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The map label for this gene is rnc

Identifier: 15672784

GI number: 15672784

Start: 809461

End: 810156

Strand: Direct

Name: rnc

Synonym: L0326

Alternate gene names: 15672784

Gene position: 809461-810156 (Clockwise)

Preceding gene: 15672783

Following gene: 15672785

Centisome position: 34.22

GC content: 37.36

Gene sequence:

>696_bases
ATGCTCAAGCTTCAAAAAAAATTAAAAAATGATTACGGATTAGTCTTCAATGATGAAGATTTATTAAAAACAGCTTTTAC
ACACTCTTCATTTACAAATGAAGAACGGCTCCCAAAGATTGCAAACAATGAACGTTTGGAATTTTTGGGAGACGTTGCCC
TATCTTTGGTTATTTCTGATTATCTTTATCGGACTTATCCTGAGAAATTAGAGGGAGAACTTTCCAAAATGCGCTCAAGC
ATTGTTCGGACAGAATCACTTGCTAATTTTTCACGCTCATGCGGTTTTGGTGAGTTCTTGCGATTAGGTCATGGTGAAGA
AAAAATGGGCGGTCGTGACCGCGAAACAACACTAGAGAACCTTTTTGAGGCTTTTTTAGGTGCGCTTTTTATTGACCAAG
GAATGGATGAAGTTCGTAAATTTATCCAACATGTAGTCATTCCTCACGTTAAAAATGATGATTATGTTAAAGTGATTGAC
TATAAAACAGAACTTCAAGAAGTGTTACAAATTGGTGGAGAAACAACGATTAGCTACAAGATTCTGAAAGAAGAAGGGCC
AGCTCATGACCGTTCCTTTGTGGCCGCGGTTTTTAACAATGGTAAAGAACTCGGACGAGGGCTTGGAAAATCTAAAAAAG
TTGCAGAACAAAAAGCAGCAGAAAATGCAATAAAAGGGCAAAACCATGTATCTTAA

Upstream 100 bases:

>100_bases
AGTCCCGTTCCACAGGGAAAGGCATACAAAAAAGGTTTTTTTTGGTATAATAAGGGATAAAACTAAAAATTAAGAGAAGT
TTTAAGTGAAGGAGATTTTT

Downstream 100 bases:

>100_bases
AAAAATGGAAATTGTCGGCTTCAAATCTTTTGCCGATAAGACTAAAGTTGAATTTGATAAAGGGATAACCGCAGTTGTCG
GTCCAAATGGTTCTGGGAAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MLKLQKKLKNDYGLVFNDEDLLKTAFTHSSFTNEERLPKIANNERLEFLGDVALSLVISDYLYRTYPEKLEGELSKMRSS
IVRTESLANFSRSCGFGEFLRLGHGEEKMGGRDRETTLENLFEAFLGALFIDQGMDEVRKFIQHVVIPHVKNDDYVKVID
YKTELQEVLQIGGETTISYKILKEEGPAHDRSFVAAVFNNGKELGRGLGKSKKVAEQKAAENAIKGQNHVS

Sequences:

>Translated_231_residues
MLKLQKKLKNDYGLVFNDEDLLKTAFTHSSFTNEERLPKIANNERLEFLGDVALSLVISDYLYRTYPEKLEGELSKMRSS
IVRTESLANFSRSCGFGEFLRLGHGEEKMGGRDRETTLENLFEAFLGALFIDQGMDEVRKFIQHVVIPHVKNDDYVKVID
YKTELQEVLQIGGETTISYKILKEEGPAHDRSFVAAVFNNGKELGRGLGKSKKVAEQKAAENAIKGQNHVS
>Mature_231_residues
MLKLQKKLKNDYGLVFNDEDLLKTAFTHSSFTNEERLPKIANNERLEFLGDVALSLVISDYLYRTYPEKLEGELSKMRSS
IVRTESLANFSRSCGFGEFLRLGHGEEKMGGRDRETTLENLFEAFLGALFIDQGMDEVRKFIQHVVIPHVKNDDYVKVID
YKTELQEVLQIGGETTISYKILKEEGPAHDRSFVAAVFNNGKELGRGLGKSKKVAEQKAAENAIKGQNHVS

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=236, Percent_Identity=32.2033898305085, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI155030236, Length=236, Percent_Identity=32.2033898305085, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1788920, Length=215, Percent_Identity=38.1395348837209, Blast_Score=122, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17506883, Length=225, Percent_Identity=34.2222222222222, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193202651, Length=225, Percent_Identity=34.2222222222222, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323895, Length=206, Percent_Identity=27.6699029126214, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17137682, Length=237, Percent_Identity=33.7552742616034, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_LACLA (Q9CHD0)

Other databases:

- EMBL:   AE005176
- PIR:   B86725
- RefSeq:   NP_266958.1
- ProteinModelPortal:   Q9CHD0
- SMR:   Q9CHD0
- GeneID:   1114429
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0326
- NMPDR:   fig|272623.1.peg.822
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   LLAC272623:L0326-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26137; Mature: 26137

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLQKKLKNDYGLVFNDEDLLKTAFTHSSFTNEERLPKIANNERLEFLGDVALSLVISD
CCCHHHHHCCCCCEEECCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHH
YLYRTYPEKLEGELSKMRSSIVRTESLANFSRSCGFGEFLRLGHGEEKMGGRDRETTLEN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHCCCCCHHHHHHH
LFEAFLGALFIDQGMDEVRKFIQHVVIPHVKNDDYVKVIDYKTELQEVLQIGGETTISYK
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCEEEEE
ILKEEGPAHDRSFVAAVFNNGKELGRGLGKSKKVAEQKAAENAIKGQNHVS
EECCCCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLKLQKKLKNDYGLVFNDEDLLKTAFTHSSFTNEERLPKIANNERLEFLGDVALSLVISD
CCCHHHHHCCCCCEEECCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHH
YLYRTYPEKLEGELSKMRSSIVRTESLANFSRSCGFGEFLRLGHGEEKMGGRDRETTLEN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHCCCCCHHHHHHH
LFEAFLGALFIDQGMDEVRKFIQHVVIPHVKNDDYVKVIDYKTELQEVLQIGGETTISYK
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCEEEEE
ILKEEGPAHDRSFVAAVFNNGKELGRGLGKSKKVAEQKAAENAIKGQNHVS
EECCCCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471