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The map label for this gene is prsA

Identifier: 15672796

GI number: 15672796

Start: 825656

End: 826630

Strand: Direct

Name: prsA

Synonym: L25614

Alternate gene names: 15672796

Gene position: 825656-826630 (Clockwise)

Preceding gene: 15672795

Following gene: 15672797

Centisome position: 34.9

GC content: 40.82

Gene sequence:

>975_bases
ATGTCGTATTCAAATTTGAAGTTGTTTTCGCTCTCTTCTAACCACGAATTAGCCCAAAAAGTGGCTAAAGAAATTGGAAT
TGAGCTTGGAAAAGTAAGTGTTGGTGCACATTCGGATGGCGAAACTGTCGTTCATATTGACGAATCAGTTCGTGGTGATC
ATGTGTTTATCCTTCAATCAACAAGTGACCCTGTCAATGATAACTTGATGGAACTCTTGATTATGATGGATGCATTGCGT
CGTGCCTCTGCTGCATCAATTAACATTGTCTTACCTTACTATGGTTATGCTCGTCAAGACCGTAAAGCTCGTGCTCGTGA
ACCAATCACATCAAAACTCGTAGCAAACATGCTTCAAATTGCTGGTGCCGACCGTTTAATTACTTTCGACCTTCACGCAC
CACAAATTCAAGGATTCTTCAACATTCCAGTTGACCACCTTATGGGTTCACCATTGATTGCTGAATATTTCCGTCGTCAA
TTGGTTTCTGCTGGTGATGATATCGTTGTCGTTTCGCCTGACCATGGTGGAGTAGGACGTGCGCGCAAGTTAGCAAACTT
CTTGAAAGCACCACTTTCTATCATTGATAAACGTCGTCCTCGTGCCAATGTGGCAGAAATTATGAATATCATCGGTGATG
TTCAAGGGAAAAAATGTATCTTGATTGATGACATGATTGATACGGCTGGAACAATTACTTTAGCGGCCAATGCCCTTAAA
GAACTTGGTGCAACAGAAGTCTACGCTTCATGTACTCATGCCGTACTTTCAGGACCAGCTATAGAGAGAATTAATAATTC
AGCAATTACTAAACTCGTTGTTTTGGATACTATTGAAATGCCAGAAGAACGTCAAAGTGAAAAAATTGTTCAACTTTCAA
TTGCTCACTTGCTTGCTGATGCGATTATTCGTATTCACGAACGCCGTCCATTGTCACCACTCTTTGAATTACATCTTCCT
TCAGAACAAATCTAA

Upstream 100 bases:

>100_bases
TAAAGCCGATGAGCGTTTGAAAAAATTGAGAATTTAATGTAAAATAGAATTACATAAAATAGAACTGCTATGTTCTGTAG
GAATTAAAGAAAGGCTCTTC

Downstream 100 bases:

>100_bases
ACTAGTAATTGTTGGAATTCAAAGTGGATTTAGGATAAGACTTCAAGCGACCAGAGGTCGCTTTTTTAAAAAATGGAACT
AGAAAAAATTAGAAAACTTT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK 1; Phosphoribosyl pyrophosphate synthase 1; P-Rib-PP synthase 1; PRPP synthase 1

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSYSNLKLFSLSSNHELAQKVAKEIGIELGKVSVGAHSDGETVVHIDESVRGDHVFILQSTSDPVNDNLMELLIMMDALR
RASAASINIVLPYYGYARQDRKARAREPITSKLVANMLQIAGADRLITFDLHAPQIQGFFNIPVDHLMGSPLIAEYFRRQ
LVSAGDDIVVVSPDHGGVGRARKLANFLKAPLSIIDKRRPRANVAEIMNIIGDVQGKKCILIDDMIDTAGTITLAANALK
ELGATEVYASCTHAVLSGPAIERINNSAITKLVVLDTIEMPEERQSEKIVQLSIAHLLADAIIRIHERRPLSPLFELHLP
SEQI

Sequences:

>Translated_324_residues
MSYSNLKLFSLSSNHELAQKVAKEIGIELGKVSVGAHSDGETVVHIDESVRGDHVFILQSTSDPVNDNLMELLIMMDALR
RASAASINIVLPYYGYARQDRKARAREPITSKLVANMLQIAGADRLITFDLHAPQIQGFFNIPVDHLMGSPLIAEYFRRQ
LVSAGDDIVVVSPDHGGVGRARKLANFLKAPLSIIDKRRPRANVAEIMNIIGDVQGKKCILIDDMIDTAGTITLAANALK
ELGATEVYASCTHAVLSGPAIERINNSAITKLVVLDTIEMPEERQSEKIVQLSIAHLLADAIIRIHERRPLSPLFELHLP
SEQI
>Mature_323_residues
SYSNLKLFSLSSNHELAQKVAKEIGIELGKVSVGAHSDGETVVHIDESVRGDHVFILQSTSDPVNDNLMELLIMMDALRR
ASAASINIVLPYYGYARQDRKARAREPITSKLVANMLQIAGADRLITFDLHAPQIQGFFNIPVDHLMGSPLIAEYFRRQL
VSAGDDIVVVSPDHGGVGRARKLANFLKAPLSIIDKRRPRANVAEIMNIIGDVQGKKCILIDDMIDTAGTITLAANALKE
LGATEVYASCTHAVLSGPAIERINNSAITKLVVLDTIEMPEERQSEKIVQLSIAHLLADAIIRIHERRPLSPLFELHLPS
EQI

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family

Homologues:

Organism=Homo sapiens, GI4506127, Length=319, Percent_Identity=48.2758620689655, Blast_Score=295, Evalue=5e-80,
Organism=Homo sapiens, GI4506129, Length=319, Percent_Identity=47.9623824451411, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI28557709, Length=317, Percent_Identity=47.6340694006309, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI84875539, Length=322, Percent_Identity=47.5155279503106, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI4506133, Length=350, Percent_Identity=37.4285714285714, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI194018537, Length=347, Percent_Identity=35.7348703170029, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI310128524, Length=150, Percent_Identity=35.3333333333333, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310115209, Length=150, Percent_Identity=35.3333333333333, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310118259, Length=150, Percent_Identity=35.3333333333333, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310119946, Length=150, Percent_Identity=35.3333333333333, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=52.0634920634921, Blast_Score=317, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI25149168, Length=317, Percent_Identity=46.3722397476341, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17554702, Length=317, Percent_Identity=46.3722397476341, Blast_Score=283, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI71989924, Length=317, Percent_Identity=46.3722397476341, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17554704, Length=314, Percent_Identity=46.1783439490446, Blast_Score=280, Evalue=8e-76,
Organism=Caenorhabditis elegans, GI17570245, Length=343, Percent_Identity=33.8192419825073, Blast_Score=181, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6319403, Length=322, Percent_Identity=43.7888198757764, Blast_Score=253, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6320946, Length=322, Percent_Identity=42.5465838509317, Blast_Score=249, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6321776, Length=318, Percent_Identity=42.7672955974843, Blast_Score=242, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6322667, Length=198, Percent_Identity=41.4141414141414, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=112, Percent_Identity=41.9642857142857, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355239, Length=314, Percent_Identity=47.4522292993631, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI45551540, Length=337, Percent_Identity=44.5103857566766, Blast_Score=274, Evalue=7e-74,
Organism=Drosophila melanogaster, GI24651458, Length=358, Percent_Identity=33.7988826815642, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24651456, Length=358, Percent_Identity=33.7988826815642, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI281362873, Length=358, Percent_Identity=33.7988826815642, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24651454, Length=358, Percent_Identity=33.7988826815642, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24651462, Length=206, Percent_Identity=37.8640776699029, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24651464, Length=206, Percent_Identity=37.8640776699029, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI45552010, Length=206, Percent_Identity=37.8640776699029, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KPRS1_LACLA (Q9CHB8)

Other databases:

- EMBL:   AE005176
- PIR:   F86726
- RefSeq:   NP_266970.1
- ProteinModelPortal:   Q9CHB8
- SMR:   Q9CHB8
- GeneID:   1114441
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L25614
- NMPDR:   fig|272623.1.peg.834
- HOGENOM:   HBG519284
- OMA:   CATHAVF
- ProtClustDB:   PRK02269
- BioCyc:   LLAC272623:L25614-MONOMER
- BRENDA:   2.7.6.1
- GO:   GO:0005737
- HAMAP:   MF_00583_B
- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01251

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.7.6.1

Molecular weight: Translated: 35546; Mature: 35414

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00114 PRPP_SYNTHASE; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSNLKLFSLSSNHELAQKVAKEIGIELGKVSVGAHSDGETVVHIDESVRGDHVFILQS
CCCCCEEEEEECCCHHHHHHHHHHHCCEECEEEECCCCCCCEEEEECCCCCCCEEEEEEC
TSDPVNDNLMELLIMMDALRRASAASINIVLPYYGYARQDRKARAREPITSKLVANMLQI
CCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHH
AGADRLITFDLHAPQIQGFFNIPVDHLMGSPLIAEYFRRQLVSAGDDIVVVSPDHGGVGR
CCCCEEEEEECCCCCCCCEECCCHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHH
ARKLANFLKAPLSIIDKRRPRANVAEIMNIIGDVQGKKCILIDDMIDTAGTITLAANALK
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECHHCCCCHHHHHHHHHH
ELGATEVYASCTHAVLSGPAIERINNSAITKLVVLDTIEMPEERQSEKIVQLSIAHLLAD
HCCCHHHHHHHHHHHHCCHHHHHCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
AIIRIHERRPLSPLFELHLPSEQI
HHHHHHCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure 
SYSNLKLFSLSSNHELAQKVAKEIGIELGKVSVGAHSDGETVVHIDESVRGDHVFILQS
CCCCEEEEEECCCHHHHHHHHHHHCCEECEEEECCCCCCCEEEEECCCCCCCEEEEEEC
TSDPVNDNLMELLIMMDALRRASAASINIVLPYYGYARQDRKARAREPITSKLVANMLQI
CCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHH
AGADRLITFDLHAPQIQGFFNIPVDHLMGSPLIAEYFRRQLVSAGDDIVVVSPDHGGVGR
CCCCEEEEEECCCCCCCCEECCCHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHH
ARKLANFLKAPLSIIDKRRPRANVAEIMNIIGDVQGKKCILIDDMIDTAGTITLAANALK
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECHHCCCCHHHHHHHHHH
ELGATEVYASCTHAVLSGPAIERINNSAITKLVVLDTIEMPEERQSEKIVQLSIAHLLAD
HCCCHHHHHHHHHHHHCCHHHHHCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
AIIRIHERRPLSPLFELHLPSEQI
HHHHHHCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471