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The map label for this gene is noxC

Identifier: 15672768

GI number: 15672768

Start: 794032

End: 795675

Strand: Direct

Name: noxC

Synonym: L194050

Alternate gene names: 15672768

Gene position: 794032-795675 (Clockwise)

Preceding gene: 15672767

Following gene: 15672769

Centisome position: 33.57

GC content: 37.83

Gene sequence:

>1644_bases
ATGACAGAAAAAATATTAATTGTTGGCGGAGTTGCGGGTGGAATGTCAGCTGCAACCCGTTTGCGACGTCTTAACGAAAA
TGCAGAAATCATCGTTTTTGAAAAAGGCCCTTACGTTTCGTTTGCCAATTGTGGCTTACCTTACTATGTGGGGGGAGAAA
TTGCAGAGCGAGAAAAGTTAATTGTTCAATCTGCTAAAGCTCTAAAAAACCGTTTTAACCTAGAGGTGCGCGAAAATTCC
GAAGTTATTGCGATTGATAGTGAAGGAAAGAAAGTGACTGTAGTTTCAAACGGCGAAAGCTATGTTGAAAGCTATGATAA
ATTGATTCTTTCACCAGGGGCTAAACCCTTAATTCCACAAATCAAAGGTTTGAACCAAGCGACAAATGTTTTTAGCTTAC
GAAATATTCCTGATGTGGATAAAATAATGACCTATTTGAAAGCCAAAGCTCCTAAAAGTGCAACAATTATTGGTGCTGGT
TTTATCGGCTTAGAAATGGCTGAAAATCTTGCTAAACGAGGGTTAAGTGTCACAATCGTCGAAAAAGCACCACATGTTTT
ACCAACCATTGATCGCGAAATGGCAGCTTTTGTCAATGAAGAATTAATTAAAAATAATCTTTCAGTAATGACAAATAGAG
GAGCTGTCGAATTTAAAAATGACGAAATTTTGCTAGATAATGGTGAAAGTCTGCAATCGGATTTAACGATTCTTTCTGTG
GGAATTCAGCCAGAAACGAGTCTAGCTAAAAGTGCGGGCATCAAATTAGGACTAAGAAATGCAATTCTTGTTGACGAACA
TTATGAAACATCGGTTAAGGATATTTACGCAGTAGGCGATGCCATTGTTGTCAAAAATCAATTAGGGCAGGATGCTTTAA
TTTCATTGGCTTCTCCAGCTAATCGTCAAGGGCGTCAGGTAGCTGATATCATTAGTGGATTACCAATTAAAAATCGCGGT
TCACTTGGAACGGCCATTGTCCGTGTTTTTGATTTGCAAGTGGCAAGTACAGGCCTTTCTGAGTTTCAGCTTAGAGGTTT
AAAGATTAATCATAAAATTGTTCATGTCACAGCAAATAATCATGCGGGATATTATCCAGATGTAACTTCTATTGTTTTGA
AATTAATTTTTGAACCAGAAAGTGGACAAATATTTGGTGCGCAAGCAATTGGTAAAGAAGGAGTAGATAAAAGAATTGAT
ATTTTATCTACGGCTATCAAAGCAAAACTAACCGTTTTTGATTTACCAGAATTGGAATTGACCTATGCCCCTCCTTTTGA
TTCAGCCAAGGACCCAGTAAATATGGCTGGCTATGCCGCAATAAACCTTCTCTTGGGGCAATCAGAAAATATTCAGTGGC
ATGAACTTGCGGCTGAATTAGCAAAAGGGAAAGTCTTACTTGATGTGAGAAATCCAAATGAGTTGGCAAAAGGGAAATTT
AAAAATTCTCAAAATATTCCGCTTGATGACTTACGTGAGCGGCTAAATGAACTCGATAAAAAGAATGAATATATTGTTAG
CTGCCAGTCAGGACTTCGCTCTTACAATGCAGAACGTATTCTAAAACAAGAGGGCTACAAAGTGAAAAATTTGGATGGTG
CCTTTGGATTATACAGCAAAGTTACCAAGGAATTACTTGATTAG

Upstream 100 bases:

>100_bases
GAATGCGGTCAAAAAAAGCCTACAAAATATTAAACAGAGCTAATTATGATGTGACAAACGTAAATGGAGGAATGCGAGCT
TGGAGAGGAAAAATTAAAAA

Downstream 100 bases:

>100_bases
GGAGCGAAACAAGAAAAGGATGACTGATGAAAAAATATGACAAAAAAATGAAAAATCGCTTGAAACGAGCGACGGGACAA
CTCACAGGAATACTTAAGAT

Product: NADH oxidase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MTEKILIVGGVAGGMSAATRLRRLNENAEIIVFEKGPYVSFANCGLPYYVGGEIAEREKLIVQSAKALKNRFNLEVRENS
EVIAIDSEGKKVTVVSNGESYVESYDKLILSPGAKPLIPQIKGLNQATNVFSLRNIPDVDKIMTYLKAKAPKSATIIGAG
FIGLEMAENLAKRGLSVTIVEKAPHVLPTIDREMAAFVNEELIKNNLSVMTNRGAVEFKNDEILLDNGESLQSDLTILSV
GIQPETSLAKSAGIKLGLRNAILVDEHYETSVKDIYAVGDAIVVKNQLGQDALISLASPANRQGRQVADIISGLPIKNRG
SLGTAIVRVFDLQVASTGLSEFQLRGLKINHKIVHVTANNHAGYYPDVTSIVLKLIFEPESGQIFGAQAIGKEGVDKRID
ILSTAIKAKLTVFDLPELELTYAPPFDSAKDPVNMAGYAAINLLLGQSENIQWHELAAELAKGKVLLDVRNPNELAKGKF
KNSQNIPLDDLRERLNELDKKNEYIVSCQSGLRSYNAERILKQEGYKVKNLDGAFGLYSKVTKELLD

Sequences:

>Translated_547_residues
MTEKILIVGGVAGGMSAATRLRRLNENAEIIVFEKGPYVSFANCGLPYYVGGEIAEREKLIVQSAKALKNRFNLEVRENS
EVIAIDSEGKKVTVVSNGESYVESYDKLILSPGAKPLIPQIKGLNQATNVFSLRNIPDVDKIMTYLKAKAPKSATIIGAG
FIGLEMAENLAKRGLSVTIVEKAPHVLPTIDREMAAFVNEELIKNNLSVMTNRGAVEFKNDEILLDNGESLQSDLTILSV
GIQPETSLAKSAGIKLGLRNAILVDEHYETSVKDIYAVGDAIVVKNQLGQDALISLASPANRQGRQVADIISGLPIKNRG
SLGTAIVRVFDLQVASTGLSEFQLRGLKINHKIVHVTANNHAGYYPDVTSIVLKLIFEPESGQIFGAQAIGKEGVDKRID
ILSTAIKAKLTVFDLPELELTYAPPFDSAKDPVNMAGYAAINLLLGQSENIQWHELAAELAKGKVLLDVRNPNELAKGKF
KNSQNIPLDDLRERLNELDKKNEYIVSCQSGLRSYNAERILKQEGYKVKNLDGAFGLYSKVTKELLD
>Mature_546_residues
TEKILIVGGVAGGMSAATRLRRLNENAEIIVFEKGPYVSFANCGLPYYVGGEIAEREKLIVQSAKALKNRFNLEVRENSE
VIAIDSEGKKVTVVSNGESYVESYDKLILSPGAKPLIPQIKGLNQATNVFSLRNIPDVDKIMTYLKAKAPKSATIIGAGF
IGLEMAENLAKRGLSVTIVEKAPHVLPTIDREMAAFVNEELIKNNLSVMTNRGAVEFKNDEILLDNGESLQSDLTILSVG
IQPETSLAKSAGIKLGLRNAILVDEHYETSVKDIYAVGDAIVVKNQLGQDALISLASPANRQGRQVADIISGLPIKNRGS
LGTAIVRVFDLQVASTGLSEFQLRGLKINHKIVHVTANNHAGYYPDVTSIVLKLIFEPESGQIFGAQAIGKEGVDKRIDI
LSTAIKAKLTVFDLPELELTYAPPFDSAKDPVNMAGYAAINLLLGQSENIQWHELAAELAKGKVLLDVRNPNELAKGKFK
NSQNIPLDDLRERLNELDKKNEYIVSCQSGLRSYNAERILKQEGYKVKNLDGAFGLYSKVTKELLD

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=285, Percent_Identity=26.3157894736842, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI226437568, Length=286, Percent_Identity=26.2237762237762, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI65787454, Length=285, Percent_Identity=25.9649122807018, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1789065, Length=236, Percent_Identity=27.1186440677966, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788892, Length=297, Percent_Identity=27.9461279461279, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789765, Length=319, Percent_Identity=25.0783699059561, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786307, Length=313, Percent_Identity=24.6006389776358, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082354, Length=309, Percent_Identity=24.2718446601942, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=318, Percent_Identity=26.7295597484277, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24639257, Length=290, Percent_Identity=26.2068965517241, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281359715, Length=290, Percent_Identity=26.2068965517241, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281359713, Length=290, Percent_Identity=26.2068965517241, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639250, Length=290, Percent_Identity=26.2068965517241, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18543267, Length=290, Percent_Identity=26.2068965517241, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639252, Length=290, Percent_Identity=26.2068965517241, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 59667; Mature: 59536

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKILIVGGVAGGMSAATRLRRLNENAEIIVFEKGPYVSFANCGLPYYVGGEIAEREKL
CCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCEEECCCHHHHHHH
IVQSAKALKNRFNLEVRENSEVIAIDSEGKKVTVVSNGESYVESYDKLILSPGAKPLIPQ
HHHHHHHHHHHCCEEEECCCCEEEEECCCCEEEEEECCHHHHHHHHHEEECCCCCCCCHH
IKGLNQATNVFSLRNIPDVDKIMTYLKAKAPKSATIIGAGFIGLEMAENLAKRGLSVTIV
HCCCCHHHCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCCEEEEE
EKAPHVLPTIDREMAAFVNEELIKNNLSVMTNRGAVEFKNDEILLDNGESLQSDLTILSV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEECCCEEEEECCCCCCCCEEEEEE
GIQPETSLAKSAGIKLGLRNAILVDEHYETSVKDIYAVGDAIVVKNQLGQDALISLASPA
CCCCCHHHHHHCCCEEECCCEEEEECCCCCHHHHHHHCCCEEEEECCCCCHHHHEECCCC
NRQGRQVADIISGLPIKNRGSLGTAIVRVFDLQVASTGLSEFQLRGLKINHKIVHVTANN
CCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHEEECEEEEEEEEEEEECC
HAGYYPDVTSIVLKLIFEPESGQIFGAQAIGKEGVDKRIDILSTAIKAKLTVFDLPELEL
CCCCCCCHHHHHHHHEECCCCCCEEEHHHHCCCCCHHHHHHHHHHHHHEEEEEECCCEEE
TYAPPFDSAKDPVNMAGYAAINLLLGQSENIQWHELAAELAKGKVLLDVRNPNELAKGKF
EECCCCCCCCCCCCHHHHHEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCCCHHHCCCC
KNSQNIPLDDLRERLNELDKKNEYIVSCQSGLRSYNAERILKQEGYKVKNLDGAFGLYSK
CCCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHCCHHHHHHHCCCEEECCCCHHHHHHH
VTKELLD
HHHHHCC
>Mature Secondary Structure 
TEKILIVGGVAGGMSAATRLRRLNENAEIIVFEKGPYVSFANCGLPYYVGGEIAEREKL
CCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCEEECCCHHHHHHH
IVQSAKALKNRFNLEVRENSEVIAIDSEGKKVTVVSNGESYVESYDKLILSPGAKPLIPQ
HHHHHHHHHHHCCEEEECCCCEEEEECCCCEEEEEECCHHHHHHHHHEEECCCCCCCCHH
IKGLNQATNVFSLRNIPDVDKIMTYLKAKAPKSATIIGAGFIGLEMAENLAKRGLSVTIV
HCCCCHHHCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCCEEEEE
EKAPHVLPTIDREMAAFVNEELIKNNLSVMTNRGAVEFKNDEILLDNGESLQSDLTILSV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEECCCEEEEECCCCCCCCEEEEEE
GIQPETSLAKSAGIKLGLRNAILVDEHYETSVKDIYAVGDAIVVKNQLGQDALISLASPA
CCCCCHHHHHHCCCEEECCCEEEEECCCCCHHHHHHHCCCEEEEECCCCCHHHHEECCCC
NRQGRQVADIISGLPIKNRGSLGTAIVRVFDLQVASTGLSEFQLRGLKINHKIVHVTANN
CCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHEEECEEEEEEEEEEEECC
HAGYYPDVTSIVLKLIFEPESGQIFGAQAIGKEGVDKRIDILSTAIKAKLTVFDLPELEL
CCCCCCCHHHHHHHHEECCCCCCEEEHHHHCCCCCHHHHHHHHHHHHHEEEEEECCCEEE
TYAPPFDSAKDPVNMAGYAAINLLLGQSENIQWHELAAELAKGKVLLDVRNPNELAKGKF
EECCCCCCCCCCCCHHHHHEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCCCHHHCCCC
KNSQNIPLDDLRERLNELDKKNEYIVSCQSGLRSYNAERILKQEGYKVKNLDGAFGLYSK
CCCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHCCHHHHHHHCCCEEECCCCHHHHHHH
VTKELLD
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA