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The map label for this gene is fabH

Identifier: 15672753

GI number: 15672753

Start: 781227

End: 782204

Strand: Direct

Name: fabH

Synonym: L0182

Alternate gene names: 15672753

Gene position: 781227-782204 (Clockwise)

Preceding gene: 15672752

Following gene: 15672754

Centisome position: 33.02

GC content: 40.39

Gene sequence:

>978_bases
ATGACTTTTGCGAAAATTACGCAAGTGGCACACTATGTGCCTGAAAATGTGGTATCTAATGATGACTTGTCCAAAATAAT
GGATACTAATGATGAATGGATTTACAGTCGGACAGGGATTAAAAATCGCCATATTTCAACTGGAGAGAACACCTCAGACT
TAGCAGCTAAAGTTGCTAAGCAGTTGATTAGCGATTCAAATTTAAGCCCAGAAACGATTGACTTCATCATTGTTGCTACA
GTAACTCCGGACTCATTGATGCCTTCAACCGCGGCACGGGTTCAAGCTCAAGTAGGAGCAGTTAATGCTTTTGCTTACGA
TTTGACTGCGGCTTGTTCAGGCTTTGTCTTTGCTCTATCAACAGCGGAAAAATTAATTTCCTCAGGAGCATATCAACGAG
GGCTTGTCATTGGCGCAGAAGTCTTTTCAAAAGTAATTGATTGGTCAGACCGATCAACTGCTGTTCTTTTCGGAGATGGA
GCTGCTGGTGTGCTTATTGAAGCTGGCGCGAGTCAACCTCTGATTATTGCTGAAAAAATGCAAACAGATGGAAGTCGTGG
GAACAGTTTACTTTCTAGTTATGCTGACATCCAAACTCCATTTGCCTCTGTTTCATACGAAAGTTCAAACTTGAGTATGG
AAGGGCGAGCAATTTTTGATTTTGCCGTACGTGATGTTCCTAAAAATATCCAGGCAACTTTAGAAAAAGCTAATTTGTCT
GCTGAAGAAGTAGATTATTATCTCCTTCATCAAGCGAATTCAAGAATCCTTGATAAAATGGCTAAAAAGCTTGGTGTGAC
GCGCCAAAAGTTCCTTCAAAATATGCAAGAATATGGTAACACATCGGCAGCAAGTATCCCTATATTGTTGTCAGAATCCG
TAAAAAATGGTATATTTAGTTTGGACGGTCAAACAAAAGTCGTCTTGACAGGATTTGGCGGTGGCCTCACTTGGGGTACA
GCAATTATTAATTTATAA

Upstream 100 bases:

>100_bases
CGATTACAGATAATCTATTTGATAGCGTTTATGGAACTACTGAAAATAAATTGGCTGGTGAACTTGCAACCTTACACGAT
TCTTTGGAGAATATGAAATA

Downstream 100 bases:

>100_bases
GAGCTTCAAAGTTTAGCAAGTTTTTCTTTAGTTGTCTATATAAGAAAACATTATCAGCTAACTTTGACTCACAAAAAGAT
TTTAAAAAATCTTCACTAAC

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTFAKITQVAHYVPENVVSNDDLSKIMDTNDEWIYSRTGIKNRHISTGENTSDLAAKVAKQLISDSNLSPETIDFIIVAT
VTPDSLMPSTAARVQAQVGAVNAFAYDLTAACSGFVFALSTAEKLISSGAYQRGLVIGAEVFSKVIDWSDRSTAVLFGDG
AAGVLIEAGASQPLIIAEKMQTDGSRGNSLLSSYADIQTPFASVSYESSNLSMEGRAIFDFAVRDVPKNIQATLEKANLS
AEEVDYYLLHQANSRILDKMAKKLGVTRQKFLQNMQEYGNTSAASIPILLSESVKNGIFSLDGQTKVVLTGFGGGLTWGT
AIINL

Sequences:

>Translated_325_residues
MTFAKITQVAHYVPENVVSNDDLSKIMDTNDEWIYSRTGIKNRHISTGENTSDLAAKVAKQLISDSNLSPETIDFIIVAT
VTPDSLMPSTAARVQAQVGAVNAFAYDLTAACSGFVFALSTAEKLISSGAYQRGLVIGAEVFSKVIDWSDRSTAVLFGDG
AAGVLIEAGASQPLIIAEKMQTDGSRGNSLLSSYADIQTPFASVSYESSNLSMEGRAIFDFAVRDVPKNIQATLEKANLS
AEEVDYYLLHQANSRILDKMAKKLGVTRQKFLQNMQEYGNTSAASIPILLSESVKNGIFSLDGQTKVVLTGFGGGLTWGT
AIINL
>Mature_324_residues
TFAKITQVAHYVPENVVSNDDLSKIMDTNDEWIYSRTGIKNRHISTGENTSDLAAKVAKQLISDSNLSPETIDFIIVATV
TPDSLMPSTAARVQAQVGAVNAFAYDLTAACSGFVFALSTAEKLISSGAYQRGLVIGAEVFSKVIDWSDRSTAVLFGDGA
AGVLIEAGASQPLIIAEKMQTDGSRGNSLLSSYADIQTPFASVSYESSNLSMEGRAIFDFAVRDVPKNIQATLEKANLSA
EEVDYYLLHQANSRILDKMAKKLGVTRQKFLQNMQEYGNTSAASIPILLSESVKNGIFSLDGQTKVVLTGFGGGLTWGTA
IINL

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=324, Percent_Identity=38.2716049382716, Blast_Score=233, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_LACLA (Q9CHG0)

Other databases:

- EMBL:   AE005176
- PIR:   C86721
- RefSeq:   NP_266927.1
- ProteinModelPortal:   Q9CHG0
- SMR:   Q9CHG0
- GeneID:   1114398
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0182
- NMPDR:   fig|272623.1.peg.791
- HOGENOM:   HBG649927
- OMA:   CEAVESG
- ProtClustDB:   PRK09352
- BioCyc:   LLAC272623:L0182-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34844; Mature: 34713

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 250-250 ACT_SITE 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFAKITQVAHYVPENVVSNDDLSKIMDTNDEWIYSRTGIKNRHISTGENTSDLAAKVAK
CCHHHHHHHHHHCCHHHCCCCHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHH
QLISDSNLSPETIDFIIVATVTPDSLMPSTAARVQAQVGAVNAFAYDLTAACSGFVFALS
HHHCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAEKLISSGAYQRGLVIGAEVFSKVIDWSDRSTAVLFGDGAAGVLIEAGASQPLIIAEKM
HHHHHHHCCCHHCCEEEHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEHH
QTDGSRGNSLLSSYADIQTPFASVSYESSNLSMEGRAIFDFAVRDVPKNIQATLEKANLS
CCCCCCHHHHHHHHHHHCCCHHHEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCC
AEEVDYYLLHQANSRILDKMAKKLGVTRQKFLQNMQEYGNTSAASIPILLSESVKNGIFS
HHHHHHHEEHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCCEE
LDGQTKVVLTGFGGGLTWGTAIINL
ECCCEEEEEEECCCCHHHHHHEECC
>Mature Secondary Structure 
TFAKITQVAHYVPENVVSNDDLSKIMDTNDEWIYSRTGIKNRHISTGENTSDLAAKVAK
CHHHHHHHHHHCCHHHCCCCHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHH
QLISDSNLSPETIDFIIVATVTPDSLMPSTAARVQAQVGAVNAFAYDLTAACSGFVFALS
HHHCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAEKLISSGAYQRGLVIGAEVFSKVIDWSDRSTAVLFGDGAAGVLIEAGASQPLIIAEKM
HHHHHHHCCCHHCCEEEHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEHH
QTDGSRGNSLLSSYADIQTPFASVSYESSNLSMEGRAIFDFAVRDVPKNIQATLEKANLS
CCCCCCHHHHHHHHHHHCCCHHHEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCC
AEEVDYYLLHQANSRILDKMAKKLGVTRQKFLQNMQEYGNTSAASIPILLSESVKNGIFS
HHHHHHHEEHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCCEE
LDGQTKVVLTGFGGGLTWGTAIINL
ECCCEEEEEEECCCCHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471