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The map label for this gene is ybhB

Identifier: 15672152

GI number: 15672152

Start: 173339

End: 174031

Strand: Direct

Name: ybhB

Synonym: L173329

Alternate gene names: 15672152

Gene position: 173339-174031 (Clockwise)

Preceding gene: 15672151

Following gene: 15672153

Centisome position: 7.33

GC content: 37.23

Gene sequence:

>693_bases
ATGAATTTTAATGAAATTAAACGAGATTTTACACGTTACAAGGCAACTTATATCTTATCAATTATCACACTCTTAGTTTG
GTTATGGCAATTTTTTACTTACGGAATATCGGCAACTTCAGCAATCAACTTGTTCAATAGTGGAGCCATACTTGGTCAAG
TTATGCTGTTTGACCCAAGCCAAATGTGGCGTTTGTTTACGGCACTCTTTATCCATATTGGTTGGGCACATGTTTTATTA
AATGTGGCGACGCTCTTTTTCATCGGTCGGCAAATTGAAAATGTTTTTGGTTGGCTACGTTTTACTCTGATTTATCTTTT
GTCAGGAATTTTTGGTAATGCCATGGTTTTTCTTTTGACACCTAGAGTGGTTTCGGCAGGAGCATCTACTTCTATATTTG
GCCTCTTTGCGGCAGTTGTTGGTCTAGCATTTTTTACAAAACATCCATTTTTACAACAAATCGGTCGAATGTTTACTGTG
TTGATTGTTGCTAACTTGGTTATGAATCTCTTTTCTTTAGGAAATGTAAGCATTTGGGCACATATTGGCGGGGCAATTGG
TGGACTGCTTTTGTCAGCAATTTTTGCTCCTAAGGCTTTCATTCCATCTATTCCCAAACAATACCGTATTTTTGCAACAG
GCGCCTTTGTTATTCTCTTGGTTCTCTTTATCGGTTTACCATTTTTCAAGTAA

Upstream 100 bases:

>100_bases
GGATCAACGGCCTCTGTACTTTATGATTTTCAAAAAATGGATTTTGAGGCAGAAAGCCATGACATCGCAGTACAAGAACT
TTTTATAGGGAGAAAAAATA

Downstream 100 bases:

>100_bases
AAATATGTTTTGCTTTTGAAAACATGAAAGTGCTTGCAAAGAATCTTTAATCTTGTTAGAATAAACTTAGTTAAAAAACT
TGCTGAGGGAGAAAAAAAGA

Product: hypothetical protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MNFNEIKRDFTRYKATYILSIITLLVWLWQFFTYGISATSAINLFNSGAILGQVMLFDPSQMWRLFTALFIHIGWAHVLL
NVATLFFIGRQIENVFGWLRFTLIYLLSGIFGNAMVFLLTPRVVSAGASTSIFGLFAAVVGLAFFTKHPFLQQIGRMFTV
LIVANLVMNLFSLGNVSIWAHIGGAIGGLLLSAIFAPKAFIPSIPKQYRIFATGAFVILLVLFIGLPFFK

Sequences:

>Translated_230_residues
MNFNEIKRDFTRYKATYILSIITLLVWLWQFFTYGISATSAINLFNSGAILGQVMLFDPSQMWRLFTALFIHIGWAHVLL
NVATLFFIGRQIENVFGWLRFTLIYLLSGIFGNAMVFLLTPRVVSAGASTSIFGLFAAVVGLAFFTKHPFLQQIGRMFTV
LIVANLVMNLFSLGNVSIWAHIGGAIGGLLLSAIFAPKAFIPSIPKQYRIFATGAFVILLVLFIGLPFFK
>Mature_230_residues
MNFNEIKRDFTRYKATYILSIITLLVWLWQFFTYGISATSAINLFNSGAILGQVMLFDPSQMWRLFTALFIHIGWAHVLL
NVATLFFIGRQIENVFGWLRFTLIYLLSGIFGNAMVFLLTPRVVSAGASTSIFGLFAAVVGLAFFTKHPFLQQIGRMFTV
LIVANLVMNLFSLGNVSIWAHIGGAIGGLLLSAIFAPKAFIPSIPKQYRIFATGAFVILLVLFIGLPFFK

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI190341097, Length=142, Percent_Identity=34.5070422535211, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI93352558, Length=143, Percent_Identity=35.6643356643357, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI301069362, Length=143, Percent_Identity=35.6643356643357, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115534507, Length=168, Percent_Identity=34.5238095238095, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI115532986, Length=161, Percent_Identity=31.055900621118, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI133901888, Length=161, Percent_Identity=31.055900621118, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 25692; Mature: 25692

Theoretical pI: Translated: 11.13; Mature: 11.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFNEIKRDFTRYKATYILSIITLLVWLWQFFTYGISATSAINLFNSGAILGQVMLFDPS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCHH
QMWRLFTALFIHIGWAHVLLNVATLFFIGRQIENVFGWLRFTLIYLLSGIFGNAMVFLLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRVVSAGASTSIFGLFAAVVGLAFFTKHPFLQQIGRMFTVLIVANLVMNLFSLGNVSIWA
HHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
HIGGAIGGLLLSAIFAPKAFIPSIPKQYRIFATGAFVILLVLFIGLPFFK
HHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNFNEIKRDFTRYKATYILSIITLLVWLWQFFTYGISATSAINLFNSGAILGQVMLFDPS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCHH
QMWRLFTALFIHIGWAHVLLNVATLFFIGRQIENVFGWLRFTLIYLLSGIFGNAMVFLLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRVVSAGASTSIFGLFAAVVGLAFFTKHPFLQQIGRMFTVLIVANLVMNLFSLGNVSIWA
HHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
HIGGAIGGLLLSAIFAPKAFIPSIPKQYRIFATGAFVILLVLFIGLPFFK
HHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]