATCA
ATGATGCTATTGCTTTAGCATCAGCGACCGTTGGGCTGGCAATGGCAACTGGGTCAGATATAGCTATGGAAGCTGGTGAT
GTGACTGTTACTAGCGGTCAGCTTCATAAAATTTCCACTTTCTTTGAAGTAGCTAAAAAAACAATTTCTAAAATTAAGCA
AAATTATTTTTGGGCTTTCGTTTATAATGTCATTGGCATTCCGCTTGCAGCTTTTGGATTACTCAATCCAATGCTCGCTG
CAGCGGCAATGAGTTTATCATCAGTTTCTGTTATTTTGAATTCCTTACTTTTGACAAAAACAAAAATAAAAAACGTTGAA
TAA

Upstream 100 bases:

>100_bases
ACAGGTCATCTTCATTCCCCAAATGGAGATGATTTTTTCTTGACTTTTTTCGTTTACGGTTGTAAATTATATTTAGAGAT
AAAATATAGAAGAGGTAAAA

Downstream 100 bases:

>100_bases
TCAACGTTTTTTTGTTTAGAATTTACTGACAGAATTTTTTAAAGACAATCTGTCTTATTTTTTATACAATTCTGGGTCAA
GCAAGCCACCTTTTTTGAAA

Product: copper/potassium-transporting ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 720; Mature: 720

Protein sequence:

>720_residues
MRSQSFVITGMTCANCVNTVSKTLNQSDKIMEATVNLATEKAKIVADDNISDQEIINLVEKAGYGAIVNDKAHQEKIARQ
AAKKARNLALSFWIALILTLPLVVAMFADIFGVHANWVMFLHEPIVQLILATPVQFVIGWRFYVGAYHALRNKSANMDVL
VALGTSVAYFSSLILAVFMSQANALNFESSMVIITLVVMGKLLEHNAKEKTTQAITGLMSSRANFVHTESTDLAIEEVQM
GQVIRILPGEKVPLDAMILSGKASFDESILTGEALPVVKMDDEVIFEGTINLDGEVKAVVVHDLNDSTISRMVKMMSEAQ
GSKPNIQKLADKISGIFVPVVLVIALITFIATWAVSGILLTAIMHSVAVLVIACPCALGLATPTAIISGTGLAAKNGLLI
KNANALELAGLVKTVFFDKTGTITTGEFELTDFKLLTESEKVTDSFNSIEEKLASDKFKLLASLEAHSNHPLAKSLKFQG
DLYELTDLSELAGRGLSAKINGQEYFAGNDKLMTDLNLSVPETDDTVIYLANKEKLLAMAVFSSSLKDDALKTIQTLQKR
GLKTVMLTGDNQNSAEKIQKLVHLDEVKSGLRPEEKAEIVQNSPNSMMVGDGINDAIALASATVGLAMATGSDIAMEAGD
VTVTSGQLHKISTFFEVAKKTISKIKQNYFWAFVYNVIGIPLAAFGLLNPMLAAAAMSLSSVSVILNSLLLTKTKIKNVE

Sequences:

>Translated_720_residues
MRSQSFVITGMTCANCVNTVSKTLNQSDKIMEATVNLATEKAKIVADDNISDQEIINLVEKAGYGAIVNDKAHQEKIARQ
AAKKARNLALSFWIALILTLPLVVAMFADIFGVHANWVMFLHEPIVQLILATPVQFVIGWRFYVGAYHALRNKSANMDVL
VALGTSVAYFSSLILAVFMSQANALNFESSMVIITLVVMGKLLEHNAKEKTTQAITGLMSSRANFVHTESTDLAIEEVQM
GQVIRILPGEKVPLDAMILSGKASFDESILTGEALPVVKMDDEVIFEGTINLDGEVKAVVVHDLNDSTISRMVKMMSEAQ
GSKPNIQKLADKISGIFVPVVLVIALITFIATWAVSGILLTAIMHSVAVLVIACPCALGLATPTAIISGTGLAAKNGLLI
KNANALELAGLVKTVFFDKTGTITTGEFELTDFKLLTESEKVTDSFNSIEEKLASDKFKLLASLEAHSNHPLAKSLKFQG
DLYELTDLSELAGRGLSAKINGQEYFAGNDKLMTDLNLSVPETDDTVIYLANKEKLLAMAVFSSSLKDDALKTIQTLQKR
GLKTVMLTGDNQNSAEKIQKLVHLDEVKSGLRPEEKAEIVQNSPNSMMVGDGINDAIALASATVGLAMATGSDIAMEAGD
VTVTSGQLHKISTFFEVAKKTISKIKQNYFWAFVYNVIGIPLAAFGLLNPMLAAAAMSLSSVSVILNSLLLTKTKIKNVE
>Mature_720_residues
MRSQSFVITGMTCANCVNTVSKTLNQSDKIMEATVNLATEKAKIVADDNISDQEIINLVEKAGYGAIVNDKAHQEKIARQ
AAKKARNLALSFWIALILTLPLVVAMFADIFGVHANWVMFLHEPIVQLILATPVQFVIGWRFYVGAYHALRNKSANMDVL
VALGTSVAYFSSLILAVFMSQANALNFESSMVIITLVVMGKLLEHNAKEKTTQAITGLMSSRANFVHTESTDLAIEEVQM
GQVIRILPGEKVPLDAMILSGKASFDESILTGEALPVVKMDDEVIFEGTINLDGEVKAVVVHDLNDSTISRMVKMMSEAQ
GSKPNIQKLADKISGIFVPVVLVIALITFIATWAVSGILLTAIMHSVAVLVIACPCALGLATPTAIISGTGLAAKNGLLI
KNANALELAGLVKTVFFDKTGTITTGEFELTDFKLLTESEKVTDSFNSIEEKLASDKFKLLASLEAHSNHPLAKSLKFQG
DLYELTDLSELAGRGLSAKINGQEYFAGNDKLMTDLNLSVPETDDTVIYLANKEKLLAMAVFSSSLKDDALKTIQTLQKR
GLKTVMLTGDNQNSAEKIQKLVHLDEVKSGLRPEEKAEIVQNSPNSMMVGDGINDAIALASATVGLAMATGSDIAMEAGD
VTVTSGQLHKISTFFEVAKKTISKIKQNYFWAFVYNVIGIPLAAFGLLNPMLAAAAMSLSSVSVILNSLLLTKTKIKNVE

Specific function: Probably involved in copper import under copper limiting conditions [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=797, Percent_Identity=33.375156838143, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI115529486, Length=830, Percent_Identity=31.4457831325301, Blast_Score=378, Evalue=1e-104,
Organism=Homo sapiens, GI55743073, Length=552, Percent_Identity=32.7898550724638, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI153946397, Length=267, Percent_Identity=26.9662921348315, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI237681109, Length=295, Percent_Identity=23.728813559322, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI21361181, Length=295, Percent_Identity=23.728813559322, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI237681111, Length=295, Percent_Identity=23.728813559322, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786691, Length=760, Percent_Identity=36.0526315789474, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI1789879, Length=737, Percent_Identity=31.0719131614654, Blast_Score=262, Evalue=5e-71,
Organism=Escherichia coli, GI1786914, Length=437, Percent_Identity=26.3157894736842, Blast_Score=106, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17556548, Length=764, Percent_Identity=31.544502617801, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17559224, Length=287, Percent_Identity=24.390243902439, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320475, Length=650, Percent_Identity=31.6923076923077, Blast_Score=294, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6319772, Length=679, Percent_Identity=28.4241531664212, Blast_Score=274, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6325221, Length=520, Percent_Identity=22.1153846153846, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321430, Length=524, Percent_Identity=22.1374045801527, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221329854, Length=526, Percent_Identity=34.6007604562738, Blast_Score=261, Evalue=9e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 77596; Mature: 77596

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSQSFVITGMTCANCVNTVSKTLNQSDKIMEATVNLATEKAKIVADDNISDQEIINLVE
CCCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHH
KAGYGAIVNDKAHQEKIARQAAKKARNLALSFWIALILTLPLVVAMFADIFGVHANWVMF
HCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
LHEPIVQLILATPVQFVIGWRFYVGAYHALRNKSANMDVLVALGTSVAYFSSLILAVFMS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHH
QANALNFESSMVIITLVVMGKLLEHNAKEKTTQAITGLMSSRANFVHTESTDLAIEEVQM
HCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHH
GQVIRILPGEKVPLDAMILSGKASFDESILTGEALPVVKMDDEVIFEGTINLDGEVKAVV
CCEEEECCCCCCCHHHEEECCCCCCCCHHHCCCCCEEEECCCCEEEEEEECCCCCEEEEE
VHDLNDSTISRMVKMMSEAQGSKPNIQKLADKISGIFVPVVLVIALITFIATWAVSGILL
EECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAIMHSVAVLVIACPCALGLATPTAIISGTGLAAKNGLLIKNANALELAGLVKTVFFDKT
HHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCC
GTITTGEFELTDFKLLTESEKVTDSFNSIEEKLASDKFKLLASLEAHSNHPLAKSLKFQG
CCEECCEEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCC
DLYELTDLSELAGRGLSAKINGQEYFAGNDKLMTDLNLSVPETDDTVIYLANKEKLLAMA
CHHHHCCHHHHHCCCCEEEECCCEEECCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHH
VFSSSLKDDALKTIQTLQKRGLKTVMLTGDNQNSAEKIQKLVHLDEVKSGLRPEEKAEIV
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
QNSPNSMMVGDGINDAIALASATVGLAMATGSDIAMEAGDVTVTSGQLHKISTFFEVAKK
HCCCCCEEECCCCCHHHHHHHHHHHHEEECCCCCEEECCCEEEECCCHHHHHHHHHHHHH
TISKIKQNYFWAFVYNVIGIPLAAFGLLNPMLAAAAMSLSSVSVILNSLLLTKTKIKNVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRSQSFVITGMTCANCVNTVSKTLNQSDKIMEATVNLATEKAKIVADDNISDQEIINLVE
CCCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHH
KAGYGAIVNDKAHQEKIARQAAKKARNLALSFWIALILTLPLVVAMFADIFGVHANWVMF
HCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
LHEPIVQLILATPVQFVIGWRFYVGAYHALRNKSANMDVLVALGTSVAYFSSLILAVFMS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHH
QANALNFESSMVIITLVVMGKLLEHNAKEKTTQAITGLMSSRANFVHTESTDLAIEEVQM
HCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHH
GQVIRILPGEKVPLDAMILSGKASFDESILTGEALPVVKMDDEVIFEGTINLDGEVKAVV
CCEEEECCCCCCCHHHEEECCCCCCCCHHHCCCCCEEEECCCCEEEEEEECCCCCEEEEE
VHDLNDSTISRMVKMMSEAQGSKPNIQKLADKISGIFVPVVLVIALITFIATWAVSGILL
EECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAIMHSVAVLVIACPCALGLATPTAIISGTGLAAKNGLLIKNANALELAGLVKTVFFDKT
HHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCC
GTITTGEFELTDFKLLTESEKVTDSFNSIEEKLASDKFKLLASLEAHSNHPLAKSLKFQG
CCEECCEEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCC
DLYELTDLSELAGRGLSAKINGQEYFAGNDKLMTDLNLSVPETDDTVIYLANKEKLLAMA
CHHHHCCHHHHHCCCCEEEECCCEEECCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHH
VFSSSLKDDALKTIQTLQKRGLKTVMLTGDNQNSAEKIQKLVHLDEVKSGLRPEEKAEIV
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
QNSPNSMMVGDGINDAIALASATVGLAMATGSDIAMEAGDVTVTSGQLHKISTFFEVAKK
HCCCCCEEECCCCCHHHHHHHHHHHHEEECCCCCEEECCCEEEECCCHHHHHHHHHHHHH
TISKIKQNYFWAFVYNVIGIPLAAFGLLNPMLAAAAMSLSSVSVILNSLLLTKTKIKNVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8048974; 7876197 [H]