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The map label for this gene is leuS

Identifier: 15672798

GI number: 15672798

Start: 827445

End: 829934

Strand: Direct

Name: leuS

Synonym: L0352

Alternate gene names: 15672798

Gene position: 827445-829934 (Clockwise)

Preceding gene: 15672797

Following gene: 15672799

Centisome position: 34.98

GC content: 39.32

Gene sequence:

>2490_bases
ATGGAATACAATCATCAAGAAATAGAAGCCAAATGGCAAAAATACTGGGCGGATAACAAAACTTTCCGTACAGGAACAGA
TAAAAATAAACCAAAATTTTATGCTCTAGATATGTTCCCTTATCCATCTGGTGCAGGACTTCACGTTGGACACCCAGAAG
GTTATACCGCAACTGATATTTTGAGCCGTTACAAACGCGCTCAAGGGTTCAATGTTCTTCATCCAATGGGCTGGGATGCC
TTTGGTTTACCTGCTGAACAATATGCAATGGATACAGGAAATGACCCAGCAGAATTTACAGCTGAAAATATTGCTAACTT
TAAACGTCAAATCAATAGCTTAGGCTTTAGTTATGACTGGGAACGTGAAGTTAATACAACTGACCCAAATTTTTATAAAT
GGACACAGTGGATTTTTACTAAACTTTATGAAAAAGGGTTAGCTTATGAAGCAGAAGTAGCTGTTAACTGGGTTGAAGAA
CTCGGAACGGCTATTGCTAATGAAGAAGTGCTTCCAGACGGAACTTCTGAACGCGGGGGTTATCCTGTTGTTCGTAAACC
AATGCGCCAATGGATGCTTAAAATTACAGCTTATGCGGAACGTTTACTTGAAGACCTTGAAGAAGTTGATTGGCCTGAAT
CAATCAAAGAAATGCAACGGAATTGGATAGGGAAATCAGTAGGAGCAGATGTGACTTTTGAAGTTGCAGGAACCGACAAA
TCATTTGAAGTCTTTACGACTCGTCCTGATACCCTTTTTGGGGCAACTTATGCTGTGCTTGCACCTGAACATGATTTAGT
TGATGCTATTACGACACCTGAGCAAAAAGAAGCTGTTGCTGAATACCGTCGCAAAGCGAGCTTGAAATCTGATTTAGCCC
GTACAGACCTTTCTAAAGAAAAAACTGGAGCATTTACCGGAGCTTACGCGATTAACCCAATTAATGGCCGTAAAATGCCA
ATTTGGGTTGCAGATTATGTTCTTGCTTCTTATGGACATGGTGCTGTTATGGCAGTTCCTGCTCACGACGAACGTGACTG
GGAATTTGCTAAGGTCTATGGACTTGAAATTTTGCCTGTTGTTGAAGGTGGAAATGTAGAAGAAGCTGTTTATACAGAAG
ATGGCCCTCATATTAATTCAGAATTTTTGAATGGACTTGACAAAGCACAAGCGATTGAAAAAGCCATTGAATTTTTAGAA
GAAAAGAAAATTGGGAAAAAGAAAATCACTTACCGCTTGCGCGACTGGCTCTTTAGTCGTCAACGTTATTGGGGTGAACC
AATTCCAATTATTCATTGGGAAGATGGCACATCAACAGCGCTCTCAGAAGATGAACTTCCTCTTGTTTTACCAGTAACCT
CTGATATCAAACCGTCAGGAACTGGTGAGTCTCCTTTGGCTAACTTGACAGATTGGTTGGAAGTCACACGCGCAGATGGC
CTAAAAGGTCGCCGTGAAACTAATACAATGCCACAATGGGCAGGTTCAAGTTGGTATTACCTTCGCTATATTGACCCAAA
TAATAGCGAAGCTTTGGCAGACCCAGAACTTCTCAAAGAATGGTTGCCAGTTGATATCTATGTGGGAGGGGCTGAACATG
CTGTTCTTCACTTACTTTACGCTCGTTTCTGGCATAAAGTGCTTTATGATTTAGGAGTTGTTCCAACTAAAGAACCTTTC
CAAAAACTCTTTAACCAAGGAATGATTCTCGGAACCTCTTATCGTGATCATCGTGGGGCCTTGGTTGCAACTGATAAGGT
TGAAAAACGTGATGGTGGCTTTTACCATATGGAAACAGGTGAAGCCCTTGAACAAGCTCCAGCTAAAATGTCTAAATCTC
TTAAAAATGTTGTTAATCCTGATGATGTTGTTGAACATTATGGAGCTGATACTTTACGTGTTTATGAAATGTTCATGGGT
CCACTTGATGCAAGTATTCCATGGTCAGAAGAAGGCCTTGAAGGGGCTCGTAAATTCCTAGACCGAGCTGTTCGAATGAT
TGAAAATTCAGAGATTAAAGCTGAAAATAATGGAGAGTTGGACAAAGTTTACAATGAAACAGTGAAAAATGTTACTGAGC
GTTTGGACTTGATGTACTTTAACACTGCAATTTCCCAATTAATGATTTTTGTTAATGCAGTTAATAAAGCAAAAGCTTTA
CCGTTAGAATACGCTAATGGCTTTGTCCAACTTTTGGCGCCATTTGCACCACATATTGCTGAAGAACTTTGGGTAAAATT
AGGTAATGAAGCTGGAATTTCTTATGTTGCTTGGCCAACATTTGACGAAAGCAAATTAATTGAATCAGAAGTTGAAATTG
TTGTTCAAATTAATGGTAAATTAAAAGCAAAAATTAAAATTGCTAAAGATTTAGCGCGTGAAGAACTTGAAAAAATTGGT
CGTGAATCAGTTGCTGAGGCTCTTGAAGGTAAAAACGTGGTCAAAGTAATTGCTGTTCCAAATAAATTAGTTAATATTGT
TGTAAAATAA

Upstream 100 bases:

>100_bases
GACCTAACTCTCGCTTATAATTTATTATAAAAGACAATTTACATTAGCAATATTATGAGAAAGGAACTGAGTTTAATAAA
ATTGAACTCAAATCTTTAAT

Downstream 100 bases:

>100_bases
AGATGACAATCTGAACATTTATCAGTTAAATCTTATAATAATTAGCTGTCAGTAAAAAAAATGAGAGCTAAAGAATAAAA
AGTAAAATAAGCTGGTTGAC

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS

Number of amino acids: Translated: 829; Mature: 829

Protein sequence:

>829_residues
MEYNHQEIEAKWQKYWADNKTFRTGTDKNKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRYKRAQGFNVLHPMGWDA
FGLPAEQYAMDTGNDPAEFTAENIANFKRQINSLGFSYDWEREVNTTDPNFYKWTQWIFTKLYEKGLAYEAEVAVNWVEE
LGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKEMQRNWIGKSVGADVTFEVAGTDK
SFEVFTTRPDTLFGATYAVLAPEHDLVDAITTPEQKEAVAEYRRKASLKSDLARTDLSKEKTGAFTGAYAINPINGRKMP
IWVADYVLASYGHGAVMAVPAHDERDWEFAKVYGLEILPVVEGGNVEEAVYTEDGPHINSEFLNGLDKAQAIEKAIEFLE
EKKIGKKKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKPSGTGESPLANLTDWLEVTRADG
LKGRRETNTMPQWAGSSWYYLRYIDPNNSEALADPELLKEWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPF
QKLFNQGMILGTSYRDHRGALVATDKVEKRDGGFYHMETGEALEQAPAKMSKSLKNVVNPDDVVEHYGADTLRVYEMFMG
PLDASIPWSEEGLEGARKFLDRAVRMIENSEIKAENNGELDKVYNETVKNVTERLDLMYFNTAISQLMIFVNAVNKAKAL
PLEYANGFVQLLAPFAPHIAEELWVKLGNEAGISYVAWPTFDESKLIESEVEIVVQINGKLKAKIKIAKDLAREELEKIG
RESVAEALEGKNVVKVIAVPNKLVNIVVK

Sequences:

>Translated_829_residues
MEYNHQEIEAKWQKYWADNKTFRTGTDKNKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRYKRAQGFNVLHPMGWDA
FGLPAEQYAMDTGNDPAEFTAENIANFKRQINSLGFSYDWEREVNTTDPNFYKWTQWIFTKLYEKGLAYEAEVAVNWVEE
LGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKEMQRNWIGKSVGADVTFEVAGTDK
SFEVFTTRPDTLFGATYAVLAPEHDLVDAITTPEQKEAVAEYRRKASLKSDLARTDLSKEKTGAFTGAYAINPINGRKMP
IWVADYVLASYGHGAVMAVPAHDERDWEFAKVYGLEILPVVEGGNVEEAVYTEDGPHINSEFLNGLDKAQAIEKAIEFLE
EKKIGKKKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKPSGTGESPLANLTDWLEVTRADG
LKGRRETNTMPQWAGSSWYYLRYIDPNNSEALADPELLKEWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPF
QKLFNQGMILGTSYRDHRGALVATDKVEKRDGGFYHMETGEALEQAPAKMSKSLKNVVNPDDVVEHYGADTLRVYEMFMG
PLDASIPWSEEGLEGARKFLDRAVRMIENSEIKAENNGELDKVYNETVKNVTERLDLMYFNTAISQLMIFVNAVNKAKAL
PLEYANGFVQLLAPFAPHIAEELWVKLGNEAGISYVAWPTFDESKLIESEVEIVVQINGKLKAKIKIAKDLAREELEKIG
RESVAEALEGKNVVKVIAVPNKLVNIVVK
>Mature_829_residues
MEYNHQEIEAKWQKYWADNKTFRTGTDKNKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRYKRAQGFNVLHPMGWDA
FGLPAEQYAMDTGNDPAEFTAENIANFKRQINSLGFSYDWEREVNTTDPNFYKWTQWIFTKLYEKGLAYEAEVAVNWVEE
LGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKEMQRNWIGKSVGADVTFEVAGTDK
SFEVFTTRPDTLFGATYAVLAPEHDLVDAITTPEQKEAVAEYRRKASLKSDLARTDLSKEKTGAFTGAYAINPINGRKMP
IWVADYVLASYGHGAVMAVPAHDERDWEFAKVYGLEILPVVEGGNVEEAVYTEDGPHINSEFLNGLDKAQAIEKAIEFLE
EKKIGKKKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKPSGTGESPLANLTDWLEVTRADG
LKGRRETNTMPQWAGSSWYYLRYIDPNNSEALADPELLKEWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPF
QKLFNQGMILGTSYRDHRGALVATDKVEKRDGGFYHMETGEALEQAPAKMSKSLKNVVNPDDVVEHYGADTLRVYEMFMG
PLDASIPWSEEGLEGARKFLDRAVRMIENSEIKAENNGELDKVYNETVKNVTERLDLMYFNTAISQLMIFVNAVNKAKAL
PLEYANGFVQLLAPFAPHIAEELWVKLGNEAGISYVAWPTFDESKLIESEVEIVVQINGKLKAKIKIAKDLAREELEKIG
RESVAEALEGKNVVKVIAVPNKLVNIVVK

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7661872, Length=879, Percent_Identity=33.3333333333333, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI94721239, Length=181, Percent_Identity=28.7292817679558, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI94721241, Length=181, Percent_Identity=28.7292817679558, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1786861, Length=866, Percent_Identity=41.6859122401848, Blast_Score=659, Evalue=0.0,
Organism=Escherichia coli, GI1790708, Length=391, Percent_Identity=25.8312020460358, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71997510, Length=270, Percent_Identity=40, Blast_Score=199, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI71997517, Length=270, Percent_Identity=40, Blast_Score=199, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI212645227, Length=323, Percent_Identity=30.6501547987616, Blast_Score=152, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6323414, Length=851, Percent_Identity=34.4300822561692, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6321531, Length=425, Percent_Identity=26.3529411764706, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319395, Length=180, Percent_Identity=28.3333333333333, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21355409, Length=841, Percent_Identity=31.7479191438763, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17864482, Length=456, Percent_Identity=23.6842105263158, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24653289, Length=456, Percent_Identity=23.6842105263158, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281366294, Length=726, Percent_Identity=22.8650137741047, Blast_Score=80, Evalue=6e-15,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYL_LACLA (Q9CHB6)

Other databases:

- EMBL:   AE005176
- PIR:   H86726
- RefSeq:   NP_266972.1
- ProteinModelPortal:   Q9CHB6
- SMR:   Q9CHB6
- GeneID:   1114443
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0352
- NMPDR:   fig|272623.1.peg.836
- HOGENOM:   HBG693845
- OMA:   ERGNFPV
- ProtClustDB:   PRK00390
- BioCyc:   LLAC272623:L0352-MONOMER
- BRENDA:   6.1.1.4
- GO:   GO:0005737
- HAMAP:   MF_00049_B
- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11946:SF7
- PRINTS:   PR00985
- TIGRFAMs:   TIGR00396

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1; SSF47323 tRNAsyn_1a_bind; SSF50677 ValRS_IleRS_edit

EC number: =6.1.1.4

Molecular weight: Translated: 93792; Mature: 93792

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 612-612

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYNHQEIEAKWQKYWADNKTFRTGTDKNKPKFYALDMFPYPSGAGLHVGHPEGYTATDI
CCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEECCCCCCCCEECCCCCCCCHHHH
LSRYKRAQGFNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINSLGFSYDW
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
EREVNTTDPNFYKWTQWIFTKLYEKGLAYEAEVAVNWVEELGTAIANEEVLPDGTSERGG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
YPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKEMQRNWIGKSVGADVTFEVAGTDK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCC
SFEVFTTRPDTLFGATYAVLAPEHDLVDAITTPEQKEAVAEYRRKASLKSDLARTDLSKE
CEEEEECCCCCHHCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
KTGAFTGAYAINPINGRKMPIWVADYVLASYGHGAVMAVPAHDERDWEFAKVYGLEILPV
HCCCEECEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECEEEEEE
VEGGNVEEAVYTEDGPHINSEFLNGLDKAQAIEKAIEFLEEKKIGKKKITYRLRDWLFSR
ECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKPSGTGESPLANLTDWLEVTRADG
HHHCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LKGRRETNTMPQWAGSSWYYLRYIDPNNSEALADPELLKEWLPVDIYVGGAEHAVLHLLY
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHH
ARFWHKVLYDLGVVPTKEPFQKLFNQGMILGTSYRDHRGALVATDKVEKRDGGFYHMETG
HHHHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCCCCCCCEEEECCCHHCCCCEEEECCC
EALEQAPAKMSKSLKNVVNPDDVVEHYGADTLRVYEMFMGPLDASIPWSEEGLEGARKFL
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DRAVRMIENSEIKAENNGELDKVYNETVKNVTERLDLMYFNTAISQLMIFVNAVNKAKAL
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PLEYANGFVQLLAPFAPHIAEELWVKLGNEAGISYVAWPTFDESKLIESEVEIVVQINGK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCEEEEEEECCC
LKAKIKIAKDLAREELEKIGRESVAEALEGKNVVKVIAVPNKLVNIVVK
EEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHEEEECC
>Mature Secondary Structure
MEYNHQEIEAKWQKYWADNKTFRTGTDKNKPKFYALDMFPYPSGAGLHVGHPEGYTATDI
CCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEECCCCCCCCEECCCCCCCCHHHH
LSRYKRAQGFNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINSLGFSYDW
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
EREVNTTDPNFYKWTQWIFTKLYEKGLAYEAEVAVNWVEELGTAIANEEVLPDGTSERGG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
YPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKEMQRNWIGKSVGADVTFEVAGTDK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCC
SFEVFTTRPDTLFGATYAVLAPEHDLVDAITTPEQKEAVAEYRRKASLKSDLARTDLSKE
CEEEEECCCCCHHCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
KTGAFTGAYAINPINGRKMPIWVADYVLASYGHGAVMAVPAHDERDWEFAKVYGLEILPV
HCCCEECEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECEEEEEE
VEGGNVEEAVYTEDGPHINSEFLNGLDKAQAIEKAIEFLEEKKIGKKKITYRLRDWLFSR
ECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKPSGTGESPLANLTDWLEVTRADG
HHHCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LKGRRETNTMPQWAGSSWYYLRYIDPNNSEALADPELLKEWLPVDIYVGGAEHAVLHLLY
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHH
ARFWHKVLYDLGVVPTKEPFQKLFNQGMILGTSYRDHRGALVATDKVEKRDGGFYHMETG
HHHHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCCCCCCCEEEECCCHHCCCCEEEECCC
EALEQAPAKMSKSLKNVVNPDDVVEHYGADTLRVYEMFMGPLDASIPWSEEGLEGARKFL
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DRAVRMIENSEIKAENNGELDKVYNETVKNVTERLDLMYFNTAISQLMIFVNAVNKAKAL
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PLEYANGFVQLLAPFAPHIAEELWVKLGNEAGISYVAWPTFDESKLIESEVEIVVQINGK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCEEEEEEECCC
LKAKIKIAKDLAREELEKIGRESVAEALEGKNVVKVIAVPNKLVNIVVK
EEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471