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The map label for this gene is lpxC

Identifier: 15835434

GI number: 15835434

Start: 952343

End: 953218

Strand: Reverse

Name: lpxC

Synonym: TC0820

Alternate gene names: 15835434

Gene position: 953218-952343 (Counterclockwise)

Preceding gene: 15835435

Following gene: 15835433

Centisome position: 88.84

GC content: 43.72

Gene sequence:

>876_bases
TTGTCAAGGTTTTGCATGTTAGGTCGAGCTCAGAGAACGTTAAAGCGTAAGGTATGCTATTCCGGGGTGGGAGTGCATTT
TGGAAAGCCAGCGATGCTTACTCTTGAGCCAGCAGAAGAGAATACTGGAGTGGTTTTCTCGCGTCATGCAGCTTCTGGAC
AGTATATTCCCGCTCGATTGGCTAACGTTTGTGGGACAGGGCGTAGCACTACATTGTCTTCACAAGGTGGTGTTGTATCC
ACTGTAGAACATTTGTTAGCAGCGCTGTACTCTTGTGGTGTAGATAATGTACGCATCCATTGCAGCGAAGACGAAATTCC
CATAGGCGATGGGAGCTCCCAAGTGTTCGTAGACCTCATAGACCAAGCAGGAGTTGAAGAACAGGGGCAAACGGTTCCTA
TAGCGAGACTTACTCACCCTGTCTATTACCAGCATCAGGATACAATTTTAGCAGCATTCCCTTCGGAGGAATTTAAGATT
TCTTATACCCTGCACTATTCGCATAACTCTGCGATAGGCACGCAATATCGTTCCCAGGTGATTTCCGAAGAATCTTTTCG
TAAAGAAATTGCTCCCTGTAGGACATTCGCTCTATACAATGAACTCTGCTTTCTTATGGAAAGGGGACTTATTGGTGGAG
GTTGTTTAGGTAATGCTGTGTTATTTAAAGATGATAGTGTCATTAGTTTGGGCAAGCTACGTTTCCCTGATGAGCCTGTT
CGCCATAAAATGTTAGATCTAATAGGAGATTTATCTCTAATTGGGAAACCTTTTTTAGCACACATTATAGCTGTGGGGTC
AGGGCATTCTTCTAATATTGCCTTAGGGAATAAAATTTTAGAGGCGTTGCAGTATGAACAGGAGTTAGTAAAATGA

Upstream 100 bases:

>100_bases
GGGAGTGACATTTGAAATAGCAAGTGTTTCAAAACTAATCAGTAATTTTTTGATATCGCTTGCTTGCTAAAAAAAAAAAA
GGATAATATACGGGGTCTCT

Downstream 100 bases:

>100_bases
GTGAAAAGCCTGTATTAGGAATCCAAGATATACAAAATTTGCTTCCACACCGATATCCCTTCCTATTAGTGGATAAAATT
CTTTCTTATGATTTAAATAC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSRFCMLGRAQRTLKRKVCYSGVGVHFGKPAMLTLEPAEENTGVVFSRHAASGQYIPARLANVCGTGRSTTLSSQGGVVS
TVEHLLAALYSCGVDNVRIHCSEDEIPIGDGSSQVFVDLIDQAGVEEQGQTVPIARLTHPVYYQHQDTILAAFPSEEFKI
SYTLHYSHNSAIGTQYRSQVISEESFRKEIAPCRTFALYNELCFLMERGLIGGGCLGNAVLFKDDSVISLGKLRFPDEPV
RHKMLDLIGDLSLIGKPFLAHIIAVGSGHSSNIALGNKILEALQYEQELVK

Sequences:

>Translated_291_residues
MSRFCMLGRAQRTLKRKVCYSGVGVHFGKPAMLTLEPAEENTGVVFSRHAASGQYIPARLANVCGTGRSTTLSSQGGVVS
TVEHLLAALYSCGVDNVRIHCSEDEIPIGDGSSQVFVDLIDQAGVEEQGQTVPIARLTHPVYYQHQDTILAAFPSEEFKI
SYTLHYSHNSAIGTQYRSQVISEESFRKEIAPCRTFALYNELCFLMERGLIGGGCLGNAVLFKDDSVISLGKLRFPDEPV
RHKMLDLIGDLSLIGKPFLAHIIAVGSGHSSNIALGNKILEALQYEQELVK
>Mature_290_residues
SRFCMLGRAQRTLKRKVCYSGVGVHFGKPAMLTLEPAEENTGVVFSRHAASGQYIPARLANVCGTGRSTTLSSQGGVVST
VEHLLAALYSCGVDNVRIHCSEDEIPIGDGSSQVFVDLIDQAGVEEQGQTVPIARLTHPVYYQHQDTILAAFPSEEFKIS
YTLHYSHNSAIGTQYRSQVISEESFRKEIAPCRTFALYNELCFLMERGLIGGGCLGNAVLFKDDSVISLGKLRFPDEPVR
HKMLDLIGDLSLIGKPFLAHIIAVGSGHSSNIALGNKILEALQYEQELVK

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=281, Percent_Identity=38.4341637010676, Blast_Score=170, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 31775; Mature: 31644

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFCMLGRAQRTLKRKVCYSGVGVHFGKPAMLTLEPAEENTGVVFSRHAASGQYIPARL
CCCHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHH
ANVCGTGRSTTLSSQGGVVSTVEHLLAALYSCGVDNVRIHCSEDEIPIGDGSSQVFVDLI
HHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHH
DQAGVEEQGQTVPIARLTHPVYYQHQDTILAAFPSEEFKISYTLHYSHNSAIGTQYRSQV
HHCCCCCCCCCCCHHHHCCCEEEECCCEEEEECCCCCEEEEEEEEECCCCCHHHHHHHHH
ISEESFRKEIAPCRTFALYNELCFLMERGLIGGGCLGNAVLFKDDSVISLGKLRFPDEPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEECCCCCCCCHH
RHKMLDLIGDLSLIGKPFLAHIIAVGSGHSSNIALGNKILEALQYEQELVK
HHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRFCMLGRAQRTLKRKVCYSGVGVHFGKPAMLTLEPAEENTGVVFSRHAASGQYIPARL
CCHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHH
ANVCGTGRSTTLSSQGGVVSTVEHLLAALYSCGVDNVRIHCSEDEIPIGDGSSQVFVDLI
HHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHH
DQAGVEEQGQTVPIARLTHPVYYQHQDTILAAFPSEEFKISYTLHYSHNSAIGTQYRSQV
HHCCCCCCCCCCCHHHHCCCEEEECCCEEEEECCCCCEEEEEEEEECCCCCHHHHHHHHH
ISEESFRKEIAPCRTFALYNELCFLMERGLIGGGCLGNAVLFKDDSVISLGKLRFPDEPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEECCCCCCCCHH
RHKMLDLIGDLSLIGKPFLAHIIAVGSGHSSNIALGNKILEALQYEQELVK
HHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]