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The map label for this gene is mtlD

Identifier: 15672006

GI number: 15672006

Start: 33476

End: 34633

Strand: Direct

Name: mtlD

Synonym: L33416

Alternate gene names: 15672006

Gene position: 33476-34633 (Clockwise)

Preceding gene: 15672005

Following gene: 15672021

Centisome position: 1.42

GC content: 33.59

Gene sequence:

>1158_bases
ATGAAAAAAGCAGTACATTTTGGTGCAGGAAATATTGGACGTGGTTTCATAGGTGAAATTTTGAGTAAAAATGGATTTGA
TATTCACTTTGTTGACACAAATAAATCTATAATTGCCGAACTTAATAATCGGCATTCCTATGAAATTGGGATTGCAAGTA
GTGAACATGAAAAAATTTCTGTAAAAGCTGTCTCTGGTATTAACAATAGTGAGAATCCTGAGGCAGTCATTGAAGCAATT
GCAAAAGCTGATATTCTAACAACAGCGATTGGTCCTAATGTCTTGCCTTATATTGCTGAGCTTATTGCAAAAGGACTTCA
GAAACGTAAGGAAGAAAAGGTTCAGAGCCCGTTAGATATTATTGCCTGTGAGAATATGATAGGGGGCTCTGAATTTTTGG
AAGAAAAAGTGTCCGATTATCTGTCGGAATCTGATAAACTTTATCTTTCTAAATTTATTGGTTTTCCTAATGCTGCAGTT
GACCGTATTGTTCCTGCTCAAAAACATAAAGATGTTCTCTATGTTGAGGTAGAGCCTTTTAGTGAGTGGGTAATAGATGC
AAGTCATTTAAAAAATAAAGAAATCAAACTTGAAGGAGTTCATTATACAACTGACCTCGAACCATTTATTGAGCGTAAAC
TTTTTTCTGTAAACTCAGGACATGCTGCAGTTGCCTATTCTAGCGCATATAAAGGTTATAAAACAATATTAGAAGGTTTA
CAGGATGAAGAAATTTTGAATATCCTAAAAGCAGTTCAAAAAGAAACACGCGCTTTACTTTTAGCAAAATGGGCTCAATA
TTTTAAGCAAGATGAGTTAATTAAATATCATGAACTAATCATTTCTCGCTTTTCTAATCCAGAAATTATTGATGAAGTGT
CACGCGTGGCAAGAACACCTATCCGGAAATTAGGATATGATGAACGTTTTATTCGTCCAATAAGAGAATTAAACGATCGT
AAGCTTTCTTATCAAAATCATCTAGATATTGTTGGAAAAATTTTTGCTTACCATGATGAAAATGATGCTCAAGCCATTCA
ACTCCAAGAAAAACTAAAAATAACAGAACTCCCAATGCTCATTGAAGAAGTGACTGGTCTAAGCAATCAAAAGTTGATTT
TGGAAATCGAAAAGGTTATTAATCACTATAAAAAATAA

Upstream 100 bases:

>100_bases
TTTACCAGCATAATGTAAAAGCTTACAATTACTTATATAGAGGGATTTTAGAGAATTCTATTTGAACTTTTACTTTCTAA
ATAAAGGAGCAGTAAGTAAG

Downstream 100 bases:

>100_bases
AATTTGGTAGAGATGATGATTTTTTATTAATACAATTTATGATTCAAAATTTAACCGCTTTCTATTGAAAAAAAAGATAA
AAAGTGTTATTATATAATCA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKKAVHFGAGNIGRGFIGEILSKNGFDIHFVDTNKSIIAELNNRHSYEIGIASSEHEKISVKAVSGINNSENPEAVIEAI
AKADILTTAIGPNVLPYIAELIAKGLQKRKEEKVQSPLDIIACENMIGGSEFLEEKVSDYLSESDKLYLSKFIGFPNAAV
DRIVPAQKHKDVLYVEVEPFSEWVIDASHLKNKEIKLEGVHYTTDLEPFIERKLFSVNSGHAAVAYSSAYKGYKTILEGL
QDEEILNILKAVQKETRALLLAKWAQYFKQDELIKYHELIISRFSNPEIIDEVSRVARTPIRKLGYDERFIRPIRELNDR
KLSYQNHLDIVGKIFAYHDENDAQAIQLQEKLKITELPMLIEEVTGLSNQKLILEIEKVINHYKK

Sequences:

>Translated_385_residues
MKKAVHFGAGNIGRGFIGEILSKNGFDIHFVDTNKSIIAELNNRHSYEIGIASSEHEKISVKAVSGINNSENPEAVIEAI
AKADILTTAIGPNVLPYIAELIAKGLQKRKEEKVQSPLDIIACENMIGGSEFLEEKVSDYLSESDKLYLSKFIGFPNAAV
DRIVPAQKHKDVLYVEVEPFSEWVIDASHLKNKEIKLEGVHYTTDLEPFIERKLFSVNSGHAAVAYSSAYKGYKTILEGL
QDEEILNILKAVQKETRALLLAKWAQYFKQDELIKYHELIISRFSNPEIIDEVSRVARTPIRKLGYDERFIRPIRELNDR
KLSYQNHLDIVGKIFAYHDENDAQAIQLQEKLKITELPMLIEEVTGLSNQKLILEIEKVINHYKK
>Mature_385_residues
MKKAVHFGAGNIGRGFIGEILSKNGFDIHFVDTNKSIIAELNNRHSYEIGIASSEHEKISVKAVSGINNSENPEAVIEAI
AKADILTTAIGPNVLPYIAELIAKGLQKRKEEKVQSPLDIIACENMIGGSEFLEEKVSDYLSESDKLYLSKFIGFPNAAV
DRIVPAQKHKDVLYVEVEPFSEWVIDASHLKNKEIKLEGVHYTTDLEPFIERKLFSVNSGHAAVAYSSAYKGYKTILEGL
QDEEILNILKAVQKETRALLLAKWAQYFKQDELIKYHELIISRFSNPEIIDEVSRVARTPIRKLGYDERFIRPIRELNDR
KLSYQNHLDIVGKIFAYHDENDAQAIQLQEKLKITELPMLIEEVTGLSNQKLILEIEKVINHYKK

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=377, Percent_Identity=38.9920424403183, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1788497, Length=284, Percent_Identity=25.7042253521127, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787823, Length=233, Percent_Identity=26.1802575107296, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790779, Length=233, Percent_Identity=25.3218884120172, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324401, Length=199, Percent_Identity=26.1306532663317, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320765, Length=199, Percent_Identity=26.1306532663317, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_LACLA (Q9CJH1)

Other databases:

- EMBL:   AE005176
- PIR:   H86627
- RefSeq:   NP_266180.1
- ProteinModelPortal:   Q9CJH1
- GeneID:   1113623
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L33416
- NMPDR:   fig|272623.1.peg.25
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- ProtClustDB:   PRK02318
- BioCyc:   LLAC272623:L33416-MONOMER
- BRENDA:   1.1.1.17
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 43674; Mature: 43674

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAVHFGAGNIGRGFIGEILSKNGFDIHFVDTNKSIIAELNNRHSYEIGIASSEHEKIS
CCCCEECCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCEEEECCCCCCCEEE
VKAVSGINNSENPEAVIEAIAKADILTTAIGPNVLPYIAELIAKGLQKRKEEKVQSPLDI
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IACENMIGGSEFLEEKVSDYLSESDKLYLSKFIGFPNAAVDRIVPAQKHKDVLYVEVEPF
HHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCEEEEEECCH
SEWVIDASHLKNKEIKLEGVHYTTDLEPFIERKLFSVNSGHAAVAYSSAYKGYKTILEGL
HHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCC
QDEEILNILKAVQKETRALLLAKWAQYFKQDELIKYHELIISRFSNPEIIDEVSRVARTP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCH
IRKLGYDERFIRPIRELNDRKLSYQNHLDIVGKIFAYHDENDAQAIQLQEKLKITELPML
HHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHH
IEEVTGLSNQKLILEIEKVINHYKK
HHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKAVHFGAGNIGRGFIGEILSKNGFDIHFVDTNKSIIAELNNRHSYEIGIASSEHEKIS
CCCCEECCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCEEEECCCCCCCEEE
VKAVSGINNSENPEAVIEAIAKADILTTAIGPNVLPYIAELIAKGLQKRKEEKVQSPLDI
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IACENMIGGSEFLEEKVSDYLSESDKLYLSKFIGFPNAAVDRIVPAQKHKDVLYVEVEPF
HHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCEEEEEECCH
SEWVIDASHLKNKEIKLEGVHYTTDLEPFIERKLFSVNSGHAAVAYSSAYKGYKTILEGL
HHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCC
QDEEILNILKAVQKETRALLLAKWAQYFKQDELIKYHELIISRFSNPEIIDEVSRVARTP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCH
IRKLGYDERFIRPIRELNDRKLSYQNHLDIVGKIFAYHDENDAQAIQLQEKLKITELPML
HHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHH
IEEVTGLSNQKLILEIEKVINHYKK
HHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471