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The map label for this gene is argF

Identifier: 15672783

GI number: 15672783

Start: 808287

End: 809288

Strand: Direct

Name: argF

Synonym: L0108

Alternate gene names: 15672783

Gene position: 808287-809288 (Clockwise)

Preceding gene: 15672782

Following gene: 15672784

Centisome position: 34.17

GC content: 33.03

Gene sequence:

>1002_bases
ATGTTTCAAGGAAGAAGTTTTTTAAAAGAAATAGATTTTAGTAAAGATGAATTGTTATATCTGATTGATTTTGCAATTCA
TCTTAAAAAGTTAAAAAAAGAACATATTCAACATAAATATTTATTAGATAAAAATATTGCCCTTATTTTTGAAAAAACAT
CTACCAGAACAAGAGCAGCTTTTACAACGGCCGCTGTAGATTTGGGAGCACATCCTGAATTTTTAGGGCCAAATGATATT
CAGTTGGGCAAAAAAGAATCTATTTCAGATACGGCGAAAGTTTTGGGTTCAATGTTTGATGGCATTGAGTTTCGTGGGTT
TAAGCAAAGTGATGTGGAAATTCTAGCCAAGGATTCAGGTAGACCCGTTTGGAATGGATTGACTGATGTTTGGCATCCGA
CACAGATGCTGGCAGATTTTATGACAATCAAGGAGCATTTTGGCCATTTACAAGATTTAACCCTCGCTTATGTTGGTGAT
GGACGAAATAATGTGGCAAATTCTCTATTAGTGACTGGAGCAATTTTAGGCGTAAATATCACAATTATTTCGCCAGAGTC
CTTGCAACCCGCTTTAGAAATACAAAAACTGGCACGTAAATATGCCATGAAAAGTCGCAGTAAAATAAGTATCCGAACAG
ATTTAAATGGACTTGAAAATGCTGATATTGTTTATACTGATGTTTGGGTCAGTATGGGTGAGGAAGCTCAAACAGCCAAG
CGAATTAAATTATTGAAATCCTATCAAATTAATCAAAAAGTTGTTGAAAAAATTATTAATAAAAACTTTATTTTTATGCA
TTGTTTACCCAGCTTTCATGATTTAAACACGGAAGTGATGAAAGAAATTAAGGAAAATTATAACCTTAATGAATTAGAGG
TTACTGATGAAGTTTTTAATTCAAAGAATTCGGTCGTTTTTGAACAAGCTGAAAATCGAATGCATACCATAAAAGAAGTC
ATGGCGGCTACTTTAGGGGATTTATTTATTCCTAAAATATAA

Upstream 100 bases:

>100_bases
TGGCCGTGTTCCGCACGCCTTATTATTGGAATTATTTACTGACAAAGGGCAAGGGACAATGATAAATCATTGATAATTTA
AGCAAATAAGAGGAGAGAGA

Downstream 100 bases:

>100_bases
AAAAAGAGAAAAAGCGTTAATTAAGGGGGAATAGCCCAGATTTAATGTTTTTTCTCTTTTTTATGGCGCAAAAGTCCCGT
TCCACAGGGAAAGGCATACA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MFQGRSFLKEIDFSKDELLYLIDFAIHLKKLKKEHIQHKYLLDKNIALIFEKTSTRTRAAFTTAAVDLGAHPEFLGPNDI
QLGKKESISDTAKVLGSMFDGIEFRGFKQSDVEILAKDSGRPVWNGLTDVWHPTQMLADFMTIKEHFGHLQDLTLAYVGD
GRNNVANSLLVTGAILGVNITIISPESLQPALEIQKLARKYAMKSRSKISIRTDLNGLENADIVYTDVWVSMGEEAQTAK
RIKLLKSYQINQKVVEKIINKNFIFMHCLPSFHDLNTEVMKEIKENYNLNELEVTDEVFNSKNSVVFEQAENRMHTIKEV
MAATLGDLFIPKI

Sequences:

>Translated_333_residues
MFQGRSFLKEIDFSKDELLYLIDFAIHLKKLKKEHIQHKYLLDKNIALIFEKTSTRTRAAFTTAAVDLGAHPEFLGPNDI
QLGKKESISDTAKVLGSMFDGIEFRGFKQSDVEILAKDSGRPVWNGLTDVWHPTQMLADFMTIKEHFGHLQDLTLAYVGD
GRNNVANSLLVTGAILGVNITIISPESLQPALEIQKLARKYAMKSRSKISIRTDLNGLENADIVYTDVWVSMGEEAQTAK
RIKLLKSYQINQKVVEKIINKNFIFMHCLPSFHDLNTEVMKEIKENYNLNELEVTDEVFNSKNSVVFEQAENRMHTIKEV
MAATLGDLFIPKI
>Mature_333_residues
MFQGRSFLKEIDFSKDELLYLIDFAIHLKKLKKEHIQHKYLLDKNIALIFEKTSTRTRAAFTTAAVDLGAHPEFLGPNDI
QLGKKESISDTAKVLGSMFDGIEFRGFKQSDVEILAKDSGRPVWNGLTDVWHPTQMLADFMTIKEHFGHLQDLTLAYVGD
GRNNVANSLLVTGAILGVNITIISPESLQPALEIQKLARKYAMKSRSKISIRTDLNGLENADIVYTDVWVSMGEEAQTAK
RIKLLKSYQINQKVVEKIINKNFIFMHCLPSFHDLNTEVMKEIKENYNLNELEVTDEVFNSKNSVVFEQAENRMHTIKEV
MAATLGDLFIPKI

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=334, Percent_Identity=37.125748502994, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI18105007, Length=325, Percent_Identity=24, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1790703, Length=329, Percent_Identity=48.3282674772036, Blast_Score=314, Evalue=5e-87,
Organism=Escherichia coli, GI1786469, Length=328, Percent_Identity=48.1707317073171, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI48994908, Length=365, Percent_Identity=24.3835616438356, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI2367364, Length=153, Percent_Identity=37.2549019607843, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193204318, Length=135, Percent_Identity=32.5925925925926, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322373, Length=335, Percent_Identity=36.1194029850746, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6322331, Length=281, Percent_Identity=25.9786476868327, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24642586, Length=331, Percent_Identity=25.6797583081571, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): OTC_LACLA (Q9CHD1)

Other databases:

- EMBL:   AE005176
- PIR:   A86725
- RefSeq:   NP_266957.1
- ProteinModelPortal:   Q9CHD1
- SMR:   Q9CHD1
- GeneID:   1114428
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0108
- NMPDR:   fig|272623.1.peg.821
- HOGENOM:   HBG579429
- OMA:   FMTIKEH
- ProtClustDB:   PRK02102
- BioCyc:   LLAC272623:L0108-MONOMER
- BRENDA:   2.1.3.3
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 37822; Mature: 37822

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 105-105 BINDING 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQGRSFLKEIDFSKDELLYLIDFAIHLKKLKKEHIQHKYLLDKNIALIFEKTSTRTRAA
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
FTTAAVDLGAHPEFLGPNDIQLGKKESISDTAKVLGSMFDGIEFRGFKQSDVEILAKDSG
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCC
RPVWNGLTDVWHPTQMLADFMTIKEHFGHLQDLTLAYVGDGRNNVANSLLVTGAILGVNI
CCHHCCHHHHCCHHHHHHHHHHHHHHHCCHHHCEEEEECCCCHHHHHHHHHHHHEEEEEE
TIISPESLQPALEIQKLARKYAMKSRSKISIRTDLNGLENADIVYTDVWVSMGEEAQTAK
EEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEHHHHCCCHHHHHH
RIKLLKSYQINQKVVEKIINKNFIFMHCLPSFHDLNTEVMKEIKENYNLNELEVTDEVFN
HHHHHHHHCCCHHHHHHHHCCCEEEEEECCCHHCCCHHHHHHHHHCCCCCCEEECHHHHC
SKNSVVFEQAENRMHTIKEVMAATLGDLFIPKI
CCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFQGRSFLKEIDFSKDELLYLIDFAIHLKKLKKEHIQHKYLLDKNIALIFEKTSTRTRAA
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
FTTAAVDLGAHPEFLGPNDIQLGKKESISDTAKVLGSMFDGIEFRGFKQSDVEILAKDSG
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCC
RPVWNGLTDVWHPTQMLADFMTIKEHFGHLQDLTLAYVGDGRNNVANSLLVTGAILGVNI
CCHHCCHHHHCCHHHHHHHHHHHHHHHCCHHHCEEEEECCCCHHHHHHHHHHHHEEEEEE
TIISPESLQPALEIQKLARKYAMKSRSKISIRTDLNGLENADIVYTDVWVSMGEEAQTAK
EEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEHHHHCCCHHHHHH
RIKLLKSYQINQKVVEKIINKNFIFMHCLPSFHDLNTEVMKEIKENYNLNELEVTDEVFN
HHHHHHHHCCCHHHHHHHHCCCEEEEEECCCHHCCCHHHHHHHHHCCCCCCEEECHHHHC
SKNSVVFEQAENRMHTIKEVMAATLGDLFIPKI
CCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471